arXiv subjects

Imran Razzak

Publications and source records attributed to Imran Razzak.

At least 73 records · Page 4Linked to original sources

arXiv2026

SAM-aware Test-time Adaptation for Universal Medical Image Segmentation

Leveraging the Segment Anything Model (SAM) for medical image segmentation remains challenging due to its limited adaptability across diverse medical domains. Although fine-tuned variants, such as MedSAM, improve performance in scenarios similar to the training modalities or organs, they may lack generalizability to unseen data. To overcome this limitation, we propose SAM-aware Test-time Adaptation (SAM-TTA), a lightweight and flexible framework that preserves SAM's inherent generalization ability while enhancing segmentation accuracy for medical images. SAM-TTA tackles two major challenges: (1) input-level discrepancy caused by channel mismatches between natural and medical images, and (2) semantic-level discrepancy due to different object characteristics in natural versus medical images (e.g., with clear boundaries vs. ambiguous structures). To this end, we introduce two complementary components: a self-adaptive Bezier Curve-based Transformation (SBCT), which maps single-channel medical images into SAM-compatible three-channel images via a few learnable parameters to be optimized at test time; and IoU-guided Multi-scale Adaptation (IMA), which leverages SAM's intrinsic IoU scores to enforce high output confidence, dual-scale prediction consistency, and intermediate feature consistency, to improve semantic-level alignments. Extensive experiments on eight public medical image segmentation tasks, covering six grayscale and two color (endoscopic) tasks, demonstrate that SAM-TTA consistently outperforms state-of-the-art test-time adaptation methods. Notably, on six grayscale datasets, SAM-TTA even surpasses fully fine-tuned models, achieving significant Dice improvements (i.e., average 4.8% and 7.4% gains over MedSAM and SAM-Med2D) and establishing a new paradigm for universal medical image segmentation. Code is available at https://github.com/JianghaoWu/SAM-TTA.

cs.CV↗

arXiv2025

PRISM: A Personality-Driven Multi-Agent Framework for Social Media Simulation

Traditional agent-based models (ABMs) of opinion dynamics often fail to capture the psychological heterogeneity driving online polarization due to simplistic homogeneity assumptions. This limitation obscures the critical interplay between individual cognitive biases and information propagation, thereby hindering a mechanistic understanding of how ideological divides are amplified. To address this challenge, we introduce the Personality-Refracted Intelligent Simulation Model (PRISM), a hybrid framework coupling stochastic differential equations (SDE) for continuous emotional evolution with a personality-conditional partially observable Markov decision process (PC-POMDP) for discrete decision-making. In contrast to continuous trait approaches, PRISM assigns distinct Myers-Briggs Type Indicator (MBTI) based cognitive policies to multimodal large language model (MLLM) agents, initialized via data-driven priors from large-scale social media datasets. PRISM achieves superior personality consistency aligned with human ground truth, significantly outperforming standard homogeneous and Big Five benchmarks. This framework effectively replicates emergent phenomena such as rational suppression and affective resonance, offering a robust tool for analyzing complex social media ecosystems.

cs.CL↗

arXiv2025

The Eye as a Window to Systemic Health: A Survey of Retinal Imaging from Classical Techniques to Oculomics

The unique vascularized anatomy of the human eye, encased in the retina, provides an opportunity to act as a window for human health. The retinal structure assists in assessing the early detection, monitoring of disease progression and intervention for both ocular and non-ocular diseases. The advancement in imaging technology leveraging Artificial Intelligence has seized this opportunity to bridge the gap between the eye and human health. This track paves the way for unveiling systemic health insight from the ocular system and surrogating non-invasive markers for timely intervention and identification. The new frontiers of oculomics in ophthalmology cover both ocular and systemic diseases, and getting more attention to explore them. In this survey paper, we explore the evolution of retinal imaging techniques, the dire need for the integration of AI-driven analysis, and the shift of retinal imaging from classical techniques to oculomics. We also discuss some hurdles that may be faced in the progression of oculomics, highlighting the research gaps and future directions.

eess.IV↗

arXiv2025

HeSRN: Representation Learning On Heterogeneous Graphs via Slot-Aware Retentive Network

Graph Transformers have recently achieved remarkable progress in graph representation learning by capturing long-range dependencies through self-attention. However, their quadratic computational complexity and inability to effectively model heterogeneous semantics severely limit their scalability and generalization on real-world heterogeneous graphs. To address these issues, we propose HeSRN, a novel Heterogeneous Slot-aware Retentive Network for efficient and expressive heterogeneous graph representation learning. HeSRN introduces a slot-aware structure encoder that explicitly disentangles node-type semantics by projecting heterogeneous features into independent slots and aligning their distributions through slot normalization and retention-based fusion, effectively mitigating the semantic entanglement caused by forced feature-space unification in previous Transformer-based models. Furthermore, we replace the self-attention mechanism with a retention-based encoder, which models structural and contextual dependencies in linear time complexity while maintaining strong expressive power. A heterogeneous retentive encoder is further employed to jointly capture both local structural signals and global heterogeneous semantics through multi-scale retention layers. Extensive experiments on four real-world heterogeneous graph datasets demonstrate that HeSRN consistently outperforms state-of-the-art heterogeneous graph neural networks and Graph Transformer baselines on node classification tasks, achieving superior accuracy with significantly lower computational complexity.

cs.LG↗

arXiv2025

From Generation to Detection: A Multimodal Multi-Task Dataset for Benchmarking Health Misinformation

Infodemics and health misinformation have significant negative impact on individuals and society, exacerbating confusion and increasing hesitancy in adopting recommended health measures. Recent advancements in generative AI, capable of producing realistic, human like text and images, have significantly accelerated the spread and expanded the reach of health misinformation, resulting in an alarming surge in its dissemination. To combat the infodemics, most existing work has focused on developing misinformation datasets from social media and fact checking platforms, but has faced limitations in topical coverage, inclusion of AI generation, and accessibility of raw content. To address these issues, we present MM Health, a large scale multimodal misinformation dataset in the health domain consisting of 34,746 news article encompassing both textual and visual information. MM Health includes human-generated multimodal information (5,776 articles) and AI generated multimodal information (28,880 articles) from various SOTA generative AI models. Additionally, We benchmarked our dataset against three tasks (reliability checks, originality checks, and fine-grained AI detection) demonstrating that existing SOTA models struggle to accurately distinguish the reliability and origin of information. Our dataset aims to support the development of misinformation detection across various health scenarios, facilitating the detection of human and machine generated content at multimodal levels.

cs.CL↗

arXiv2025

Beyond Single Pass, Looping Through Time: KG-IRAG with Iterative Knowledge Retrieval

Graph Retrieval-Augmented Generation (GraphRAG) has proven highly effective in enhancing the performance of Large Language Models (LLMs) on tasks that require external knowledge. By leveraging Knowledge Graphs (KGs), GraphRAG improves information retrieval for complex reasoning tasks, providing more precise and comprehensive retrieval and generating more accurate responses to QAs. However, most RAG methods fall short in addressing multi-step reasoning, particularly when both information extraction and inference are necessary. To address this limitation, this paper presents Knowledge Graph-Based Iterative Retrieval-Augmented Generation (KG-IRAG), a novel framework that integrates KGs with iterative reasoning to improve LLMs' ability to handle queries involving temporal and logical dependencies. Through iterative retrieval steps, KG-IRAG incrementally gathers relevant data from external KGs, enabling step-by-step reasoning. The proposed approach is particularly suited for scenarios where reasoning is required alongside dynamic temporal data extraction, such as determining optimal travel times based on weather conditions or traffic patterns. Experimental results show that KG-IRAG improves accuracy in complex reasoning tasks by effectively integrating external knowledge with iterative, logic-based retrieval. Additionally, three new datasets: weatherQA-Irish, weatherQA-Sydney, and trafficQA-TFNSW, are formed to evaluate KG-IRAG's performance, demonstrating its potential beyond traditional RAG applications.

cs.AI↗

arXiv2025

Robust Atypical Mitosis Classification with DenseNet121: Stain-Aware Augmentation and Hybrid Loss for Domain Generalization

Atypical mitotic figures are important biomarkers of tumor aggressiveness in histopathology, yet reliable recognition remains challenging due to severe class imbalance and variability across imaging domains. We present a DenseNet-121-based framework tailored for atypical mitosis classification in the MIDOG 2025 (Track 2) setting. Our method integrates stain-aware augmentation (Macenko), geometric and intensity transformations, and imbalance-aware learning via weighted sampling with a hybrid objective combining class-weighted binary cross-entropy and focal loss. Trained end-to-end with AdamW and evaluated across multiple independent domains, the model demonstrates strong generalization under scanner and staining shifts, achieving balanced accuracy 85.0%, AUROC 0.927, sensitivity 89.2%, and specificity 80.9% on the official test set. These results indicate that combining DenseNet-121 with stain-aware augmentation and imbalance-adaptive objectives yields a robust, domain-generalizable framework for atypical mitosis classification suitable for real-world computational pathology workflows.

cs.CV↗

arXiv2025

Electric Vehicle Charging Load Modeling: A Survey, Trends, Challenges and Opportunities

The evolution of electric vehicles (EVs) is reshaping the automotive industry, advocating for more sustainable transportation practices. Accurately predicting EV charging behavior is essential for effective infrastructure planning and optimization. However, the charging load of EVs is significantly influenced by uncertainties and randomness, posing challenges for accurate estimation. Furthermore, existing literature reviews lack a systematic analysis of modeling approaches focused on information fusion. This paper comprehensively reviews EV charging load models from the past five years. We categorize state-of-the-art modeling methods into statistical, simulated, and data-driven approaches, examining the advantages and drawbacks of each. Additionally, we analyze the three bottom-up level operations of information fusion in existing models. We conclude by discussing the challenges and opportunities in the field, offering guidance for future research endeavors to advance our understanding and explore practical research directions.

eess.SY↗

arXiv2025

Rolling Ball Optimizer: Learning by ironing out loss landscape wrinkles

Training large neural networks (NNs) requires optimizing high-dimensional data-dependent loss functions. The optimization landscape of these functions is often highly complex and textured, even fractal-like, with many spurious local minima, ill-conditioned valleys, degenerate points, and saddle points. Complicating things further is the fact that these landscape characteristics are a function of the data, meaning that noise in the training data can propagate forward and give rise to unrepresentative small-scale geometry. This poses a difficulty for gradient-based optimization methods, which rely on local geometry to compute updates and are, therefore, vulnerable to being derailed by noisy data. In practice,this translates to a strong dependence of the optimization dynamics on the noise in the data, i.e., poor generalization performance. To remediate this problem, we propose a new optimization procedure: Rolling Ball Optimizer (RBO), that breaks this spatial locality by incorporating information from a larger region of the loss landscape in its updates. We achieve this by simulating the motion of a rigid sphere of finite radius rolling on the loss landscape, a straightforward generalization of Gradient Descent (GD) that simplifies into it in the infinitesimal limit. The radius serves as a hyperparameter that determines the scale at which RBO sees the loss landscape, allowing control over the granularity of its interaction therewith. We are motivated by the intuition that the large-scale geometry of the loss landscape is less data-specific than its fine-grained structure, and that it is easier to optimize. We support this intuition by proving that our algorithm has a smoothing effect on the loss function. Evaluation against SGD, SAM, and Entropy-SGD, on MNIST and CIFAR-10/100 demonstrates promising results in terms of convergence speed, training accuracy, and generalization performance.

cs.LG↗

arXiv2025

Phenome-Wide Multi-Omics Integration Uncovers Distinct Archetypes of Human Aging

Aging is a highly complex and heterogeneous process that progresses at different rates across individuals, making biological age (BA) a more accurate indicator of physiological decline than chronological age. While previous studies have built aging clocks using single-omics data, they often fail to capture the full molecular complexity of human aging. In this work, we leveraged the Human Phenotype Project, a large-scale cohort of 10,000 adults aged 40-70 years, with extensive longitudinal profiling that includes clinical, behavioral, environmental, and multi-omics datasets spanning transcriptomics, lipidomics, metabolomics, and the microbiome. By employing advanced machine learning frameworks capable of modeling nonlinear biological dynamics, we developed and rigorously validated a multi-omics aging clock that robustly predicts diverse health outcomes and future disease risk. Unsupervised clustering of the integrated molecular profiles from multi-omics uncovered distinct biological subtypes of aging, revealing striking heterogeneity in aging trajectories and pinpointing pathway-specific alterations associated with different aging patterns. These findings demonstrate the power of multi-omics integration to decode the molecular landscape of aging and lay the groundwork for personalized healthspan monitoring and precision strategies to prevent age-related diseases.

q-bio.GN↗

arXiv2025

A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers

Scientific Large Language Models (Sci-LLMs) are transforming how knowledge is represented, integrated, and applied in scientific research, yet their progress is shaped by the complex nature of scientific data. This survey presents a comprehensive, data-centric synthesis that reframes the development of Sci-LLMs as a co-evolution between models and their underlying data substrate. We formulate a unified taxonomy of scientific data and a hierarchical model of scientific knowledge, emphasizing the multimodal, cross-scale, and domain-specific challenges that differentiate scientific corpora from general natural language processing datasets. We systematically review recent Sci-LLMs, from general-purpose foundations to specialized models across diverse scientific disciplines, alongside an extensive analysis of over 270 pre-/post-training datasets, showing why Sci-LLMs pose distinct demands -- heterogeneous, multi-scale, uncertainty-laden corpora that require representations preserving domain invariance and enabling cross-modal reasoning. On evaluation, we examine over 190 benchmark datasets and trace a shift from static exams toward process- and discovery-oriented assessments with advanced evaluation protocols. These data-centric analyses highlight persistent issues in scientific data development and discuss emerging solutions involving semi-automated annotation pipelines and expert validation. Finally, we outline a paradigm shift toward closed-loop systems where autonomous agents based on Sci-LLMs actively experiment, validate, and contribute to a living, evolving knowledge base. Collectively, this work provides a roadmap for building trustworthy, continually evolving artificial intelligence (AI) systems that function as a true partner in accelerating scientific discovery.

cs.CL↗

arXiv2025

Few-Label Multimodal Modeling of SNP Variants and ECG Phenotypes Using Large Language Models for Cardiovascular Risk Stratification

Cardiovascular disease (CVD) risk stratification remains a major challenge due to its multifactorial nature and limited availability of high-quality labeled datasets. While genomic and electrophysiological data such as SNP variants and ECG phenotypes are increasingly accessible, effectively integrating these modalities in low-label settings is non-trivial. This challenge arises from the scarcity of well-annotated multimodal datasets and the high dimensionality of biological signals, which limit the effectiveness of conventional supervised models. To address this, we present a few-label multimodal framework that leverages large language models (LLMs) to combine genetic and electrophysiological information for cardiovascular risk stratification. Our approach incorporates a pseudo-label refinement strategy to adaptively distill high-confidence labels from weakly supervised predictions, enabling robust model fine-tuning with only a small set of ground-truth annotations. To enhance the interpretability, we frame the task as a Chain of Thought (CoT) reasoning problem, prompting the model to produce clinically relevant rationales alongside predictions. Experimental results demonstrate that the integration of multimodal inputs, few-label supervision, and CoT reasoning improves robustness and generalizability across diverse patient profiles. Experimental results using multimodal SNP variants and ECG-derived features demonstrated comparable performance to models trained on the full dataset, underscoring the promise of LLM-based few-label multimodal modeling for advancing personalized cardiovascular care.

q-bio.QM↗

arXiv2025

HIPPD: Brain-Inspired Hierarchical Information Processing for Personality Detection

Personality detection from text aims to infer an individual's personality traits based on linguistic patterns. However, existing machine learning approaches often struggle to capture contextual information spanning multiple posts and tend to fall short in extracting representative and robust features in semantically sparse environments. This paper presents HIPPD, a brain-inspired framework for personality detection that emulates the hierarchical information processing of the human brain. HIPPD utilises a large language model to simulate the cerebral cortex, enabling global semantic reasoning and deep feature abstraction. A dynamic memory module, modelled after the prefrontal cortex, performs adaptive gating and selective retention of critical features, with all adjustments driven by dopaminergic prediction error feedback. Subsequently, a set of specialised lightweight models, emulating the basal ganglia, are dynamically routed via a strict winner-takes-all mechanism to capture the personality-related patterns they are most proficient at recognising. Extensive experiments on the Kaggle and Pandora datasets demonstrate that HIPPD consistently outperforms state-of-the-art baselines.

cs.CL↗

arXiv2025

SAM-DCE: Addressing Token Uniformity and Semantic Over-Smoothing in Medical Segmentation

The Segment Anything Model (SAM) demonstrates impressive zero-shot segmentation ability on natural images but encounters difficulties in medical imaging due to domain shifts, anatomical variability, and its reliance on user-provided prompts. Recent prompt-free adaptations alleviate the need for expert intervention, yet still suffer from limited robustness and adaptability, often overlooking the issues of semantic over-smoothing and token uniformity. We propose SAM-DCE, which balances local discrimination and global semantics while mitigating token uniformity, enhancing inter-class separability, and enriching mask decoding with fine-grained, consistent representations. Extensive experiments on diverse medical benchmarks validate its effectiveness.

cs.CV↗

arXiv2025

Towards Robust Visual Continual Learning with Multi-Prototype Supervision

Language-guided supervision, which utilizes a frozen semantic target from a Pretrained Language Model (PLM), has emerged as a promising paradigm for visual Continual Learning (CL). However, relying on a single target introduces two critical limitations: 1) semantic ambiguity, where a polysemous category name results in conflicting visual representations, and 2) intra-class visual diversity, where a single prototype fails to capture the rich variety of visual appearances within a class. To this end, we propose MuproCL, a novel framework that replaces the single target with multiple, context-aware prototypes. Specifically, we employ a lightweight LLM agent to perform category disambiguation and visual-modal expansion to generate a robust set of semantic prototypes. A LogSumExp aggregation mechanism allows the vision model to adaptively align with the most relevant prototype for a given image. Extensive experiments across various CL baselines demonstrate that MuproCL consistently enhances performance and robustness, establishing a more effective path for language-guided continual learning.

cs.CV↗

arXiv2025

A Knowledge-driven Adaptive Collaboration of LLMs for Enhancing Medical Decision-making

Medical decision-making often involves integrating knowledge from multiple clinical specialties, typically achieved through multidisciplinary teams. Inspired by this collaborative process, recent work has leveraged large language models (LLMs) in multi-agent collaboration frameworks to emulate expert teamwork. While these approaches improve reasoning through agent interaction, they are limited by static, pre-assigned roles, which hinder adaptability and dynamic knowledge integration. To address these limitations, we propose KAMAC, a Knowledge-driven Adaptive Multi-Agent Collaboration framework that enables LLM agents to dynamically form and expand expert teams based on the evolving diagnostic context. KAMAC begins with one or more expert agents and then conducts a knowledge-driven discussion to identify and fill knowledge gaps by recruiting additional specialists as needed. This supports flexible, scalable collaboration in complex clinical scenarios, with decisions finalized through reviewing updated agent comments. Experiments on two real-world medical benchmarks demonstrate that KAMAC significantly outperforms both single-agent and advanced multi-agent methods, particularly in complex clinical scenarios (i.e., cancer prognosis) requiring dynamic, cross-specialty expertise. Our code is publicly available at: https://github.com/XiaoXiao-Woo/KAMAC.

cs.AI↗

arXiv2025

EmoPerso: Enhancing Personality Detection with Self-Supervised Emotion-Aware Modelling

Personality detection from text is commonly performed by analysing users' social media posts. However, existing methods heavily rely on large-scale annotated datasets, making it challenging to obtain high-quality personality labels. Moreover, most studies treat emotion and personality as independent variables, overlooking their interactions. In this paper, we propose a novel self-supervised framework, EmoPerso, which improves personality detection through emotion-aware modelling. EmoPerso first leverages generative mechanisms for synthetic data augmentation and rich representation learning. It then extracts pseudo-labeled emotion features and jointly optimizes them with personality prediction via multi-task learning. A cross-attention module is employed to capture fine-grained interactions between personality traits and the inferred emotional representations. To further refine relational reasoning, EmoPerso adopts a self-taught strategy to enhance the model's reasoning capabilities iteratively. Extensive experiments on two benchmark datasets demonstrate that EmoPerso surpasses state-of-the-art models. The source code is available at https://github.com/slz0925/EmoPerso.

cs.CL↗

arXiv2025

Task Allocation for Autonomous Machines using Computational Intelligence and Deep Reinforcement Learning

Enabling multiple autonomous machines to perform reliably requires the development of efficient cooperative control algorithms. This paper presents a survey of algorithms that have been developed for controlling and coordinating autonomous machines in complex environments. We especially focus on task allocation methods using computational intelligence (CI) and deep reinforcement learning (RL). The advantages and disadvantages of the surveyed methods are analysed thoroughly. We also propose and discuss in detail various future research directions that shed light on how to improve existing algorithms or create new methods to enhance the employability and performance of autonomous machines in real-world applications. The findings indicate that CI and deep RL methods provide viable approaches to addressing complex task allocation problems in dynamic and uncertain environments. The recent development of deep RL has greatly contributed to the literature on controlling and coordinating autonomous machines, and it has become a growing trend in this area. It is envisaged that this paper will provide researchers and engineers with a comprehensive overview of progress in machine learning research related to autonomous machines. It also highlights underexplored areas, identifies emerging methodologies, and suggests new avenues for exploration in future research within this domain.

cs.RO↗