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Can Zhao

Publications and source records attributed to Can Zhao.

At least 19 recordsLinked to original sources
arXiv2026

NV-Generate-Body: 3D Latent Diffusion Model forControllable Anatomy, Tumor, and Demographic Body Mask Synthesis

Curating large labeled CT datasets is expensive and constrained by patient privacy. We present NV-Generate-BodyMask, a 3D latent diffusion model that synthesizes whole-body CT segmentation masks with precise, joint control over organ anatomy, tumor burden, and patient demographics. The model operates in the compressed latent space of a frozen mask autoencoder, generating $256^3$ volumetric label maps conditioned on a 19-dimensional vector via Adaptive Group Normalization and cross-attention. A size-adaptive ROI loss with spatial halo weighting and a paired tumor injection pipeline enable accurate tumor size conditioning despite the scarcity of annotated tumor cases. Trained on 8,571 masks across 26 cohorts spanning 132 labels, the model achieves Spearman $ρ= 0.70$--$0.92$ for organ size, 85--100\% tumor recall for lung, pancreatic, colon, and bone lesions, and strong demographic alignment (BMI $ρ= 0.78$, sex-conditioned perfect prostate control).

cs.CV↗
arXiv2026

ClinSeekAgent: Automating Multimodal Evidence Seeking for Agentic Clinical Reasoning

Large language models (LLMs) and agentic systems have shown promise for clinical decision support, but existing works largely assume that evidence has already been curated and handed to the model. Real-world clinical workflows instead require agents to actively seek, iteratively plan, and synthesize multimodal evidence from heterogeneous sources. In this paper, we introduce ClinSeekAgent, an automated agentic framework for dynamic multimodal evidence seeking that shifts the paradigm from passive evidence consumption to active evidence acquisition. Given a clinical task and access to raw patient data, ClinSeekAgent queries longitudinal EHR records and invokes imaging analysis tools when relevant; refines its hypotheses as new information emerges; and integrates the collected evidence into grounded clinical decisions. We validate ClinSeekAgent in two roles: as an inference-time agent for frontier LLMs and as a training pipeline for open-source models. For inference-time validation, we construct ClinSeek-Bench, which covers 13 text-only EHR task categories and 6 multimodal EHR--chest X-ray task categories, and pairs each question with both a Curated Input of pre-selected evidence and the raw patient data for automated evidence seeking. Without any benchmark-specific curation, ClinSeekAgent significantly outperforms curated input for both Claude Opus 5 and GPT-5.6 Sol, improving overall F1 from 66.5 to 68.8 and from 60.0 to 62.5 on multimodal tasks. The ablations show that the performance gain come from multi-round evidence seeking rather than from access to more of the patient record. For training-time validation, we fine-tune Qwen3.5-35B-A3B on ClinSeekAgent trajectories generated by GPT-5.6 Sol. The resulting ClinSeek-35B-A3B reaches 35.6 average F1 on AgentEHR-Bench, outperforming all evaluated open-source models, including ones more than ten times larger, as well as Claude Opus 5.

cs.CL↗
arXiv2026

Frozen Models, Evolving Expertise: Model-Agnostic Learning from Deployment Experience for Multimodal Medical AI

Large language models (LLMs) and vision-language models (VLMs) are usually frozen after deployment, so they do not learn from the cases they solve. This is especially concerning in medicine, where new clinical evidence, updated guidelines, and new therapies can change established practice. Fine-tuning can update the model, but it requires access to model weights and additional training. Parameter-free methods avoid training, but they may overfit a fixed validation set, lack reliable domain knowledge, or lose visual details by saving experience only as text. To address these limitations, we present a model-agnostic framework that allows frozen LLMs and VLMs to learn from deployment experience through three forms of external expertise: a Skill that guides reasoning and tool use, a Knowledge Memory that stores reliable facts supported by earlier cases or trusted external evidence, and a Multimodal Knowledge Base that keeps visual examples and guides the model to relate each retrieved case to the current image. Instead of relying on a fixed validation set, a validation strategy keeps an update only if it helps on new cases without degrading performance on earlier ones. Across six benchmarks covering clinical diagnosis, clinical workflows, medical reasoning, and medical and non-medical visual reasoning, and with four open-weight and closed-source base models, our framework improves performance during online deployment by up to 34.2% over the base model on medical tasks, generalizes to unseen cases, transfers to other models without further optimization, and works in non-medical domains.

cs.AI↗
arXiv2026

EgoJEPA: Beyond Retargeting for Dexterous Manipulation from Egocentric Videos

Egocentric human videos offer a scalable alternative to costly robot demonstra- tions, yet transferring their manipulation priors to robot control remains chal- lenging. The commonly adopted retargeting-based approaches convert human wrist and finger poses into embodiment-specific action commands through hand- crafted geometric mappings. However, such mappings require meticulous recal- ibration across different embodiments and risk propagating hand-tracking errors into downstream robot control pipelines. To this end, we propose EgoJEPA, a three-stage framework that learns embodiment-agnostic representations from ego- centric human videos without rule-based human-to-robot retargeting: 1) Human- action pre-training learns effect-aware latent actions through JEPA-style visual prediction conditioned on hand-motion differences; 2) Latent-action-based world modeling jointly predicts future visual dynamics and latent actions, which decou- ples human prior pre-training from robot-specific control parameterizations; 3) Embodiment-specific tuning adapts the pretrained model to diverse robots through lightweight action adapters. Experiments on five real-world manipulation tasks across three robot embodiments demonstrate the effectiveness and efficiency of EgoJEPA. It achieves a 74% average success rate under the out-of-domain evalu- ation, compared with 65% for the retargeting baseline, while reducing cumulative cross-embodiment wall-clock cost by 47.2%, from 743.2 to 392.7 hours.

cs.RO↗
arXiv2026

VERA: Scaling Verifiable Environments for Agentic co-Evolution

Competent agents need precise and verifiable environments, such as sandboxes that are resumable at any stage and evolve from observable evidence. However, most long-horizon work exposes how rare these are: for example, an agent in medical research must ground a finding, classify it, and write a report over dozens of dependent steps, yet recent environments score only the outcome. To address the challenges in stable training, we present VERA, which builds such environments at scale and lets agents evolve on them. VERA builds these environments from initial trajectories: an agent writes rubrics, executable checks, a judge verifies each sandbox, and only those that pass enter the training bank. On these environments, VERA alternates between two updates: train the model with rubric rewards, or edit the harness skills. We also create a verifier which gates model checkpoints and harness edits using explicit development-set acceptance criteria. This attribution distinguishes VERA's co-evolution from single-axis baselines: its updates target not only the cause but the outcome. With an open-source corpus of 9,000+ long-horizon verifiable environments, a 9B model paired with its co-evolved agent beats the strongest baseline by 10.3 and 13.0 points in the two domains. At 27B, it surpasses the baseline on AutoCoWorkBench (71.6) and AutoMedBench (80.7), transfers to unseen workflows, and retains general capabilities.

cs.AI↗
arXiv2026

BaT: Towards Self-Evolving Medical Research Agent with Stage Rubrics

Long-horizon agents are beginning to automate complete workflows that produce code, reports, and research artifacts. Medical imaging workflows are multi-stage and data-sensitive, while expert trajectories remain scarce and difficult to share. Structured benchmarks can localize failures through stage-level rubrics, but standard post-training discards these diagnostics before the next training round. We present Benchmark-as-Teacher (BaT), a recursive self-improvement system for agent post-training. BaT contains two linked components: the asynchronous Stage Bank data pipeline and BiCuRL (Bilevel Curriculum Reinforcement Learning), its self-improving post-training method. Stage Bank synthesizes content-isolated training states outside the policy-update loop. BiCuRL uses a fixed held-out evaluation to select the next stage curriculum, verifies rollouts with task rubrics, updates the policy with GRPO, and returns the candidate checkpoint to evaluation. On AutoMedBench-Lite, BaT-4B and BaT-9B more than double the Overall scores of their Qwen Instruct baselines. BaT-9B Agent reaches 79.6 Overall, exceeding Claude Opus 4.6 with Claude Code at 77.5.

cs.AI↗
arXiv2026

Latent Interpolation Learning Using Diffusion Models for Cardiac Volume Reconstruction

Cardiac Magnetic Resonance (CMR) imaging is a critical tool for diagnosing and managing cardiovascular disease, yet its utility is often limited by the sparse acquisition of 2D short-axis slices, resulting in incomplete volumetric information. Accurate 3D reconstruction from these sparse slices is essential for comprehensive cardiac assessment, but existing methods face challenges, including reliance on predefined interpolation schemes (e.g., linear or spherical), computational inefficiency, and dependence on additional semantic inputs such as segmentation labels or motion data. To address these limitations, we propose a novel Cardiac Latent Interpolation Diffusion (CaLID) framework that introduces three key innovations. First, we present a data-driven interpolation scheme based on diffusion models, which can capture complex, non-linear relationships between sparse slices and improves reconstruction accuracy. Second, we design a computationally efficient method that operates in the latent space and speeds up 3D whole-heart upsampling time by a factor of 24, reducing computational overhead compared to previous methods. Third, with only sparse 2D CMR images as input, our method achieves SOTA performance against baseline methods, eliminating the need for auxiliary input such as morphological guidance, thus simplifying workflows. We further extend our method to 2D+T data, enabling the effective modeling of spatiotemporal dynamics and ensuring temporal coherence. Extensive volumetric evaluations and downstream segmentation tasks demonstrate that CaLID achieves superior reconstruction quality and efficiency. By addressing the fundamental limitations of existing approaches, our framework advances the state of the art for spatio and spatiotemporal whole-heart reconstruction, offering a robust and clinically practical solution for cardiovascular imaging.

eess.IV↗
arXiv2026

AutoMedBench: Towards Medical AutoResearch with Agentic AI Models

Autonomous agents are increasingly expected to support end-to-end medical-AI research workflows, moving beyond isolated prediction tasks or short-form clinical question answering. However, existing medical agent benchmarks primarily evaluate final outputs, providing limited visibility into agent behavior within the research process. To address this gap, we present AutoMedBench, a workflow-aware benchmark for autonomous medical-AI research across diverse medical imaging and multimodal inference tasks, organizing agent execution into a unified five-stage workflow (S1-S5): Plan, Setup, Validate, Inference, and Submit. It comprises long-horizon tasks with each run averaging 33 agent turns, spanning five research tracks: segmentation, image enhancement, visual question answering (VQA), report generation, and lesion detection. Each task is evaluated under two difficulty tiers, Lite and Standard, which use the same data and metrics but differ in the amount of task-brief scaffolding, and each run is scored using both final task performance and S1-S5 stage scores, enabling stage-level analysis from the initial task brief to the final submitted artifact. Across thousands of recorded runs, stage-level scoring reveals that Validate is the weakest workflow stage on average, whereas Setup is the strongest, suggesting that current agents are better at making pipelines executable than at verifying their reliability. Post-run error analysis further shows that verification and submission failures dominate tagged errors, accounting for 37.7% and 38.1% of fired codes respectively, whereas task-understanding errors are rare at 0.9%, and runs with one fired error code have a 48% lower overall score than runs with no error code on average.

cs.AI↗
arXiv2026

TouchGuide: Inference-Time Steering of Visuomotor Policies via Touch Guidance

Fine-grained and contact-rich manipulation remain challenging for robots, largely due to the underutilization of tactile feedback. To address this, we introduce TouchGuide, a novel cross-policy visuo-tactile fusion paradigm that fuses modalities within a low-dimensional action space. Specifically, TouchGuide operates in two stages to guide a pre-trained diffusion or flow-matching visuomotor policy at inference time. First, the policy produces a coarse, visually-plausible action using only visual inputs during early sampling. Second, a task-specific Contact Physical Model (CPM) provides tactile guidance to steer and refine the action, ensuring it aligns with realistic physical contact conditions. Trained through contrastive learning on limited expert demonstrations, the CPM provides a tactile-informed feasibility score to steer the sampling process toward refined actions that satisfy physical contact constraints. Furthermore, to facilitate TouchGuide training with high-quality and cost-effective data, we introduce TacUMI, a data collection system. TacUMI achieves a favorable trade-off between precision and affordability; by leveraging rigid fingertips, it obtains direct tactile feedback, thereby enabling the collection of reliable tactile data. Extensive experiments on five challenging contact-rich tasks, such as shoe lacing and chip handover, show that TouchGuide consistently and significantly outperforms state-of-the-art visuo-tactile policies.

cs.RO↗
arXiv2026

BAAI Cardiac Agent: An intelligent multimodal agent for automated reasoning and diagnosis of cardiovascular diseases from cardiac magnetic resonance imaging

Cardiac magnetic resonance (CMR) is a cornerstone for diagnosing cardiovascular disease. However, it remains underutilized due to complex, time-consuming interpretation across multi-sequences, phases, quantitative measures that heavily reliant on specialized expertise. Here, we present BAAI Cardiac Agent, a multimodal intelligent system designed for end-to-end CMR interpretation. The agent integrates specialized cardiac expert models to perform automated segmentation of cardiac structures, functional quantification, tissue characterization and disease diagnosis, and generates structured clinical reports within a unified workflow. Evaluated on CMR datasets from two hospitals (2413 patients) spanning 7-types of major cardiovascular diseases, the agent achieved an area under the receiver-operating-characteristic curve exceeding 0.93 internally and 0.81 externally. In the task of estimating left ventricular function indices, the results generated by this system for core parameters such as ejection fraction, stroke volume, and left ventricular mass are highly consistent with clinical reports, with Pearson correlation coefficients all exceeding 0.90. The agent outperformed state-of-the-art models in segmentation and diagnostic tasks, and generated clinical reports showing high concordance with expert radiologists (six readers across three experience levels). By dynamically orchestrating expert models for coordinated multimodal analysis, this agent framework enables accurate, efficient CMR interpretation and highlights its potentials for complex clinical imaging workflows. Code is available at https://github.com/plantain-herb/Cardiac-Agent.

eess.IV↗
arXiv2026

Cross-Modal Attention Network with Dual Graph Learning in Multimodal Recommendation

Multimedia recommendation systems leverage user-item interactions and multimodal information to capture user preferences, enabling more accurate and personalized recommendations. Despite notable advancements, existing approaches still face two critical limitations: first, shallow modality fusion often relies on simple concatenation, failing to exploit rich synergic intra- and inter-modal relationships; second, asymmetric feature treatment-where users are only characterized by interaction IDs while items benefit from rich multimodal content-hinders the learning of a shared semantic space. To address these issues, we propose a Cross-modal Recursive Attention Network with dual graph Embedding (CRANE). To tackle shallow fusion, we design a core Recursive Cross-Modal Attention (RCA) mechanism that iteratively refines modality features based on cross-correlations in a joint latent space, effectively capturing high-order intra- and inter-modal dependencies. For symmetric multimodal learning, we explicitly construct users' multimodal profiles by aggregating features of their interacted items. Furthermore, CRANE integrates a symmetric dual-graph framework-comprising a heterogeneous user-item interaction graph and a homogeneous item-item semantic graph-unified by a self-supervised contrastive learning objective to fuse behavioral and semantic signals. Despite these complex modeling capabilities, CRANE maintains high computational efficiency. Theoretical and empirical analyses confirm its scalability and high practical efficiency, achieving faster convergence on small datasets and superior performance ceilings on large-scale ones. Comprehensive experiments on four public real-world datasets validate an average 5% improvement in key metrics over state-of-the-art baselines.

cs.IR↗
arXiv2025

MAISI: Medical AI for Synthetic Imaging

Medical imaging analysis faces challenges such as data scarcity, high annotation costs, and privacy concerns. This paper introduces the Medical AI for Synthetic Imaging (MAISI), an innovative approach using the diffusion model to generate synthetic 3D computed tomography (CT) images to address those challenges. MAISI leverages the foundation volume compression network and the latent diffusion model to produce high-resolution CT images (up to a landmark volume dimension of 512 x 512 x 768 ) with flexible volume dimensions and voxel spacing. By incorporating ControlNet, MAISI can process organ segmentation, including 127 anatomical structures, as additional conditions and enables the generation of accurately annotated synthetic images that can be used for various downstream tasks. Our experiment results show that MAISI's capabilities in generating realistic, anatomically accurate images for diverse regions and conditions reveal its promising potential to mitigate challenges using synthetic data.

eess.IV↗
arXiv2025

MAISI-v2: Accelerated 3D High-Resolution Medical Image Synthesis with Rectified Flow and Region-specific Contrastive Loss

Medical image synthesis is an important topic for both clinical and research applications. Recently, diffusion models have become a leading approach in this area. Despite their strengths, many existing methods struggle with (1) limited generalizability that only work for specific body regions or voxel spacings, (2) slow inference, which is a common issue for diffusion models, and (3) weak alignment with input conditions, which is a critical issue for medical imaging. MAISI, a previously proposed framework, addresses generalizability issues but still suffers from slow inference and limited condition consistency. In this work, we present MAISI-v2, the first accelerated 3D medical image synthesis framework that integrates rectified flow to enable fast and high quality generation. To further enhance condition fidelity, we introduce a novel region-specific contrastive loss to enhance the sensitivity to region of interest. Our experiments show that MAISI-v2 can achieve SOTA image quality with $33 \times$ acceleration for latent diffusion model. We also conducted a downstream segmentation experiment to show that the synthetic images can be used for data augmentation. We release our code, training details, model weights, and a GUI demo to facilitate reproducibility and promote further development within the community.

cs.CV↗
arXiv2025

Knots: A Large-Scale Multi-Agent Enhanced Expert-Annotated Dataset and LLM Prompt Optimization for NOTAM Semantic Parsing

Notice to Air Missions (NOTAMs) serve as a critical channel for disseminating key flight safety information, yet their complex linguistic structures and implicit reasoning pose significant challenges for automated parsing. Existing research mainly focuses on surface-level tasks such as classification and named entity recognition, lacking deep semantic understanding. To address this gap, we propose NOTAM semantic parsing, a task emphasizing semantic inference and the integration of aviation domain knowledge to produce structured, inference-rich outputs. To support this task, we construct Knots (Knowledge and NOTAM Semantics), a high-quality dataset of 12,347 expert-annotated NOTAMs covering 194 Flight Information Regions, enhanced through a multi-agent collaborative framework for comprehensive field discovery. We systematically evaluate a wide range of prompt-engineering strategies and model-adaptation techniques, achieving substantial improvements in aviation text understanding and processing. Our experimental results demonstrate the effectiveness of the proposed approach and offer valuable insights for automated NOTAM analysis systems. Our code is available at: https://github.com/Estrellajer/Knots.

cs.CL↗
arXiv2025

NOTAM-Evolve: A Knowledge-Guided Self-Evolving Optimization Framework with LLMs for NOTAM Interpretation

Accurate interpretation of Notices to Airmen (NOTAMs) is critical for aviation safety, yet their condensed and cryptic language poses significant challenges to both manual and automated processing. Existing automated systems are typically limited to shallow parsing, failing to extract the actionable intelligence needed for operational decisions. We formalize the complete interpretation task as deep parsing, a dual-reasoning challenge requiring both dynamic knowledge grounding (linking the NOTAM to evolving real-world aeronautical data) and schema-based inference (applying static domain rules to deduce operational status). To tackle this challenge, we propose NOTAM-Evolve, a self-evolving framework that enables a large language model (LLM) to autonomously master complex NOTAM interpretation. Leveraging a knowledge graph-enhanced retrieval module for data grounding, the framework introduces a closed-loop learning process where the LLM progressively improves from its own outputs, minimizing the need for extensive human-annotated reasoning traces. In conjunction with this framework, we introduce a new benchmark dataset of 10,000 expert-annotated NOTAMs. Our experiments demonstrate that NOTAM-Evolve achieves a 30.4% absolute accuracy improvement over the base LLM, establishing a new state of the art on the task of structured NOTAM interpretation.

cs.CL↗
arXiv2025

Discrete Diffusion Models with MLLMs for Unified Medical Multimodal Generation

Recent advances in generative medical models are constrained by modality-specific scenarios that hinder the integration of complementary evidence from imaging, pathology, and clinical notes. This fragmentation limits their evolution into foundation models that can learn and reason across the full spectrum of biomedical data. We propose MeDiM, the first medical discrete diffusion model that learns shared distributions across modalities without modality-specific components. MeDiM unifies multiple generative tasks: translating between images and text, and jointly producing image-report pairs across domains in response to prompts. Built on a discrete diffusion framework, MeDiM bridges vision and language representations through a shared probabilistic space. To enable unified and flexible medical generation, we employ a multimodal large language model (MLLM) as the diffusion backbone, leveraging its prior knowledge and cross-modal reasoning. Two key designs are introduced: (1) removing the causal attention mask for bidirectional context, and (2) injecting continuous timestep embeddings for diffusion awareness. Experiments demonstrate high-fidelity medical generation (FID 16.60 on MIMIC-CXR and FID 24.19 on PathGen) and accurate report generation (METEOR 0.2650 and 0.2580). Jointly generated image-report pairs further enhance downstream performance (plus6.43 percent BLEU-1, plus18.57 percent BLEU-2, plus31.58 percent BLEU-3, plus4.80 percent METEOR), showing that MeDiM supports coherent and clinically grounded multimodal outputs.

cs.CV↗
arXiv2025

RANA: Robust Active Learning for Noisy Network Alignment

Network alignment has attracted widespread attention in various fields. However, most existing works mainly focus on the problem of label sparsity, while overlooking the issue of noise in network alignment, which can substantially undermine model performance. Such noise mainly includes structural noise from noisy edges and labeling noise caused by human-induced and process-driven errors. To address these problems, we propose RANA, a Robust Active learning framework for noisy Network Alignment. RANA effectively tackles both structure noise and label noise while addressing the sparsity of anchor link annotations, which can improve the robustness of network alignment models. Specifically, RANA introduces the proposed Noise-aware Selection Module and the Label Denoising Module to address structural noise and labeling noise, respectively. In the first module, we design a noise-aware maximization objective to select node pairs, incorporating a cleanliness score to address structural noise. In the second module, we propose a novel multi-source fusion denoising strategy that leverages model and twin node pairs labeling to provide more accurate labels for node pairs. Empirical results on three real-world datasets demonstrate that RANA outperforms state-of-the-art active learning-based methods in alignment accuracy. Our code is available at https://github.com/YXNan0110/RANA.

cs.LG↗