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K. Anguige

Publications and source records attributed to K. Anguige.

6 recordsLinked to original sources

A one-dimensional model for the interaction between cell-to-cell adhesion and chemotactic signalling

We develop and analyse a discrete, one-dimensional model of cell motility which incorporates the effects of volume filling, cell-to-cell adhesion and chemotaxis. The formal continuum limit of the model is a nonlinear generalisation of the parabolic-elliptic Keller-Segel equations, with a diffusivity which can become negative if the adhesion coefficient is large. The consequent ill-posedness results in the appearance of spatial oscillations and the development of plateaus in numerical solutions of the underlying discrete model. A global-existence result is obtained for the continuum equations in the case of favourable parameter values and data, and a steady-state analysis which, amongst other things, accounts for high-adhesion plateaus is carried out. For ill-posed cases, a singular Stefan-problem formulation of the continuum limit is written down and solved numerically, and the numerical solutions are compared with those of the original discrete model

math.AP

Multi-phase Stefan problems for a nonlinear 1-d model of cell-to-cell adhesion and diffusion

We consider a family of multi-phase Stefan problems for a certain 1-d model of cell-to-cell adhesion and diffusion, which takes the form of a nonlinear forward-backward parabolic equation. In each material phase the cell density stays either high or low, and phases are connected by jumps across an `unstable' interval. We develop an existence theory for such problems which allows for the annihilation of phases and the subsequent continuation of solutions. Stability results for the long-time behaviour of solutions are also obtained, and, where necessary, the analysis is complemented by numerical simulations.

math.AP

Isotropic cosmological singularities 1: Polytropic perfect fluid spacetimes

We consider the conformal Einstein equations for polytropic perfect fluid cosmologies which admit an isotropic singularity. For the polytropic index gamma strictly greater than 1 and less than or equal to 2 it is shown that the Cauchy problem for these equations is well-posed, that is to say that solutions exist, are unique and depend smoothly on the data, with data consisting of simply the 3-metric of the singularity. The analogous result for gamma=1 (dust) is obtained when Bianchi type symmetry is assumed.

gr-qc

Isotropic cosmological singularities 2: The Einstein-Vlasov system

We consider the conformal Einstein equations for massless collisionless gas cosmologies which admit an isotropic singularity. After developing the general theory, we restrict to spatially-homogeneous cosmologies. We show that the Cauchy problem for these equations is well-posed with data consisting of the limiting particle distribution function at the singularity.

gr-qc