arXiv subjects

Ling Huang

Publications and source records attributed to Ling Huang.

At least 37 records · Page 2Linked to original sources

arXiv2024

Evidential time-to-event prediction with calibrated uncertainty quantification

Time-to-event analysis provides insights into clinical prognosis and treatment recommendations. However, this task is more challenging than standard regression problems due to the presence of censored observations. Additionally, the lack of confidence assessment, model robustness, and prediction calibration raises concerns about the reliability of predictions. To address these challenges, we propose an evidential regression model specifically designed for time-to-event prediction. The proposed model quantifies both epistemic and aleatory uncertainties using Gaussian Random Fuzzy Numbers and belief functions, providing clinicians with uncertainty-aware survival time predictions. The model is trained by minimizing a generalized negative log-likelihood function accounting for data censoring. Experimental evaluations using simulated datasets with different data distributions and censoring conditions, as well as real-world datasets across diverse clinical applications, demonstrate that our model delivers both accurate and reliable performance, outperforming state-of-the-art methods. These results highlight the potential of our approach for enhancing clinical decision-making in survival analysis.

cs.LG↗

arXiv2024

EsurvFusion: An evidential multimodal survival fusion model based on Gaussian random fuzzy numbers

Multimodal survival analysis aims to combine heterogeneous data sources (e.g., clinical, imaging, text, genomics) to improve the prediction quality of survival outcomes. However, this task is particularly challenging due to high heterogeneity and noise across data sources, which vary in structure, distribution, and context. Additionally, the ground truth is often censored (uncertain) due to incomplete follow-up data. In this paper, we propose a novel evidential multimodal survival fusion model, EsurvFusion, designed to combine multimodal data at the decision level through an evidence-based decision fusion layer that jointly addresses both data and model uncertainty while incorporating modality-level reliability. Specifically, EsurvFusion first models unimodal data with newly introduced Gaussian random fuzzy numbers, producing unimodal survival predictions along with corresponding aleatoric and epistemic uncertainties. It then estimates modality-level reliability through a reliability discounting layer to correct the misleading impact of noisy data modalities. Finally, a multimodal evidence-based fusion layer is introduced to combine the discounted predictions to form a unified, interpretable multimodal survival analysis model, revealing each modality's influence based on the learned reliability coefficients. This is the first work that studies multimodal survival analysis with both uncertainty and reliability. Extensive experiments on four multimodal survival datasets demonstrate the effectiveness of our model in handling high heterogeneity data, establishing new state-of-the-art on several benchmarks.

cs.LG↗

arXiv2024

Has Multimodal Learning Delivered Universal Intelligence in Healthcare? A Comprehensive Survey

The rapid development of artificial intelligence has constantly reshaped the field of intelligent healthcare and medicine. As a vital technology, multimodal learning has increasingly garnered interest due to data complementarity, comprehensive modeling form, and great application potential. Currently, numerous researchers are dedicating their attention to this field, conducting extensive studies and constructing abundant intelligent systems. Naturally, an open question arises that has multimodal learning delivered universal intelligence in healthcare? To answer the question, we adopt three unique viewpoints for a holistic analysis. Firstly, we conduct a comprehensive survey of the current progress of medical multimodal learning from the perspectives of datasets, task-oriented methods, and universal foundation models. Based on them, we further discuss the proposed question from five issues to explore the real impacts of advanced techniques in healthcare, from data and technologies to performance and ethics. The answer is that current technologies have NOT achieved universal intelligence and there remains a significant journey to undertake. Finally, in light of the above reviews and discussions, we point out ten potential directions for exploration towards the goal of universal intelligence in healthcare.

cs.AI↗

arXiv2024

Deep evidential fusion with uncertainty quantification and contextual discounting for multimodal medical image segmentation

Single-modality medical images generally do not contain enough information to reach an accurate and reliable diagnosis. For this reason, physicians generally diagnose diseases based on multimodal medical images such as, e.g., PET/CT. The effective fusion of multimodal information is essential to reach a reliable decision and explain how the decision is made as well. In this paper, we propose a fusion framework for multimodal medical image segmentation based on deep learning and the Dempster-Shafer theory of evidence. In this framework, the reliability of each single modality image when segmenting different objects is taken into account by a contextual discounting operation. The discounted pieces of evidence from each modality are then combined by Dempster's rule to reach a final decision. Experimental results with a PET-CT dataset with lymphomas and a multi-MRI dataset with brain tumors show that our method outperforms the state-of-the-art methods in accuracy and reliability.

eess.IV↗

arXiv2024

The mass-mixed case for normalized solutions to NLS equations in dimension two

\noindent We are concerned with positive normalized solutions $(u,λ)\in H^1(\mathbb{R}^2)\times\mathbb{R}$ to the following semi-linear Schrödinger equations $$ -Δu+λu=f(u), \quad\text{in}~\mathbb{R}^2, $$ satisfying the mass constraint $$\int_{\mathbb{R}^2}|u|^2\, dx=c^2\ .$$ We are interested in the so-called mass mixed case in which $f$ has $L^2$-subcritical growth at zero and critical growth at infinity, which in dimension two turns out to be of exponential rate. Under mild conditions, we establish the existence of two positive normalized solutions provided the prescribed mass is sufficiently small: one is a local minimizer and the second one is of mountain pass type. We also investigate the asymptotic behavior of solutions approaching the zero mass case, namely when $c\to 0^+$.

math.AP↗

arXiv2024

Tracking Reflected Objects: A Benchmark

Visual tracking has advanced significantly in recent years, mainly due to the availability of large-scale training datasets. These datasets have enabled the development of numerous algorithms that can track objects with high accuracy and robustness.However, the majority of current research has been directed towards tracking generic objects, with less emphasis on more specialized and challenging scenarios. One such challenging scenario involves tracking reflected objects. Reflections can significantly distort the appearance of objects, creating ambiguous visual cues that complicate the tracking process. This issue is particularly pertinent in applications such as autonomous driving, security, smart homes, and industrial production, where accurately tracking objects reflected in surfaces like mirrors or glass is crucial. To address this gap, we introduce TRO, a benchmark specifically for Tracking Reflected Objects. TRO includes 200 sequences with around 70,000 frames, each carefully annotated with bounding boxes. This dataset aims to encourage the development of new, accurate methods for tracking reflected objects, which present unique challenges not sufficiently covered by existing benchmarks. We evaluated 20 state-of-the-art trackers and found that they struggle with the complexities of reflections. To provide a stronger baseline, we propose a new tracker, HiP-HaTrack, which uses hierarchical features to improve performance, significantly outperforming existing algorithms. We believe our benchmark, evaluation, and HiP-HaTrack will inspire further research and applications in tracking reflected objects. The TRO and code are available at https://github.com/OpenCodeGithub/HIP-HaTrack.

cs.CV↗

arXiv2024

An evidential time-to-event prediction model based on Gaussian random fuzzy numbers

We introduce an evidential model for time-to-event prediction with censored data. In this model, uncertainty on event time is quantified by Gaussian random fuzzy numbers, a newly introduced family of random fuzzy subsets of the real line with associated belief functions, generalizing both Gaussian random variables and Gaussian possibility distributions. Our approach makes minimal assumptions about the underlying time-to-event distribution. The model is fit by minimizing a generalized negative log-likelihood function that accounts for both normal and censored data. Comparative experiments on two real-world datasets demonstrate the very good performance of our model as compared to the state-of-the-art.

cs.LG↗

arXiv2024

Broad Recommender System: An Efficient Nonlinear Collaborative Filtering Approach

Recently, Deep Neural Networks (DNNs) have been widely introduced into Collaborative Filtering (CF) to produce more accurate recommendation results due to their capability of capturing the complex nonlinear relationships between items and users.However, the DNNs-based models usually suffer from high computational complexity, i.e., consuming very long training time and storing huge amount of trainable parameters. To address these problems, we propose a new broad recommender system called Broad Collaborative Filtering (BroadCF), which is an efficient nonlinear collaborative filtering approach. Instead of DNNs, Broad Learning System (BLS) is used as a mapping function to learn the complex nonlinear relationships between users and items, which can avoid the above issues while achieving very satisfactory recommendation performance. However, it is not feasible to directly feed the original rating data into BLS. To this end, we propose a user-item rating collaborative vector preprocessing procedure to generate low-dimensional user-item input data, which is able to harness quality judgments of the most similar users/items. Extensive experiments conducted on seven benchmark datasets have confirmed the effectiveness of the proposed BroadCF algorithm

cs.IR↗

arXiv2023

A review of uncertainty quantification in medical image analysis: probabilistic and non-probabilistic methods

The comprehensive integration of machine learning healthcare models within clinical practice remains suboptimal, notwithstanding the proliferation of high-performing solutions reported in the literature. A predominant factor hindering widespread adoption pertains to an insufficiency of evidence affirming the reliability of the aforementioned models. Recently, uncertainty quantification methods have been proposed as a potential solution to quantify the reliability of machine learning models and thus increase the interpretability and acceptability of the result. In this review, we offer a comprehensive overview of prevailing methods proposed to quantify uncertainty inherent in machine learning models developed for various medical image tasks. Contrary to earlier reviews that exclusively focused on probabilistic methods, this review also explores non-probabilistic approaches, thereby furnishing a more holistic survey of research pertaining to uncertainty quantification for machine learning models. Analysis of medical images with the summary and discussion on medical applications and the corresponding uncertainty evaluation protocols are presented, which focus on the specific challenges of uncertainty in medical image analysis. We also highlight some potential future research work at the end. Generally, this review aims to allow researchers from both clinical and technical backgrounds to gain a quick and yet in-depth understanding of the research in uncertainty quantification for medical image analysis machine learning models.

eess.IV↗

arXiv2023

Medical Image Segmentation with Belief Function Theory and Deep Learning

Deep learning has shown promising contributions in medical image segmentation with powerful learning and feature representation abilities. However, it has limitations for reasoning with and combining imperfect (imprecise, uncertain, and partial) information. In this thesis, we study medical image segmentation approaches with belief function theory and deep learning, specifically focusing on information modeling and fusion based on uncertain evidence. First, we review existing belief function theory-based medical image segmentation methods and discuss their advantages and challenges. Second, we present a semi-supervised medical image segmentation framework to decrease the uncertainty caused by the lack of annotations with evidential segmentation and evidence fusion. Third, we compare two evidential classifiers, evidential neural network and radial basis function network, and show the effectiveness of belief function theory in uncertainty quantification; we use the two evidential classifiers with deep neural networks to construct deep evidential models for lymphoma segmentation. Fourth, we present a multimodal medical image fusion framework taking into account the reliability of each MR image source when performing different segmentation tasks using mass functions and contextual discounting.

cs.CV↗

arXiv2022

Application of belief functions to medical image segmentation: A review

The investigation of uncertainty is of major importance in risk-critical applications, such as medical image segmentation. Belief function theory, a formal framework for uncertainty analysis and multiple evidence fusion, has made significant contributions to medical image segmentation, especially since the development of deep learning. In this paper, we provide an introduction to the topic of medical image segmentation methods using belief function theory. We classify the methods according to the fusion step and explain how information with uncertainty or imprecision is modeled and fused with belief function theory. In addition, we discuss the challenges and limitations of present belief function-based medical image segmentation and propose orientations for future research. Future research could investigate both belief function theory and deep learning to achieve more promising and reliable segmentation results.

cs.CV↗

arXiv2022

Evidence fusion with contextual discounting for multi-modality medical image segmentation

As information sources are usually imperfect, it is necessary to take into account their reliability in multi-source information fusion tasks. In this paper, we propose a new deep framework allowing us to merge multi-MR image segmentation results using the formalism of Dempster-Shafer theory while taking into account the reliability of different modalities relative to different classes. The framework is composed of an encoder-decoder feature extraction module, an evidential segmentation module that computes a belief function at each voxel for each modality, and a multi-modality evidence fusion module, which assigns a vector of discount rates to each modality evidence and combines the discounted evidence using Dempster's rule. The whole framework is trained by minimizing a new loss function based on a discounted Dice index to increase segmentation accuracy and reliability. The method was evaluated on the BraTs 2021 database of 1251 patients with brain tumors. Quantitative and qualitative results show that our method outperforms the state of the art, and implements an effective new idea for merging multi-information within deep neural networks.

cs.CV↗

arXiv2022

Lymphoma segmentation from 3D PET-CT images using a deep evidential network

An automatic evidential segmentation method based on Dempster-Shafer theory and deep learning is proposed to segment lymphomas from three-dimensional Positron Emission Tomography (PET) and Computed Tomography (CT) images. The architecture is composed of a deep feature-extraction module and an evidential layer. The feature extraction module uses an encoder-decoder framework to extract semantic feature vectors from 3D inputs. The evidential layer then uses prototypes in the feature space to compute a belief function at each voxel quantifying the uncertainty about the presence or absence of a lymphoma at this location. Two evidential layers are compared, based on different ways of using distances to prototypes for computing mass functions. The whole model is trained end-to-end by minimizing the Dice loss function. The proposed combination of deep feature extraction and evidential segmentation is shown to outperform the baseline UNet model as well as three other state-of-the-art models on a dataset of 173 patients.

cs.CV↗

arXiv2022

G$^3$SR: Global Graph Guided Session-based Recommendation

Session-based recommendation tries to make use of anonymous session data to deliver high-quality recommendation under the condition that user-profiles and the complete historical behavioral data of a target user are unavailable. Previous works consider each session individually and try to capture user interests within a session. Despite their encouraging results, these models can only perceive intra-session items and cannot draw upon the massive historical relational information. To solve this problem, we propose a novel method named G$^3$SR (Global Graph Guided Session-based Recommendation). G$^3$SR decomposes the session-based recommendation workflow into two steps. First, a global graph is built upon all session data, from which the global item representations are learned in an unsupervised manner. Then, these representations are refined on session graphs under the graph networks, and a readout function is used to generate session representations for each session. Extensive experiments on two real-world benchmark datasets show remarkable and consistent improvements of the G$^3$SR method over the state-of-the-art methods, especially for cold items.

cs.IR↗

arXiv2021

Deep PET/CT fusion with Dempster-Shafer theory for lymphoma segmentation

Lymphoma detection and segmentation from whole-body Positron Emission Tomography/Computed Tomography (PET/CT) volumes are crucial for surgical indication and radiotherapy. Designing automatic segmentation methods capable of effectively exploiting the information from PET and CT as well as resolving their uncertainty remain a challenge. In this paper, we propose an lymphoma segmentation model using an UNet with an evidential PET/CT fusion layer. Single-modality volumes are trained separately to get initial segmentation maps and an evidential fusion layer is proposed to fuse the two pieces of evidence using Dempster-Shafer theory (DST). Moreover, a multi-task loss function is proposed: in addition to the use of the Dice loss for PET and CT segmentation, a loss function based on the concordance between the two segmentation is added to constrain the final segmentation. We evaluate our proposal on a database of polycentric PET/CT volumes of patients treated for lymphoma, delineated by the experts. Our method get accurate segmentation results with Dice score of 0.726, without any user interaction. Quantitative results show that our method is superior to the state-of-the-art methods.

eess.IV↗

arXiv2021

Study on higher moments of net-charge multiplicity distributions using a multiphase transport model

The moments and moment products of conserved charges are believed to be sensitive to critical fluctuations, which have been adopted in determining the QCD critical point. Using a dynamical multiphase transport model, we reproduce the centrality and energy dependences of moments and moment products of net-charge multiplicity distributions in Au+Au collisions measured by the Beam Energy Scan program at the RHIC. No non-monotonic energy dependence is observed. We infer that the moment products develop during the dynamical evolution of heavy-ion collisions. The observed difference based on the expectation of the Poisson baseline indicates a positive two-particle correlation between positively and negatively charged particles, which can arise from different dynamical processes at different stages. Therefore, to adopt moments and moment products of net-charge multiplicity distributions in determining the QCD critical point of relativistic heavy-ion collisions, it is essential to take the dynamical evolution.

nucl-th↗

arXiv2021

Evidential segmentation of 3D PET/CT images

PET and CT are two modalities widely used in medical image analysis. Accurately detecting and segmenting lymphomas from these two imaging modalities are critical tasks for cancer staging and radiotherapy planning. However, this task is still challenging due to the complexity of PET/CT images, and the computation cost to process 3D data. In this paper, a segmentation method based on belief functions is proposed to segment lymphomas in 3D PET/CT images. The architecture is composed of a feature extraction module and an evidential segmentation (ES) module. The ES module outputs not only segmentation results (binary maps indicating the presence or absence of lymphoma in each voxel) but also uncertainty maps quantifying the classification uncertainty. The whole model is optimized by minimizing Dice and uncertainty loss functions to increase segmentation accuracy. The method was evaluated on a database of 173 patients with diffuse large b-cell lymphoma. Quantitative and qualitative results show that our method outperforms the state-of-the-art methods.

eess.IV↗

arXiv2021

BCFNet: A Balanced Collaborative Filtering Network with Attention Mechanism

Collaborative Filtering (CF) based recommendation methods have been widely studied, which can be generally categorized into two types, i.e., representation learning-based CF methods and matching function learning-based CF methods. Representation learning tries to learn a common low dimensional space for the representations of users and items. In this case, a user and item match better if they have higher similarity in that common space. Matching function learning tries to directly learn the complex matching function that maps user-item pairs to matching scores. Although both methods are well developed, they suffer from two fundamental flaws, i.e., the representation learning resorts to applying a dot product which has limited expressiveness on the latent features of users and items, while the matching function learning has weakness in capturing low-rank relations. To overcome such flaws, we propose a novel recommendation model named Balanced Collaborative Filtering Network (BCFNet), which has the strengths of the two types of methods. In addition, an attention mechanism is designed to better capture the hidden information within implicit feedback and strengthen the learning ability of the neural network. Furthermore, a balance module is designed to alleviate the over-fitting issue in DNNs. Extensive experiments on eight real-world datasets demonstrate the effectiveness of the proposed model.

cs.IR↗