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L. Peliti

Publications and source records attributed to L. Peliti.

24 records · Page 2Linked to original sources

Detachment of molecular motors under tangential loading

We introduce a general framework to study the processivity of molecular motors moving along a polar filament and discuss the average time spent attached to the filament as a function of a tangentially applied load. Our study of specific models suggests that the attachment time of a motor decreases with increasing ATP concentration and that double-headed motors such as kinesins lose their processivity under forcing conditions while processive single-headed motors are less sensitive to tangential forcing.

cond-mat.stat-mech↗

Melting and unzipping of DNA

Experimental studies of the thermal denaturation of DNA yield a strong indication that the transition is first order. This transition has been theoretically studied since the early sixties, mostly within an approach in which the microscopic configurations of a DNA molecule are given by an alternating sequence of non-interacting bound segments and denaturated loops. Studies of these models neglect the repulsive, self-avoiding, interaction between different loops and segments and have invariably yielded continuous denaturation transitions. In this study we exploit recent results on scaling properties of polymer networks of arbitrary topology in order to take into account the excluded-volume interaction between denaturated loops and the rest of the chain. We thus obtain a first-order phase transition in d=2 dimensions and above, in agreement with experiments. We also consider within our approach the unzipping transition, which takes place when the two DNA strands are pulled apart by an external force acting on one end. We find that the unzipping transition is also first order. Although the denaturation and unzipping transitions are thermodynamically first order, they do exhibit critical fluctuations in some of their properties. For instance, the loop size distribution decays algebraically at the transition and the length of the denaturated end segment diverges as the transition is approached. We evaluate these critical properties within our approach.

cond-mat.stat-mech↗

Effective Area-Elasticity and Tension of Micro-manipulated Membranes

We evaluate the effective Hamiltonian governing, at the optically resolved scale, the elastic properties of micro-manipulated membranes. We identify floppy, entropic-tense and stretched-tense regimes, representing different behaviors of the effective area-elasticity of the membrane. The corresponding effective tension depends on the microscopic parameters (total area, bending rigidity) and on the optically visible area, which is controlled by the imposed external constraints. We successfully compare our predictions with recent data on micropipette experiments.

cond-mat.soft↗

The response of glassy systems to random perturbations: A bridge between equilibrium and off-equilibrium

We discuss the response of aging systems with short-range interactions to a class of random perturbations. Although these systems are out of equilibrium, the limit value of the free energy at long times is equal to the equilibrium free energy. By exploiting this fact, we define a new order parameter function, and we relate it to the ratio between response and fluctuation, which is in principle measurable in an aging experiment. For a class of systems possessing stochastic stability, we show that this new order parameter function is intimately related to the static order parameter function, describing the distribution of overlaps between clustering states. The same method is applied to investigate the geometrical organization of pure states. We show that the ultrametric organization in the dynamics implies static ultrametricity, and we relate these properties to static separability, i.e., the property that the measure of the overlap between pure states is essentially unique. Our results, especially relevant for spin glasses, pave the way to an experimental determination of the order parameter function.

cond-mat.dis-nn↗

Bi-defects of Nematic Surfactant Bilayers

We consider the effects of the coupling between the orientational order of the two monolayers in flat nematic bilayers. We show that the presence of a topological defect on one bilayer generates a nontrivial orientational texture on both monolayers. Therefore, one cannot consider isolated defects on one monolayer, but rather associated pairs of defects on either monolayer, which we call bi-defects. Bi-defects generally produce walls, such that the textures of the two monolayers are identical outside the walls, and different in their interior. We suggest some experimental conditions in which these structures could be observed.

cond-mat.soft↗

The selection of altruistic behaviour

Altruistic behaviour is disadvantageous for the individual while is advantageous for its group. If the target of the selection is the individual, one would expect the selection process to lead to populations formed by wholly homogeneous groups, made up of either altruistic or egoistic individuals, where the winning choice depends on the balance beetwen group advantage and individual disadvantage. We show in a simple model that populations formed by inhomogeneous groups can be stabilized in some circumstances. We argue that this condition is realized when there is a relative advantage conferred by the presence of a few altruists to all the members of the group.

adap-org↗