arXiv subjects

Hua Yang

Publications and source records attributed to Hua Yang.

At least 37 records · Page 2Linked to original sources

arXiv2025

A dispersal recolonisation 3D biofilm in vitro model based on co-assembled peptide amphiphiles and clinical wound fluid

Chronic wound infections are sustained by dynamic 3D biofilm cycles involving maturation, dispersal, and recolonisation, yet existing in vitro models fail to reproduce these temporal and structural complexities. Here, we report a strategy that co-assembles a designed protease-inhibitory peptide amphiphile (PA-GF) with patient-derived wound fluid (WF) to reconstruct the complete biofilm life cycle in vitro. The PA-GF sequence incorporates an HWGF motif capable of binding and inhibiting matrix metalloproteinase-9 (MMP-9), thereby preserving the integrity of recolonised biofilms under proteolytic stress. Co-assembling with WF generated a living material that faithfully mimicked the biochemical and mechanical microenvironment of chronic wounds, supporting the formation of stable 3D biofilms capable of dispersal and recolonisation. Furthermore, we established a controllable polymicrobial infection model and validated its translational relevance through antibiotic susceptibility profiling and spatial microbiological analyses. Notably, the antibiotic response patterns of the PA/WF-derived biofilms closely mirrored those observed in a rat wound infection in vivo model. Collectively, our findings demonstrate that co-assembling living materials can recapitulate the nutritional composition, 3D architecture, and recolonisation dynamics of in vivo infectious biofilms, offering a physiologically relevant and customisable platform for investigating chronic wound infections and accelerating anti-biofilm drug discovery.

physics.med-ph↗

arXiv2025

MTIL: Encoding Full History with Mamba for Temporal Imitation Learning

Standard imitation learning (IL) methods have achieved considerable success in robotics, yet often rely on the Markov assumption, which falters in long-horizon tasks where history is crucial for resolving perceptual ambiguity. This limitation stems not only from a conceptual gap but also from a fundamental computational barrier: prevailing architectures like Transformers are often constrained by quadratic complexity, rendering the processing of long, high-dimensional observation sequences infeasible. To overcome this dual challenge, we introduce Mamba Temporal Imitation Learning (MTIL). Our approach represents a new paradigm for robotic learning, which we frame as a practical synthesis of World Model and Dynamical System concepts. By leveraging the linear-time recurrent dynamics of State Space Models (SSMs), MTIL learns an implicit, action-oriented world model that efficiently encodes the entire trajectory history into a compressed, evolving state. This allows the policy to be conditioned on a comprehensive temporal context, transcending the confines of Markovian approaches. Through extensive experiments on simulated benchmarks (ACT, Robomimic, LIBERO) and on challenging real-world tasks, MTIL demonstrates superior performance against SOTA methods like ACT and Diffusion Policy, particularly in resolving long-term temporal ambiguities. Our findings not only affirm the necessity of full temporal context but also validate MTIL as a powerful and a computationally feasible approach for learning long-horizon, non-Markovian behaviors from high-dimensional observations.

cs.RO↗

arXiv2025

MM-HELIX: Boosting Multimodal Long-Chain Reflective Reasoning with Holistic Platform and Adaptive Hybrid Policy Optimization

While current Multimodal Large Language Models (MLLMs) have demonstrated proficiency in reasoning tasks such as mathematics and logic, their capacity for long-chain reflective reasoning, a prerequisite for solving complex real-world problems, remains largely underexplored. In this work, we first conduct an extensive empirical investigation to evaluate this capability. Leveraging a carefully designed data synthesis engine, we construct MM-HELIX, a multimodal benchmark consisting 1,260 samples of 42 challenging synthetic tasks that require iterative thinking and backtracking. Empirical results on this benchmark reveal that existing MLLMs exhibit significant performance deficits in long-chain reflective reasoning. To address this limitation, we generate post-training data and further explore learning paradigms for exploiting such data. We first develop the Step-Elicited Response Generation pipeline to create MM-HELIX-100K, a large-scale dataset of 100k high-quality, reflective reasoning traces for instruction-tuning stage. Given that standard Reinforcement Learning fails on complex tasks due to sparse reward signals and catastrophic forgetting after Supervised Fine-Tuning, we propose Adaptive Hybrid Policy Optimization (AHPO), a novel training strategy that dynamically unifies offline supervision and online optimization into a single stage. This strategy enables the model to learn from expert data when rewards are sparse and conduct independent exploration once proficient. When applied to the Qwen2.5-VL-7B baseline, our method achieves a +18.6\% accuracy improvement on MM-HELIX benchmark and demonstrates strong generalization with a +5.7\% average performance gain on general mathematic and logic tasks. Our work demonstrate that reflective reasoning in MLLMs can be effectively learned and generalized, paving the way for developing more capable MLLMs.

cs.CV↗

arXiv2025

How Quantization Impacts Privacy Risk on LLMs for Code?

Large language models for code (LLMs4Code) rely heavily on massive training data, including sensitive data, such as cloud service credentials of the projects and personal identifiable information of the developers, raising serious privacy concerns. Membership inference (MI) has recently emerged as an effective tool for assessing privacy risk by identifying whether specific data belong to a model's training set. In parallel, model compression techniques, especially quantization, have gained traction for reducing computational costs and enabling the deployment of large models. However, while quantized models still retain knowledge learned from the original training data, it remains unclear whether quantization affects their ability to retain and expose privacy information. Answering this question is of great importance to understanding privacy risks in real-world deployments. In this work, we conduct the first empirical study on how quantization influences task performance and privacy risk simultaneously in LLMs4Code. To do this, we implement widely used quantization techniques (static and dynamic) to three representative model families, namely Pythia, CodeGen, and GPTNeo. Our results demonstrate that quantization has a significant impact on reducing the privacy risk relative to the original model. We also uncover a positive correlation between task performance and privacy risk, indicating an underlying tradeoff. Moreover, we reveal the possibility that quantizing larger models could yield better balance than using full-precision small models. Finally, we demonstrate that these findings generalize across different architectures, model sizes and MI methods, offering practical guidance for safeguarding privacy when deploying compressed LLMs4Code.

cs.SE↗

arXiv2025

De novo design of alpha-helical peptide amphiphiles repairing fragmented collagen type I via supramolecular co-assembly

The hierarchical triple-helix structure of collagen type I, Col I, is essential for extracellular matrix support and integrity. However, current reconstruction strategies face challenges such as chain mismatch, preventing proper fibril formation. Here, we report a supramolecular co-assembly strategy using a de novo-designed alpha-helical peptide amphiphile (APA) of just seven amino acids. The APA features a hydrophobic palmitic acid tail, which stabilizes the helical structure and promotes co-assembly upon interaction with complementary molecular structures. This minimal design enables selective recognition of fragmented collagen (FC), restoring triple-helix conformation and guiding fibre formation. We applied this mechanism to engineer FC-rich nanofat (NF) into a mechanically reinforced biomaterial. Integration of APA-NF with coaxial 3D printing enabled spatial control of structure and function. In a porcine model, this platform enhanced in situ vascularized adipose tissue regeneration. Our results demonstrate that hierarchical reconstruction of collagen via peptide-guided supramolecular assembly offers a promising strategy for soft tissue repair.

physics.chem-ph↗

arXiv2025

3D Vision-tactile Reconstruction from Infrared and Visible Images for Robotic Fine-grained Tactile Perception

To achieve human-like haptic perception in anthropomorphic grippers, the compliant sensing surfaces of vision tactile sensor (VTS) must evolve from conventional planar configurations to biomimetically curved topographies with continuous surface gradients. However, planar VTSs have challenges when extended to curved surfaces, including insufficient lighting of surfaces, blurring in reconstruction, and complex spatial boundary conditions for surface structures. With an end goal of constructing a human-like fingertip, our research (i) develops GelSplitter3D by expanding imaging channels with a prism and a near-infrared (NIR) camera, (ii) proposes a photometric stereo neural network with a CAD-based normal ground truth generation method to calibrate tactile geometry, and (iii) devises a normal integration method with boundary constraints of depth prior information to correcting the cumulative error of surface integrals. We demonstrate better tactile sensing performance, a 40$\%$ improvement in normal estimation accuracy, and the benefits of sensor shapes in grasping and manipulation tasks.

cs.RO↗

arXiv2025

Envisioning Beyond the Pixels: Benchmarking Reasoning-Informed Visual Editing

Large Multi-modality Models (LMMs) have made significant progress in visual understanding and generation, but they still face challenges in General Visual Editing, particularly in following complex instructions, preserving appearance consistency, and supporting flexible input formats. To study this gap, we introduce RISEBench, the first benchmark for evaluating Reasoning-Informed viSual Editing (RISE). RISEBench focuses on four key reasoning categories: Temporal, Causal, Spatial, and Logical Reasoning. We curate high-quality test cases for each category and propose an robust evaluation framework that assesses Instruction Reasoning, Appearance Consistency, and Visual Plausibility with both human judges and the LMM-as-a-judge approach. We conducted experiments evaluating nine prominent visual editing models, comprising both open-source and proprietary models. The evaluation results demonstrate that current models face significant challenges in reasoning-based editing tasks. Even the most powerful model evaluated, GPT-4o-Image, achieves an accuracy of merely 28.8%. RISEBench effectively highlights the limitations of contemporary editing models, provides valuable insights, and indicates potential future directions for the field of reasoning-aware visual editing. Our code and data have been released at https://github.com/PhoenixZ810/RISEBench.

cs.CV↗

arXiv2025

Novel Direct Alpha Spectroscopy Technique for $^{225}$Ac Radiopharmaceutical detection in Cancer Cells

Targeted alpha-particle therapy (TAT) employs alpha-emitting radionuclides conjugated to tumor-targeting molecules to deliver localized radiation to cancer cells, showing great promise in treating metastatic cancers. Among these radionuclides, Actinium-225 ($^{225}$Ac, t$_{1/2}$ = 9.9 days) has emerged as a clinically promising candidate. Its decay chain generates four successive alpha emissions, resulting in highly localized and effective cytotoxic damage to cancer cells when delivered to tumor sites. However, the assumption of complete retention of $^{225}$Ac and its radioactive daughters at these target sites is often inaccurate. The nuclear recoil effect can lead to off-target distribution and unintended toxicity. Our results revealed distinct spectral differences between radiolabeled cells and reference samples, demonstrating [$^{225}$Ac]Ac-crown-TATE uptake by AR42J cells. Detection of $^{213}$Po, one of the $^{225}$Ac decay daughters, highlighted partial retention and release of decay products from cells, providing information on intracellular retention and daughter redistribution. Geant4 simulations confirmed the alignment of experimental data with theoretical models, validating the method's accuracy. This study establishes a direct alpha spectroscopy approach for investigating $^{225}$Ac and its daughters' behavior in cells and offers a powerful tool for microdosimetry estimation.

physics.med-ph↗

arXiv2025

Lightweight Multimodal Artificial Intelligence Framework for Maritime Multi-Scene Recognition

Maritime Multi-Scene Recognition is crucial for enhancing the capabilities of intelligent marine robotics, particularly in applications such as marine conservation, environmental monitoring, and disaster response. However, this task presents significant challenges due to environmental interference, where marine conditions degrade image quality, and the complexity of maritime scenes, which requires deeper reasoning for accurate recognition. Pure vision models alone are insufficient to address these issues. To overcome these limitations, we propose a novel multimodal Artificial Intelligence (AI) framework that integrates image data, textual descriptions and classification vectors generated by a Multimodal Large Language Model (MLLM), to provide richer semantic understanding and improve recognition accuracy. Our framework employs an efficient multimodal fusion mechanism to further enhance model robustness and adaptability in complex maritime environments. Experimental results show that our model achieves 98$\%$ accuracy, surpassing previous SOTA models by 3.5$\%$. To optimize deployment on resource-constrained platforms, we adopt activation-aware weight quantization (AWQ) as a lightweight technique, reducing the model size to 68.75MB with only a 0.5$\%$ accuracy drop while significantly lowering computational overhead. This work provides a high-performance solution for real-time maritime scene recognition, enabling Autonomous Surface Vehicles (ASVs) to support environmental monitoring and disaster response in resource-limited settings.

cs.CV↗

arXiv2025

OmniAlign-V: Towards Enhanced Alignment of MLLMs with Human Preference

Recent advancements in open-source multi-modal large language models (MLLMs) have primarily focused on enhancing foundational capabilities, leaving a significant gap in human preference alignment. This paper introduces OmniAlign-V, a comprehensive dataset of 200K high-quality training samples featuring diverse images, complex questions, and varied response formats to improve MLLMs' alignment with human preferences. We also present MM-AlignBench, a human-annotated benchmark specifically designed to evaluate MLLMs' alignment with human values. Experimental results show that finetuning MLLMs with OmniAlign-V, using Supervised Fine-Tuning (SFT) or Direct Preference Optimization (DPO), significantly enhances human preference alignment while maintaining or enhancing performance on standard VQA benchmarks, preserving their fundamental capabilities. Our datasets, benchmark, code and checkpoints have been released at https://github.com/PhoenixZ810/OmniAlign-V.

cs.CV↗

arXiv2024

MCSD: An Efficient Language Model with Diverse Fusion

Transformers excel in Natural Language Processing (NLP) due to their prowess in capturing long-term dependencies but suffer from exponential resource consumption with increasing sequence lengths. To address these challenges, we propose MCSD model, an efficient language model with linear scaling and fast inference speed. MCSD model leverages diverse feature fusion, primarily through the multi-channel slope and decay (MCSD) block, to robustly represent features. This block comprises slope and decay sections that extract features across diverse temporal receptive fields, facilitating capture of both local and global information. In addition, MCSD block conducts element-wise fusion of diverse features to further enhance the delicate feature extraction capability. For inference, we formulate the inference process into a recurrent representation, slashing space complexity to $O(1)$ and time complexity to $O(N)$ respectively. Our experiments show that MCSD attains higher throughput and lower GPU memory consumption compared to Transformers, while maintaining comparable performance to larger-scale language learning models on benchmark tests. These attributes position MCSD as a promising base for edge deployment and embodied intelligence.

cs.CL↗

arXiv2024

MG-LLaVA: Towards Multi-Granularity Visual Instruction Tuning

Multi-modal large language models (MLLMs) have made significant strides in various visual understanding tasks. However, the majority of these models are constrained to process low-resolution images, which limits their effectiveness in perception tasks that necessitate detailed visual information. In our study, we present MG-LLaVA, an innovative MLLM that enhances the model's visual processing capabilities by incorporating a multi-granularity vision flow, which includes low-resolution, high-resolution, and object-centric features. We propose the integration of an additional high-resolution visual encoder to capture fine-grained details, which are then fused with base visual features through a Conv-Gate fusion network. To further refine the model's object recognition abilities, we incorporate object-level features derived from bounding boxes identified by offline detectors. Being trained solely on publicly available multimodal data through instruction tuning, MG-LLaVA demonstrates exceptional perception skills. We instantiate MG-LLaVA with a wide variety of language encoders, ranging from 3.8B to 34B, to evaluate the model's performance comprehensively. Extensive evaluations across multiple benchmarks demonstrate that MG-LLaVA outperforms existing MLLMs of comparable parameter sizes, showcasing its remarkable efficacy. The code will be available at https://github.com/PhoenixZ810/MG-LLaVA.

cs.CV↗

arXiv2024

Exploring Interactive Semantic Alignment for Efficient HOI Detection with Vision-language Model

Human-Object Interaction (HOI) detection aims to localize human-object pairs and comprehend their interactions. Recently, two-stage transformer-based methods have demonstrated competitive performance. However, these methods frequently focus on object appearance features and ignore global contextual information. Besides, vision-language model CLIP which effectively aligns visual and text embeddings has shown great potential in zero-shot HOI detection. Based on the former facts, We introduce a novel HOI detector named ISA-HOI, which extensively leverages knowledge from CLIP, aligning interactive semantics between visual and textual features. We first extract global context of image and local features of object to Improve interaction Features in images (IF). On the other hand, we propose a Verb Semantic Improvement (VSI) module to enhance textual features of verb labels via cross-modal fusion. Ultimately, our method achieves competitive results on the HICO-DET and V-COCO benchmarks with much fewer training epochs, and outperforms the state-of-the-art under zero-shot settings.

cs.CV↗

arXiv2023

GelSplitter: Tactile Reconstruction from Near Infrared and Visible Images

The GelSight-like visual tactile (VT) sensor has gained popularity as a high-resolution tactile sensing technology for robots, capable of measuring touch geometry using a single RGB camera. However, the development of multi-modal perception for VT sensors remains a challenge, limited by the mono camera. In this paper, we propose the GelSplitter, a new framework approach the multi-modal VT sensor with synchronized multi-modal cameras and resemble a more human-like tactile receptor. Furthermore, we focus on 3D tactile reconstruction and implement a compact sensor structure that maintains a comparable size to state-of-the-art VT sensors, even with the addition of a prism and a near infrared (NIR) camera. We also design a photometric fusion stereo neural network (PFSNN), which estimates surface normals of objects and reconstructs touch geometry from both infrared and visible images. Our results demonstrate that the accuracy of RGB and NIR fusion is higher than that of RGB images alone. Additionally, our GelSplitter framework allows for a flexible configuration of different camera sensor combinations, such as RGB and thermal imaging.

cs.RO↗

arXiv2023

GelFlow: Self-supervised Learning of Optical Flow for Vision-Based Tactile Sensor Displacement Measurement

High-resolution multi-modality information acquired by vision-based tactile sensors can support more dexterous manipulations for robot fingers. Optical flow is low-level information directly obtained by vision-based tactile sensors, which can be transformed into other modalities like force, geometry and depth. Current vision-tactile sensors employ optical flow methods from OpenCV to estimate the deformation of markers in gels. However, these methods need to be more precise for accurately measuring the displacement of markers during large elastic deformation of the gel, as this can significantly impact the accuracy of downstream tasks. This study proposes a self-supervised optical flow method based on deep learning to achieve high accuracy in displacement measurement for vision-based tactile sensors. The proposed method employs a coarse-to-fine strategy to handle large deformations by constructing a multi-scale feature pyramid from the input image. To better deal with the elastic deformation caused by the gel, the Helmholtz velocity decomposition constraint combined with the elastic deformation constraint are adopted to address the distortion rate and area change rate, respectively. A local flow fusion module is designed to smooth the optical flow, taking into account the prior knowledge of the blurred effect of gel deformation. We trained the proposed self-supervised network using an open-source dataset and compared it with traditional and deep learning-based optical flow methods. The results show that the proposed method achieved the highest displacement measurement accuracy, thereby demonstrating its potential for enabling more precise measurement of downstream tasks using vision-based tactile sensors.

cs.CV↗

arXiv2023

Fine-Grained Music Plagiarism Detection: Revealing Plagiarists through Bipartite Graph Matching and a Comprehensive Large-Scale Dataset

Music plagiarism detection is gaining more and more attention due to the popularity of music production and society's emphasis on intellectual property. We aim to find fine-grained plagiarism in music pairs since conventional methods are coarse-grained and cannot match real-life scenarios. Considering that there is no sizeable dataset designed for the music plagiarism task, we establish a large-scale simulated dataset, named Music Plagiarism Detection Dataset (MPD-Set) under the guidance and expertise of renowned researchers from national-level professional institutions in the field of music. MPD-Set considers diverse music plagiarism cases found in real life from the melodic, rhythmic, and tonal levels respectively. Further, we establish a Real-life Dataset for evaluation, where all plagiarism pairs are real cases. To detect the fine-grained plagiarism pairs effectively, we propose a graph-based method called Bipatite Melody Matching Detector (BMM-Det), which formulates the problem as a max matching problem in the bipartite graph. Experimental results on both the simulated and Real-life Datasets demonstrate that BMM-Det outperforms the existing plagiarism detection methods, and is robust to common plagiarism cases like transpositions, pitch shifts, duration variance, and melody change. Datasets and source code are open-sourced at https://github.com/xuan301/BMMDet_MPDSet.

cs.SD↗

arXiv2023

Co-training with High-Confidence Pseudo Labels for Semi-supervised Medical Image Segmentation

Consistency regularization and pseudo labeling-based semi-supervised methods perform co-training using the pseudo labels from multi-view inputs. However, such co-training models tend to converge early to a consensus, degenerating to the self-training ones, and produce low-confidence pseudo labels from the perturbed inputs during training. To address these issues, we propose an Uncertainty-guided Collaborative Mean-Teacher (UCMT) for semi-supervised semantic segmentation with the high-confidence pseudo labels. Concretely, UCMT consists of two main components: 1) collaborative mean-teacher (CMT) for encouraging model disagreement and performing co-training between the sub-networks, and 2) uncertainty-guided region mix (UMIX) for manipulating the input images according to the uncertainty maps of CMT and facilitating CMT to produce high-confidence pseudo labels. Combining the strengths of UMIX with CMT, UCMT can retain model disagreement and enhance the quality of pseudo labels for the co-training segmentation. Extensive experiments on four public medical image datasets including 2D and 3D modalities demonstrate the superiority of UCMT over the state-of-the-art. Code is available at: https://github.com/Senyh/UCMT.

cs.CV↗

arXiv2023

Understanding radioactive ion beam production at ISAC through yield measurements and simulations

The high-intensity proton beam of the TRIUMF 500 MeV cyclotron offers unique opportunities to produce rare isotopes by irradiating a variety of targets. In particular, the ISAC (Isotope Separation and ACceleration) facility provides the infrastructure to deliver customized rare ion beams for fundamental research in nuclear physics, astrophysics, material science, and nuclear medicine. A continuous effort is made to develop new radioactive ion beams (RIB) and improve their intensity or purity, properties that depend strongly on the type of target, operating conditions, the ion source, and beam transport efficiency. Yield data and theoretical production rates based on FLUKA and Geant4 simulations are collected in the TRIUMF Isotope Database, providing a valuable resource for RIB development and experiment planning. This paper introduces the newly upgraded TRIUMF Isotope Database and presents examples on how it's resources can be used to plan experiments and understand the origin of certain RIB. In particular we discuss the collection of 155Tb which is an important component of medical isotope research at TRIUMF.

physics.acc-ph↗