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arXiv · 1306.3392

Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity

Li Chen·Peter L. Choyke·Niya Wang·Robert Clarke·Zaver M. Bhujwalla·Elizabeth M. C. Hillman·Yue Wang
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Abstract

Intratumor heterogeneity is often manifested by vascular compartments with distinct pharmacokinetics that cannot be resolved directly by in vivo dynamic imaging. We developed tissue-specific compartment modeling (TSCM), an unsupervised computational method of deconvolving dynamic imaging series from heterogeneous tumors that can improve vascular phenotyping in many biological contexts. Applying TSCM to dynamic contrast-enhanced MRI of breast cancers revealed characteristic intratumor vascular heterogeneity and therapeutic responses that were otherwise undetectable.

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Li Chen, Peter L. Choyke, Niya Wang, Robert Clarke, Zaver M. Bhujwalla, Elizabeth M. C. Hillman, Yue Wang. 2014-09-04. Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity. https://doi.org/10.1371/journal.pone.0112143

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