arXiv subjects

Haojie Yang

Publications and source records attributed to Haojie Yang.

5 recordsLinked to original sources

arXiv2026

GRIPNet: Gaussian Radial Intensity Prior Guided Architecture for Pulmonary Nodule Detection in CT

Lung cancer causes more deaths than any other malignancy, and low-dose CT screening is the main pathway to early diagnosis. That pathway hinges on the smallest lesions, yet nodules below six millimeters remain hard to detect, because most methods treat a nodule as a generic object and ignore the imaging physics behind its appearance. We show that this appearance is highly regular. Intensity peaks at the geometric center of a nodule and decays radially in a Gaussian pattern, and a fit to 18,218 annotated lesions from three public benchmarks yields a mean radial coefficient of determination above 0.86 in every dataset and size stratum. A square convolution samples both axes uniformly and is mismatched to this radial signal, most severely for small nodules. Guided by this evidence, we propose GRIPNet (Gaussian Radial Intensity Prior Network), a detector in which every module maps to a measurable property of the intensity distribution. Pinwheel convolutions decompose radial gradients, a dual-frequency module separates boundary detail from structural context, dilated masked attention matches the decay extent, and an adaptive loss reweights samples by conspicuity. GRIPNet raises mAP@0.5 to 95.3, 91.6 and 97.9 percent on KanserSet, LUNA16 and Lung-PET-CT-Dx while sharpening high-IoU localization at real-time speed.

cs.CV↗

arXiv2026

Intelligent Diagnosis Using Dual-Branch Attention Network for Rare Thyroid Carcinoma Recognition with Ultrasound Imaging

Heterogeneous morphological features and data imbalance pose significant challenges in rare thyroid carcinoma classification using ultrasound imaging. To address this issue, we propose a novel multitask learning framework, Channel-Spatial Attention Synergy Network (CSASN), which integrates a dual-branch feature extractor - combining EfficientNet for local spatial encoding and ViT for global semantic modeling, with a cascaded channel-spatial attention refinement module. A residual multiscale classifier and dynamically weighted loss function further enhance classification stability and accuracy. Trained on a multicenter dataset comprising more than 2000 patients from four clinical institutions, our framework leverages a residual multiscale classifier and dynamically weighted loss function to enhance classification stability and accuracy. Extensive ablation studies demonstrate that each module contributes significantly to model performance, particularly in recognizing rare subtypes such as FTC and MTC carcinomas. Experimental results show that CSASN outperforms existing single-stream CNN or Transformer-based models, achieving a superior balance between precision and recall under class-imbalanced conditions. This framework provides a promising strategy for AI-assisted thyroid cancer diagnosis.

eess.IV↗

arXiv2025

CDI-DTI: A Strong Cross-domain Interpretable Drug-Target Interaction Prediction Framework Based on Multi-Strategy Fusion

Accurate prediction of drug-target interactions (DTI) is pivotal for drug discovery, yet existing methods often fail to address challenges like cross-domain generalization, cold-start prediction, and interpretability. In this work, we propose CDI-DTI, a novel cross-domain interpretable framework for DTI prediction, designed to overcome these limitations. By integrating multi-modal features-textual, structural, and functional-through a multi-strategy fusion approach, CDI-DTI ensures robust performance across different domains and in cold-start scenarios. A multi-source cross-attention mechanism is introduced to align and fuse features early, while a bidirectional cross-attention layer captures fine-grained intra-modal drug-target interactions. To enhance model interpretability, we incorporate Gram Loss for feature alignment and a deep orthogonal fusion module to eliminate redundancy. Experimental results on several benchmark datasets demonstrate that CDI-DTI significantly outperforms existing methods, particularly in cross-domain and cold-start tasks, while maintaining high interpretability for practical applications in drug-target interaction prediction.

cs.MM↗

arXiv2025

Adaptive Multi-Objective Bayesian Optimization for Capacity Planning of Hybrid Heat Sources in Electric-Heat Coupling Systems of Cold Regions

The traditional heat-load generation pattern of combined heat and power generators has become a problem leading to renewable energy source (RES) power curtailment in cold regions, motivating the proposal of a planning model for alternative heat sources. The model aims to identify non-dominant capacity allocation schemes for heat pumps, thermal energy storage, electric boilers, and combined storage heaters to construct a Pareto front, considering both economic and sustainable objectives. The integration of various heat sources from both generation and consumption sides enhances flexibility in utilization. The study introduces a novel optimization algorithm, the adaptive multi-objective Bayesian optimization (AMBO). Compared to other widely used multi-objective optimization algorithms, AMBO eliminates predefined parameters that may introduce subjectivity from planners. Beyond the algorithm, the proposed model incorporates a noise term to account for inevitable simulation deviations, enabling the identification of better-performing planning results that meet the unique requirements of cold regions. What's more, the characteristics of electric-thermal coupling scenarios are captured and reflected in the operation simulation model to make sure the simulation is close to reality. Numerical simulation verifies the superiority of the proposed approach in generating a more diverse and evenly distributed Pareto front in a sample-efficient manner, providing comprehensive and objective planning choices.

eess.SY↗

arXiv2018

Femtosecond Photonic Viral Inactivation Probed Using Solid-State Nanopores

We report on the detection of inactivation of virus particles using femtosecond laser radiation by measuring the conductance of a solid state nanopore designed for detecting single virus particles. Conventional methods of assaying for viral inactivation based on plaque forming assays require 24-48 hours for bacterial growth. Nanopore conductance measurements provide information on morphological changes at a single virion level. We show that analysis of a time series of nanopore conductance can quantify the detection of inactivation, requiring only a few minutes from collection to analysis. Morphological changes were verified by Dynamic Light Scattering (DLS). Statistical analysis maximizing the information entropy provides a measure of the Log-reduction value. Taken together, our work provides a rapid method for assaying viral inactivation with femtosecond lasers using solid-state nanopores.

physics.bio-ph↗