arXiv subjects

Martin Renqiang Min

Publications and source records attributed to Martin Renqiang Min.

At least 37 records · Page 2Linked to original sources

arXiv2023

Exploring Compositional Visual Generation with Latent Classifier Guidance

Diffusion probabilistic models have achieved enormous success in the field of image generation and manipulation. In this paper, we explore a novel paradigm of using the diffusion model and classifier guidance in the latent semantic space for compositional visual tasks. Specifically, we train latent diffusion models and auxiliary latent classifiers to facilitate non-linear navigation of latent representation generation for any pre-trained generative model with a semantic latent space. We demonstrate that such conditional generation achieved by latent classifier guidance provably maximizes a lower bound of the conditional log probability during training. To maintain the original semantics during manipulation, we introduce a new guidance term, which we show is crucial for achieving compositionality. With additional assumptions, we show that the non-linear manipulation reduces to a simple latent arithmetic approach. We show that this paradigm based on latent classifier guidance is agnostic to pre-trained generative models, and present competitive results for both image generation and sequential manipulation of real and synthetic images. Our findings suggest that latent classifier guidance is a promising approach that merits further exploration, even in the presence of other strong competing methods.

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arXiv2023

Conditional Image-to-Video Generation with Latent Flow Diffusion Models

Conditional image-to-video (cI2V) generation aims to synthesize a new plausible video starting from an image (e.g., a person's face) and a condition (e.g., an action class label like smile). The key challenge of the cI2V task lies in the simultaneous generation of realistic spatial appearance and temporal dynamics corresponding to the given image and condition. In this paper, we propose an approach for cI2V using novel latent flow diffusion models (LFDM) that synthesize an optical flow sequence in the latent space based on the given condition to warp the given image. Compared to previous direct-synthesis-based works, our proposed LFDM can better synthesize spatial details and temporal motion by fully utilizing the spatial content of the given image and warping it in the latent space according to the generated temporally-coherent flow. The training of LFDM consists of two separate stages: (1) an unsupervised learning stage to train a latent flow auto-encoder for spatial content generation, including a flow predictor to estimate latent flow between pairs of video frames, and (2) a conditional learning stage to train a 3D-UNet-based diffusion model (DM) for temporal latent flow generation. Unlike previous DMs operating in pixel space or latent feature space that couples spatial and temporal information, the DM in our LFDM only needs to learn a low-dimensional latent flow space for motion generation, thus being more computationally efficient. We conduct comprehensive experiments on multiple datasets, where LFDM consistently outperforms prior arts. Furthermore, we show that LFDM can be easily adapted to new domains by simply finetuning the image decoder. Our code is available at https://github.com/nihaomiao/CVPR23_LFDM.

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arXiv2023

T-Cell Receptor Optimization with Reinforcement Learning and Mutation Policies for Precesion Immunotherapy

T cells monitor the health status of cells by identifying foreign peptides displayed on their surface. T-cell receptors (TCRs), which are protein complexes found on the surface of T cells, are able to bind to these peptides. This process is known as TCR recognition and constitutes a key step for immune response. Optimizing TCR sequences for TCR recognition represents a fundamental step towards the development of personalized treatments to trigger immune responses killing cancerous or virus-infected cells. In this paper, we formulated the search for these optimized TCRs as a reinforcement learning (RL) problem, and presented a framework TCRPPO with a mutation policy using proximal policy optimization. TCRPPO mutates TCRs into effective ones that can recognize given peptides. TCRPPO leverages a reward function that combines the likelihoods of mutated sequences being valid TCRs measured by a new scoring function based on deep autoencoders, with the probabilities of mutated sequences recognizing peptides from a peptide-TCR interaction predictor. We compared TCRPPO with multiple baseline methods and demonstrated that TCRPPO significantly outperforms all the baseline methods to generate positive binding and valid TCRs. These results demonstrate the potential of TCRPPO for both precision immunotherapy and peptide-recognizing TCR motif discovery.

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arXiv2023

Attribute-Centric Compositional Text-to-Image Generation

Despite the recent impressive breakthroughs in text-to-image generation, generative models have difficulty in capturing the data distribution of underrepresented attribute compositions while over-memorizing overrepresented attribute compositions, which raises public concerns about their robustness and fairness. To tackle this challenge, we propose ACTIG, an attribute-centric compositional text-to-image generation framework. We present an attribute-centric feature augmentation and a novel image-free training scheme, which greatly improves model's ability to generate images with underrepresented attributes. We further propose an attribute-centric contrastive loss to avoid overfitting to overrepresented attribute compositions. We validate our framework on the CelebA-HQ and CUB datasets. Extensive experiments show that the compositional generalization of ACTIG is outstanding, and our framework outperforms previous works in terms of image quality and text-image consistency.

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arXiv2022

StyleT2I: Toward Compositional and High-Fidelity Text-to-Image Synthesis

Although progress has been made for text-to-image synthesis, previous methods fall short of generalizing to unseen or underrepresented attribute compositions in the input text. Lacking compositionality could have severe implications for robustness and fairness, e.g., inability to synthesize the face images of underrepresented demographic groups. In this paper, we introduce a new framework, StyleT2I, to improve the compositionality of text-to-image synthesis. Specifically, we propose a CLIP-guided Contrastive Loss to better distinguish different compositions among different sentences. To further improve the compositionality, we design a novel Semantic Matching Loss and a Spatial Constraint to identify attributes' latent directions for intended spatial region manipulations, leading to better disentangled latent representations of attributes. Based on the identified latent directions of attributes, we propose Compositional Attribute Adjustment to adjust the latent code, resulting in better compositionality of image synthesis. In addition, we leverage the $\ell_2$-norm regularization of identified latent directions (norm penalty) to strike a nice balance between image-text alignment and image fidelity. In the experiments, we devise a new dataset split and an evaluation metric to evaluate the compositionality of text-to-image synthesis models. The results show that StyleT2I outperforms previous approaches in terms of the consistency between the input text and synthesized images and achieves higher fidelity.

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arXiv2022

Learning Transferable Reward for Query Object Localization with Policy Adaptation

We propose a reinforcement learning based approach to query object localization, for which an agent is trained to localize objects of interest specified by a small exemplary set. We learn a transferable reward signal formulated using the exemplary set by ordinal metric learning. Our proposed method enables test-time policy adaptation to new environments where the reward signals are not readily available, and outperforms fine-tuning approaches that are limited to annotated images. In addition, the transferable reward allows repurposing the trained agent from one specific class to another class. Experiments on corrupted MNIST, CU-Birds, and COCO datasets demonstrate the effectiveness of our approach.

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arXiv2022

A Deep Generative Model for Molecule Optimization via One Fragment Modification

Molecule optimization is a critical step in drug development to improve desired properties of drug candidates through chemical modification. We developed a novel deep generative model Modof over molecular graphs for molecule optimization. Modof modifies a given molecule through the prediction of a single site of disconnection at the molecule and the removal and/or addition of fragments at that site. A pipeline of multiple, identical Modof models is implemented into Modof-pipe to modify an input molecule at multiple disconnection sites. Here we show that Modof-pipe is able to retain major molecular scaffolds, allow controls over intermediate optimization steps and better constrain molecule similarities. Modof-pipe outperforms the state-of-the-art methods on benchmark datasets: without molecular similarity constraints, Modof-pipe achieves 81.2% improvement in octanol-water partition coefficient penalized by synthetic accessibility and ring size; and 51.2%, 25.6% and 9.2% improvement if the optimized molecules are at least 0.2, 0.4 and 0.6 similar to those before optimization, respectively. Modof-pipe is further enhanced into Modof-pipem to allow modifying one molecule to multiple optimized ones. Modof-pipem achieves additional performance improvement as at least 17.8% better than Modof-pipe.

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arXiv2022

Improving Disentangled Text Representation Learning with Information-Theoretic Guidance

Learning disentangled representations of natural language is essential for many NLP tasks, e.g., conditional text generation, style transfer, personalized dialogue systems, etc. Similar problems have been studied extensively for other forms of data, such as images and videos. However, the discrete nature of natural language makes the disentangling of textual representations more challenging (e.g., the manipulation over the data space cannot be easily achieved). Inspired by information theory, we propose a novel method that effectively manifests disentangled representations of text, without any supervision on semantics. A new mutual information upper bound is derived and leveraged to measure dependence between style and content. By minimizing this upper bound, the proposed method induces style and content embeddings into two independent low-dimensional spaces. Experiments on both conditional text generation and text-style transfer demonstrate the high quality of our disentangled representation in terms of content and style preservation.

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arXiv2021

Dual Projection Generative Adversarial Networks for Conditional Image Generation

Conditional Generative Adversarial Networks (cGANs) extend the standard unconditional GAN framework to learning joint data-label distributions from samples, and have been established as powerful generative models capable of generating high-fidelity imagery. A challenge of training such a model lies in properly infusing class information into its generator and discriminator. For the discriminator, class conditioning can be achieved by either (1) directly incorporating labels as input or (2) involving labels in an auxiliary classification loss. In this paper, we show that the former directly aligns the class-conditioned fake-and-real data distributions $P(\text{image}|\text{class})$ ({\em data matching}), while the latter aligns data-conditioned class distributions $P(\text{class}|\text{image})$ ({\em label matching}). Although class separability does not directly translate to sample quality and becomes a burden if classification itself is intrinsically difficult, the discriminator cannot provide useful guidance for the generator if features of distinct classes are mapped to the same point and thus become inseparable. Motivated by this intuition, we propose a Dual Projection GAN (P2GAN) model that learns to balance between {\em data matching} and {\em label matching}. We then propose an improved cGAN model with Auxiliary Classification that directly aligns the fake and real conditionals $P(\text{class}|\text{image})$ by minimizing their $f$-divergence. Experiments on a synthetic Mixture of Gaussian (MoG) dataset and a variety of real-world datasets including CIFAR100, ImageNet, and VGGFace2 demonstrate the efficacy of our proposed models.

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arXiv2021

AE-StyleGAN: Improved Training of Style-Based Auto-Encoders

StyleGANs have shown impressive results on data generation and manipulation in recent years, thanks to its disentangled style latent space. A lot of efforts have been made in inverting a pretrained generator, where an encoder is trained ad hoc after the generator is trained in a two-stage fashion. In this paper, we focus on style-based generators asking a scientific question: Does forcing such a generator to reconstruct real data lead to more disentangled latent space and make the inversion process from image to latent space easy? We describe a new methodology to train a style-based autoencoder where the encoder and generator are optimized end-to-end. We show that our proposed model consistently outperforms baselines in terms of image inversion and generation quality. Supplementary, code, and pretrained models are available on the project website.

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arXiv2021

Hopper: Multi-hop Transformer for Spatiotemporal Reasoning

This paper considers the problem of spatiotemporal object-centric reasoning in videos. Central to our approach is the notion of object permanence, i.e., the ability to reason about the location of objects as they move through the video while being occluded, contained or carried by other objects. Existing deep learning based approaches often suffer from spatiotemporal biases when applied to video reasoning problems. We propose Hopper, which uses a Multi-hop Transformer for reasoning object permanence in videos. Given a video and a localization query, Hopper reasons over image and object tracks to automatically hop over critical frames in an iterative fashion to predict the final position of the object of interest. We demonstrate the effectiveness of using a contrastive loss to reduce spatiotemporal biases. We evaluate over CATER dataset and find that Hopper achieves 73.2% Top-1 accuracy using just 1 FPS by hopping through just a few critical frames. We also demonstrate Hopper can perform long-term reasoning by building a CATER-h dataset that requires multi-step reasoning to localize objects of interest correctly.

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arXiv2021

Disentangled Recurrent Wasserstein Autoencoder

Learning disentangled representations leads to interpretable models and facilitates data generation with style transfer, which has been extensively studied on static data such as images in an unsupervised learning framework. However, only a few works have explored unsupervised disentangled sequential representation learning due to challenges of generating sequential data. In this paper, we propose recurrent Wasserstein Autoencoder (R-WAE), a new framework for generative modeling of sequential data. R-WAE disentangles the representation of an input sequence into static and dynamic factors (i.e., time-invariant and time-varying parts). Our theoretical analysis shows that, R-WAE minimizes an upper bound of a penalized form of the Wasserstein distance between model distribution and sequential data distribution, and simultaneously maximizes the mutual information between input data and different disentangled latent factors, respectively. This is superior to (recurrent) VAE which does not explicitly enforce mutual information maximization between input data and disentangled latent representations. When the number of actions in sequential data is available as weak supervision information, R-WAE is extended to learn a categorical latent representation of actions to improve its disentanglement. Experiments on a variety of datasets show that our models outperform other baselines with the same settings in terms of disentanglement and unconditional video generation both quantitatively and qualitatively.

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arXiv2020

Ranking-based Convolutional Neural Network Models for Peptide-MHC Binding Prediction

T-cell receptors can recognize foreign peptides bound to major histocompatibility complex (MHC) class-I proteins, and thus trigger the adaptive immune response. Therefore, identifying peptides that can bind to MHC class-I molecules plays a vital role in the design of peptide vaccines. Many computational methods, for example, the state-of-the-art allele-specific method MHCflurry, have been developed to predict the binding affinities between peptides and MHC molecules. In this manuscript, we develop two allele-specific Convolutional Neural Network (CNN)-based methods named ConvM and SpConvM to tackle the binding prediction problem. Specifically, we formulate the problem as to optimize the rankings of peptide-MHC bindings via ranking-based learning objectives. Such optimization is more robust and tolerant to the measurement inaccuracy of binding affinities, and therefore enables more accurate prioritization of binding peptides. In addition, we develop a new position encoding method in ConvM and SpConvM to better identify the most important amino acids for the binding events. Our experimental results demonstrate that our models significantly outperform the state-of-the-art methods including MHCflurry with an average percentage improvement of 6.70% on AUC and 17.10% on ROC5 across 128 alleles.

q-bio.QM↗

arXiv2020

S3VAE: Self-Supervised Sequential VAE for Representation Disentanglement and Data Generation

We propose a sequential variational autoencoder to learn disentangled representations of sequential data (e.g., videos and audios) under self-supervision. Specifically, we exploit the benefits of some readily accessible supervisory signals from input data itself or some off-the-shelf functional models and accordingly design auxiliary tasks for our model to utilize these signals. With the supervision of the signals, our model can easily disentangle the representation of an input sequence into static factors and dynamic factors (i.e., time-invariant and time-varying parts). Comprehensive experiments across videos and audios verify the effectiveness of our model on representation disentanglement and generation of sequential data, and demonstrate that, our model with self-supervision performs comparable to, if not better than, the fully-supervised model with ground truth labels, and outperforms state-of-the-art unsupervised models by a large margin.

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arXiv2019

Rethinking Zero-Shot Learning: A Conditional Visual Classification Perspective

Zero-shot learning (ZSL) aims to recognize instances of unseen classes solely based on the semantic descriptions of the classes. Existing algorithms usually formulate it as a semantic-visual correspondence problem, by learning mappings from one feature space to the other. Despite being reasonable, previous approaches essentially discard the highly precious discriminative power of visual features in an implicit way, and thus produce undesirable results. We instead reformulate ZSL as a conditioned visual classification problem, i.e., classifying visual features based on the classifiers learned from the semantic descriptions. With this reformulation, we develop algorithms targeting various ZSL settings: For the conventional setting, we propose to train a deep neural network that directly generates visual feature classifiers from the semantic attributes with an episode-based training scheme; For the generalized setting, we concatenate the learned highly discriminative classifiers for seen classes and the generated classifiers for unseen classes to classify visual features of all classes; For the transductive setting, we exploit unlabeled data to effectively calibrate the classifier generator using a novel learning-without-forgetting self-training mechanism and guide the process by a robust generalized cross-entropy loss. Extensive experiments show that our proposed algorithms significantly outperform state-of-the-art methods by large margins on most benchmark datasets in all the ZSL settings. Our code is available at \url{https://github.com/kailigo/cvcZSL}

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arXiv2019

A Deep Spatio-Temporal Fuzzy Neural Network for Passenger Demand Prediction

In spite of its importance, passenger demand prediction is a highly challenging problem, because the demand is simultaneously influenced by the complex interactions among many spatial and temporal factors and other external factors such as weather. To address this problem, we propose a Spatio-TEmporal Fuzzy neural Network (STEF-Net) to accurately predict passenger demands incorporating the complex interactions of all known important factors. We design an end-to-end learning framework with different neural networks modeling different factors. Specifically, we propose to capture spatio-temporal feature interactions via a convolutional long short-term memory network and model external factors via a fuzzy neural network that handles data uncertainty significantly better than deterministic methods. To keep the temporal relations when fusing two networks and emphasize discriminative spatio-temporal feature interactions, we employ a novel feature fusion method with a convolution operation and an attention layer. As far as we know, our work is the first to fuse a deep recurrent neural network and a fuzzy neural network to model complex spatial-temporal feature interactions with additional uncertain input features for predictive learning. Experiments on a large-scale real-world dataset show that our model achieves more than 10% improvement over the state-of-the-art approaches.

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arXiv2019

Disentangled Deep Autoencoding Regularization for Robust Image Classification

In spite of achieving revolutionary successes in machine learning, deep convolutional neural networks have been recently found to be vulnerable to adversarial attacks and difficult to generalize to novel test images with reasonably large geometric transformations. Inspired by a recent neuroscience discovery revealing that primate brain employs disentangled shape and appearance representations for object recognition, we propose a general disentangled deep autoencoding regularization framework that can be easily applied to any deep embedding based classification model for improving the robustness of deep neural networks. Our framework effectively learns disentangled appearance code and geometric code for robust image classification, which is the first disentangling based method defending against adversarial attacks and complementary to standard defense methods. Extensive experiments on several benchmark datasets show that, our proposed regularization framework leveraging disentangled embedding significantly outperforms traditional unregularized convolutional neural networks for image classification on robustness against adversarial attacks and generalization to novel test data.

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arXiv2018

Optimal Transport Classifier: Defending Against Adversarial Attacks by Regularized Deep Embedding

Recent studies have demonstrated the vulnerability of deep convolutional neural networks against adversarial examples. Inspired by the observation that the intrinsic dimension of image data is much smaller than its pixel space dimension and the vulnerability of neural networks grows with the input dimension, we propose to embed high-dimensional input images into a low-dimensional space to perform classification. However, arbitrarily projecting the input images to a low-dimensional space without regularization will not improve the robustness of deep neural networks. Leveraging optimal transport theory, we propose a new framework, Optimal Transport Classifier (OT-Classifier), and derive an objective that minimizes the discrepancy between the distribution of the true label and the distribution of the OT-Classifier output. Experimental results on several benchmark datasets show that, our proposed framework achieves state-of-the-art performance against strong adversarial attack methods.

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