arXiv subjects

Andrea Cossettini

Publications and source records attributed to Andrea Cossettini.

29 records · Page 2Linked to original sources

arXiv2025

Real-Time, Single-Ear, Wearable ECG Reconstruction, R-Peak Detection, and HR/HRV Monitoring

Biosignal monitoring, in particular heart activity through heart rate (HR) and heart rate variability (HRV) tracking, is vital in enabling continuous, non-invasive tracking of physiological and cognitive states. Recent studies have explored compact, head-worn devices for HR and HRV monitoring to improve usability and reduce stigma. However, this approach is challenged by the current reliance on wet electrodes, which limits usability, the weakness of ear-derived signals, making HR/HRV extraction more complex, and the incompatibility of current algorithms for embedded deployment. This work introduces a single-ear wearable system for real-time ECG (Electrocardiogram) parameter estimation, which directly runs on BioGAP, an energy-efficient device for biosignal acquisition and processing. By combining SoA in-ear electrode technology, an optimized DeepMF algorithm, and BioGAP, our proposed subject-independent approach allows for robust extraction of HR/HRV parameters directly on the device with just 36.7 uJ/inference at comparable performance with respect to the current state-of-the-art architecture, achieving 0.49 bpm and 25.82 ms for HR/HRV mean errors, respectively and an estimated battery life of 36h with a total system power consumption of 7.6 mW. Clinical relevance: The ability to reconstruct ECG signals and extract HR and HRV paves the way for continuous, unobtrusive cardiovascular monitoring with head-worn devices. In particular, the integration of cardiovascular measurements in everyday-use devices (such as earbuds) has potential in continuous at-home monitoring to enable early detection of cardiovascular irregularities.

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arXiv2024

Train-On-Request: An On-Device Continual Learning Workflow for Adaptive Real-World Brain Machine Interfaces

Brain-machine interfaces (BMIs) are expanding beyond clinical settings thanks to advances in hardware and algorithms. However, they still face challenges in user-friendliness and signal variability. Classification models need periodic adaptation for real-life use, making an optimal re-training strategy essential to maximize user acceptance and maintain high performance. We propose TOR, a train-on-request workflow that enables user-specific model adaptation to novel conditions, addressing signal variability over time. Using continual learning, TOR preserves knowledge across sessions and mitigates inter-session variability. With TOR, users can refine, on demand, the model through on-device learning (ODL) to enhance accuracy adapting to changing conditions. We evaluate the proposed methodology on a motor-movement dataset recorded with a non-stigmatizing wearable BMI headband, achieving up to 92% accuracy and a re-calibration time as low as 1.6 minutes, a 46% reduction compared to a naive transfer learning workflow. We additionally demonstrate that TOR is suitable for ODL in extreme edge settings by deploying the training procedure on a RISC-V ultra-low-power SoC (GAP9), resulting in 21.6 ms of latency and 1 mJ of energy consumption per training step. To the best of our knowledge, this work is the first demonstration of an online, energy-efficient, dynamic adaptation of a BMI model to the intrinsic variability of EEG signals in real-time settings.

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arXiv2024

An Ultra-Low Power Wearable BMI System with Continual Learning Capabilities

Driven by the progress in efficient embedded processing, there is an accelerating trend toward running machine learning models directly on wearable Brain-Machine Interfaces (BMIs) to improve portability and privacy and maximize battery life. However, achieving low latency and high classification performance remains challenging due to the inherent variability of electroencephalographic (EEG) signals across sessions and the limited onboard resources. This work proposes a comprehensive BMI workflow based on a CNN-based Continual Learning (CL) framework, allowing the system to adapt to inter-session changes. The workflow is deployed on a wearable, parallel ultra-low power BMI platform (BioGAP). Our results based on two in-house datasets, Dataset A and Dataset B, show that the CL workflow improves average accuracy by up to 30.36% and 10.17%, respectively. Furthermore, when implementing the continual learning on a Parallel Ultra-Low Power (PULP) microcontroller (GAP9), it achieves an energy consumption as low as 0.45mJ per inference and an adaptation time of only 21.5ms, yielding around 25h of battery life with a small 100mAh, 3.7V battery on BioGAP. Our setup, coupled with the compact CNN model and on-device CL capabilities, meets users' needs for improved privacy, reduced latency, and enhanced inter-session performance, offering good promise for smart embedded real-world BMIs.

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arXiv2024

BISeizuRe: BERT-Inspired Seizure Data Representation to Improve Epilepsy Monitoring

This study presents a novel approach for EEG-based seizure detection leveraging a BERT-based model. The model, BENDR, undergoes a two-phase training process. Initially, it is pre-trained on the extensive Temple University Hospital EEG Corpus (TUEG), a 1.5 TB dataset comprising over 10,000 subjects, to extract common EEG data patterns. Subsequently, the model is fine-tuned on the CHB-MIT Scalp EEG Database, consisting of 664 EEG recordings from 24 pediatric patients, of which 198 contain seizure events. Key contributions include optimizing fine-tuning on the CHB-MIT dataset, where the impact of model architecture, pre-processing, and post-processing techniques are thoroughly examined to enhance sensitivity and reduce false positives per hour (FP/h). We also explored custom training strategies to ascertain the most effective setup. The model undergoes a novel second pre-training phase before subject-specific fine-tuning, enhancing its generalization capabilities. The optimized model demonstrates substantial performance enhancements, achieving as low as 0.23 FP/h, 2.5$\times$ lower than the baseline model, with a lower but still acceptable sensitivity rate, showcasing the effectiveness of applying a BERT-based approach on EEG-based seizure detection.

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arXiv2024

Enhancing Performance, Calibration Time and Efficiency in Brain-Machine Interfaces through Transfer Learning and Wearable EEG Technology

Brain-machine interfaces (BMIs) have emerged as a transformative force in assistive technologies, empowering individuals with motor impairments by enabling device control and facilitating functional recovery. However, the persistent challenge of inter-session variability poses a significant hurdle, requiring time-consuming calibration at every new use. Compounding this issue, the low comfort level of current devices further restricts their usage. To address these challenges, we propose a comprehensive solution that combines a tiny CNN-based Transfer Learning (TL) approach with a comfortable, wearable EEG headband. The novel wearable EEG device features soft dry electrodes placed on the headband and is capable of on-board processing. We acquire multiple sessions of motor-movement EEG data and achieve up to 96% inter-session accuracy using TL, greatly reducing the calibration time and improving usability. By executing the inference on the edge every 100ms, the system is estimated to achieve 30h of battery life. The comfortable BMI setup with tiny CNN and TL paves the way to future on-device continual learning, essential for tackling inter-session variability and improving usability.

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arXiv2024

SzCORE: A Seizure Community Open-source Research Evaluation framework for the validation of EEG-based automated seizure detection algorithms

The need for high-quality automated seizure detection algorithms based on electroencephalography (EEG) becomes ever more pressing with the increasing use of ambulatory and long-term EEG monitoring. Heterogeneity in validation methods of these algorithms influences the reported results and makes comprehensive evaluation and comparison challenging. This heterogeneity concerns in particular the choice of datasets, evaluation methodologies, and performance metrics. In this paper, we propose a unified framework designed to establish standardization in the validation of EEG-based seizure detection algorithms. Based on existing guidelines and recommendations, the framework introduces a set of recommendations and standards related to datasets, file formats, EEG data input content, seizure annotation input and output, cross-validation strategies, and performance metrics. We also propose the 10-20 seizure detection benchmark, a machine-learning benchmark based on public datasets converted to a standardized format. This benchmark defines the machine-learning task as well as reporting metrics. We illustrate the use of the benchmark by evaluating a set of existing seizure detection algorithms. The SzCORE (Seizure Community Open-source Research Evaluation) framework and benchmark are made publicly available along with an open-source software library to facilitate research use, while enabling rigorous evaluation of the clinical significance of the algorithms, fostering a collective effort to more optimally detect seizures to improve the lives of people with epilepsy.

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arXiv2023

A Wearable Ultra-Low-Power sEMG-Triggered Ultrasound System for Long-Term Muscle Activity Monitoring

Surface electromyography (sEMG) is a well-established approach to monitor muscular activity on wearable and resource-constrained devices. However, when measuring deeper muscles, its low signal-to-noise ratio (SNR), high signal attenuation, and crosstalk degrade sensing performance. Ultrasound (US) complements sEMG effectively with its higher SNR at high penetration depths. In fact, combining US and sEMG improves the accuracy of muscle dynamic assessment, compared to using only one modality. However, the power envelope of US hardware is considerably higher than that of sEMG, thus inflating energy consumption and reducing the battery life. This work proposes a wearable solution that integrates both modalities and utilizes an EMG-driven wake-up approach to achieve ultra-low power consumption as needed for wearable long-term monitoring. We integrate two wearable state-of-the-art (SoA) US and ExG biosignal acquisition devices to acquire time-synchronized measurements of the short head of the biceps. To minimize power consumption, the US probe is kept in a sleep state when there is no muscle activity. sEMG data are processed on the probe (filtering, envelope extraction and thresholding) to identify muscle activity and generate a trigger to wake-up the US counterpart. The US acquisition starts before muscle fascicles displacement thanks to a triggering time faster than the electromechanical delay (30-100 ms) between the neuromuscular junction stimulation and the muscle contraction. Assuming a muscle contraction of 200 ms at a contraction rate of 1 Hz, the proposed approach enables more than 59% energy saving (with a full-system average power consumption of 12.2 mW) as compared to operating both sEMG and US continuously.

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arXiv2023

EpiDeNet: An Energy-Efficient Approach to Seizure Detection for Embedded Systems

Epilepsy is a prevalent neurological disorder that affects millions of individuals globally, and continuous monitoring coupled with automated seizure detection appears as a necessity for effective patient treatment. To enable long-term care in daily-life conditions, comfortable and smart wearable devices with long battery life are required, which in turn set the demand for resource-constrained and energy-efficient computing solutions. In this context, the development of machine learning algorithms for seizure detection faces the challenge of heavily imbalanced datasets. This paper introduces EpiDeNet, a new lightweight seizure detection network, and Sensitivity-Specificity Weighted Cross-Entropy (SSWCE), a new loss function that incorporates sensitivity and specificity, to address the challenge of heavily unbalanced datasets. The proposed EpiDeNet-SSWCE approach demonstrates the successful detection of 91.16% and 92.00% seizure events on two different datasets (CHB-MIT and PEDESITE, respectively), with only four EEG channels. A three-window majority voting-based smoothing scheme combined with the SSWCE loss achieves 3x reduction of false positives to 1.18 FP/h. EpiDeNet is well suited for implementation on low-power embedded platforms, and we evaluate its performance on two ARM Cortex-based platforms (M4F/M7) and two parallel ultra-low power (PULP) systems (GAP8, GAP9). The most efficient implementation (GAP9) achieves an energy efficiency of 40 GMAC/s/W, with an energy consumption per inference of only 0.051 mJ at high performance (726.46 MMAC/s), outperforming the best ARM Cortex-based solutions by approximately 160x in energy efficiency. The EpiDeNet-SSWCE method demonstrates effective and accurate seizure detection performance on heavily imbalanced datasets, while being suited for implementation on energy-constrained platforms.

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arXiv2023

BioGAP: a 10-Core FP-capable Ultra-Low Power IoT Processor, with Medical-Grade AFE and BLE Connectivity for Wearable Biosignal Processing

Wearable biosignal processing applications are driving significant progress toward miniaturized, energy-efficient Internet-of-Things solutions for both clinical and consumer applications. However, scaling toward high-density multi-channel front-ends is only feasible by performing data processing and machine Learning (ML) near-sensor through energy-efficient edge processing. To tackle these challenges, we introduce BioGAP, a novel, compact, modular, and lightweight (6g) medical-grade biosignal acquisition and processing platform powered by GAP9, a ten-core ultra-low-power SoC designed for efficient multi-precision (from FP to aggressively quantized integer) processing, as required for advanced ML and DSP. BioGAPs form factor is 16x21x14 mm$^3$ and comprises two stacked PCBs: a baseboard integrating the GAP9 SoC, a wireless Bluetooth Low Energy (BLE) capable SoC, a power management circuit, and an accelerometer; and a shield including an analog front-end (AFE) for ExG acquisition. Finally, the system also includes a flexibly placeable photoplethysmogram (PPG) PCB with a size of 9x7x3 mm$^3$ and a rechargeable battery ($ϕ$ 12x5 mm$^2$). We demonstrate BioGAP on a Steady State Visually Evoked Potential (SSVEP)-based Brain-Computer Interface (BCI) application. We achieve 3.6 uJ/sample in streaming and 2.2 uJ/sample in onboard processing mode, thanks to an efficiency on the FFT computation task of 16.7 Mflops/s/mW with wireless bandwidth reduction of 97%, within a power budget of just 18.2 mW allowing for an operation time of 15 h.

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arXiv2022

Energy-Efficient Tree-Based EEG Artifact Detection

In the context of epilepsy monitoring, EEG artifacts are often mistaken for seizures due to their morphological similarity in both amplitude and frequency, making seizure detection systems susceptible to higher false alarm rates. In this work we present the implementation of an artifact detection algorithm based on a minimal number of EEG channels on a parallel ultra-low-power (PULP) embedded platform. The analyses are based on the TUH EEG Artifact Corpus dataset and focus on the temporal electrodes. First, we extract optimal feature models in the frequency domain using an automated machine learning framework, achieving a 93.95% accuracy, with a 0.838 F1 score for a 4 temporal EEG channel setup. The achieved accuracy levels surpass state-of-the-art by nearly 20%. Then, these algorithms are parallelized and optimized for a PULP platform, achieving a 5.21 times improvement of energy-efficient compared to state-of-the-art low-power implementations of artifact detection frameworks. Combining this model with a low-power seizure detection algorithm would allow for 300h of continuous monitoring on a 300 mAh battery in a wearable form factor and power budget. These results pave the way for implementing affordable, wearable, long-term epilepsy monitoring solutions with low false-positive rates and high sensitivity, meeting both patients' and caregivers' requirements.

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arXiv2021

Towards Long-term Non-invasive Monitoring for Epilepsy via Wearable EEG Devices

We present the implementation of seizure detection algorithms based on a minimal number of EEG channels on a parallel ultra-low-power embedded platform. The analyses are based on the CHB-MIT dataset, and include explorations of different classification approaches (Support Vector Machines, Random Forest, Extra Trees, AdaBoost) and different pre/post-processing techniques to maximize sensitivity while guaranteeing no false alarms. We analyze global and subject-specific approaches, considering all 23-electrodes or only 4 temporal channels. For 8s window size and subject-specific approach, we report zero false positives and 100% sensitivity. These algorithms are parallelized and optimized for a parallel ultra-low power (PULP) platform, enabling 300h of continuous monitoring on a 300 mAh battery, in a wearable form factor and power budget. These results pave the way for the implementation of affordable, wearable, long-term epilepsy monitoring solutions with low false-positive rates and high sensitivity, meeting both patient and caregiver requirements.

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