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Michael Hwang

Publications and source records attributed to Michael Hwang.

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On sketching approximations for symmetric Boolean CSPs

A Boolean maximum constraint satisfaction problem, Max-CSP($f$), is specified by a predicate $f:\{-1,1\}^k\to\{0,1\}$. An $n$-variable instance of Max-CSP($f$) consists of a list of constraints, each of which applies $f$ to $k$ distinct literals drawn from the $n$ variables. For $k=2$, Chou, Golovnev, and Velusamy [CGV20, FOCS 2020] obtained explicit ratios characterizing the $\sqrt n$-space streaming approximability of every predicate. For $k \geq 3$, Chou, Golovnev, Sudan, and Velusamy [CGSV21, arXiv:2102.12351] proved a general dichotomy theorem for $\sqrt n$-space sketching algorithms: For every $f$, there exists $\alpha(f)\in (0,1]$ such that for every $\epsilon>0$, Max-CSP($f$) is $(\alpha(f)-\epsilon)$-approximable by an $O(\log n)$-space linear sketching algorithm, but $(\alpha(f)+\epsilon)$-approximation sketching algorithms require $\Omega(\sqrt{n})$ space. In this work, we give closed-form expressions for the sketching approximation ratios of multiple families of symmetric Boolean functions. Letting $\alpha'_k = 2^{-(k-1)} (1-k^{-2})^{(k-1)/2}$, we show that for odd $k \geq 3$, $\alpha(k$AND$) = \alpha'_k$, and for even $k \geq 2$, $\alpha(k$AND$) = 2\alpha'_{k+1}$. We also resolve the ratio for the "at-least-$(k-1)$-$1$'s" function for all even $k$; the "exactly-$\frac{k+1}2$-$1$'s" function for odd $k \in \{3,\ldots,51\}$; and fifteen other functions. We stress here that for general $f$, according to [CGSV21], closed-form expressions for $\alpha(f)$ need not have existed a priori. Separately, for all threshold functions, we give optimal "bias-based" approximation algorithms generalizing [CGV20] while simplifying [CGSV21]. Finally, we investigate the $\sqrt n$-space streaming lower bounds in [CGSV21], and show that they are incomplete for $3$AND.

cs.DS

A generative adversarial approach to facilitate archival-quality histopathologic diagnoses from frozen tissue sections

In clinical diagnostics and research involving histopathology, formalin fixed paraffin embedded (FFPE) tissue is almost universally favored for its superb image quality. However, tissue processing time (more than 24 hours) can slow decision-making. In contrast, fresh frozen (FF) processing (less than 1 hour) can yield rapid information but diagnostic accuracy is suboptimal due to lack of clearing, morphologic deformation and more frequent artifacts. Here, we bridge this gap using artificial intelligence. We synthesize FFPE-like images ,virtual FFPE, from FF images using a generative adversarial network (GAN) from 98 paired kidney samples derived from 40 patients. Five board-certified pathologists evaluated the results in a blinded test. Image quality of the virtual FFPE data was assessed to be high and showed a close resemblance to real FFPE images. Clinical assessments of disease on the virtual FFPE images showed a higher inter-observer agreement compared to FF images. The nearly instantaneously generated virtual FFPE images can not only reduce time to information but can facilitate more precise diagnosis from routine FF images without extraneous costs and effort.

eess.IV