arXiv subjects

Hans-Georg Müller

Publications and source records attributed to Hans-Georg Müller.

At least 19 recordsLinked to original sources

arXiv2026

Geodesic Difference-in-Differences

Difference-in-differences (DID) is a widely used quasi-experimental design for causal inference, traditionally applied to scalar or Euclidean outcomes, while extensions to outcomes residing in non-Euclidean spaces remain limited. Existing methods for such outcomes have primarily focused on univariate distributions, leveraging linear operations in the space of quantile functions, but these approaches cannot be directly extended to outcomes in general metric spaces. In this paper, we propose geodesic DID, a novel DID framework for outcomes in uniquely geodesic metric spaces that admit a geodesic transport structure, including distributions, networks, and manifold-valued data. To address the absence of algebraic operations in these spaces, we use geodesics as proxies for differences and introduce the geodesic average treatment effect on the treated (ATT) as the causal estimand. We establish the identification of the geodesic ATT and derive the convergence rate of its sample versions, employing tools from metric geometry and empirical process theory. This framework is further extended to the case of staggered DID settings, allowing for multiple time periods and varying treatment timings. To illustrate the practical utility of geodesic DID, we analyze health impacts of the Soviet Union's collapse using age-at-death distributions and assess effects of U.S. electricity market liberalization on electricity generation compositions.

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arXiv2026

Geodesic Synthetic Control Methods for Random Objects and Functional Data

We introduce a geodesic synthetic control method for causal inference with panel outcomes that are random objects in a geodesic metric space. Examples include distributions, compositions, networks, symmetric positive-definite matrices, trees and functional data, among other data types that require a geometry beyond Euclidean vector spaces. The proposed method replaces Euclidean weighted averages by weighted Fréchet means and defines treatment effects as geodesics connecting untreated and treated potential outcomes. We develop a causal model with stochastic perturbations for object-valued untreated outcomes, establish consistency of the estimated weights for the perturbed population target, derive a bound on post-treatment prediction error, and give sufficient conditions for consistent recovery of the untreated counterfactual. For uncertainty quantification, we propose an intrinsic metric conformal calibration procedure that yields prediction regions for untreated counterfactual objects, confidence sets for geodesic treatment effects, confidence intervals for their magnitudes, and global no-effect tests. The method is illustrated through simulation studies for networks and symmetric positive-definite matrices, and through applications to employment composition changes following the 2011 Great East Japan Earthquake and the impact of abortion liberalization on fertility patterns in East Germany.

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arXiv2026

Regression Discontinuity Designs for Functional Data and Random Objects in Geodesic Spaces

Regression discontinuity designs (RDDs) are widely used for causal inference in observational studies with cutoff-based treatment assignment, primarily for Euclidean outcomes. We propose the geodesic regression discontinuity design (GRDD), which extends RDDs to complex non-Euclidean outcomes, including networks, compositional data, functional data, and other random objects in geodesic metric spaces. Since algebraic operations are unavailable in such spaces, we define the causal effect at the cutoff as the geodesic connecting the local Fréchet means of untreated and treated outcomes, recovering the classical local average treatment effect in the scalar case. Estimation is conducted intrinsically via local Fréchet regression to preserve geometric validity and interpretability. For inference, we adopt an extrinsic approach by embedding the metric space into a Hilbert space, enabling tractable asymptotic analysis. We establish asymptotic normality and develop bootstrap-based procedures for hypothesis testing and confidence intervals for the treatment effect magnitude. We also propose a data-adaptive bandwidth selection method tailored to RDDs in metric spaces and study its empirical performance. Applications include compositional voting outcomes in UK elections and daily CO concentration curves after the Taipei metro introduction, and we extend the framework to fuzzy designs with imperfect compliance.

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arXiv2026

Geodesic Causal Inference

Adjusting for confounding and imbalance when establishing statistical relationships is an increasingly important task, and causal inference methods have emerged as the most popular tool to achieve this. Existing methodology has been developed primarily for outcomes that lie in Euclidean spaces. We introduce here a general framework for causal inference when outcomes reside in general geodesic metric spaces, where we draw on a novel geodesic calculus that facilitates scalar multiplication for geodesics and the quantification of treatment effects through the concept of geodesic average treatment effect. Using ideas from Fréchet regression, we obtain a doubly robust estimation of the geodesic average treatment effect and results on consistency and rates of convergence for the proposed estimators. We also develop an intrinsic uncertainty quantification framework for the treatment effect based on Fréchet objective functions. The proposed framework is illustrated through simulations and real data applications, including network-valued outcomes from New York City taxi trips to assess the impact of the COVID-19 pandemic, and compositional data on U.S. state-level energy sources to study the effect of coal mining.

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arXiv2026

Deep Single-Index Fréchet Regression

Predicting outputs that are located in non-Euclidean spaces, such as probability distributions, networks, and symmetric positive-definite matrices, is becoming increasingly important in modern data analysis, particularly when inputs are high-dimensional. We propose DeSI (Deep Single-Index Fréchet Regression), a semiparametric framework for regression with metric space-valued outputs and multivariate inputs that assumes a single-index structure for the conditional Fréchet mean. DeSI estimates an interpretable index direction, which quantifies the relative importance of inputs, using a deep neural network, and performs Fréchet regression along the resulting one-dimensional index in the target metric space. This structure mitigates the curse of dimensionality while retaining interpretability, which stands in contrast to standard deep neural networks. We establish theoretical guarantees for DeSI, including uniform approximation and convergence rates, and demonstrate its strong predictive performance through simulations on distributions, networks, and symmetric positive-definite matrices, as well as an application to compositional mood data from New Jersey.

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arXiv2026

End-to-End Deep Learning for Predicting Metric Space-Valued Outputs

Many modern applications involve predicting structured, non-Euclidean outputs such as probability distributions, networks, and symmetric positive-definite matrices. These outputs are naturally modeled as elements of general metric spaces, where classical regression techniques that rely on vector space structure no longer apply. We introduce E2M (End-to-End Metric regression), a deep learning framework for predicting metric space-valued outputs. E2M performs prediction via weighted Fréchet means over training outputs, where the weights are learned by a neural network conditioned on the input. This construction provides a principled mechanism for geometry-aware prediction that avoids surrogate embeddings and restrictive parametric assumptions, while fully preserving the intrinsic geometry of the output space. We establish theoretical guarantees, including a universal approximation theorem that characterizes the expressive capacity of the model and a convergence analysis of the entropy-regularized training objective. Through extensive simulations involving probability distributions, networks, and symmetric positive-definite matrices, we show that E2M consistently achieves state-of-the-art performance, with its advantages becoming more pronounced at larger sample sizes. Applications to human mortality distributions and New York City taxi networks further demonstrate the flexibility and practical utility of this framework.

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arXiv2026

Inference for Fréchet Regression

Linear regression is widely used to model relationships between responses and predictors. In modern applications, one encounters data where the responses are non-Euclidean random objects situated in a metric space, paired with Euclidean predictors. Global Fréchet regression generalizes linear regression to such general settings, however statistical inference has remained largely unexplored. We develop a significance test for the null hypothesis that the Fréchet regression function does not depend on the predictors, addressing the challenge of an absence of linear operations in metric spaces. We also develop a test for the partial effect of a subset of the predictors in analogy to, but quite different from, the partial F-tests commonly used in classical linear regression under Gaussian assumptions. Key ideas are to employ random multipliers to obtain non-degenerate null distributions for the proposed test statistics and the Cauchy combination method. We obtain consistency and convergence results under the null hypothesis and contiguous alternatives and demonstrate the finite sample performance of the proposed tests through simulations on network data represented by graph Laplacians and spherical data with geodesic distances. We further illustrate our method using transport networks arising from New York City taxi trip data and U.S. energy source compositional data.

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arXiv2026

Predictive Distributions and the Transition from Sparse to Dense Functional Data

A representation of Gaussian distributed sparsely sampled longitudinal data in terms of predictive distributions for their functional principal component scores (FPCs) maps available data for each subject to a multivariate Gaussian predictive distribution. Of special interest is the case where the number of observations per subject increases in the transition from sparse (longitudinal) to dense (functional) sampling of underlying stochastic processes. We study the convergence of the predicted scores given noisy longitudinal observations towards the true but unobservable FPCs, and under Gaussianity demonstrate the shrinkage of the entire predictive distribution towards a point mass located at the true FPCs and also extensions to the shrinkage of functional $K$-truncated predictive distributions when the truncation point $K=K(n)$ diverges with sample size $n$. To address the problem of non-consistency of point predictions, we construct predictive distributions aimed at predicting outcomes for the case of sparsely sampled longitudinal predictors in functional linear models and derive asymptotic rates of convergence for the $2$-Wasserstein metric between true and estimated predictive distributions. Predictive distributions are illustrated for longitudinal data from the Baltimore Longitudinal Study of Aging.

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arXiv2025

ADOPT: Additive Optimal Transport Regression

Regression analysis for responses taking values in general metric spaces has received increasing attention, particularly for settings with Euclidean predictors $X \in \mathbb{R}^p$ and non-Euclidean responses $Y$ in metric spaces. While additive regression is a powerful tool for enhancing interpretability and mitigating the curse of dimensionality in the presence of multivariate predictors, its direct extension is hindered by the absence of vector space operations in general metric spaces. We propose a novel framework for additive optimal transport regression, which incorporates additive structure through optimal geodesic transports. A key idea is to extend the notion of optimal transports in Wasserstein spaces to general geodesic metric spaces. This unified approach accommodates a wide range of responses, including probability distributions, symmetric positive definite (SPD) matrices with various metrics and spherical data. The practical utility of the method is illustrated with correlation matrices derived from resting state fMRI brain imaging data.

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arXiv2025

Sensitivity Analysis when Generalizing Causal Effects from Multiple Studies to a Target Population: Motivation from the ECHO Program

Unobserved effect modifiers can induce bias when generalizing causal effect estimates to target populations. In this work, we extend a sensitivity analysis framework assessing the robustness of study results to unobserved effect modification that adapts to various generalizability scenarios, including multiple (conditionally) randomized trials, observational studies, or combinations thereof. This framework is interpretable and does not rely on distributional or functional assumptions about unknown parameters. We demonstrate how to leverage the multi-study setting to detect violation of the generalizability assumption through hypothesis testing, showing with simulations that the proposed test achieves high power under real-world sample sizes. Finally, we apply our sensitivity analysis framework to analyze the generalized effect estimate of secondhand smoke exposure on birth weight using cohort sites from the Environmental influences on Child Health Outcomes (ECHO) study.

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arXiv2025

Sliced Wasserstein Regression

While statistical modeling of distributional data has gained increased attention, the case of multivariate distributions has been somewhat neglected despite its relevance in various applications. This is because the Wasserstein distance, commonly used in distributional data analysis, poses challenges for multivariate distributions. A promising alternative is the sliced Wasserstein distance, which offers a computationally simpler solution. We propose distributional regression models with multivariate distributions as responses paired with Euclidean vector predictors. The foundation of our methodology is a slicing transform from the multivariate distribution space to the sliced distribution space for which we establish a theoretical framework, with the Radon transform as a prominent example. We introduce and study the asymptotic properties of sample-based estimators for two regression approaches, one based on utilizing the sliced Wasserstein distance directly in the multivariate distribution space, and a second approach based on a new slice-wise distance, employing a univariate distribution regression for each slice. Both global and local Fréchet regression methods are deployed for these approaches and illustrated in simulations and through applications. These include joint distributions of excess winter death rates and winter temperature anomalies in European countries as a function of base winter temperature and also data from finance.

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arXiv2025

Association and Independence Test for Random Objects

We develop a unified framework for testing independence and quantifying association between random objects that are located in general metric spaces. Special cases include functional and high-dimensional data as well as networks, covariance matrices and data on Riemannian manifolds, among other metric space-valued data. A key concept is the profile association, a measure based on distance profiles that intrinsically characterize the distributions of random objects in metric spaces. We rigorously establish a connection between the Hoeffding D statistic and the profile association and derive a permutation test with theoretical guarantees for consistency and power under alternatives to the null hypothesis of independence/no association. We extend this framework to the conditional setting, where the independence between random objects given a Euclidean predictor is of interest. In simulations across various metric spaces, the proposed profile independence test is found to outperform existing approaches. The practical utility of this framework is demonstrated with applications to brain connectivity networks derived from magnetic resonance imaging and age-at-death distributions for males and females obtained from human mortality data.

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arXiv2025

Fréchet Geodesic Boosting

Gradient boosting has become a cornerstone of machine learning, enabling base learners such as decision trees to achieve exceptional predictive performance. While existing algorithms primarily handle scalar or Euclidean outputs, increasingly prevalent complex-structured data, such as distributions, networks, and manifold-valued outputs, present challenges for traditional methods. Such non-Euclidean data lack algebraic structures such as addition, subtraction, or scalar multiplication required by standard gradient boosting frameworks. To address these challenges, we introduce Fréchet geodesic boosting (FGBoost), a novel approach tailored for outputs residing in geodesic metric spaces. FGBoost leverages geodesics as proxies for residuals and constructs ensembles in a way that respects the intrinsic geometry of the output space. Through theoretical analysis, extensive simulations, and real-world applications, we demonstrate the strong performance and adaptability of FGBoost, showcasing its potential for modeling complex data.

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arXiv2025

Measure Selection for Functional Linear Model

Advancements in modern science have led to an increased prevalence of functional data, which are usually viewed as elements of the space of square-integrable functions $L^2$. Core methods in functional data analysis, such as functional principal component analysis, are typically grounded in the Hilbert structure of $L^2$ and rely on inner products based on integrals with respect to the Lebesgue measure over a fixed domain. A more flexible framework is proposed, where the measure can be arbitrary, allowing natural extensions to unbounded domains and prompting the question of optimal measure choice. Specifically, a novel functional linear model is introduced that incorporates a data-adaptive choice of the measure that defines the space, alongside an enhanced function principal component analysis. Selecting a good measure can improve the model's predictive performance, especially when the underlying processes are not well-represented when adopting the default Lebesgue measure. Simulations, as well as applications to COVID-19 data and the National Health and Nutrition Examination Survey data, show that the proposed approach consistently outperforms the conventional functional linear model.

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arXiv2025

Inference for Dispersion and Curvature of Random Objects

There are many open questions pertaining to the statistical analysis of random objects, which are increasingly encountered. A major challenge is the absence of linear operations in such spaces. A basic statistical task is to quantify statistical dispersion or spread. For two measures of dispersion for data objects in geodesic metric spaces, Fréchet variance and metric variance, we derive a central limit theorem (CLT) for their joint distribution. This analysis reveals that the Alexandrov curvature of the geodesic space determines the relationship between these two dispersion measures. This suggests a novel test for inferring the curvature of a space based on the asymptotic distribution of the dispersion measures. We demonstrate how this test can be employed to detect the intrinsic curvature of an unknown underlying space, which emerges as a joint property of the space and the underlying probability measure that generates the random objects. We investigate the asymptotic properties of the test and its finite-sample behavior for various data types, including distributional data and point cloud data. We illustrate the proposed inference for intrinsic curvature of random objects using gait synchronization data represented as symmetric positive definite matrices and energy compositional data on the sphere.

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arXiv2025

Conformal inference for random objects

We develop an inferential toolkit for analyzing object-valued responses, which correspond to data situated in general metric spaces, paired with Euclidean predictors within the conformal framework. To this end we introduce conditional profile average transport costs, where we compare distance profiles that correspond to one-dimensional distributions of probability mass falling into balls of increasing radius through the optimal transport cost when moving from one distance profile to another. The average transport cost to transport a given distance profile to all others is crucial for statistical inference in metric spaces and underpins the proposed conditional profile scores. A key feature of the proposed approach is to utilize the distribution of conditional profile average transport costs as conformity score for general metric space-valued responses, which facilitates the construction of prediction sets by the split conformal algorithm. We derive the uniform convergence rate of the proposed conformity score estimators and establish asymptotic conditional validity for the prediction sets. The finite sample performance for synthetic data in various metric spaces demonstrates that the proposed conditional profile score outperforms existing methods in terms of both coverage level and size of the resulting prediction sets, even in the special case of scalar Euclidean responses. We also demonstrate the practical utility of conditional profile scores for network data from New York taxi trips and for compositional data reflecting energy sourcing of U.S. states.

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arXiv2025

Deep Fréchet Regression

Advancements in modern science have led to the increasing availability of non-Euclidean data in metric spaces. This paper addresses the challenge of modeling relationships between non-Euclidean responses and multivariate Euclidean predictors. We propose a flexible regression model capable of handling high-dimensional predictors without imposing parametric assumptions. Two primary challenges are addressed: the curse of dimensionality in nonparametric regression and the absence of linear structure in general metric spaces. The former is tackled using deep neural networks, while for the latter we demonstrate the feasibility of mapping the metric space where responses reside to a low-dimensional Euclidean space using manifold learning. We introduce a reverse mapping approach, employing local Fréchet regression, to map the low-dimensional manifold representations back to objects in the original metric space. We develop a theoretical framework, investigating the convergence rate of deep neural networks under dependent sub-Gaussian noise with bias. The convergence rate of the proposed regression model is then obtained by expanding the scope of local Fréchet regression to accommodate multivariate predictors in the presence of errors in predictors. Simulations and case studies show that the proposed model outperforms existing methods for non-Euclidean responses, focusing on the special cases of probability distributions and networks.

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arXiv2025

Exceedance and force of centrality for functional data

Exceedance refers to instances where a dynamic process surpasses given thresholds, e.g., the occurrence of a heat wave. We propose a novel exceedance framework for functional data, where each observed random trajectory is transformed into an exceedance function, which quantifies exceedance durations as a function of threshold levels. An inherent relationship between exceedance functions and probability distributions makes it possible to draw on distributional data analysis techniques such as Fréchet regression to study the dependence of exceedances on Euclidean predictors, e.g., calendar year when the exceedances are observed. We use local linear estimators to obtain exceedance functions from discretely observed functional data with noise and study the convergence of the proposed estimators. New concepts of interest include the force of centrality that quantifies the propensity of a system to revert to lower levels when a given threshold has been exceeded, conditional exceedance functions when conditioning on Euclidean covariates, and threshold exceedance functions, which characterize the size of exceedance sets in dependence on covariates for any fixed threshold. We establish consistent estimation with rates of convergence for these targets. The practical merits of the proposed methodology are illustrated through simulations and applications for annual temperature curves and medfly activity profiles.

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