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Brownian Dynamics Simulation of Nucleosome Formation and Disruption under Stretching

Wei Li·Shuo-Xing Dou·Peng-Ye Wang
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Abstract

Using a Brownian dynamics simulation, we numerically studied the interaction of DNA with histone and proposed an octamer-rotation model to describe the process of nucleosome formation. Nucleosome disruption under stretching was also simulated. The theoretical curves of extension versus time as well as of force versus extension are consistent with previous experimental results.

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Wei Li, Shuo-Xing Dou, Peng-Ye Wang. 2004-11-16. Brownian Dynamics Simulation of Nucleosome Formation and Disruption under Stretching. https://arxiv.org/abs/q-bio/0312036

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