Positron Emission Tomography with quantum-entangled Compton events: first imaging results at clinically relevant activities

Abstract

In Positron Emission Tomography, a potential, yet unutilized enhancement, may come from exploiting the quantum entanglement of the annihilation quanta, inscribed in the correlation of their polarizations. To investigate this, we built a PET demonstrator capable of measuring polarization correlations of annihilation quanta by their Compton scattering, based on single-layer scintillator polarimeters. We present a detailed study of the imaging of two $^{68}$Ge line sources, 45 MBq each, to extract the spatial resolution and assess image quality. The results show that a spatial resolution of 2.5$\pm$0.1 mm is obtained using single-pixel events, while resolutions obtained with polarization-correlated Compton events range from 3.6$\pm$0.3 mm to 4.9$\pm$0.3 mm, depending on data selection criteria. We also found that the polarization-correlated Compton events exhibit up to 20% higher average signal to random background ratio compared to the single-pixel events. We also present the first imaging of the NEMA NU-4 phantom filled with a $^{68}$Ga solution of 378 MBq initial activity, successfully combining polarization-correlated events with conventional single-pixel event selection. Based on the extracted spatial resolution, signal-to-background, signal-to-noise, contrast, and contrast-to-noise ratio, we estimate that up to 10% sensitivity increase may be attained by exploiting the polarization-correlated events, while preserving a high image quality.