arXiv subjects

Andrea Tosin

Publications and source records attributed to Andrea Tosin.

At least 55 records · Page 3Linked to original sources

arXiv2018

Well-posedness of a mathematical model for Alzheimer's disease

We consider the existence and uniqueness of solutions of an initial-boundary value problem for a coupled system of PDE's arising in a model for Alzheimer's disease. Apart from reaction diffusion equations, the system contains a transport equation in a bounded interval for a probability measure which is related to the malfunctioning of neurons. The main ingredients to prove existence are: the method of characteristics for the transport equation, a priori estimates for solutions of the reaction diffusion equations, a variant of the classical contraction theorem, and the Wasserstein metric for the part concerning the probability measure. We stress that all hypotheses on the data are not suggested by mathematical artefacts, but are naturally imposed by modelling considerations. In particular the use of a probability measure is natural from a modelling point of view. The nontrivial part of the analysis is the suitable combination of the various mathematical tools, which is not quite routine and requires various technical adjustments.

math.AP↗

arXiv2017

Hybrid stochastic kinetic description of two-dimensional traffic dynamics

In this work we present a two-dimensional kinetic traffic model which takes into account speed changes both when vehicles interact along the road lanes and when they change lane. Assuming that lane changes are less frequent than interactions along the same lane and considering that their mathematical description can be done up to some uncertainty in the model parameters, we derive a hybrid stochastic Fokker-Planck-Boltzmann equation in the quasi-invariant interaction limit. By means of suitable numerical methods, precisely structure preserving and direct Monte Carlo schemes, we use this equation to compute theoretical speed-density diagrams of traffic both along and across the lanes, including estimates of the data dispersion, and validate them against real data.

math.NA↗

arXiv2017

Boltzmann-type models with uncertain binary interactions

In this paper we study binary interaction schemes with uncertain parameters for a general class of Boltzmann-type equations with applications in classical gas and aggregation dynamics. We consider deterministic (i.e., a priori averaged) and stochastic kinetic models, corresponding to different ways of understanding the role of uncertainty in the system dynamics, and compare some thermodynamic quantities of interest, such as the mean and the energy, which characterise the asymptotic trends. Furthermore, via suitable scaling techniques we derive the corresponding deterministic and stochastic Fokker-Planck equations in order to gain more detailed insights into the respective asymptotic distributions. We also provide numerical evidences of the trends estimated theoretically by resorting to recently introduced structure preserving uncertainty quantification methods.

math.AP↗

arXiv2017

Reducing complexity of multiagent systems with symmetry breaking: an application to opinion dynamics with polls

In this paper we investigate the possibility of reducing the complexity of a system composed of a large number of interacting agents, whose dynamics feature a symmetry breaking. We consider first order stochastic differential equations describing the behavior of the system at the particle (i.e., Lagrangian) level and we get its continuous (i.e., Eulerian) counterpart via a kinetic description. However, the resulting continuous model alone fails to describe adequately the evolution of the system, due to the loss of granularity which prevents it from reproducing the symmetry breaking of the particle system. By suitably coupling the two models we are able to reduce considerably the necessary number of particles while still keeping the symmetry breaking and some of its large-scale statistical properties. We describe such a multiscale technique in the context of opinion dynamics, where the symmetry breaking is induced by the results of some opinion polls reported by the media.

physics.soc-ph↗

arXiv2017

Microscopic and macroscopic models for the onset and progression of Alzheimer's disease

In the first part of this paper we review a mathematical model for the onset and progression of Alzheimer's disease (AD) that was developed in subsequent steps over several years. The model is meant to describe the evolution of AD in vivo. In [Y. Achdou et al., 2013] we treated the problem at a microscopic scale, where the typical length scale is a multiple of the size of the soma of a single neuron. Subsequently, in [M. Bertsch at al., 2016] we concentrated on the macroscopic scale, where brain neurons are regarded as a continuous medium, structured by their degree of malfunctioning. In the second part of the paper we consider the relation between the microscopic and the macroscopic models. In particular we show under which assumptions the kinetic transport equation, which in the macroscopic model governs the evolution of the probability measure for the degree of malfunctioning of neurons, can be derived from a particle-based setting. In the microscopic model we consider basically mechanism i), modelling it by a system of Smoluchowski equations for the amyloid concentration (describing the agglomeration phenomenon), with the addition of a diffusion term as well as of a source term on the neuronal membrane. At the macroscopic level instead we model processes i) and ii) by a system of Smoluchowski equations for the amyloid concentration, coupled to a kinetic-type transport equation for the distribution function of the degree of malfunctioning of the neurons. The second equation contains an integral term describing the random onset of the disease as a jump process localized in particularly sensitive areas of the brain. Even though we deliberately neglected many aspects of the complexity of the brain and the disease, numerical simulations are in both cases (microscopic and macroscopic) in good qualitative agreement with clinical data.

physics.bio-ph↗

arXiv2017

Transport of measures on networks

In this paper we formulate a theory of measure-valued linear transport equations on networks. The building block of our approach is the initial/boundary-value problem for the measure-valued linear transport equation on a bounded interval, which is the prototype of an arc of the network. For this problem we give an explicit representation formula of the solution, which also considers the total mass flowing out of the interval. Then we construct the global solution on the network by gluing all the measure-valued solutions on the arcs by means of appropriate distribution rules at the vertexes. The measure-valued approach makes our framework suitable to deal with multiscale flows on networks, with the microscopic and macroscopic phases represented by Lebesgue-singular and Lebesgue-absolutely continuous measures, respectively, in time and space.

math.AP↗

arXiv2016

Kinetic description of collision avoidance in pedestrian crowds by sidestepping

In this paper we study a kinetic model for pedestrians, who are assumed to adapt their motion towards a desired direction while avoiding collisions with others by stepping aside. These minimal microscopic interaction rules lead to complex emergent macroscopic phenomena, such as velocity alignment in unidirectional flows and lane or stripe formation in bidirectional flows. We start by discussing collision avoidance mechanisms at the microscopic scale, then we study the corresponding Boltzmann-type kinetic description and its hydrodynamic mean-field approximation in the grazing collision limit. In the spatially homogeneous case we prove directional alignment under specific conditions on the sidestepping rules for both the collisional and the mean-field model. In the spatially inhomogeneous case we illustrate, by means of various numerical experiments, the rich dynamics that the proposed model is able to reproduce.

physics.soc-ph↗

arXiv2016

Multivalued fundamental diagrams of traffic flow in the kinetic Fokker-Planck limit

Starting from interaction rules based on two levels of stochasticity we study the influence of the microscopic dynamics on the macroscopic properties of vehicular flow. In particular, we study the qualitative structure of the resulting flux-density and speed-density diagrams for different choices of the desired speeds. We are able to recover multivalued diagrams as a result of the existence of a one-parameter family of stationary distributions, whose expression is analytically found by means of a Fokker-Planck approximation of the initial Boltzmann-type model.

cond-mat.stat-mech↗

arXiv2016

Kinetic models for traffic flow resulting in a reduced space of microscopic velocities

The purpose of this paper is to study the properties of kinetic models for traffic flow described by a Boltzmann-type approach and based on a continuous space of microscopic velocities. In our models, the particular structure of the collision kernel allows one to find the analytical expression of a class of steady-state distributions, which are characterized by being supported on a quantized space of microscopic speeds. The number of these velocities is determined by a physical parameter describing the typical acceleration of a vehicle and the uniqueness of this class of solutions is supported by numerical investigations. This shows that it is possible to have the full richness of a kinetic approach with the simplicity of a space of microscopic velocities characterized by a small number of modes. Moreover, the explicit expression of the asymptotic distribution paves the way to deriving new macroscopic equations using the closure provided by the kinetic model.

math.NA↗

arXiv2016

Analysis of a heterogeneous kinetic model for traffic flow

In this work we extend a recent kinetic traffic model to the case of more than one class of vehicles, each of which is characterized by few different microscopic features. We consider a Boltzmann-like framework with only binary interactions, which take place among vehicles belonging to the various classes. Our approach differs from the multi-population kinetic model based on a lattice of speeds because here we assume continuous velocity spaces and we introduce a parameter describing the physical velocity jump performed by a vehicle that increases its speed after an interaction. The model is discretized in order to investigate numerically the structure of the resulting fundamental diagrams and the system of equations is analyzed by studying well posedness. Moreover, we compute the equilibria of the discretized model and we show that the exact asymptotic kinetic distributions can be obtained with a small number of velocities in the grid. Finally, we introduce a new probability law in order to attenuate the sharp capacity drop occurring in the diagrams of traffic.

math.NA↗

arXiv2016

Proposal of a risk model for vehicular traffic: A Boltzmann-type kinetic approach

This paper deals with a Boltzmann-type kinetic model describing the interplay between vehicle dynamics and safety aspects in vehicular traffic. Sticking to the idea that the macroscopic characteristics of traffic flow, including the distribution of the driving risk along a road, are ultimately generated by one-to-one interactions among drivers, the model links the personal (i.e., individual) risk to the changes of speeds of single vehicles and implements a probabilistic description of such microscopic interactions in a Boltzmann-type collisional operator. By means of suitable statistical moments of the kinetic distribution function, it is finally possible to recover macroscopic relationships between the average risk and the road congestion, which show an interesting and reasonable correlation with the well-known free and congested phases of the flow of vehicles.

physics.soc-ph↗

arXiv2016

Alzheimer's disease: a mathematical model for onset and progression

In this paper we propose a mathematical model for the onset and progression of Alzheimer's disease based on transport and diffusion equations. We regard brain neurons as a continuous medium, and structure them by their degree of malfunctioning. Two different mechanisms are assumed to be relevant for the temporal evolution of the disease: i) diffusion and agglomeration of soluble polymers of amyloid, produced by damaged neurons; ii) neuron-to-neuron prion-like transmission. We model these two processes by a system of Smoluchowski equations for the amyloid concentration, coupled to a kinetic-type transport equation for the distribution function of the degree of malfunctioning of neurons. The second equation contains an integral term describing the random onset of the disease as a jump process localised in particularly sensitive areas of the brain. Our numerical simulations are in good qualitative agreement with clinical images of the disease distribution in the brain which vary from early to advanced stages.

physics.bio-ph↗

arXiv2016

From individual behaviour to an evaluation of the collective evolution of crowds along footbridges

This paper proposes a crowd dynamic macroscopic model grounded on microscopic phenomenological observations which are upscaled by means of a formal mathematical procedure. The actual applicability of the model to real world problems is tested by considering the pedestrian traffic along footbridges, of interest for Structural and Transportation Engineering. The genuinely macroscopic quantitative description of the crowd flow directly matches the engineering need of bulk results. However, three issues beyond the sole modelling are of primary importance: the pedestrian inflow conditions, the numerical approximation of the equations for non trivial footbridge geometries, and the calibration of the free parameters of the model on the basis of in situ measurements currently available. These issues are discussed and a solution strategy is proposed.

math-ph↗

arXiv2016

Comparing first order microscopic and macroscopic crowd models for an increasing number of massive agents

In this paper a comparison between first order microscopic and macroscopic differential models of crowd dynamics is established for an increasing number $N$ of pedestrians. The novelty is the fact of considering massive agents, namely particles whose individual mass does not become infinitesimal when $N$ grows. This implies that the total mass of the system is not constant but grows with $N$. The main result is that the two types of models approach one another in the limit $N\to\infty$, provided the strength and/or the domain of pedestrian interactions are properly modulated by $N$ at either scale. This is consistent with the idea that pedestrians may adapt their interpersonal attitudes according to the overall level of congestion.

math.AP↗

arXiv2015

Moving in a crowd: human perception as a multiscale process

The strategic behaviour of pedestrians is largely determined by how they perceive and react to neighbouring people. This issue is addressed in this paper by a model which combines, in a time and space-dependent way, discrete and continuous effects of pedestrian interactions. Numerical simulations and qualitative analysis suggest that human perception, and its impact on crowd dynamics, can be effectively modelled as a multiscale process based on a dual microscopic/macroscopic representation of groups of agents.

physics.soc-ph↗

arXiv2015

Modeling rationality to control self-organization of crowds: An environmental approach

In this paper we propose a classification of crowd models in built environments based on the assumed pedestrian ability to foresee the movements of other walkers. At the same time, we introduce a new family of macroscopic models, which make it possible to tune the degree of predictiveness (i.e., rationality) of the individuals. By means of these models we describe both the natural behavior of pedestrians, i.e., their expected behavior according to their real limited predictive ability, and a target behavior, i.e., a particularly efficient behavior one would like them to assume (for, e.g., logistic or safety reasons). Then we tackle a challenging shape optimization problem, which consists in controlling the environment in such a way that the natural behavior is as close as possible to the target one, thereby inducing pedestrians to behave more rationally than what they would naturally do. We present numerical tests which elucidate the role of rational/predictive abilities and show some promising results about the shape optimization problem.

math.OC↗

arXiv2015

Fundamental diagrams in traffic flow: the case of heterogeneous kinetic models

Experimental studies on vehicular traffic provide data on quantities like density, flux, and mean speed of the vehicles. However, the diagrams relating these variables (the fundamental and speed diagrams) show some peculiarities not yet fully reproduced nor explained by mathematical models. In this paper, resting on the methods of kinetic theory, we introduce a new traffic model which takes into account the heterogeneous nature of the flow of vehicles along a road. In more detail, the model considers traffic as a mixture of two or more populations of vehicles (e.g., cars and trucks) with different microscopic characteristics, in particular different lengths and/or maximum speeds. With this approach we gain some insights into the scattering of the data in the regime of congested traffic clearly shown by actual measurements.

math.NA↗

arXiv2014

Differentiated cell behavior: a multiscale approach using measure theory

This paper deals with the derivation of a collective model of cell populations out of an individual-based description of the underlying physical particle system. By looking at the spatial distribution of cells in terms of time-evolving measures, rather than at individual cell paths, we obtain an ensemble representation stemming from the phenomenological behavior of the single component cells. In particular, as a key advantage of our approach, the scale of representation of the system, i.e., microscopic/discrete vs. macroscopic/continuous, can be chosen a posteriori according only to the spatial structure given to the aforesaid measures. The paper focuses in particular on the use of different scales based on the specific functions performed by cells. A two-population hybrid system is considered, where cells with a specialized/differentiated phenotype are treated as a discrete population of point masses while unspecialized/undifferentiated cell aggregates are represented with a continuous approximation. Numerical simulations and analytical investigations emphasize the role of some biologically relevant parameters in determining the specific evolution of such a hybrid cell system.

math-ph↗