Searcharxiv⌕ Search

arXiv subjects

Ana Marija Kožuljević

Publications and source records attributed to Ana Marija Kožuljević.

6 recordsLinked to original sources

Omnidirectional Radiation Detector with Perpendicular Dual Silicon Photomultiplier Readout - Directional Sensitivity and Machine Learning Source Positioning

Directional information of incident gamma rays in radiation detection is essential to many applications, from medical imaging to mapping radioactive contamination after nuclear accidents, characterization of nuclear waste during decommissioning, and nuclear security. In this work, we present a radiation detector capable of detecting gamma-ray photons in 4$π$, utilizing Gadolinium Aluminum Gallium Garnet (GAGG) scintillating crystals and silicon photomultipliers (SiPMs). The GAGG crystals are assembled in a cubical 4$\times$4$\times$4 matrix, and their light output is read out by SiPMs from two neighboring sides. The size of each crystal is 3$\times$3$\times$3 mm$^3$, while the matrix pitch is 3.2 mm, matching the size and the pitch of the 4$\times$4 SiPMs for one-to-one coupling. The layers perpendicular to the SiPMs are separated by optical reflectors, providing efficient light collection while lowering the probability of inter-crystal leakage. The design of the radiation detector offers high detection efficiency and full-view imaging of gamma-ray sources through Compton scattering. Monte Carlo simulations were performed in Geant4 to evaluate the detection efficiency of the proposed design due to its geometrical non-uniformity. Machine learning models developed with the XGBoost algorithm were trained and tested on the simulated data to assess the capability of the detector to localize point sources of 511, 662, and 1275 keV energies. We find that the proposed design does not influence the collection efficiency of the high-energy gamma-ray photons and offers sensitivity to the direction of the incoming gamma rays. The trained models are capable of determining the source-to-detector distance of the Na-22 and Cs-137 point sources from measurements, thus providing initial conditions for faster image reconstruction.

physics.ins-det↗

Roadmap Towards Quantum Entanglement Positron Emission Tomography (QE-PET)

Annihilation photons are quantum entangled in their polarization, a property that is not accessible in state-of-the-art clinical Positron Emission Tomography (PET). This roadmap describes the current status of research in the emerging field of quantum entanglement applications involving these photons for medical diagnosis. It outlines the underlying physics phenomena and the development of detector systems that can serve as a foundation for future Quantum Entanglement PET (QE-PET) scanners. These scanners will be capable of utilizing the entanglement between annihilation photons by measuring their Compton scattering on electrons. This roadmap comprises up-to-date experimental results on the study of quantum entanglement and the decoherence of annihilation photons, alongside the current theoretical understanding of these phenomena. The methods and detector technologies described herein are being developed (i) in order to enhance standard PET imaging by suppressing random coincidences in the reconstruction of annihilation site density distributions, (ii) in order to establish the degree of quantum entanglement as a diagnostic biomarker for tissue pathology and oxygenation, and (iii) in order to elaborate a method for pH imaging. Whether entanglement-based imaging and pH mapping can be successfully translated into clinical practice remains an open question and a subject of exciting ongoing research. This roadmap serves as an invitation to the scientific community to join this burgeoning field.

physics.med-ph↗

Positron Emission Tomography with quantum-entangled Compton events: first imaging results at clinically relevant activities

In Positron Emission Tomography, a potential, yet unutilized enhancement, may come from exploiting the quantum entanglement of the annihilation quanta, inscribed in the correlation of their polarizations. To investigate this, we built a PET demonstrator capable of measuring polarization correlations of annihilation quanta by their Compton scattering, based on single-layer scintillator polarimeters. We present a detailed study of the imaging of two $^{68}$Ge line sources, 45 MBq each, to extract the spatial resolution and assess image quality. The results show that a spatial resolution of 2.5$\pm$0.1 mm is obtained using single-pixel events, while resolutions obtained with polarization-correlated Compton events range from 3.6$\pm$0.3 mm to 4.9$\pm$0.3 mm, depending on data selection criteria. We also found that the polarization-correlated Compton events exhibit up to 20% higher average signal to random background ratio compared to the single-pixel events. We also present the first imaging of the NEMA NU-4 phantom filled with a $^{68}$Ga solution of 378 MBq initial activity, successfully combining polarization-correlated events with conventional single-pixel event selection. Based on the extracted spatial resolution, signal-to-background, signal-to-noise, contrast, and contrast-to-noise ratio, we estimate that up to 10% sensitivity increase may be attained by exploiting the polarization-correlated events, while preserving a high image quality.

physics.ins-det↗

Towards polarization-enhanced PET: Study of random background in polarization-correlated Compton events

Positron Emission Tomography (PET) is a medical imaging modality that utilizes positron-emitting isotopes, such as Ga-68 and F-18, for many diagnostic purposes. The positron annihilates with an electron from the surrounding area, creating two photons of 511 keV energy and opposite momenta, entangled in their orthogonal polarizations. When each photon undergoes a Compton scattering process, the difference of their azimuthal scattering angles reflects the initial orthogonality of their polarizations, peaking at $\pm$90$^{\circ}$. This type of correlation is not yet utilized in conventional PET scanners, but could potentially offer an energy-independent method for background reduction. Measurements of these kinds of correlations can be achieved using Compton polarimeters, built from a single layer of segmented scintillating crystals such as Gadolinium Aluminium Gallium Garnet doped with Cerium (GAGG:Ce), read out by silicon photomultipliers (SiPMs). In this paper, we study the signal-to-random background ratios in measurements of these correlated annihilation photons from coincidence time spectra across clinically relevant source activities, from $\sim$200 MBq to $\sim$378 MBq. These are then compared to the standard single-pixel (photoelectric) measurements. We find that the signal-to-random background ratios (SBRs) obtained from the polarization-correlated events for Compton scattering angles $θ_{1,2}\in[72^{\circ}, 90^{\circ}]$ and azimuthal angle difference $Δϕ=90^{\circ}\pm20^{\circ}$ are consistently higher than those from single-pixel events, with the ratio of their SBR values of 1.23. The SBR of the selected events also increases with the polarimetric modulation factor $μ$, gaining $\sim$50\% in value during the experiment.

physics.ins-det↗

Investigation of the spatial resolution of PET imaging system measuring polarization-correlated Compton events

Recent studies of positron emission tomography (PET) devices have shown that the detection of polarization-correlated annihilation quanta can potentially reduce the background and creation of false lines of response (LORs) leading to improved image quality. We developed a novel PET demonstrator system, capable of measuring correlated gamma photons with single-layer Compton polarimeters to explore the potential of the method. We tested the system using sources with clinically relevant activities at the University Hospital Centre Zagreb. Here we present, for the first time, the images of two Ge-68 line sources, reconstructed solely from the correlated annihilation events. The spatial resolution at two different diameters is determined and compared to the one obtained from events with photoelectric interaction.

physics.ins-det↗

Optimization of detector modules for measuring gamma-ray polarization in Positron Emission Tomography

Detection of $γ$-ray polarization in Positron Emission Tomography (PET) is as yet an unexploited feature that could be used as an additional handle to improve signal-to-background ratio in this imaging modality. The $γ$ polarization is related to the azimuthal angle in the Compton scattering process, so the initial correlation of polarizations of the annihilation quanta translates to the correlation of the azimuthal angles in events where both annihilation photons undergo Compton scattering. This results in a modulated distribution of the azimuthal angle difference for true events, while this modulation is lacking for the background events. We present a comprehensive experimental study of five detector configurations based on scintillator matrices and silicon photomultipliers, suitable for measuring the azimuthal modulation. The modules consist of either GaGG:Ce or LYSO:Ce pixels with sizes varying from 1.9x1.9x20 $\mathrm{mm^3}$ to 3x3x20 $\mathrm{mm^3}$. The distinctive feature of the modules is that they can reconstruct the Compton scattering by detecting the recoil electron and the scattered gamma in a single detector layer, which simplifies extension to larger systems. The amplitude modulation of the azimuthal angles' difference is clearly observable in all configurations ranging from $0.26\pm0.01$ to $0.34\pm 0.02$ depending on the event selection criteria. The results suggest that finer detector segmentation plays a leading role in achieving higher modulation factors.

physics.ins-det↗