arXiv subjects

Elizabeth M. C. Hillman

Publications and source records attributed to Elizabeth M. C. Hillman.

2 recordsLinked to original sources

arXiv2017

Whole-Volume Clustering of Time Series Data from Zebrafish Brain Calcium Images via Mixture Modeling

Calcium is a ubiquitous messenger in neural signaling events. An increasing number of techniques are enabling visualization of neurological activity in animal models via luminescent proteins that bind to calcium ions. These techniques generate large volumes of spatially correlated time series. A model-based functional data analysis methodology via Gaussian mixtures is suggested for the clustering of data from such visualizations is proposed. The methodology is theoretically justified and a computationally efficient approach to estimation is suggested. An example analysis of a zebrafish imaging experiment is presented.

stat.ME↗

arXiv2014

Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity

Intratumor heterogeneity is often manifested by vascular compartments with distinct pharmacokinetics that cannot be resolved directly by in vivo dynamic imaging. We developed tissue-specific compartment modeling (TSCM), an unsupervised computational method of deconvolving dynamic imaging series from heterogeneous tumors that can improve vascular phenotyping in many biological contexts. Applying TSCM to dynamic contrast-enhanced MRI of breast cancers revealed characteristic intratumor vascular heterogeneity and therapeutic responses that were otherwise undetectable.

q-bio.QM↗