arXiv subjects

Mei Li

Publications and source records attributed to Mei Li.

At least 37 records · Page 2Linked to original sources

arXiv2024

Synthetic frequency-controlled gene circuits unlock expanded cellular states

Natural biological systems process environmental information through both amplitude and frequency-modulated signals, yet engineered biological circuits have largely relied on amplitude-based regulation alone. Despite the prevalence of frequency-encoded signals in natural systems, fundamental challenges in designing and implementing frequency-responsive gene circuits have limited their development in synthetic biology. Here we present a Time-Resolved Gene Circuit (TRGC) architecture that enables frequency-to-amplitude signal conversion in engineered biological systems. Through systematic analysis, we establish a theoretical framework that guides the design of synthetic circuits capable of distinct frequency-dependent responses, implementing both high-pass and low-pass filtering behaviors. To enable rigorous characterization of these dynamic circuits, we developed a high-throughput automated platform that ensures stable and reproducible measurements of frequency-dependent r esponses across diverse conditions. Using this platform, we demonstrate that these frequency-modulated circuits can access cellular states unreachable through conventional amplitude modulation, significantly expanding the controllable gene expression space in multi-gene systems. Our results show that frequency modulation expands the range of achievable expression patterns when controlling multiple genes through a single input, demonstrating a new paradigm for engineering cellular behaviors. This work establishes frequency modulation as a powerful strategy for expanding the capabilities of engineered biological systems and enhancing cellular response to dynamic signals.

physics.bio-ph↗

arXiv2024

Qwen2 Technical Report

This report introduces the Qwen2 series, the latest addition to our large language models and large multimodal models. We release a comprehensive suite of foundational and instruction-tuned language models, encompassing a parameter range from 0.5 to 72 billion, featuring dense models and a Mixture-of-Experts model. Qwen2 surpasses most prior open-weight models, including its predecessor Qwen1.5, and exhibits competitive performance relative to proprietary models across diverse benchmarks on language understanding, generation, multilingual proficiency, coding, mathematics, and reasoning. The flagship model, Qwen2-72B, showcases remarkable performance: 84.2 on MMLU, 37.9 on GPQA, 64.6 on HumanEval, 89.5 on GSM8K, and 82.4 on BBH as a base language model. The instruction-tuned variant, Qwen2-72B-Instruct, attains 9.1 on MT-Bench, 48.1 on Arena-Hard, and 35.7 on LiveCodeBench. Moreover, Qwen2 demonstrates robust multilingual capabilities, proficient in approximately 30 languages, spanning English, Chinese, Spanish, French, German, Arabic, Russian, Korean, Japanese, Thai, Vietnamese, and more, underscoring its versatility and global reach. To foster community innovation and accessibility, we have made the Qwen2 model weights openly available on Hugging Face and ModelScope, and the supplementary materials including example code on GitHub. These platforms also include resources for quantization, fine-tuning, and deployment, facilitating a wide range of applications and research endeavors.

cs.CL↗

arXiv2024

Spin-wave Goos-Hänchen effect induced by 360 degree domain walls in magnetic heterostructures

In this work, lateral displacements of transmitted and reflected spin waves at a 360 degree domain wall (360DW), which is referred to as the spin-wave Goos-Hänchen effect (SWGHE), are systematically investigated in magnetic heterostructures with perpendicular easy/hard axis and wall-extension direction. Similar to the counterpart at heterochiral interfaces, the interfacial Dzyaloshinskii-Moriya interactions (IDMI) originating from a heavy-metal substrate is important for the emergence of SWGHE. More interestingly, the SWGHE can even survive in ferromagnets with biaxial anisotropy (either intrinsic or caused by shape anisotropy) in the absence of IDMI due to the unique 360DW-induced potentials which are distinct to the well-known Pöschl-Teller ones. Numerics shows that these lateral displacements are generally fractions of the spin-wave wavelength. They can be further enhanced by an array of well-separated 360DWs thus provide a large variety for spin-wave manipulation.

cond-mat.mes-hall↗

arXiv2024

Global smooth solution for the 3D generalized tropical climate model with partial viscosity and damping

The three-dimensional generalized tropical climate model with partial viscosity and damping is considered in this paper. Global well-posedness of solutions of the three-dimensional generalized tropical climate model with partial viscosity and damping is proved for $α\geq\frac{3}{2}$ and $β\geq4$. Global smooth solution of the three-dimensional generalized tropical climate model with partial viscosity and damping is proved in $H^s(\mathbb R^3)$ $(s>2)$ for $α\geq\frac{3}{2}$ and $4\leqβ\leq5$.

math.AP↗

arXiv2023

High Q and high gradient performance of the first medium-temperature baking 1.3 GHz cryomodule

World's first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (RF) cavities treated by medium-temperature furnace baking (mid-T bake) was developed, assembled and tested at IHEP for the Dalian Advanced Light Source (DALS) and CEPC R&D. The 9-cell cavities in the cryomodule achieved an unprecedented highest average Q0 of 3.8E10 at 16 MV/m and 3.6E10 at 21 MV/m in the horizontal test. The cryomodule can operate stably up to a total CW RF voltage greater than 191 MV, with an average cavity CW accelerating gradient of more than 23 MV/m. The results significantly exceed the specifications of CEPC, DALS and the other high repetition rate free electron laser facilities (LCLS-II, LCLS-II-HE, SHINE, S3FEL). There is evidence that the mid-T bake cavity may not require fast cool-down or long processing time in the cryomodule. This paper reviews the cryomodule performance and discusses some important issues in cryomodule assembly and testing.

physics.acc-ph↗

arXiv2023

Qwen Technical Report

Large language models (LLMs) have revolutionized the field of artificial intelligence, enabling natural language processing tasks that were previously thought to be exclusive to humans. In this work, we introduce Qwen, the first installment of our large language model series. Qwen is a comprehensive language model series that encompasses distinct models with varying parameter counts. It includes Qwen, the base pretrained language models, and Qwen-Chat, the chat models finetuned with human alignment techniques. The base language models consistently demonstrate superior performance across a multitude of downstream tasks, and the chat models, particularly those trained using Reinforcement Learning from Human Feedback (RLHF), are highly competitive. The chat models possess advanced tool-use and planning capabilities for creating agent applications, showcasing impressive performance even when compared to bigger models on complex tasks like utilizing a code interpreter. Furthermore, we have developed coding-specialized models, Code-Qwen and Code-Qwen-Chat, as well as mathematics-focused models, Math-Qwen-Chat, which are built upon base language models. These models demonstrate significantly improved performance in comparison with open-source models, and slightly fall behind the proprietary models.

cs.CL↗

arXiv2023

Slonczewski-spin-current driven dynamics of 180$^{\circ}$ domain walls in spin valves with interfacial Dzyaloshinskii-Moriya interaction

Steady-flow dynamics of ferromagnetic 180$^{\circ}$ domain walls (180DWs) in long and narrow spin valves (LNSVs) with interfacial Dzyaloshinskii-Moriya interaction (IDMI) under spin currents with Slonczewski $g-$factor are examined. Depending on the magnetization orientation of polarizers (pinned layers of LNSVs), dynamics of 180DWs in free layers of LNSVs are subtly manipulated: (i) For parallel polarizers, stronger spin polarization leads to higher Walker limit thus ensures the longevity of faster steady flows. Meantime, IDMI induces both the stable-region flapping and its width enlargement. (ii) For perpendicular polarizers, a wandering of 180DWs between bi- and tri-stability persists with the criticality adjusted by the IDMI. (iii) For planar-transverse polarizers, IDMI makes the stable region of steady flows completely asymmetric and further imparts a high saturation wall velocity under large current density. Under the last two polarizers, the ultrahigh differential mobility of 180DWs survives. The combination of Slonczewski spin current and IDMI provides rich possibilities of fine controlling on 180DW dynamics, hence opens avenues for magnetic nanodevices with rich functionality and high robustness.

cond-mat.mes-hall↗

arXiv2023

PolyLM: An Open Source Polyglot Large Language Model

Large language models (LLMs) demonstrate remarkable ability to comprehend, reason, and generate following nature language instructions. However, the development of LLMs has been primarily focused on high-resource languages, such as English, thereby limiting their applicability and research in other languages. Consequently, we present PolyLM, a multilingual LLM trained on 640 billion (B) tokens, avaliable in two model sizes: 1.7B and 13B. To enhance its multilingual capabilities, we 1) integrate bilingual data into training data; and 2) adopt a curriculum learning strategy that increases the proportion of non-English data from 30% in the first stage to 60% in the final stage during pre-training. Further, we propose a multilingual self-instruct method which automatically generates 132.7K diverse multilingual instructions for model fine-tuning. To assess the model's performance, we collect several existing multilingual tasks, including multilingual understanding, question answering, generation, and translation. Extensive experiments show that PolyLM surpasses other open-source models such as LLaMA and BLOOM on multilingual tasks while maintaining comparable performance in English. Our models, alone with the instruction data and multilingual benchmark, are available at: \url{https://modelscope.cn/models/damo/nlp_polylm_13b_text_generation}.

cs.CL↗

arXiv2023

iEmoTTS: Toward Robust Cross-Speaker Emotion Transfer and Control for Speech Synthesis based on Disentanglement between Prosody and Timbre

The capability of generating speech with specific type of emotion is desired for many applications of human-computer interaction. Cross-speaker emotion transfer is a common approach to generating emotional speech when speech with emotion labels from target speakers is not available for model training. This paper presents a novel cross-speaker emotion transfer system, named iEmoTTS. The system is composed of an emotion encoder, a prosody predictor, and a timbre encoder. The emotion encoder extracts the identity of emotion type as well as the respective emotion intensity from the mel-spectrogram of input speech. The emotion intensity is measured by the posterior probability that the input utterance carries that emotion. The prosody predictor is used to provide prosodic features for emotion transfer. The timber encoder provides timbre-related information for the system. Unlike many other studies which focus on disentangling speaker and style factors of speech, the iEmoTTS is designed to achieve cross-speaker emotion transfer via disentanglement between prosody and timbre. Prosody is considered as the main carrier of emotion-related speech characteristics and timbre accounts for the essential characteristics for speaker identification. Zero-shot emotion transfer, meaning that speech of target speakers are not seen in model training, is also realized with iEmoTTS. Extensive experiments of subjective evaluation have been carried out. The results demonstrate the effectiveness of iEmoTTS as compared with other recently proposed systems of cross-speaker emotion transfer. It is shown that iEmoTTS can produce speech with designated emotion type and controllable emotion intensity. With appropriate information bottleneck capacity, iEmoTTS is able to effectively transfer emotion information to a new speaker. Audio samples are publicly available https://patrick-g-zhang.github.io/iemotts/

eess.AS↗

arXiv2022

Ground states and magnonics in orthogonally-coupled symmetric all-antiferromagnetic junctions

In this work, the rich ground-state structure of orthogonally-coupled symmetric all-antiferromagnetic junctions with easy-plane anisotropy is reported. Spin reorientation process rather than the traditional spin flop (SF) occurs, resulting in a novel phase in which Néel vectors preserve the mirror-reflection symmetry (termed as ``MRS phase"). The phase transitions between SF and MRS phases can be either the first- or second-order. After disturbed by external stimuli, magnons with different parities emerge. For in-plane dc fields, no couplings between magnons occur. When dc fields become oblique, coherent couplings between magnons with opposite parity emerge, leading to anticrossings in resonance frequencies. However, self-hybridization among magnons with the same parity never happens. More interestingly, spin waves based on MRS phase are linearly polarized and their polarization directions can be fine controlled.

cond-mat.mes-hall↗

arXiv2022

Toward a Fairness-Aware Scoring System for Algorithmic Decision-Making

Scoring systems, as a type of predictive model, have significant advantages in interpretability and transparency and facilitate quick decision-making. As such, scoring systems have been extensively used in a wide variety of industries such as healthcare and criminal justice. However, the fairness issues in these models have long been criticized, and the use of big data and machine learning algorithms in the construction of scoring systems heightens this concern. In this paper, we propose a general framework to create fairness-aware, data-driven scoring systems. First, we develop a social welfare function that incorporates both efficiency and group fairness. Then, we transform the social welfare maximization problem into the risk minimization task in machine learning, and derive a fairness-aware scoring system with the help of mixed integer programming. Lastly, several theoretical bounds are derived for providing parameter selection suggestions. Our proposed framework provides a suitable solution to address group fairness concerns in the development of scoring systems. It enables policymakers to set and customize their desired fairness requirements as well as other application-specific constraints. We test the proposed algorithm with several empirical data sets. Experimental evidence supports the effectiveness of the proposed scoring system in achieving the optimal welfare of stakeholders and in balancing the needs for interpretability, fairness, and efficiency.

cs.LG↗

arXiv2021

Chiral domain wall dynamics in magnetic heterostructures with bulk Dzyaloshinskii-Moriya interactions

In this work, dynamics of chiral domain walls in long and narrow magnetic heterostructures based on non-centrosymmetric chiral magnets with bulk Dzyaloshinskii-Moriya interactions (DMI) and perpendicular magnetic anisotropy is systematically investigated. The driving forces can be out-of-plane magnetic fields and in-plane currents, correspondingly both steady and precessional flows are considered. Their dividing points (the Walker critical field and current density) are obtained as functions of bulk DMI strength ($D_{\mathrm{b}}$) and the ratio ($κ$) of total (crystalline plus shape) anisotropy in the hard axis over that in the easy one. When far beyond Walker breakdown, the dependence curve of wall velocity on external in-plane bias field takes parabolic shape around the compensation point where the total in-plane field disappears. The center shift is determined by $D_{\mathrm{b}}$, $κ$, and the wall's topological charge, thus can be used to measure the bulk DMI strength in chiral magnets.

cond-mat.mes-hall↗

arXiv2021

Stabilizing current-driven steady flows of 180$^{\circ}$ domain walls in spin valves by interfacial Dzyaloshinskii-Moriya interaction

Modulations of interfacial Dzyaloshinskii-Moriya interaction (iDMI) on current-driven dynamics of 180$^{\circ}$ domain walls (180DWs) in long and narrow spin valves (LNSVs) with heavy-metal caplayers are systematically investigated. We focus on LNSVs with in-plane magnetic anisotropy in their free layers. For planar-transverse polarizers (pinned layers of LNSVs), the Walker breakdown can be postponed considerably (practical infinity) by iDMI. More interestingly, the originally unstable traveling mode is also stabilized by iDMI with high saturation velocity thus serves as fast carrier of information. For parallel polarizers, the Walker limit is increased and the corresponding modifications of iDMI to wall velocity in both steady and precessional flows of 180DWs are provided. For perpendicular polarizers, precessional flow of 180DWs is absent due to the stability of stationary mode beyond the modified Walker limit. For LNSVs with perpendicular magnetic anisotropy in their free layers, similar results are obtained. Our findings open new possibilities for developing magnetic nanodevices based on 180DW propagation with low energy consumption and high robustness.

cond-mat.mes-hall↗

arXiv2021

Explainable Deep Behavioral Sequence Clustering for Transaction Fraud Detection

In e-commerce industry, user behavior sequence data has been widely used in many business units such as search and merchandising to improve their products. However, it is rarely used in financial services not only due to its 3V characteristics - i.e. Volume, Velocity and Variety - but also due to its unstructured nature. In this paper, we propose a Financial Service scenario Deep learning based Behavior data representation method for Clustering (FinDeepBehaviorCluster) to detect fraudulent transactions. To utilize the behavior sequence data, we treat click stream data as event sequence, use time attention based Bi-LSTM to learn the sequence embedding in an unsupervised fashion, and combine them with intuitive features generated by risk experts to form a hybrid feature representation. We also propose a GPU powered HDBSCAN (pHDBSCAN) algorithm, which is an engineering optimization for the original HDBSCAN algorithm based on FAISS project, so that clustering can be carried out on hundreds of millions of transactions within a few minutes. The computation efficiency of the algorithm has increased 500 times compared with the original implementation, which makes flash fraud pattern detection feasible. Our experimental results show that the proposed FinDeepBehaviorCluster framework is able to catch missed fraudulent transactions with considerable business values. In addition, rule extraction method is applied to extract patterns from risky clusters using intuitive features, so that narrative descriptions can be attached to the risky clusters for case investigation, and unknown risk patterns can be mined for real-time fraud detection. In summary, FinDeepBehaviorCluster as a complementary risk management strategy to the existing real-time fraud detection engine, can further increase our fraud detection and proactive risk defense capabilities.

cs.LG↗

arXiv2020

Symmetry breaking induced magnon-magnon coupling in synthetic antiferromagnets

We propose a general theory of microwave absorption spectroscopy for symmetry-breaking synthetic antiferromagnets (SAFs). Generally, inhomogeneity or different thickness of the two ferromagnetic sublayers of a SAF results in the intrinsic symmetry breaking, while out-of-plane components of dc magnetic fields lead to the extrinsic one. The broken symmetry of SAFs excludes the original symmetry-protected crossing between pure in-phase and out-of-phase resonance modes with opposite parity. Alternatively, new frequency branches become hybridization of original bare modes in terms of symmetry-breaking-induced magnon-magnon coupling, which results in an indirect gap in ferromagnetic resonance frequencies. Also, the dependence of gap width on the degree of symmetry breaking for several typical cases are presented and compared with existing experiments. Our theory provides a simple but physical understanding on the rich structure of ferromagnetic resonance spectra for asymmetric SAFs.

cond-mat.mes-hall↗

arXiv2020

Survey of 360$^{\circ}$ domain walls in magnetic heterostructures: topology, chirality and current-driven dynamics

Chirality and current-driven dynamics of topologically nontrivial 360$^{\circ}$ domain walls (360DWs) in magnetic heterostructures (MHs) are systematically investigated. For MHs with normal substrates, the static 360DWs are Néel-type with no chirality. While for those with heavy-metal substrates, the interfacial Dzyaloshinskii-Moriya interaction (iDMI) therein makes 360DWs prefer specific chirality. Under in-plane driving charge currents, as the direct result of "full-circle" topology a certain 360DW does not undergo the "Walker breakdown"-type process like a well-studied 180$^{\circ}$ domain wall as the current density increases. Alternatively, it keeps a fixed propagating mode (either steady-flow or precessional-flow, depending on the effective damping constant of the MH) until it collapses or changes to other types of solition when the current density becomes too high. Similarly, the field-like spin-orbit torque (SOT) has no effects on the dynamics of 360DWs, while the anti-damping SOT has. For both modes, modifications to the mobility of 360DWs by iDMI and anti-damping SOT are provided.

cond-mat.mes-hall↗

arXiv2020

Taking the pulse of COVID-19: A spatiotemporal perspective

The sudden outbreak of the Coronavirus disease (COVID-19) swept across the world in early 2020, triggering the lockdowns of several billion people across many countries, including China, Spain, India, the U.K., Italy, France, Germany, and most states of the U.S. The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S., and New York City became an epicenter of the pandemic by the end of March. In response to this national and global emergency, the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implemented strategies to rapidly respond to this crisis, for supporting research, saving lives, and protecting the health of global citizens. This perspective paper presents our collective view on the global health emergency and our effort in collecting, analyzing, and sharing relevant data on global policy and government responses, geospatial indicators of the outbreak and evolving forecasts; in developing research capabilities and mitigation measures with global scientists, promoting collaborative research on outbreak dynamics, and reflecting on the dynamic responses from human societies.

physics.soc-ph↗

arXiv2020

Study on possible molecular states composed of $Λ_c\bar D$ ($Λ_b B$) and $Σ_c\bar D$ ($Σ_b B$) within the Bethe-Salpeter framework

$P_c(4312)$ observed by the LHCb collaboration is confirmed as a pentaquark and its structure, production, and decay behaviors attract great attention from theorists and experimentalists. Since its mass is very close to sum of $Σ_c$ and $\bar D$ masses, it is naturally tempted to be considered as a molecular state composed of $Σ_c$ and $\bar D$. Moreover, $P_c(4312)$ is observed in the channel with $J/ψp$ final state, requiring that isospin conservation $P_c(4312)$ is an isospin-1/2 eigenstate. In literature, several groups used various models to estimate its spectrum. We systematically study the pentaquarks within the framework of the Bethe-Salpeter equation; thus $P_c(4312)$ is an excellent target because of the available data. We calculate the spectrum of $P_c(4312)$ in terms of the Bethe-Salpter equations and further study its decay modes. Some predictions on other possible pentaquark states that can be tested in future experiments are made.

hep-ph↗