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Lei Liu

Publications and source records attributed to Lei Liu.

At least 91 records · Page 5Linked to original sources

LiveClin: A Live Clinical Benchmark without Leakage

The reliability of medical LLM evaluation is critically undermined by data contamination and knowledge obsolescence, leading to inflated scores on static benchmarks. To address these challenges, we introduce LiveClin, a live benchmark designed for approximating real-world clinical practice. Built from contemporary, peer-reviewed case reports and updated biannually, LiveClin ensures clinical currency and resists data contamination. Using a verified AI-human workflow involving 239 physicians, we transform authentic patient cases into complex, multimodal evaluation scenarios that span the entire clinical pathway. The benchmark currently comprises 1,407 case reports and 6,605 questions. Our evaluation of 26 models on LiveClin reveals the profound difficulty of these real-world scenarios, with the top-performing model achieving a Case Accuracy of just 35.7%. In benchmarking against human experts, Chief Physicians achieved the highest accuracy, followed closely by Attending Physicians, with both surpassing most models. LiveClin thus provides a continuously evolving, clinically grounded framework to guide the development of medical LLMs towards closing this gap and achieving greater reliability and real-world utility. Our data and code are publicly available at https://github.com/AQ-MedAI/LiveClin.

cs.LG↗

ClinAlign: Scaling Healthcare Alignment from Clinician Preference

Although large language models (LLMs) demonstrate expert-level medical knowledge, aligning their open-ended outputs with fine-grained clinician preferences remains challenging. Existing methods often rely on coarse objectives or unreliable automated judges that are weakly grounded in professional guidelines. We propose a two-stage framework to address this gap. First, we introduce HealthRubrics, a dataset of 7,034 physician-verified preference examples in which clinicians refine LLM-drafted rubrics to meet rigorous medical standards. Second, we distill these rubrics into HealthPrinciples: 119 broadly reusable, clinically grounded principles organized by clinical dimensions, enabling scalable supervision beyond manual annotation. We use HealthPrinciples for (1) offline alignment by synthesizing rubrics for unlabeled queries and (2) an inference-time tool for guided self-revision. A 30B-A3B model trained with our framework achieves 33.4% on HealthBench-Hard, outperforming much larger models including Deepseek-R1 and o3, establishing a resource-efficient baseline for clinical alignment.

cs.AI↗

VFGS-Net: Frequency-Guided State-Space Learning for Topology-Preserving Retinal Vessel Segmentation

Accurate retinal vessel segmentation is a critical prerequisite for quantitative analysis of retinal images and computer-aided diagnosis of vascular diseases such as diabetic retinopathy. However, the elongated morphology, wide scale variation, and low contrast of retinal vessels pose significant challenges for existing methods, making it difficult to simultaneously preserve fine capillaries and maintain global topological continuity. To address these challenges, we propose the Vessel-aware Frequency-domain and Global Spatial modeling Network (VFGS-Net), an end-to-end segmentation framework that seamlessly integrates frequency-aware feature enhancement, dual-path convolutional representation learning, and bidirectional asymmetric spatial state-space modeling within a unified architecture. Specifically, VFGS-Net employs a dual-path feature convolution module to jointly capture fine-grained local textures and multi-scale contextual semantics. A novel vessel-aware frequency-domain channel attention mechanism is introduced to adaptively reweight spectral components, thereby enhancing vessel-relevant responses in high-level features. Furthermore, at the network bottleneck, we propose a bidirectional asymmetric Mamba2-based spatial modeling block to efficiently capture long-range spatial dependencies and strengthen the global continuity of vascular structures. Extensive experiments on four publicly available retinal vessel datasets demonstrate that VFGS-Net achieves competitive or superior performance compared to state-of-the-art methods. Notably, our model consistently improves segmentation accuracy for fine vessels, complex branching patterns, and low-contrast regions, highlighting its robustness and clinical potential.

cs.CV↗

Hidden in-plane long-range order in an amorphized crystal

Solid materials are commonly classified as crystalline or amorphous based on the presence or absence of long-range order.Metal-organic frameworks (MOFs), like other solids,also display markedly different properties and functions in these two phases. Here, we identify a previously unrecognized structural state that retains long-range in-plane translational order while losing order along the stacking direction. Hypothesized since 1941 but not experimentally verified, this intermediate phase emerges in a crystalline MOFs via controlled thermal desolvation, which selectively disrupts the intrinsically weak interlayer interactions while preserving macroscopic structural coherence. Although the resulting material appears amorphous under conventional characterization, systematic synchrotron PXRD, total X-ray scattering, and low-dose high resolution TEM reveal clear in-plane periodicity. This material spontaneously delaminates in water into uniform, high-quality two-dimensional crystalline nanosheets, forming stable colloidal suspensions and exhibiting superlubricity comparable to graphene - but at less than 0.1% of the production cost. Our discovery finds a missing link within the long-standing crystalline-amorphous dichotomy, while providing an inherently scalable route to high-quality 2D crystals, and offering a conceptual and practical advance in phase engineering.

cond-mat.mtrl-sci↗

KidMesh: Computational Mesh Reconstruction for Pediatric Congenital Hydronephrosis Using Deep Neural Networks

Pediatric congenital hydronephrosis (CH) is a common urinary tract disorder, primarily caused by obstruction at the renal pelvis-ureter junction. Magnetic resonance urography (MRU) can visualize hydronephrosis, including renal pelvis and calyces, by utilizing the natural contrast provided by water. Existing voxel-based segmentation approaches can extract CH regions from MRU, facilitating disease diagnosis and prognosis. However, these segmentation methods predominantly focus on morphological features, such as size, shape, and structure. To enable functional assessments, such as urodynamic simulations, external complex post-processing steps are required to convert these results into mesh-level representations. To address this limitation, we propose an end-to-end method based on deep neural networks, namely KidMesh, which could automatically reconstruct CH meshes directly from MRU. Generally, KidMesh extracts feature maps from MRU images and converts them into feature vertices through grid sampling. It then deforms a template mesh according to these feature vertices to generate the specific CH meshes of MRU images. Meanwhile, we develop a novel schema to train KidMesh without relying on accurate mesh-level annotations, which are difficult to obtain due to the sparsely sampled MRU slices. Experimental results show that KidMesh could reconstruct CH meshes in an average of 0.4 seconds, and achieve comparable performance to conventional methods without requiring post-processing. The reconstructed meshes exhibited no self-intersections, with only 3.7% and 0.2% of the vertices having error distances exceeding 3.2mm and 6.4mm, respectively. After rasterization, these meshes achieved a Dice score of 0.86 against manually delineated CH masks. Furthermore, these meshes could be used in renal urine flow simulations, providing valuable urodynamic information for clinical practice.

cs.CV↗

A Quantum Computing Framework for VLBI Data Correlation

We present a quantum computing framework for VLBI data correlation. We point out that a classical baseband time series data of length $N$ can be embedded into a quantum superposition state using amplitude encoding with only $\log_2 N$ qubits. The basic VLBI correlation and fringe fitting operations, including fringe rotation, Fourier transform, delay compensation, and cross correlation, can be implemented via quantum algorithms with significantly reduced computational complexity. We construct a full quantum processing pipeline and validate its feasibility and accuracy through direct comparison with a classical VLBI pipeline. We recognize that amplitude encoding of large data volumes remains the primary bottleneck in quantum computing; however, the quantized nature of VLBI raw data helps reduce the state-preparation complexity. Our investigation demonstrates that quantum computation offers a promising paradigm for VLBI data correlation and is likely to play a role in future VLBI systems.

astro-ph.IM↗

CTRL-RAG: Contrastive Likelihood Reward Based Reinforcement Learning for Context-Faithful RAG Models

With the growing use of Retrieval-Augmented Generation (RAG), training large language models (LLMs) for context-sensitive reasoning and faithfulness is increasingly important. Existing RAG-oriented reinforcement learning (RL) methods rely on external rewards that often fail to evaluate document faithfulness, and may misjudge similar answers in open-domain settings. In addition, there is no RAG-based selfreward mechanism. Moreover, although such a mechanism could in principle estimate answer confidence given documents, the absence of objective feedback in a self-judgment can cause hallucination accumulation and eventual model collapse. To tackle these issues, we propose a novel "internal-external" hybrid reward framework centered on a Contrastive Likelihood Reward (CLR). CLR directly optimizes the log-likelihood gap between responses conditioned on prompts with and without supporting evidence. This encourages the model to extract relevant evidence and increases its confidence when grounded in a specific context. Experiments show that our method (used alone or combined with external correctness rewards) achieves strong performance on singlehop, multi-hop, vertical-domain, and faithfulness benchmarks. Our training code and models are coming soon.

cs.CL↗

Unleashing Scientific Reasoning for Bio-experimental Protocol Generation via Structured Component-based Reward Mechanism

The foundation of reproducible science lies in protocols that are precise, logically ordered, and executable. The autonomous generation of these protocols through natural language queries could greatly improve the efficiency of the reproduction process. However, current leading large language models (LLMs) often generate incomplete or inconsistent protocols, limiting their utility. To address this limitation, we first introduce SciRecipe, a large-scale dataset of over 12K structured protocols spanning 27 biological subfields and encompassing both comprehension and problem-solving tasks. To further improve protocol generation, we propose the "Sketch-and-Fill" paradigm, which separates analysis, structuring, and expression to ensure each step is explicit and verifiable. Complementing this, the structured component-based reward mechanism evaluates step granularity, action order, and semantic fidelity, aligning model optimization with experimental reliability. Building on these components, we develop Thoth, trained through a staged Knowledge-to-Action process that progresses from knowledge acquisition to operational reasoning and ultimately to robust, executable protocol generation. Across multiple benchmarks, Thoth consistently surpasses both proprietary and open-source LLMs, achieving significant improvements in step alignment, logical sequencing, and semantic accuracy. Our approach paves the way for reliable scientific assistants that bridge knowledge with experimental execution. All data, code, and models will be released publicly.

cs.AI↗

LoD-Structured 3D Gaussian Splatting for Streaming Video Reconstruction

Free-Viewpoint Video (FVV) reconstruction enables photorealistic and interactive 3D scene visualization; however, real-time streaming is often bottlenecked by sparse-view inputs, prohibitive training costs, and bandwidth constraints. While recent 3D Gaussian Splatting (3DGS) has advanced FVV due to its superior rendering speed, Streaming Free-Viewpoint Video (SFVV) introduces additional demands for rapid optimization, high-fidelity reconstruction under sparse constraints, and minimal storage footprints. To bridge this gap, we propose StreamLoD-GS, an LoD-based Gaussian Splatting framework designed specifically for SFVV. Our approach integrates three core innovations: 1) an Anchor- and Octree-based LoD-structured 3DGS with a hierarchical Gaussian dropout technique to ensure efficient and stable optimization while maintaining high-quality rendering; 2) a GMM-based motion partitioning mechanism that separates dynamic and static content, refining dynamic regions while preserving background stability; and 3) a quantized residual refinement framework that significantly reduces storage requirements without compromising visual fidelity. Extensive experiments demonstrate that StreamLoD-GS achieves competitive or state-of-the-art performance in terms of quality, efficiency, and storage.

cs.GR↗

Generative Diffusion Contrastive Network for Multi-View Clustering

In recent years, Multi-View Clustering (MVC) has been significantly advanced under the influence of deep learning. By integrating heterogeneous data from multiple views, MVC enhances clustering analysis, making multi-view fusion critical to clustering performance. However, there is a problem of low-quality data in multi-view fusion. This problem primarily arises from two reasons: 1) Certain views are contaminated by noisy data. 2) Some views suffer from missing data. This paper proposes a novel Stochastic Generative Diffusion Fusion (SGDF) method to address this problem. SGDF leverages a multiple generative mechanism for the multi-view feature of each sample. It is robust to low-quality data. Building on SGDF, we further present the Generative Diffusion Contrastive Network (GDCN). Extensive experiments show that GDCN achieves the state-of-the-art results in deep MVC tasks. The source code is publicly available at https://github.com/HackerHyper/GDCN.

cs.CV↗

TimeGMM: Single-Pass Probabilistic Forecasting via Adaptive Gaussian Mixture Models with Reversible Normalization

Probabilistic time series forecasting is crucial for quantifying future uncertainty, with significant applications in fields such as energy and finance. However, existing methods often rely on computationally expensive sampling or restrictive parametric assumptions to characterize future distributions, which limits predictive performance and introduces distributional mismatch. To address these challenges, this paper presents TimeGMM, a novel probabilistic forecasting framework based on Gaussian Mixture Models (GMM) that captures complex future distributions in a single forward pass. A key component is GMM-adapted Reversible Instance Normalization (GRIN), a novel module designed to dynamically adapt to temporal-probabilistic distribution shifts. The framework integrates a dedicated Temporal Encoder (TE-Module) with a Conditional Temporal-Probabilistic Decoder (CTPD-Module) to jointly capture temporal dependencies and mixture distribution parameters. Extensive experiments demonstrate that TimeGMM consistently outperforms state-of-the-art methods, achieving maximum improvements of 22.48\% in CRPS and 21.23\% in NMAE.

cs.LG↗

Service Provisioning and Path Planning with Obstacle Avoidance for Low-Altitude Wireless Networks

This paper investigates the three-dimensional (3D) deployment of uncrewed aerial vehicles (UAVs) as aerial base stations in heterogeneous communication networks under constraints imposed by diverse ground obstacles. Given the diverse data demands of user equipments (UEs), a user satisfaction model is developed to provide personalized services. In particular, when a UE is located within a ground obstacle, the UAV must approach the obstacle boundary to ensure reliable service quality. Considering constraints such as UAV failures due to battery depletion, heterogeneous UEs, and obstacles, we aim to maximize overall user satisfaction by jointly optimizing the 3D trajectories of UAVs, transmit beamforming vectors, and binary association indicators between UAVs and UEs. To address the complexity and dynamics of the problem, a block coordinate descent method is adopted to decompose it into two subproblems. The beamforming subproblem is efficiently addressed via a bisection-based water-filling algorithm. For the trajectory and association subproblem, we design a deep reinforcement learning algorithm based on proximal policy optimization to learn an adaptive control policy. Simulation results demonstrate that the proposed scheme outperforms baseline schemes in terms of convergence speed and overall system performance. Moreover, it achieves efficient association and accurate obstacle avoidance.

eess.SP↗

Random Multiplexing

As wireless communication applications evolve from traditional multipath environments to high-mobility scenarios like unmanned aerial vehicles, multiplexing techniques have advanced accordingly. Traditional single-carrier frequency-domain equalization (SC-FDE) and orthogonal frequency-division multiplexing (OFDM) have given way to emerging orthogonal time-frequency space (OTFS) and affine frequency-division multiplexing (AFDM). These approaches exploit specific channel structures to diagonalize or sparsify the effective channel, thereby enabling low-complexity detection. However, their reliance on these structures significantly limits their robustness in dynamic, real-world environments. To address these challenges, this paper studies a random multiplexing technique that is decoupled from the physical channels, enabling its application to arbitrary norm-bounded and spectrally convergent channel matrices. Random multiplexing achieves statistical fading-channel ergodicity for transmitted signals by constructing an equivalent input-isotropic channel matrix in the random transform domain. It guarantees the asymptotic replica MAP bit-error rate (BER) optimality of AMP-type detectors for linear systems with arbitrary norm-bounded, spectrally convergent channel matrices and signaling configurations, under the unique fixed point assumption. A low-complexity cross-domain memory AMP (CD-MAMP) detector is considered, leveraging the sparsity of the time-domain channel and the randomness of the equivalent channel. Optimal power allocations are derived to minimize the replica MAP BER and maximize the replica constrained capacity of random multiplexing systems. The optimal coding principle and replica constrained-capacity optimality of CD-MAMP detector are investigated for random multiplexing systems. Additionally, the versatility of random multiplexing in diverse wireless applications is explored.

cs.IT↗

Achievable Rate and Coding Principle for MIMO Multicarrier Systems With Cross-Domain MAMP Receiver Over Doubly Selective Channels

The integration of multicarrier modulation and multiple-input-multiple-output (MIMO) is critical for reliable transmission of wireless signals in complex environments, which significantly improve spectrum efficiency. Existing studies have shown that popular orthogonal time frequency space (OTFS) and affine frequency division multiplexing (AFDM) offer significant advantages over orthogonal frequency division multiplexing (OFDM) in uncoded doubly selective channels. However, it remains uncertain whether these benefits extend to coded systems. Meanwhile, the information-theoretic limit analysis of coded MIMO multicarrier systems and the corresponding low-complexity receiver design remain unclear. To overcome these challenges, this paper proposes a multi-slot cross-domain memory approximate message passing (MS-CD-MAMP) receiver as well as develops its information-theoretic (i.e., achievable rate) limit and optimal coding principle for MIMO-multicarrier modulation (e.g., OFDM, OTFS, and AFDM) systems. The proposed MS-CD-MAMP receiver can exploit not only the time domain channel sparsity for low complexity but also the corresponding symbol domain constellation constraints for performance enhancement. Meanwhile, limited by the high-dimensional complex state evolution (SE), a simplified single-input single-output variational SE is proposed to derive the achievable rate of MS-CD-MAMP and the optimal coding principle with the goal of maximizing the achievable rate. Numerical results show that coded MIMO-OFDM/OTFS/AFDM with MS-CD-MAMP achieve the same maximum achievable rate in doubly selective channels, whose finite-length performance with practical optimized low-density parity-check (LDPC) codes is only 0.5 $\sim$ 1.8 dB away from the associated theoretical limit, and has 0.8 $\sim$ 4.4 dB gain over the well-designed point-to-point LDPC codes.

cs.IT↗

Perplexity-Aware Data Scaling Law: Perplexity Landscapes Predict Performance for Continual Pre-training

Continual Pre-training (CPT) serves as a fundamental approach for adapting foundation models to domain-specific applications. Scaling laws for pre-training define a power-law relationship between dataset size and the test loss of an LLM. However, the marginal gains from simply increasing data for CPT diminish rapidly, yielding suboptimal data utilization and inefficient training. To address this challenge, we propose a novel perplexity-aware data scaling law to establish a predictive relationship between the perplexity landscape of domain-specific data and the test loss. Our approach leverages the perplexity derived from the pre-trained model on domain data as a proxy for estimating the knowledge gap, effectively quantifying the informational perplexity landscape of candidate training samples. By fitting this scaling law across diverse perplexity regimes, we enable adaptive selection of high-utility data subsets, prioritizing content that maximizes knowledge absorption while minimizing redundancy and noise. Extensive experiments demonstrate that our method consistently identifies near-optimal training subsets and achieves superior performance on both medical and general-domain benchmarks.

cs.LG↗

Large Model Enabled Embodied Intelligence for 6G Integrated Perception, Communication, and Computation Network

The advent of sixth-generation (6G) places intelligence at the core of wireless architecture, fusing perception, communication, and computation into a single closed-loop. This paper argues that large artificial intelligence models (LAMs) can endow base stations with perception, reasoning, and acting capabilities, thus transforming them into intelligent base station agents (IBSAs). We first review the historical evolution of BSs from single-functional analog infrastructure to distributed, software-defined, and finally LAM-empowered IBSA, highlighting the accompanying changes in architecture, hardware platforms, and deployment. We then present an IBSA architecture that couples a perception-cognition-execution pipeline with cloud-edge-end collaboration and parameter-efficient adaptation. Subsequently,we study two representative scenarios: (i) cooperative vehicle-road perception for autonomous driving, and (ii) ubiquitous base station support for low-altitude uncrewed aerial vehicle safety monitoring and response against unauthorized drones. On this basis, we analyze key enabling technologies spanning LAM design and training, efficient edge-cloud inference, multi-modal perception and actuation, as well as trustworthy security and governance. We further propose a holistic evaluation framework and benchmark considerations that jointly cover communication performance, perception accuracy, decision-making reliability, safety, and energy efficiency. Finally, we distill open challenges on benchmarks, continual adaptation, trustworthy decision-making, and standardization. Together, this work positions LAM-enabled IBSAs as a practical path toward integrated perception, communication, and computation native, safety-critical 6G systems.

eess.SP↗

Proxy-Tuning: Tailoring Multimodal Autoregressive Models for Subject-Driven Image Generation

Multimodal autoregressive (AR) models, based on next-token prediction and transformer architecture, have demonstrated remarkable capabilities in various multimodal tasks including text-to-image (T2I) generation. Despite their strong performance in general T2I tasks, our research reveals that these models initially struggle with subject-driven image generation compared to dominant diffusion models. To address this limitation, we introduce Proxy-Tuning, leveraging diffusion models to enhance AR models' capabilities in subject-specific image generation. Our method reveals a striking weak-to-strong phenomenon: fine-tuned AR models consistently outperform their diffusion model supervisors in both subject fidelity and prompt adherence. We analyze this performance shift and identify scenarios where AR models excel, particularly in multi-subject compositions and contextual understanding. This work not only demonstrates impressive results in subject-driven AR image generation, but also unveils the potential of weak-to-strong generalization in the image generation domain, contributing to a deeper understanding of different architectures' strengths and limitations.

cs.CV↗

Where Is Self-admitted Code Generated by Large Language Models on GitHub?

The increasing use of Large Language Models (LLMs) in software development has garnered significant attention from researchers evaluating the capabilities and limitations of LLMs for code generation. However, much of the research focuses on controlled datasets such as HumanEval, which do not adequately capture the characteristics of LLM-generated code in real-world development scenarios. To address this gap, our study investigates self-admitted code generated by LLMs on GitHub, specifically focusing on instances where developers in projects with over five stars acknowledge the use of LLMs to generate code through code comments. Our findings reveal several key insights: (1) ChatGPT and Copilot dominate code generation, with minimal contributions from other LLMs. (2) Projects containing ChatGPT/Copilot-generated code appears in small/medium-sized projects led by small teams, which are continuously evolving. (3) ChatGPT/Copilot-generated code generally is a minor project portion, primarily generating short/moderate-length, low-complexity snippets (e.g., algorithms and data structures code; text processing code). (4) ChatGPT/Copilot-generated code generally undergoes minimal modifications, with bug-related changes ranging from 4% to 12%. (5) Most code comments only state LLM use, while few include details like prompts, human edits, or code testing status. Based on these findings, we discuss the implications for researchers and practitioners.

cs.SE↗