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Ling Huang

Publications and source records attributed to Ling Huang.

At least 19 recordsLinked to original sources
arXiv2026

What Is Missing in Surgical Risk Stratification and Outcome Prediction: A Scoping Review of End-to-End Machine Learning Approaches

Postoperative adverse events, including mortality and morbidity, remain a major global burden, many of which are preventable through early identification of high-risk patients and targeted perioperative care. Accurate risk stratification is therefore essential. With the growing availability of large-scale electronic health records (EHRs), machine learning (ML) provides a data-driven approach to model complex clinical patterns. However, existing studies vary widely in design, and methodological practices remain fragmented. This scoping review characterizes ML pipelines for surgical risk stratification and outcome prediction using EHR data. We reviewed 190 studies covering the ML workflow, including data preprocessing, algorithm selection, model evaluation, and explainability. Most studies relied on single-center private datasets with limited data modalities, while the scarcity of open-access surgical datasets constrained reproducibility and generalizability. Reporting of key preprocessing steps, including missing data handling, feature selection, and class imbalance, was often incomplete. Conventional ML models and simple neural networks predominated, whereas deep learning and multimodal approaches remained uncommon. Benchmark datasets and standardized evaluation protocols were largely absent, hindering cross-study comparisons. Only about one-third of studies incorporated explainability methods. This review identifies methodological gaps limiting clinically robust postoperative ML tools and provides a structured reference to support more rigorous, reproducible, and clinically meaningful ML development for perioperative care.

cs.LG↗
arXiv2026

Semantic-Anchored Evidential Fusion for Domain-Robust Whole-Slide Survival Analysis

Whole-slide images (WSIs) are widely used for computational cancer prognosis. However, most existing methods primarily focus on in-domain performance and fail to generalize across clinical centers. This limitation stems from their reliance on pixel-derived representations that are highly susceptible to domain-specific artifacts caused by staining protocols and scanner hardware. We hypothesize that high-level pathology semantics, such as tumor grade and micro-environmental architecture, provide a domain-invariant semantic representation that mirrors the robust diagnostic logic of human pathologists. Therefore, we propose a Semantic-Anchored Evidential Fusion Survival (SAEFS) framework, where SAEFS derives semantic anchors from WSIs via Visual Question Answering (VQA), employs a dual-stream WSI evidence extraction architecture, uses Dirichlet-based Subjective Logic to model uncertainty, and fuses semantic and visual evidence through a cautious conjunction rule to avoid overconfident fusion from correlated sources. Trained exclusively on one source domain and evaluated zero-shot across four unseen domains, SAEFS consistently outperforms state-of-the-art models both in prediction accuracy and reliability, improving the average C-index by 10.2%. Quantitative analyses further show that VQA-derived semantic features exhibit significantly lower cross-center divergence than pixel-derived features, highlighting their robustness for cross-center clinical applications.

cs.CV↗
arXiv2026

Evidential Fusion Network for Multimodal Survival Prediction under Missing Modalities

Recent multimodal survival prediction models have demonstrated strong predictive performance by leveraging complementary information across modalities. However, such models generally assume data completeness and exhibit limited robustness toward missing modalities, which are frequently encountered in real-world clinical settings. We propose the Evidential Missing Modality Survival Fusion (EMMS) model for multimodal survival prediction under missing modalities. EMMS offers a straightforward, computationally effective approach to survival analysis without requiring a generative phase for missing data. By employing Dempster-Shafer theory and Gaussian Random Fuzzy Numbers for multimodal decision fusion, it considers both aleatoric and epistemic uncertainty alongside modality reliability for fusion. Moreover, the model treats missing modalities as vacuous evidence, preventing interference with available inputs and naturally reflecting increased uncertainty and calibrated predictions. Extensive experiments on four cancer datasets demonstrate state-of-the-art performance while providing calibrated and interpretable uncertainty estimates under incomplete multimodal observations, without introducing additional computational overhead.

cs.LG↗
arXiv2026

Bridging the Modality Bottleneck in Pathology MIL through Virtual Molecular Staining

Multiple instance learning (MIL) is the dominant framework for whole-slide image analysis in computational pathology, typically combining a frozen patch encoder, a projection layer, and a slide-level aggregator. While encoders and aggregators have been extensively studied, the projection layer remains a largely morphology-only bottleneck. This limits endpoints such as biomarker status and survival, which are governed by a molecular state that is not fully captured by H&E morphology. We introduce Molecularly Informed Staining Transform (MIST), a plug-in replacement for the MIL projection layer that uses paired spatial transcriptomics only during training to construct virtual molecular stains. MIST clusters gene expression profiles into cross-modal prototypes, anchors them in the frozen foundation model feature space, and uses them to reorganize H&E patch features along molecularly guided axes. It requires no transcriptomics at inference and can be inserted before standard MIL aggregators. We evaluate MIST across 23 downstream tasks and 8 MIL aggregators. MIST improves 240 of 256 configurations over the standard projection layer, with an average gain of +3.5%, observed consistently across endpoint types: +5.2% on survival prediction, +3.3% on tissue subtyping, and +2.6% on biomarker prediction. Ablations confirm that gene-derived prototypes are the primary source of the gains, while spatial, biological, and pathological analyses show that cross-modal prototype affinities capture spatially coherent molecular programs from H&E alone.

q-bio.QM↗
arXiv2026

Beyond Semantics: An Evidential Reasoning-Aware Multi-View Learning Framework for Trustworthy Mental Health Prediction

Automated mental health prediction using textual data has shown promising results with deep learning and large language models. However, deploying these models in high-stakes real-world settings remains challenging, as existing approaches largely rely on semantic representations and often produce overconfident predictions under ambiguous, noisy, or shifted data. Moreover, most methods lack reliable uncertainty estimation, undermining trust in risk-sensitive mental health applications. To address these limitations, we formulate the task as a multi-view learning problem that integrates semantic information from encoder-only models with higher-level reasoning information from decoder-only models, where reasoning-aware representations and uncertainty modeling are obtained in a trustworthy manner. To ensure reliable fusion, we adopt an evidential learning framework based on Subjective Logic to explicitly model uncertainty and introduce an evidential fusion strategy that balances complementary views while discounting unreliable evidence. Benchmarking on three real-world datasets, Dreaddit, SDCNL, and DepSeverity, reports accuracies of 0.835, 0.731, and 0.751, respectively, demonstrating its potential for reliable mental health prediction. Additional experiments on robustness to noise and case studies for interpretability confirm that our proposed framework not only improves predictive performance but also provides trustworthy uncertainty estimates and human-understandable reasoning signals, making it suitable for risk-sensitive applications in mental health assessment.

cs.CL↗
arXiv2026

Online semi-supervised perception: Real-time learning without explicit feedback

This paper proposes an algorithm for real-time learning without explicit feedback. The algorithm combines the ideas of semi-supervised learning on graphs and online learning. In particular, it iteratively builds a graphical representation of its world and updates it with observed examples. Labeled examples constitute the initial bias of the algorithm and are provided offline, and a stream of unlabeled examples is collected online to update this bias. We motivate the algorithm, discuss how to implement it efficiently, prove a regret bound on the quality of its solutions, and apply it to the problem of real-time face recognition. Our recognizer runs in real time, and achieves superior precision and recall on 3 challenging video datasets.

cs.LG↗
arXiv2026

Semi-supervised learning with max-margin graph cuts

This paper proposes a novel algorithm for semisupervised learning. This algorithm learns graph cuts that maximize the margin with respect to the labels induced by the harmonic function solution. We motivate the approach, compare it to existing work, and prove a bound on its generalization error. The quality of our solutions is evaluated on a synthetic problem and three UCI ML repository datasets. In most cases, we outperform manifold regularization of support vector machines, which is a state-of-the-art approach to semi-supervised max-margin learning.

cs.LG↗
arXiv2026

Sell More, Play Less: Benchmarking LLM Realistic Selling Skill

Sales dialogues require multi-turn, goal-directed persuasion under asymmetric incentives, which makes them a challenging setting for large language models (LLMs). Yet existing dialogue benchmarks rarely measure deal progression and outcomes. We introduce SalesLLM benchmark, a bilingual (ZH/EN) benchmark derived from realistic applications covering Financial Services and Consumer Goods, built from 30,074 scripted configurations and 1,805 curated multi-turn scenarios with controllable difficulty and personas. We propose a fully automatic evaluation pipeline that combines (i) an LLM judge for sales-process progress, and (ii) fine-tuned BERT classifiers for end-of-dialogue buying intent. To improve simulation fidelity, we train a user model, CustomerLM, with SFT and DPO on 8,000+ crowdworker-involved sales conversations, reducing role inversion from 17.44% (GPT-4o) to 8.8%. SalesLLM benchmark scores correlate strongly with human ratings (average Pearson r=0.86; inter-annotator agreement Krippendorff's alpha=0.86, 500 annotations per model). Across 15 mainstream LLMs, in Chinese the strongest models are competitive with typical (junior-to-intermediate) human salespeople -- not with sales experts -- while weaker ones fall below this baseline, and cross-lingual consistency remains poor. SalesLLM benchmark serves as a scalable benchmark for outcome-oriented sales agents. Our code and data are released at https://github.com/Bairong-Xdynamics/Benchmarking-LLM-Realistic-Selling-Skill

cs.CL↗
arXiv2025

Detecting LLM-Generated Spam Reviews by Integrating Language Model Embeddings and Graph Neural Network

The rise of large language models (LLMs) has enabled the generation of highly persuasive spam reviews that closely mimic human writing. These reviews pose significant challenges for existing detection systems and threaten the credibility of online platforms. In this work, we first create three realistic LLM-generated spam review datasets using three distinct LLMs, each guided by product metadata and genuine reference reviews. Evaluations by GPT-4.1 confirm the high persuasion and deceptive potential of these reviews. To address this threat, we propose FraudSquad, a hybrid detection model that integrates text embeddings from a pre-trained language model with a gated graph transformer for spam node classification. FraudSquad captures both semantic and behavioral signals without relying on manual feature engineering or massive training resources. Experiments show that FraudSquad outperforms state-of-the-art baselines by up to 44.22% in precision and 43.01% in recall on three LLM-generated datasets, while also achieving promising results on two human-written spam datasets. Furthermore, FraudSquad maintains a modest model size and requires minimal labeled training data, making it a practical solution for real-world applications. Our contributions include new synthetic datasets, a practical detection framework, and empirical evidence highlighting the urgency of adapting spam detection to the LLM era. Our code and datasets are available at: https://anonymous.4open.science/r/FraudSquad-5389/.

cs.CL↗
arXiv2025

DPsurv: Dual-Prototype Evidential Fusion for Uncertainty-Aware and Interpretable Whole-Slide Image Survival Prediction

Pathology whole-slide images (WSIs) are widely used for cancer survival analysis because of their comprehensive histopathological information at both cellular and tissue levels, enabling quantitative, large-scale, and prognostically rich tumor feature analysis. However, most existing methods in WSI survival analysis struggle with limited interpretability and often overlook predictive uncertainty in heterogeneous slide images. In this paper, we propose DPsurv, a dual-prototype whole-slide image evidential fusion network that outputs uncertainty-aware survival intervals, while enabling interpretation of predictions through patch prototype assignment maps, component prototypes, and component-wise relative risk aggregation. Experiments on five publicly available datasets achieve the highest mean concordance index and the lowest mean integrated Brier score, validating the effectiveness and reliability of DPsurv. The interpretation of prediction results provides transparency at the feature, reasoning, and decision levels, thereby enhancing the trustworthiness and interpretability of DPsurv.

eess.IV↗
arXiv2025

Toward Clinically Explainable AI for Medical Diagnosis: A Foundation Model with Human-Compatible Reasoning via Reinforcement Learning

The clinical adoption of artificial intelligence (AI) in medical diagnostics is critically hampered by its black-box nature, which prevents clinicians from verifying the rationale behind automated decisions. To overcome this fundamental barrier, we introduce DeepMedix-R1, a foundation model (FM) for chest X-ray (CXR) interpretation that generates not only accurate diagnoses but also a transparent, step-by-step reasoning process grounded in specific visual evidence. Our methodology employs a sequential training strategy, beginning with instruction fine-tuning, followed by a cold-start phase to elicit reasoning capabilities. Critically, we then implement reinforcement learning with grounded rewards to meticulously refine the model, aligning both its diagnostic outputs and its reasoning pathways with clinical plausibility. Quantitative assessments show that DeepMedix-R1 substantially outperforms advanced FMs, achieving improvements in report generation and visual question answering tasks. We also introduce Report Arena, a novel LLM-based benchmark that ranks DeepMedix-R1 first among competing models for output quality. Most significantly, a formal review by clinical experts reveals a profound preference for DeepMedix-R1's generated reasoning over the broadly adopted Qwen2.5-VL-7B model, confirming its superior interpretability and clinical utility.

cs.AI↗
arXiv2025

CATS: Clustering-Aggregated and Time Series for Business Customer Purchase Intention Prediction

Accurately predicting customers' purchase intentions is critical to the success of a business strategy. Current researches mainly focus on analyzing the specific types of products that customers are likely to purchase in the future, little attention has been paid to the critical factor of whether customers will engage in repurchase behavior. Predicting whether a customer will make the next purchase is a classic time series forecasting task. However, in real-world purchasing behavior, customer groups typically exhibit imbalance - i.e., there are a large number of occasional buyers and a small number of loyal customers. This head-to-tail distribution makes traditional time series forecasting methods face certain limitations when dealing with such problems. To address the above challenges, this paper proposes a unified Clustering and Attention mechanism GRU model (CAGRU) that leverages multi-modal data for customer purchase intention prediction. The framework first performs customer profiling with respect to the customer characteristics and clusters the customers to delineate the different customer clusters that contain similar features. Then, the time series features of different customer clusters are extracted by GRU neural network and an attention mechanism is introduced to capture the significance of sequence locations. Furthermore, to mitigate the head-to-tail distribution of customer segments, we train the model separately for each customer segment, to adapt and capture more accurately the differences in behavioral characteristics between different customer segments, as well as the similar characteristics of the customers within the same customer segment. We constructed four datasets and conducted extensive experiments to demonstrate the superiority of the proposed CAGRU approach.

econ.EM↗
arXiv2025

Self-supervised Quantized Representation for Seamlessly Integrating Knowledge Graphs with Large Language Models

Due to the presence of the natural gap between Knowledge Graph (KG) structures and the natural language, the effective integration of holistic structural information of KGs with Large Language Models (LLMs) has emerged as a significant question. To this end, we propose a two-stage framework to learn and apply quantized codes for each entity, aiming for the seamless integration of KGs with LLMs. Firstly, a self-supervised quantized representation (SSQR) method is proposed to compress both KG structural and semantic knowledge into discrete codes (\ie, tokens) that align the format of language sentences. We further design KG instruction-following data by viewing these learned codes as features to directly input to LLMs, thereby achieving seamless integration. The experiment results demonstrate that SSQR outperforms existing unsupervised quantized methods, producing more distinguishable codes. Further, the fine-tuned LLaMA2 and LLaMA3.1 also have superior performance on KG link prediction and triple classification tasks, utilizing only 16 tokens per entity instead of thousands in conventional prompting methods.

cs.CL↗
arXiv2025

Towards accurate and reliable ICU outcome prediction: a multimodal learning framework based on belief function theory using structured EHRs and free-text notes

Accurate Intensive Care Unit (ICU) outcome prediction is critical for improving patient treatment quality and ICU resource allocation. Existing research mainly focuses on structured data, e.g. demographics and vital signs, and lacks effective frameworks to integrate clinical notes from heterogeneous electronic health records (EHRs). This study aims to explore a multimodal framework based on belief function theory that can effectively fuse heterogeneous structured EHRs and free-text notes for accurate and reliable ICU outcome prediction. The fusion strategy accounts for prediction uncertainty within each modality and conflicts between multimodal data. The experiments on MIMIC-III dataset show that our framework provides more accurate and reliable predictions than existing approaches. Specifically, it outperformed the best baseline by 1.05%/1.02% in BACC, 9.74%/6.04% in F1 score, 1.28%/0.9% in AUROC, and 6.21%/2.68% in AUPRC for predicting mortality and PLOS, respectively. Additionally, it improved the reliability of the predictions with a 26.8%/15.1% reduction in the Brier score and a 25.0%/13.3% reduction in negative log-likelihood. By effectively reducing false positives, the model can aid in better allocation of medical resources in the ICU. Furthermore, the proposed method is very versatile and can be extended to analyzing multimodal EHRs for other clinical tasks. The code implementation is available on https://github.com/yuchengruan/evid_multimodal_ehr.

cs.IT↗
arXiv2024

EsurvFusion: An evidential multimodal survival fusion model based on Gaussian random fuzzy numbers

Multimodal survival analysis aims to combine heterogeneous data sources (e.g., clinical, imaging, text, genomics) to improve the prediction quality of survival outcomes. However, this task is particularly challenging due to high heterogeneity and noise across data sources, which vary in structure, distribution, and context. Additionally, the ground truth is often censored (uncertain) due to incomplete follow-up data. In this paper, we propose a novel evidential multimodal survival fusion model, EsurvFusion, designed to combine multimodal data at the decision level through an evidence-based decision fusion layer that jointly addresses both data and model uncertainty while incorporating modality-level reliability. Specifically, EsurvFusion first models unimodal data with newly introduced Gaussian random fuzzy numbers, producing unimodal survival predictions along with corresponding aleatoric and epistemic uncertainties. It then estimates modality-level reliability through a reliability discounting layer to correct the misleading impact of noisy data modalities. Finally, a multimodal evidence-based fusion layer is introduced to combine the discounted predictions to form a unified, interpretable multimodal survival analysis model, revealing each modality's influence based on the learned reliability coefficients. This is the first work that studies multimodal survival analysis with both uncertainty and reliability. Extensive experiments on four multimodal survival datasets demonstrate the effectiveness of our model in handling high heterogeneity data, establishing new state-of-the-art on several benchmarks.

cs.LG↗
arXiv2024

Evidential time-to-event prediction with calibrated uncertainty quantification

Time-to-event analysis provides insights into clinical prognosis and treatment recommendations. However, this task is more challenging than standard regression problems due to the presence of censored observations. Additionally, the lack of confidence assessment, model robustness, and prediction calibration raises concerns about the reliability of predictions. To address these challenges, we propose an evidential regression model specifically designed for time-to-event prediction. The proposed model quantifies both epistemic and aleatory uncertainties using Gaussian Random Fuzzy Numbers and belief functions, providing clinicians with uncertainty-aware survival time predictions. The model is trained by minimizing a generalized negative log-likelihood function accounting for data censoring. Experimental evaluations using simulated datasets with different data distributions and censoring conditions, as well as real-world datasets across diverse clinical applications, demonstrate that our model delivers both accurate and reliable performance, outperforming state-of-the-art methods. These results highlight the potential of our approach for enhancing clinical decision-making in survival analysis.

cs.LG↗
arXiv2024

Has Multimodal Learning Delivered Universal Intelligence in Healthcare? A Comprehensive Survey

The rapid development of artificial intelligence has constantly reshaped the field of intelligent healthcare and medicine. As a vital technology, multimodal learning has increasingly garnered interest due to data complementarity, comprehensive modeling form, and great application potential. Currently, numerous researchers are dedicating their attention to this field, conducting extensive studies and constructing abundant intelligent systems. Naturally, an open question arises that has multimodal learning delivered universal intelligence in healthcare? To answer the question, we adopt three unique viewpoints for a holistic analysis. Firstly, we conduct a comprehensive survey of the current progress of medical multimodal learning from the perspectives of datasets, task-oriented methods, and universal foundation models. Based on them, we further discuss the proposed question from five issues to explore the real impacts of advanced techniques in healthcare, from data and technologies to performance and ethics. The answer is that current technologies have NOT achieved universal intelligence and there remains a significant journey to undertake. Finally, in light of the above reviews and discussions, we point out ten potential directions for exploration towards the goal of universal intelligence in healthcare.

cs.AI↗
arXiv2024

Positive solutions with prescribed mass for a planar Choquard equation with critical growth

We study normalised solutions for a Choquard equation in the plane with polynomial Riesz kernel and exponential nonlinearities, which are critical in the sense of Trudinger-Moser. For all prescribed values of the mass, we prove existence of a positive radial solution by a variational argument, which exploits a delicate analysis on the mountain pass level. Under an additional monotonicity assumption on the nonlinearity, such a solution turns out to be also a ground state in $H^1(\mathbb R^2)$. Our work extends the results by Dou, Huang, and Zhong (J Geom Anal 34(10):317, 2024) to the Choquard setting, improving in several directions those by Deng and Yu in (Z Angew Math Phys 74(3):103, 2023).

math.AP↗