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Base sequence dependent sliding of proteins on DNA

M. Barbi·C. Place·V. Popkov·M. Salerno
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Abstract

The possibility that the sliding motion of proteins on DNA is influenced by the base sequence through a base pair reading interaction, is considered. Referring to the case of the T7 RNA-polymerase, we show that the protein should follow a noise-influenced sequence-dependent motion which deviate from the standard random walk usually assumed. The general validity and the implications of the results are discussed.

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M. Barbi, C. Place, V. Popkov, M. Salerno. 2004-03-19. Base sequence dependent sliding of proteins on DNA. https://doi.org/10.1103/physreve.70.041901

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