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Guneet Mummaneni

Publications and source records attributed to Guneet Mummaneni.

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OptiGAN for Crystal Arrays: Physics-Informed Generative Modeling of Optical Photon Transport in PET Detector Arrays

Monte Carlo simulations of optical photon transport are computationally prohibitive for large-scale optical systems including detector arrays and PET systems, restricting their practical use to single-crystal studies. This work presents an enhanced conditional generative adversarial network capable of replacing optical simulations at the crystal array level, extending our previous single-crystal approach to a 3x3 BGO detector array. We introduce Fourier feature encoding and a learnable latent mapping network as the modifications enabling stable training on the array geometry, together with a physics-informed loss term enforcing the unit-sphere state space $S^2$ of the generated propagation directions as a soft constraint. Training data requirements are reduced eight-fold by exploiting the array's symmetry. Performance is benchmarked against GATE10/Geant4 ground truth, using the fluctuations between independent Monte Carlo runs. The enhanced optiGAN achieves similarity values within 3$\sigma$ agreement of the Monte Carlo baseline across all evaluation conditions. An ablation and attribution analysis shows that the physics-informed loss term reduces low-SSIM bin fractions by a factor of 3.6 on the outer crystals, with a localized trade-off at the central crystal, yielding a net 48% reduction over the full array. The model transitions from electron-emission training data to realistic gamma-photon interactions, producing flood maps that reproduce experimental patterns including photopeak clusters and inter-crystal scatter lines. This proof-of-concept demonstrates that a physics-informed generative model can simulate optical photon transport in segmented scintillator arrays at a training and inference cost accessible on a single workstation GPU.

physics.ins-det

Towards Digital Twins for Optimal Radioembolization

Radioembolization is a localized liver cancer treatment that delivers radioactive microspheres (30 micron) to tumors via a catheter inserted in the hepatic arterial tree. The goal is to maximize therapeutic efficacy while minimizing damage to healthy liver tissue. However, optimization is challenging due to complex hepatic artery anatomy, variable blood flow, and uncertainty in microsphere transport. The creation of dynamic, patient-specific digital twins may provide a transformative solution to these challenges. This work outlines a framework for a liver radioembolization digital twin using high-fidelity computational fluid dynamics (CFD) and/or recent physics-informed machine learning approaches. The CFD approach involves microsphere transport calculations in the hepatic arterial tree with individual patient data, which enables personalized treatment planning. Although accurate, traditional CFD is computationally expensive and limits clinical applicability. To accelerate simulations, physics-informed neural networks (PINNs) and their generative extensions play an increasingly important role. PINNs integrate governing equations, such as the Navier-Stokes equations, directly into the neural network training process, enabling mesh-free, data-efficient approximation of blood flow and microsphere transport. Physics-informed generative adversarial networks (PI-GANs), diffusion models (PI-DMs), and transformer-based architectures further enable uncertainty-aware, temporally resolved predictions with reduced computational cost. These AI surrogates not only maintain physical fidelity but also support rapid sampling of diverse flow scenarios, facilitating real-time decision support. Together, CFD and physics-informed AI methods form the foundation of dynamic, patient-specific digital twin to optimize radioembolization planning and ultimately improve clinical outcomes.

eess.IV

GATE 10 Monte Carlo particle transport simulation -- Part II: architecture and innovations

Over the past years, we have developed GATE version 10, a major re-implementation of the long-standing Geant4-based Monte Carlo application for particle and radiation transport simulation in medical physics. This release introduces many new features and significant improvements, most notably a Python-based user interface replacing the legacy static input files. The new functionality of GATE version 10 is described in the part 1 companion paper. The development brought significant challenges. In this paper, we present the solutions that we have developed to overcome these challenges. In particular, we present a modular design that robustly manages the core components of a simulation: particle sources, geometry, physics processes, and data acquisition. The architecture consists of parts written in C++ and Python, which needed to be coupled. We explain how this framework allows for the precise, time-aware generation of primary particles, a critical requirement for accurately modeling positron emission tomography (PET), radionuclide therapies, and prompt-gamma timing systems. We present how GATE 10 handles complex Geant4 physics settings while exposing a simple interface to the user. Furthermore, we describe the technical solutions that facilitate the seamless integration of advanced physics models and variance reduction techniques. The architecture supports sophisticated scoring of physical quantities (such as Linear Energy Transfer and Relative Biological Effectiveness) and is designed for multithreaded execution. The new user interface allows researchers to script complex simulation workflows and directly couple external tools, such as artificial intelligence models for source generation or detector response. By detailing these architectural innovations, we demonstrate how GATE 10 provides a more powerful and flexible tool for research and innovation in medical physics.

physics.med-ph

GATE 10 Monte Carlo particle transport simulation -- Part I: development and new features

We present GATE version 10, a major evolution of the open-source Monte Carlo simulation application for medical physics, built on Geant4. This release marks a transformative evolution, featuring a modern Python-based user interface, enhanced multithreading and multiprocessing capabilities, the ability to be embedded as a library within other software, and a streamlined framework for collaborative development. In this Part 1 paper, we outline GATE's position among other Monte Carlo codes, the core principles driving this evolution, and the robust development cycle employed. We also detail the new features and improvements. Part 2 will detail the architectural innovations and technical challenges. By combining an open, collaborative framework with cutting-edge features, such a Monte Carlo platform supports a wide range of academic and industrial research, solidifying its role as a critical tool for innovation in medical physics.

physics.med-ph