arXiv subjects

Chang Jiang

Publications and source records attributed to Chang Jiang.

At least 19 recordsLinked to original sources

arXiv2026

CaseMaster: Designing and Evaluating a Probe for Oral Case Presentation Training with LLM Assistance

Preparing an oral case presentation (OCP) is a crucial skill for medical students, requiring clear communication of patient information, clinical findings, and treatment plans. However, inconsistent student participation and limited guidance can make this task challenging. While Large Language Models (LLMs) can provide structured content to streamline the process, their role in facilitating skill development and supporting medical education integration remains underexplored. To address this, we conducted a formative study with six medical educators and developed CaseMaster, an interactive probe that leverages LLM-generated content tailored to medical education to help users enhance their OCP skills. The controlled study suggests CaseMaster has the potential to both improve presentation quality and reduce workload compared to traditional methods, an implication reinforced by expert feedback. We propose guidelines for educators to develop adaptive, user-centered training methods using LLMs, while considering the implications of integrating advanced technologies into medical education.

cs.HC↗

arXiv2026

"Do I Trust the AI?" Towards Trustworthy AI-Assisted Diagnosis: Understanding User Perception in LLM-Supported Reasoning

Large language models (LLMs) have shown considerable potential in supporting medical diagnosis. However, their effective integration into clinical workflows is hindered by physicians' difficulties in perceiving and trusting LLM capabilities, which often results in miscalibrated trust. Existing model evaluations primarily emphasize standardized benchmarks and predefined tasks, offering limited insights into clinical reasoning practices. Moreover, research on human-AI collaboration has rarely examined physicians' perceptions of LLMs' clinical reasoning capability. In this work, we investigate how physicians perceive LLMs' capabilities in the clinical reasoning process. We designed clinical cases, collected the corresponding analyses, and obtained evaluations from physicians (N=37) to quantitatively represent their perceived LLM diagnostic capabilities. By comparing the perceived evaluations with benchmark performance, our study highlights the aspects of clinical reasoning that physicians value and underscores the limitations of benchmark-based evaluation. We further discuss the implications of opportunities for enhancing trustworthy collaboration between physicians and LLMs in LLM-supported clinical reasoning.

cs.HC↗

arXiv2026

When Seconds Count: Designing Real-Time VR Interventions for Stress Inoculation Training in Novice Physicians

Surgical emergencies often trigger acute cognitive overload in novice physicians, impairing their decision-making under pressure. Although Virtual Reality-based Stress Inoculation Training (VR-SIT) shows promise, current systems fall short in delivering real-time, effective support during moments of peak stress. To bridge this gap, we first conducted a formative study (N=12) to uncover the core needs of novice physicians for immediate assistance under acute stress and identified three key intervention strategies: self-regulation aids, procedure guidance, and emotional/sensory support. Building on these insights, we designed and implemented a novel VR-SIT system that incorporates a just-in-time adaptive intervention framework, dynamically tailoring support to learners' cognitive and emotional states. We then validated these strategies in a user study (N=26). Our findings provide empirical evidence and design implications for next-generation VR medical training systems, supporting physicians in sustaining cognitive clarity and accurate decision-making in critical situations.

cs.HC↗

arXiv2025

HypoChainer: A Collaborative System Combining LLMs and Knowledge Graphs for Hypothesis-Driven Scientific Discovery

Modern scientific discovery faces growing challenges in integrating vast and heterogeneous knowledge critical to breakthroughs in biomedicine and drug development. Traditional hypothesis-driven research, though effective, is constrained by human cognitive limits, the complexity of biological systems, and the high cost of trial-and-error experimentation. Deep learning models, especially graph neural networks (GNNs), have accelerated prediction generation, but the sheer volume of outputs makes manual selection for validation unscalable. Large language models (LLMs) offer promise in filtering and hypothesis generation, yet suffer from hallucinations and lack grounding in structured knowledge, limiting their reliability. To address these issues, we propose HypoChainer, a collaborative visualization framework that integrates human expertise, LLM-driven reasoning, and knowledge graphs (KGs) to enhance hypothesis generation and validation. HypoChainer operates in three stages: First, exploration and contextualization -- experts use retrieval-augmented LLMs (RAGs) and dimensionality reduction to navigate large-scale GNN predictions, assisted by interactive explanations. Second, hypothesis chain formation -- experts iteratively examine KG relationships around predictions and semantically linked entities, refining hypotheses with LLM and KG suggestions. Third, validation prioritization -- refined hypotheses are filtered based on KG-supported evidence to identify high-priority candidates for experimentation, with visual analytics further strengthening weak links in reasoning. We demonstrate HypoChainer's effectiveness through case studies in two domains and expert interviews, highlighting its potential to support interpretable, scalable, and knowledge-grounded scientific discovery.

cs.HC↗

arXiv2025

Room-temperature intrinsic nonlinear planar Hall effect in TaIrTe$_4$

Intrinsic responses are of paramount importance in physics research, as they represent the inherent properties of materials, independent of extrinsic factors that vary from sample to sample, and often reveal the intriguing quantum geometry of the band structure. Here, we report the experimental discovery of a new intrinsic response in charge transport, specifically the intrinsic nonlinear planar Hall effect (NPHE), in the topological semimetal TaIrTe$_4$. This effect is characterized by an induced Hall current that is quadratic in the driving electric field and linear in the in-plane magnetic field. The response coefficient is determined by the susceptibility tensor of Berry-connection polarizability dipole, which is an intrinsic band geometric quantity. Remarkably, the signal persists up to room temperature. Our theoretical calculations show excellent agreement with the experimental results and further elucidate the significance of a previously unknown orbital mechanism in intrinsic NPHE. This finding not only establishes a novel intrinsic material property but also opens a new route toward innovative nonlinear devices capable of operating at room temperature.

cond-mat.mes-hall↗

arXiv2025

Advancing Problem-Based Learning with Clinical Reasoning for Improved Differential Diagnosis in Medical Education

Medical education increasingly emphasizes students' ability to apply knowledge in real-world clinical settings, focusing on evidence-based clinical reasoning and differential diagnoses. Problem-based learning (PBL) addresses traditional teaching limitations by embedding learning into meaningful contexts and promoting active participation. However, current PBL practices are often confined to medical instructional settings, limiting students' ability to self-direct and refine their approaches based on targeted improvements. Additionally, the unstructured nature of information organization during analysis poses challenges for record-keeping and subsequent review. Existing research enhances PBL realism and immersion but overlooks the construction of logic chains and evidence-based reasoning. To address these gaps, we designed e-MedLearn, a learner-centered PBL system that supports more efficient application and practice of evidence-based clinical reasoning. Through controlled study (N=19) and testing interviews (N=13), we gathered data to assess the system's impact. The findings demonstrate that e-MedLearn improves PBL experiences and provides valuable insights for advancing clinical reasoning-based learning.

cs.HC↗

arXiv2024

Medillustrator: Improving Retrospective Learning in Physicians' Continuous Medical Education via Multimodal Diagnostic Data Alignment and Representation

Continuous Medical Education (CME) plays a vital role in physicians' ongoing professional development. Beyond immediate diagnoses, physicians utilize multimodal diagnostic data for retrospective learning, engaging in self-directed analysis and collaborative discussions with peers. However, learning from such data effectively poses challenges for novice physicians, including screening and identifying valuable research cases, achieving fine-grained alignment and representation of multimodal data at the semantic level, and conducting comprehensive contextual analysis aided by reference data. To tackle these challenges, we introduce Medillustrator, a visual analytics system crafted to facilitate novice physicians' retrospective learning. Our structured approach enables novice physicians to explore and review research cases at an overview level and analyze specific cases with consistent alignment of multimodal and reference data. Furthermore, physicians can record and review analyzed results to facilitate further retrospection. The efficacy of Medillustrator in enhancing physicians' retrospective learning processes is demonstrated through a comprehensive case study and a controlled in-lab between-subject user study.

cs.HC↗

arXiv2024

UPdec-Webb: A Dataset for Coaddition of JWST NIRCam Images

We present the application of the image coaddition algorithm, Up-sampling and PSF Deconvolution Coaddition (UPDC), for stacking multiple exposure images captured by the James Webb Space Telescope (JWST) Near-Infrared Camera (NIRCam). By addressing the point spread function (PSF) effect, UPDC provides visually enhanced and sharper images. Furthermore, the anti-aliasing and super-resolution capabilities of UPDC make it easier to deblend sources overlapped on images, yielding a higher accuracy of aperture photometry. We apply this algorithm to the SMACS J0723 imaging data. Comparative analysis with the Drizzle algorithm demonstrates significant improvements in detecting faint sources, achieving accurate photometry, and effectively deblending (super-resolution) closely packed sources. {As a result, we have newly detected a pair of close binary stars that were previously unresolvable in the original exposures or the Drizzled image.} These improvements significantly benefit various scientific projects conducted by JWST. The resulting dataset, named "UPdec-Webb", can be accessible through the official website of the Chinese Virtual Observatory (ChinaVO).

astro-ph.IM↗

arXiv2024

A Two-Phase Visualization System for Continuous Human-AI Collaboration in Sequelae Analysis and Modeling

In healthcare, AI techniques are widely used for tasks like risk assessment and anomaly detection. Despite AI's potential as a valuable assistant, its role in complex medical data analysis often oversimplifies human-AI collaboration dynamics. To address this, we collaborated with a local hospital, engaging six physicians and one data scientist in a formative study. From this collaboration, we propose a framework integrating two-phase interactive visualization systems: one for Human-Led, AI-Assisted Retrospective Analysis and another for AI-Mediated, Human-Reviewed Iterative Modeling. This framework aims to enhance understanding and discussion around effective human-AI collaboration in healthcare.

cs.HC↗

arXiv2024

Training-free image style alignment for self-adapting domain shift on handheld ultrasound devices

Handheld ultrasound devices face usage limitations due to user inexperience and cannot benefit from supervised deep learning without extensive expert annotations. Moreover, the models trained on standard ultrasound device data are constrained by training data distribution and perform poorly when directly applied to handheld device data. In this study, we propose the Training-free Image Style Alignment (TISA) framework to align the style of handheld device data to those of standard devices. The proposed TISA can directly infer handheld device images without extra training and is suited for clinical applications. We show that TISA performs better and more stably in medical detection and segmentation tasks for handheld device data. We further validate TISA as the clinical model for automatic measurements of spinal curvature and carotid intima-media thickness. The automatic measurements agree well with manual measurements made by human experts and the measurement errors remain within clinically acceptable ranges. We demonstrate the potential for TISA to facilitate automatic diagnosis on handheld ultrasound devices and expedite their eventual widespread use.

eess.IV↗

arXiv2023

An Association Test Based on Kernel-Based Neural Networks for Complex Genetic Association Analysis

The advent of artificial intelligence, especially the progress of deep neural networks, is expected to revolutionize genetic research and offer unprecedented potential to decode the complex relationships between genetic variants and disease phenotypes, which could mark a significant step toward improving our understanding of the disease etiology. While deep neural networks hold great promise for genetic association analysis, limited research has been focused on developing neural-network-based tests to dissect complex genotype-phenotype associations. This complexity arises from the opaque nature of neural networks and the absence of defined limiting distributions. We have previously developed a kernel-based neural network model (KNN) that synergizes the strengths of linear mixed models with conventional neural networks. KNN adopts a computationally efficient minimum norm quadratic unbiased estimator (MINQUE) algorithm and uses KNN structure to capture the complex relationship between large-scale sequencing data and a disease phenotype of interest. In the KNN framework, we introduce a MINQUE-based test to assess the joint association of genetic variants with the phenotype, which considers non-linear and non-additive effects and follows a mixture of chi-square distributions. We also construct two additional tests to evaluate and interpret linear and non-linear/non-additive genetic effects, including interaction effects. Our simulations show that our method consistently controls the type I error rate under various conditions and achieves greater power than a commonly used sequence kernel association test (SKAT), especially when involving non-linear and interaction effects. When applied to real data from the UK Biobank, our approach identified genes associated with hippocampal volume, which can be further replicated and evaluated for their role in the pathogenesis of Alzheimer's disease.

q-bio.QM↗

arXiv2023

A Kernel-Based Neural Network Test for High-dimensional Sequencing Data Analysis

The recent development of artificial intelligence (AI) technology, especially the advance of deep neural network (DNN) technology, has revolutionized many fields. While DNN plays a central role in modern AI technology, it has been rarely used in sequencing data analysis due to challenges brought by high-dimensional sequencing data (e.g., overfitting). Moreover, due to the complexity of neural networks and their unknown limiting distributions, building association tests on neural networks for genetic association analysis remains a great challenge. To address these challenges and fill the important gap of using AI in high-dimensional sequencing data analysis, we introduce a new kernel-based neural network (KNN) test for complex association analysis of sequencing data. The test is built on our previously developed KNN framework, which uses random effects to model the overall effects of high-dimensional genetic data and adopts kernel-based neural network structures to model complex genotype-phenotype relationships. Based on KNN, a Wald-type test is then introduced to evaluate the joint association of high-dimensional genetic data with a disease phenotype of interest, considering non-linear and non-additive effects (e.g., interaction effects). Through simulations, we demonstrated that our proposed method attained higher power compared to the sequence kernel association test (SKAT), especially in the presence of non-linear and interaction effects. Finally, we apply the methods to the whole genome sequencing (WGS) dataset from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, investigating new genes associated with the hippocampal volume change over time.

stat.ML↗

arXiv2023

Human-Inspired Facial Sketch Synthesis with Dynamic Adaptation

Facial sketch synthesis (FSS) aims to generate a vivid sketch portrait from a given facial photo. Existing FSS methods merely rely on 2D representations of facial semantic or appearance. However, professional human artists usually use outlines or shadings to covey 3D geometry. Thus facial 3D geometry (e.g. depth map) is extremely important for FSS. Besides, different artists may use diverse drawing techniques and create multiple styles of sketches; but the style is globally consistent in a sketch. Inspired by such observations, in this paper, we propose a novel Human-Inspired Dynamic Adaptation (HIDA) method. Specially, we propose to dynamically modulate neuron activations based on a joint consideration of both facial 3D geometry and 2D appearance, as well as globally consistent style control. Besides, we use deformable convolutions at coarse-scales to align deep features, for generating abstract and distinct outlines. Experiments show that HIDA can generate high-quality sketches in multiple styles, and significantly outperforms previous methods, over a large range of challenging faces. Besides, HIDA allows precise style control of the synthesized sketch, and generalizes well to natural scenes and other artistic styles. Our code and results have been released online at: https://github.com/AiArt-HDU/HIDA.

cs.CV↗

arXiv2023

Leveraging Historical Medical Records as a Proxy via Multimodal Modeling and Visualization to Enrich Medical Diagnostic Learning

Simulation-based Medical Education (SBME) has been developed as a cost-effective means of enhancing the diagnostic skills of novice physicians and interns, thereby mitigating the need for resource-intensive mentor-apprentice training. However, feedback provided in most SBME is often directed towards improving the operational proficiency of learners, rather than providing summative medical diagnoses that result from experience and time. Additionally, the multimodal nature of medical data during diagnosis poses significant challenges for interns and novice physicians, including the tendency to overlook or over-rely on data from certain modalities, and difficulties in comprehending potential associations between modalities. To address these challenges, we present DiagnosisAssistant, a visual analytics system that leverages historical medical records as a proxy for multimodal modeling and visualization to enhance the learning experience of interns and novice physicians. The system employs elaborately designed visualizations to explore different modality data, offer diagnostic interpretive hints based on the constructed model, and enable comparative analyses of specific patients. Our approach is validated through two case studies and expert interviews, demonstrating its effectiveness in enhancing medical training.

cs.HC↗

arXiv2023

Semantic-aware Generation of Multi-view Portrait Drawings

Neural radiance fields (NeRF) based methods have shown amazing performance in synthesizing 3D-consistent photographic images, but fail to generate multi-view portrait drawings. The key is that the basic assumption of these methods -- a surface point is consistent when rendered from different views -- doesn't hold for drawings. In a portrait drawing, the appearance of a facial point may changes when viewed from different angles. Besides, portrait drawings usually present little 3D information and suffer from insufficient training data. To combat this challenge, in this paper, we propose a Semantic-Aware GEnerator (SAGE) for synthesizing multi-view portrait drawings. Our motivation is that facial semantic labels are view-consistent and correlate with drawing techniques. We therefore propose to collaboratively synthesize multi-view semantic maps and the corresponding portrait drawings. To facilitate training, we design a semantic-aware domain translator, which generates portrait drawings based on features of photographic faces. In addition, use data augmentation via synthesis to mitigate collapsed results. We apply SAGE to synthesize multi-view portrait drawings in diverse artistic styles. Experimental results show that SAGE achieves significantly superior or highly competitive performance, compared to existing 3D-aware image synthesis methods. The codes are available at https://github.com/AiArt-HDU/SAGE.

cs.CV↗

arXiv2023

Masked and Adaptive Transformer for Exemplar Based Image Translation

We present a novel framework for exemplar based image translation. Recent advanced methods for this task mainly focus on establishing cross-domain semantic correspondence, which sequentially dominates image generation in the manner of local style control. Unfortunately, cross-domain semantic matching is challenging; and matching errors ultimately degrade the quality of generated images. To overcome this challenge, we improve the accuracy of matching on the one hand, and diminish the role of matching in image generation on the other hand. To achieve the former, we propose a masked and adaptive transformer (MAT) for learning accurate cross-domain correspondence, and executing context-aware feature augmentation. To achieve the latter, we use source features of the input and global style codes of the exemplar, as supplementary information, for decoding an image. Besides, we devise a novel contrastive style learning method, for acquire quality-discriminative style representations, which in turn benefit high-quality image generation. Experimental results show that our method, dubbed MATEBIT, performs considerably better than state-of-the-art methods, in diverse image translation tasks. The codes are available at \url{https://github.com/AiArt-HDU/MATEBIT}.

cs.CV↗

arXiv2022

A Sieve Quasi-likelihood Ratio Test for Neural Networks with Applications to Genetic Association Studies

Neural networks (NN) play a central role in modern Artificial intelligence (AI) technology and has been successfully used in areas such as natural language processing and image recognition. While majority of NN applications focus on prediction and classification, there are increasing interests in studying statistical inference of neural networks. The study of NN statistical inference can enhance our understanding of NN statistical proprieties. Moreover, it can facilitate the NN-based hypothesis testing that can be applied to hypothesis-driven clinical and biomedical research. In this paper, we propose a sieve quasi-likelihood ratio test based on NN with one hidden layer for testing complex associations. The test statistic has asymptotic chi-squared distribution, and therefore it is computationally efficient and easy for implementation in real data analysis. The validity of the asymptotic distribution is investigated via simulations. Finally, we demonstrate the use of the proposed test by performing a genetic association analysis of the sequencing data from Alzheimer's Disease Neuroimaging Initiative (ADNI).

stat.ML↗

arXiv2021

Magnetized Rutherford scattering angle for electron-ion collision in plasma

Rutherford scattering formula plays an important role in plasma classical transport. It is urgent to need a magnetized Rutherford scattering formula since the magnetic field increases significantly in different fusion areas (e.g. tokamak magnetic field, self-generated magnetic field, and compressed magnetic field). The electron-ion Coulomb collisions perpendicular to the external magnetic field are studied in this paper. The scattering angle is defined according to the electron trajectory and asymptotic line (without magnetic field). A magnetized Rutherford scattering formula is obtained analytically under the weak magnetic field approximation. It is found that the scattering angle decreases as external magnetic field increases. It is easy to find the scattering angle decreasing significantly as incident distance, and incident velocity increasing. It is shown that the theoretical results agree well with numerical calculation by checking the dependence of scattering angle on external magnetic field.

physics.plasm-ph↗