arXiv subjects

Lei Tian

Publications and source records attributed to Lei Tian.

At least 55 records · Page 3Linked to original sources

arXiv2024

Wide-Field, High-Resolution Reconstruction in Computational Multi-Aperture Miniscope Using a Fourier Neural Network

Traditional fluorescence microscopy is constrained by inherent trade-offs among resolution, field-of-view, and system complexity. To navigate these challenges, we introduce a simple and low-cost computational multi-aperture miniature microscope, utilizing a microlens array for single-shot wide-field, high-resolution imaging. Addressing the challenges posed by extensive view multiplexing and non-local, shift-variant aberrations in this device, we present SV-FourierNet, a novel multi-channel Fourier neural network. SV-FourierNet facilitates high-resolution image reconstruction across the entire imaging field through its learned global receptive field. We establish a close relationship between the physical spatially-varying point-spread functions and the network's learned effective receptive field. This ensures that SV-FourierNet has effectively encapsulated the spatially-varying aberrations in our system, and learned a physically meaningful function for image reconstruction. Training of SV-FourierNet is conducted entirely on a physics-based simulator. We showcase wide-field, high-resolution video reconstructions on colonies of freely moving C. elegans and imaging of a mouse brain section. Our computational multi-aperture miniature microscope, augmented with SV-FourierNet, represents a major advancement in computational microscopy and may find broad applications in biomedical research and other fields requiring compact microscopy solutions.

physics.optics↗

arXiv2024

Empirical Studies of Propagation Characteristics and Modeling Based on XL-MIMO Channel Measurement: From Far-Field to Near-Field

In the sixth-generation (6G), the extremely large-scale multiple-input-multiple-output (XL-MIMO) is considered a promising enabling technology. With the further expansion of array element number and frequency bands, near-field effects will be more likely to occur in 6G communication systems. The near-field radio communications (NFRC) will become crucial in 6G communication systems. It is known that the channel research is very important for the development and performance evaluation of the communication systems. In this paper, we will systematically investigate the channel measurements and modeling for the emerging NFRC. First, the principle design of massive MIMO channel measurement platform are solved. Second, an indoor XL-MIMO channel measurement campaign with 1600 array elements is conducted, and the channel characteristics are extracted and validated in the near-field region. Then, the outdoor XL-MIMO channel measurement campaign with 320 array elements is conducted, and the channel characteristics are extracted and modeled from near-field to far-field (NF-FF) region. The spatial non-stationary characteristics of angular spread at the transmitting end are more important in modeling. We hope that this work will give some reference to the near-field and far-field research for 6G.

cs.IT↗

arXiv2024

Analysis of Near-Field Effects, Spatial Non-Stationary Characteristics Based on 11-15 GHz Channel Measurement in Indoor Scenario

In the sixth-generation (6G), with the further expansion of array element number and frequency bands, the wireless communications are expected to operate in the near-field region. The near-field radio communications (NFRC) will become crucial in 6G communication systems. The new mid-band (6-24 GHz) is the 6G potential candidate spectrum. In this paper, we will investigate the channel measurements and characteristics for the emerging NFRC. First, the near-field spherical-wave signal model is derived in detail, and the stationary interval (SI) division method is discussed based on the channel statistical properties. Then, the influence of line-of-sight (LOS) and obstructed-LOS (OLOS) environments on the near-field effects and spatial non-stationary (SnS) characteristic are explored based on the near-field channel measurements at 11-15 GHz band. We hope that this work will give some reference to the NFRC research.

eess.SP↗

arXiv2024

EventLFM: Event Camera integrated Fourier Light Field Microscopy for Ultrafast 3D imaging

Ultrafast 3D imaging is indispensable for visualizing complex and dynamic biological processes. Conventional scanning-based techniques necessitate an inherent trade-off between acquisition speed and space-bandwidth product (SBP). Emerging single-shot 3D wide-field techniques offer a promising alternative but are bottlenecked by the synchronous readout constraints of conventional CMOS systems, thus restricting data throughput to maintain high SBP at limited frame rates. To address this, we introduce EventLFM, a straightforward and cost-effective system that overcomes these challenges by integrating an event camera with Fourier light field microscopy (LFM), a state-of-the-art single-shot 3D wide-field imaging technique. The event camera operates on a novel asynchronous readout architecture, thereby bypassing the frame rate limitations inherent to conventional CMOS systems. We further develop a simple and robust event-driven LFM reconstruction algorithm that can reliably reconstruct 3D dynamics from the unique spatiotemporal measurements captured by EventLFM. Experimental results demonstrate that EventLFM can robustly reconstruct fast-moving and rapidly blinking 3D fluorescent samples at kHz frame rates. Furthermore, we highlight EventLFM's capability for imaging of blinking neuronal signals in scattering mouse brain tissues and 3D tracking of GFP-labeled neurons in freely moving C. elegans. We believe that the combined ultrafast speed and large 3D SBP offered by EventLFM may open up new possibilities across many biomedical applications.

physics.optics↗

arXiv2024

UniVG: Towards UNIfied-modal Video Generation

Diffusion based video generation has received extensive attention and achieved considerable success within both the academic and industrial communities. However, current efforts are mainly concentrated on single-objective or single-task video generation, such as generation driven by text, by image, or by a combination of text and image. This cannot fully meet the needs of real-world application scenarios, as users are likely to input images and text conditions in a flexible manner, either individually or in combination. To address this, we propose a Unified-modal Video Genearation system that is capable of handling multiple video generation tasks across text and image modalities. To this end, we revisit the various video generation tasks within our system from the perspective of generative freedom, and classify them into high-freedom and low-freedom video generation categories. For high-freedom video generation, we employ Multi-condition Cross Attention to generate videos that align with the semantics of the input images or text. For low-freedom video generation, we introduce Biased Gaussian Noise to replace the pure random Gaussian Noise, which helps to better preserve the content of the input conditions. Our method achieves the lowest Fréchet Video Distance (FVD) on the public academic benchmark MSR-VTT, surpasses the current open-source methods in human evaluations, and is on par with the current close-source method Gen2. For more samples, visit https://univg-baidu.github.io.

cs.CV↗

arXiv2024

HiCAST: Highly Customized Arbitrary Style Transfer with Adapter Enhanced Diffusion Models

The goal of Arbitrary Style Transfer (AST) is injecting the artistic features of a style reference into a given image/video. Existing methods usually focus on pursuing the balance between style and content, whereas ignoring the significant demand for flexible and customized stylization results and thereby limiting their practical application. To address this critical issue, a novel AST approach namely HiCAST is proposed, which is capable of explicitly customizing the stylization results according to various source of semantic clues. In the specific, our model is constructed based on Latent Diffusion Model (LDM) and elaborately designed to absorb content and style instance as conditions of LDM. It is characterized by introducing of \textit{Style Adapter}, which allows user to flexibly manipulate the output results by aligning multi-level style information and intrinsic knowledge in LDM. Lastly, we further extend our model to perform video AST. A novel learning objective is leveraged for video diffusion model training, which significantly improve cross-frame temporal consistency in the premise of maintaining stylization strength. Qualitative and quantitative comparisons as well as comprehensive user studies demonstrate that our HiCAST outperforms the existing SoTA methods in generating visually plausible stylization results.

cs.CV↗

arXiv2023

Robust single-shot 3D fluorescence imaging in scattering media with a simulator-trained neural network

Imaging through scattering is a pervasive and difficult problem in many biological applications. The high background and the exponentially attenuated target signals due to scattering fundamentally limits the imaging depth of fluorescence microscopy. Light-field systems are favorable for high-speed volumetric imaging, but the 2D-to-3D reconstruction is fundamentally ill-posed, and scattering exacerbates the condition of the inverse problem. Here, we develop a scattering simulator that models low-contrast target signals buried in heterogeneous strong background. We then train a deep neural network solely on synthetic data to descatter and reconstruct a 3D volume from a single-shot light-field measurement with low signal-to-background ratio (SBR). We apply this network to our previously developed Computational Miniature Mesoscope and demonstrate the robustness of our deep learning algorithm on scattering phantoms with different scattering conditions. The network can robustly reconstruct emitters in 3D with a 2D measurement of SBR as low as 1.05 and as deep as a scattering length. We analyze fundamental tradeoffs based on network design factors and out-of-distribution data that affect the deep learning model's generalizability to real experimental data. Broadly, we believe that our simulator-based deep learning approach can be applied to a wide range of imaging through scattering techniques where experimental paired training data is lacking.

eess.SP↗

arXiv2023

MixTEA: Semi-supervised Entity Alignment with Mixture Teaching

Semi-supervised entity alignment (EA) is a practical and challenging task because of the lack of adequate labeled mappings as training data. Most works address this problem by generating pseudo mappings for unlabeled entities. However, they either suffer from the erroneous (noisy) pseudo mappings or largely ignore the uncertainty of pseudo mappings. In this paper, we propose a novel semi-supervised EA method, termed as MixTEA, which guides the model learning with an end-to-end mixture teaching of manually labeled mappings and probabilistic pseudo mappings. We firstly train a student model using few labeled mappings as standard. More importantly, in pseudo mapping learning, we propose a bi-directional voting (BDV) strategy that fuses the alignment decisions in different directions to estimate the uncertainty via the joint matching confidence score. Meanwhile, we also design a matching diversity-based rectification (MDR) module to adjust the pseudo mapping learning, thus reducing the negative influence of noisy mappings. Extensive results on benchmark datasets as well as further analyses demonstrate the superiority and the effectiveness of our proposed method.

cs.LG↗

arXiv2023

Asymmetric metasurface photodetectors for single-shot quantitative phase imaging

The visualization of pure phase objects by wavefront sensing has important applications ranging from surface profiling to biomedical microscopy, and generally requires bulky and complicated setups involving optical spatial filtering, interferometry, or structured illumination. Here we introduce a new type of image sensors that are uniquely sensitive to the local direction of light propagation, based on standard photodetectors coated with a specially designed plasmonic metasurface that creates an asymmetric dependence of responsivity on angle of incidence around the surface normal. The metasurface design, fabrication, and angle-sensitive operation are demonstrated using a simple photoconductive detector platform. The measurement results, combined with computational imaging calculations, are then used to show that a standard camera or microscope based on these metasurface pixels can directly visualize phase objects without any additional optical elements, with state-of-the-art minimum detectable phase contrasts below 10 mrad. Furthermore, the combination of sensors with equal and opposite angular response on the same pixel array can be used to perform quantitative phase imaging in a single shot, with a customized reconstruction algorithm which is also developed in this work. By virtue of its system miniaturization and measurement simplicity, the phase imaging approach enabled by these devices is particularly significant for applications involving space-constrained and portable setups (such as point-of-care imaging and endoscopy) and measurements involving freely moving objects.

physics.optics↗

arXiv2023

Local Conditional Neural Fields for Versatile and Generalizable Large-Scale Reconstructions in Computational Imaging

Deep learning has transformed computational imaging, but traditional pixel-based representations limit their ability to capture continuous, multiscale details of objects. Here we introduce a novel Local Conditional Neural Fields (LCNF) framework, leveraging a continuous implicit neural representation to address this limitation. LCNF enables flexible object representation and facilitates the reconstruction of multiscale information. We demonstrate the capabilities of LCNF in solving the highly ill-posed inverse problem in Fourier ptychographic microscopy (FPM) with multiplexed measurements, achieving robust, scalable, and generalizable large-scale phase retrieval. Unlike traditional neural fields frameworks, LCNF incorporates a local conditional representation that promotes model generalization, learning multiscale information, and efficient processing of large-scale imaging data. By combining an encoder and a decoder conditioned on a learned latent vector, LCNF achieves versatile continuous-domain super-resolution image reconstruction. We demonstrate accurate reconstruction of wide field-of-view, high-resolution phase images using only a few multiplexed measurements. LCNF robustly captures the continuous object priors and eliminates various phase artifacts, even when it is trained on imperfect datasets. The framework exhibits strong generalization, reconstructing diverse objects even with limited training data. Furthermore, LCNF can be trained on a physics simulator using natural images and successfully applied to experimental measurements on biological samples. Our results highlight the potential of LCNF for solving large-scale inverse problems in computational imaging, with broad applicability in various deep-learning-based techniques.

eess.IV↗

arXiv2023

Roadmap on Deep Learning for Microscopy

Through digital imaging, microscopy has evolved from primarily being a means for visual observation of life at the micro- and nano-scale, to a quantitative tool with ever-increasing resolution and throughput. Artificial intelligence, deep neural networks, and machine learning are all niche terms describing computational methods that have gained a pivotal role in microscopy-based research over the past decade. This Roadmap is written collectively by prominent researchers and encompasses selected aspects of how machine learning is applied to microscopy image data, with the aim of gaining scientific knowledge by improved image quality, automated detection, segmentation, classification and tracking of objects, and efficient merging of information from multiple imaging modalities. We aim to give the reader an overview of the key developments and an understanding of possibilities and limitations of machine learning for microscopy. It will be of interest to a wide cross-disciplinary audience in the physical sciences and life sciences.

physics.optics↗

arXiv2023

Mid-infrared Chemical Imaging of Intracellular Tau Fibrils using Fluorescence-guided Computational Photothermal Microscopy

Amyloid proteins are associated with a broad spectrum of neurodegenerative diseases. However, it remains a grand challenge to extract molecular structure information from intracellular amyloid proteins in their native cellular environment. To address this challenge, we developed a computational chemical microscope integrating 3D mid-infrared photothermal imaging with fluorescence imaging, termed Fluorescence-guided Bond-Selective Intensity Diffraction Tomography (FBS-IDT). Based on a low-cost and simple optical design, FBS-IDT enables chemical-specific volumetric imaging and 3D site-specific mid-IR fingerprint spectroscopic analysis of tau fibrils, an important type of amyloid protein aggregates, in their intracellular environment. Label-free volumetric chemical imaging of human cells with/without seeded tau fibrils is demonstrated to show the potential correlation between lipid accumulation and tau aggregate formation. Depth-resolved mid-infrared fingerprint spectroscopy is performed to reveal the protein secondary structure of the intracellular tau fibrils. 3D visualization of the \b{eta}-sheet for tau fibril structure is achieved.

physics.optics↗

arXiv2023

Cross-Domain Label Propagation for Domain Adaptation with Discriminative Graph Self-Learning

Domain adaptation manages to transfer the knowledge of well-labeled source data to unlabeled target data. Many recent efforts focus on improving the prediction accuracy of target pseudo-labels to reduce conditional distribution shift. In this paper, we propose a novel domain adaptation method, which infers target pseudo-labels through cross-domain label propagation, such that the underlying manifold structure of two domain data can be explored. Unlike existing cross-domain label propagation methods that separate domain-invariant feature learning, affinity matrix constructing and target labels inferring into three independent stages, we propose to integrate them into a unified optimization framework. In such way, these three parts can boost each other from an iterative optimization perspective and thus more effective knowledge transfer can be achieved. Furthermore, to construct a high-quality affinity matrix, we propose a discriminative graph self-learning strategy, which can not only adaptively capture the inherent similarity of the data from two domains but also effectively exploit the discriminative information contained in well-labeled source data and pseudo-labeled target data. An efficient iterative optimization algorithm is designed to solve the objective function of our proposal. Notably, the proposed method can be extended to semi-supervised domain adaptation in a simple but effective way and the corresponding optimization problem can be solved with the identical algorithm. Extensive experiments on six standard datasets verify the significant superiority of our proposal in both unsupervised and semi-supervised domain adaptation settings.

cs.LG↗

arXiv2023

Channel Sparsity Variation and Model-Based Analysis on 6, 26, and 132 GHz Measurements

In this paper, the level of sparsity is examined at 6, 26, and 132 GHz carrier frequencies by conducting channel measurements in an indoor office environment. By using the Gini index (value between 0 and 1) as a metric for characterizing sparsity, we show that increasing carrier frequency leads to increased levels of sparsity. The measured channel impulse responses are used to derive a Third-Generation Partnership Project (3GPP)-style propagation model, used to calculate the Gini index for the comparison of the channel sparsity between the measurement and simulation based on the 3GPP model. Our results show that the mean value of the Gini index in measurement is over twice the value in simulation, implying that the 3GPP channel model does not capture the effects of sparsity in the delay domain as frequency increases. In addition, a new intra-cluster power allocation model based on measurements is proposed to characterize the effects of sparsity in the delay domain of the 3GPP channel model. The accuracy of the proposed model is analyzed using theoretical derivations and simulations. Using the derived intra-cluster power allocation model, the mean value of the Gini index is 0.97, while the spread of variability is restricted to 0.01, demonstrating that the proposed model is suitable for 3GPP-type channels. To our best knowledge, this paper is the first to perform measurements and analysis at three different frequencies for the evaluation of channel sparsity in the same environment.

eess.SP↗

arXiv2023

Adversarial Learning-based Stance Classifier for COVID-19-related Health Policies

The ongoing COVID-19 pandemic has caused immeasurable losses for people worldwide. To contain the spread of the virus and further alleviate the crisis, various health policies (e.g., stay-at-home orders) have been issued which spark heated discussions as users turn to share their attitudes on social media. In this paper, we consider a more realistic scenario on stance detection (i.e., cross-target and zero-shot settings) for the pandemic and propose an adversarial learning-based stance classifier to automatically identify the public's attitudes toward COVID-19-related health policies. Specifically, we adopt adversarial learning that allows the model to train on a large amount of labeled data and capture transferable knowledge from source topics, so as to enable generalize to the emerging health policies with sparse labeled data. To further enhance the model's deeper understanding, we incorporate policy descriptions as external knowledge into the model. Meanwhile, a GeoEncoder is designed which encourages the model to capture unobserved background factors specified by each region and then represent them as non-text information. We evaluate the performance of a broad range of baselines on the stance detection task for COVID-19-related health policies, and experimental results show that our proposed method achieves state-of-the-art performance in both cross-target and zero-shot settings.

cs.CL↗

arXiv2022

Zero-shot stance detection based on cross-domain feature enhancement by contrastive learning

Zero-shot stance detection is challenging because it requires detecting the stance of previously unseen targets in the inference phase. The ability to learn transferable target-invariant features is critical for zero-shot stance detection. In this work, we propose a stance detection approach that can efficiently adapt to unseen targets, the core of which is to capture target-invariant syntactic expression patterns as transferable knowledge. Specifically, we first augment the data by masking the topic words of sentences, and then feed the augmented data to an unsupervised contrastive learning module to capture transferable features. Then, to fit a specific target, we encode the raw texts as target-specific features. Finally, we adopt an attention mechanism, which combines syntactic expression patterns with target-specific features to obtain enhanced features for predicting previously unseen targets. Experiments demonstrate that our model outperforms competitive baselines on four benchmark datasets.

cs.CL↗

arXiv2022

Deep-learning-augmented Computational Miniature Mesoscope

Fluorescence microscopy is essential to study biological structures and dynamics. However, existing systems suffer from a tradeoff between field-of-view (FOV), resolution, and complexity, and thus cannot fulfill the emerging need of miniaturized platforms providing micron-scale resolution across centimeter-scale FOVs. To overcome this challenge, we developed Computational Miniature Mesoscope (CM$^2$) that exploits a computational imaging strategy to enable single-shot 3D high-resolution imaging across a wide FOV in a miniaturized platform. Here, we present CM$^2$ V2 that significantly advances both the hardware and computation. We complement the 3$\times$3 microlens array with a new hybrid emission filter that improves the imaging contrast by 5$\times$, and design a 3D-printed freeform collimator for the LED illuminator that improves the excitation efficiency by 3$\times$. To enable high-resolution reconstruction across the large imaging volume, we develop an accurate and efficient 3D linear shift-variant (LSV) model that characterizes the spatially varying aberrations. We then train a multi-module deep learning model, CM$^2$Net, using only the 3D-LSV simulator. We show that CM$^2$Net generalizes well to experiments and achieves accurate 3D reconstruction across a $\sim$7-mm FOV and 800-$μ$m depth, and provides $\sim$6-$μ$m lateral and $\sim$25-$μ$m axial resolution. This provides $\sim$8$\times$ better axial localization and $\sim$1400$\times$ faster speed as compared to the previous model-based algorithm. We anticipate this simple and low-cost computational miniature imaging system will be impactful to many large-scale 3D fluorescence imaging applications.

physics.optics↗

arXiv2022

Bond-Selective Intensity Diffraction Tomography

Recovering molecular information remains a grand challenge in the widely used holographic and computational imaging technologies. To address this challenge, we developed a computational mid-infrared photothermal microscope, termed Bond-selective Intensity Diffraction Tomography (BS-IDT). Based on a low-cost brightfield microscope with an add-on pulsed light source, BS-IDT recovers both infrared spectra and bond-selective 3D refractive index maps from intensity-only measurements. High-fidelity infrared fingerprint spectra extraction is validated. Volumetric chemical imaging of biological cells is demonstrated at a speed of ~20 seconds per volume, with a lateral and axial resolution of ~350 nm and ~1.1 micron, respectively. BS-IDT's application potential is investigated by chemically quantifying lipids stored in cancer cells and volumetric chemical imaging on Caenorhabditis elegans with a large field of view (~100 micron X 100 micron).

physics.optics↗