arXiv subjects

Mingkun Xu

Publications and source records attributed to Mingkun Xu.

48 records · Page 3Linked to original sources

arXiv2024

Distance-Forward Learning: Enhancing the Forward-Forward Algorithm Towards High-Performance On-Chip Learning

The Forward-Forward (FF) algorithm was recently proposed as a local learning method to address the limitations of backpropagation (BP), offering biological plausibility along with memory-efficient and highly parallelized computational benefits. However, it suffers from suboptimal performance and poor generalization, largely due to inadequate theoretical support and a lack of effective learning strategies. In this work, we reformulate FF using distance metric learning and propose a distance-forward algorithm (DF) to improve FF performance in supervised vision tasks while preserving its local computational properties, making it competitive for efficient on-chip learning. To achieve this, we reinterpret FF through the lens of centroid-based metric learning and develop a goodness-based N-pair margin loss to facilitate the learning of discriminative features. Furthermore, we integrate layer-collaboration local update strategies to reduce information loss caused by greedy local parameter updates. Our method surpasses existing FF models and other advanced local learning approaches, with accuracies of 99.7\% on MNIST, 88.2\% on CIFAR-10, 59\% on CIFAR-100, 95.9\% on SVHN, and 82.5\% on ImageNette, respectively. Moreover, it achieves comparable performance with less than 40\% memory cost compared to BP training, while exhibiting stronger robustness to multiple types of hardware-related noise, demonstrating its potential for online learning and energy-efficient computation on neuromorphic chips.

cs.NE↗

arXiv2024

Advancements in Programmable Lipid Nanoparticles: Exploring the Four-Domain Model for Targeted Drug Delivery

Programmable lipid nanoparticles, or LNPs, represent a breakthrough in the realm of targeted drug delivery, offering precise spatiotemporal control essential for the treatment of complex diseases such as cancer and genetic disorders. In order to provide a more modular perspective and a more balanced analysis of the mechanism, this review presents a novel Four-Domain Model that consists of Architecture, Interface, Payload, and Dispersal Domain. We explored the dynamical equilibrium between LNPs components and the surroundings throughout their destiny, from formulation to release. On the basis of this, we delve deep into manufacturing challenges, scalability issues, and regulatory hurdles, associated with the clinical translation of LNP technology. Within the framework focusing on the programmability in each domain, we prioritized patient-centric factors like dosing regimens, administration techniques, and potential consequences. Notably, this review expands to innovative anatomical routes, such as intranasal and intraocular administration, offering a thorough examination of the advantages and disadvantages of each route. We also offered a comprehensive comparison between artificial LNPs and natural exosomes in terms of functionality, biocompatibility, and therapeutic potential. Ultimately, this review highlights the potential of programmable LNPs to evolve into more intelligent, naturally integrated systems, achieving optimal biocompatibility and functionality.

q-bio.BM↗

arXiv2024

Unveiling the Potential of Spiking Dynamics in Graph Representation Learning through Spatial-Temporal Normalization and Coding Strategies

In recent years, spiking neural networks (SNNs) have attracted substantial interest due to their potential to replicate the energy-efficient and event-driven processing of biological neurons. Despite this, the application of SNNs in graph representation learning, particularly for non-Euclidean data, remains underexplored, and the influence of spiking dynamics on graph learning is not yet fully understood. This work seeks to address these gaps by examining the unique properties and benefits of spiking dynamics in enhancing graph representation learning. We propose a spike-based graph neural network model that incorporates spiking dynamics, enhanced by a novel spatial-temporal feature normalization (STFN) technique, to improve training efficiency and model stability. Our detailed analysis explores the impact of rate coding and temporal coding on SNN performance, offering new insights into their advantages for deep graph networks and addressing challenges such as the oversmoothing problem. Experimental results demonstrate that our SNN models can achieve competitive performance with state-of-the-art graph neural networks (GNNs) while considerably reducing computational costs, highlighting the potential of SNNs for efficient neuromorphic computing applications in complex graph-based scenarios.

cs.AI↗

arXiv2024

Artificial Intelligence Enhanced Digital Nucleic Acid Amplification Testing for Precision Medicine and Molecular Diagnostics

The precise quantification of nucleic acids is pivotal in molecular biology, underscored by the rising prominence of nucleic acid amplification tests (NAAT) in diagnosing infectious diseases and conducting genomic studies. This review examines recent advancements in digital Polymerase Chain Reaction (dPCR) and digital Loop-mediated Isothermal Amplification (dLAMP), which surpass the limitations of traditional NAAT by offering absolute quantification and enhanced sensitivity. In this review, we summarize the compelling advancements of dNNAT in addressing pressing public health issues, especially during the COVID-19 pandemic. Further, we explore the transformative role of artificial intelligence (AI) in enhancing dNAAT image analysis, which not only improves efficiency and accuracy but also addresses traditional constraints related to cost, complexity, and data interpretation. In encompassing the state-of-the-art (SOTA) development and potential of both software and hardware, the all-encompassing Point-of-Care Testing (POCT) systems cast new light on benefits including higher throughput, label-free detection, and expanded multiplex analyses. While acknowledging the enhancement of AI-enhanced dNAAT technology, this review aims to both fill critical gaps in the existing technologies through comparative assessments and offer a balanced perspective on the current trajectory, including attendant challenges and future directions. Leveraging AI, next-generation dPCR and dLAMP technologies promises integration into clinical practice, improving personalized medicine, real-time epidemic surveillance, and global diagnostic accessibility.

q-bio.QM↗

arXiv2024

Enhancing Graph Representation Learning with Attention-Driven Spiking Neural Networks

Graph representation learning has become a crucial task in machine learning and data mining due to its potential for modeling complex structures such as social networks, chemical compounds, and biological systems. Spiking neural networks (SNNs) have recently emerged as a promising alternative to traditional neural networks for graph learning tasks, benefiting from their ability to efficiently encode and process temporal and spatial information. In this paper, we propose a novel approach that integrates attention mechanisms with SNNs to improve graph representation learning. Specifically, we introduce an attention mechanism for SNN that can selectively focus on important nodes and corresponding features in a graph during the learning process. We evaluate our proposed method on several benchmark datasets and show that it achieves comparable performance compared to existing graph learning techniques.

cs.AI↗

arXiv2023

A mempolar transistor made from tellurium

The classic three-terminal electronic transistors and the emerging two-terminal ion-based memristors are complementary to each other in various nonconventional information processing systems in a heterogeneous integration approach, such as hybrid CMOS/memristive neuromorphic crossbar arrays. Recent attempts to introduce transitive functions into memristors have given rise to gate-tunable memristive functions, hetero-plasticity and mixed-plasticity functions. However, it remains elusive under what application scenarios and in what ways transistors can benefit from the incorporation of ion-based memristive effects. Here, we introduce a new type of transistor named 'mempolar transistor' to the transistor family. Its polarity can be converted reversibly, in a nonvolatile fashion, between n-type and p-type depending on the history of the applied electrical stimulus. This is achieved by the use of the emerging semiconducting tellurium as the electrochemically active source/drain contact material, in combination with monolayer two-dimensional MoS2 channel, which results in a gated lateral Te/MoS2/Te memristor, or from a different perspective, a transistor whose channel can be converted reversibly between n-type MoS2 and p-type Te. With this unique mempolar function, our transistor holds the promise for reconfigurable logic circuits and secure circuits. In addition, we propose and demonstrate experimentally, a ternary content-addressable memory made of only two mempolar transistors, which used to require a dozen normal transistors, and by simulations, a device-inspired and hardware matched regularization method 'FlipWeight' for training artificial neural networks, which can achieve comparable performance to that achieved by the prevalent 'Dropout' and 'DropConnect' methods. This work represents a major advance in diversifying the functionality of transistors.

physics.app-ph↗

arXiv2022

Bio-realistic and versatile artificial dendrites made of anti-ambipolar transistors

The understanding of neural networks as neuron-synapse binaries has been the foundation of neuroscience, and therefore, the emerging neuromorphic computing technology that takes inspiration from the brain. This dogma, however, has been increasingly challenged by recent neuroscience research in which the downplayed dendrites were found to be active, dynamically unique and computationally powerful. To date, research on artificial dendrites is scarce and the few existing devices are still far from versatile or (and) bio-realistic. A breakthrough is hampered by the limited available physical mechanisms in mainstream device architectures. Here, we experimentally demonstrate a bio-realistic and versatile artificial dendrite made of WSe2/MoS2 heterojunction-channel anti-ambipolar transistor, which can closely mimic the experimentally recorded non-monotonic dendritic Ca2+ action potential that underpins various sophisticated computations. Spiking neural network simulations reveal that the incorporation of this nonconventional but bio-realistic dendritic activation enhances the robustness and representational capability of the network in non-stationary environments. By further exploiting the memristive effect, dendritic anti-ambipolar transistor can naturally mimic Ca2+-mediated regulation of synaptic plasticity (meta-plasticity) at dendritic spine, an important homeostatic phenomenon due to dendritic modulation. The invention of dendritic anti-ambipolar transistor completes the family of neuromorphic transistors and represents a major advance in diversifying the functionality of transistors.

physics.app-ph↗

arXiv2021

Detecting Out-of-distribution Samples via Variational Auto-encoder with Reliable Uncertainty Estimation

Variational autoencoders (VAEs) are influential generative models with rich representation capabilities from the deep neural network architecture and Bayesian method. However, VAE models have a weakness that assign a higher likelihood to out-of-distribution (OOD) inputs than in-distribution (ID) inputs. To address this problem, a reliable uncertainty estimation is considered to be critical for in-depth understanding of OOD inputs. In this study, we propose an improved noise contrastive prior (INCP) to be able to integrate into the encoder of VAEs, called INCPVAE. INCP is scalable, trainable and compatible with VAEs, and it also adopts the merits from the INCP for uncertainty estimation. Experiments on various datasets demonstrate that compared to the standard VAEs, our model is superior in uncertainty estimation for the OOD data and is robust in anomaly detection tasks. The INCPVAE model obtains reliable uncertainty estimation for OOD inputs and solves the OOD problem in VAE models.

cs.LG↗

arXiv2021

Exploiting Spiking Dynamics with Spatial-temporal Feature Normalization in Graph Learning

Biological spiking neurons with intrinsic dynamics underlie the powerful representation and learning capabilities of the brain for processing multimodal information in complex environments. Despite recent tremendous progress in spiking neural networks (SNNs) for handling Euclidean-space tasks, it still remains challenging to exploit SNNs in processing non-Euclidean-space data represented by graph data, mainly due to the lack of effective modeling framework and useful training techniques. Here we present a general spike-based modeling framework that enables the direct training of SNNs for graph learning. Through spatial-temporal unfolding for spiking data flows of node features, we incorporate graph convolution filters into spiking dynamics and formalize a synergistic learning paradigm. Considering the unique features of spike representation and spiking dynamics, we propose a spatial-temporal feature normalization (STFN) technique suitable for SNN to accelerate convergence. We instantiate our methods into two spiking graph models, including graph convolution SNNs and graph attention SNNs, and validate their performance on three node-classification benchmarks, including Cora, Citeseer, and Pubmed. Our model can achieve comparable performance with the state-of-the-art graph neural network (GNN) models with much lower computation costs, demonstrating great benefits for the execution on neuromorphic hardware and prompting neuromorphic applications in graphical scenarios.

cs.NE↗

arXiv2021

Brain-inspired global-local learning incorporated with neuromorphic computing

Two main routes of learning methods exist at present including error-driven global learning and neuroscience-oriented local learning. Integrating them into one network may provide complementary learning capabilities for versatile learning scenarios. At the same time, neuromorphic computing holds great promise, but still needs plenty of useful algorithms and algorithm-hardware co-designs for exploiting the advantages. Here, we report a neuromorphic hybrid learning model by introducing a brain-inspired meta-learning paradigm and a differentiable spiking model incorporating neuronal dynamics and synaptic plasticity. It can meta-learn local plasticity and receive top-down supervision information for multiscale synergic learning. We demonstrate the advantages of this model in multiple different tasks, including few-shot learning, continual learning, and fault-tolerance learning in neuromorphic vision sensors. It achieves significantly higher performance than single-learning methods, and shows promise in empowering neuromorphic applications revolution. We further implemented the hybrid model in the Tianjic neuromorphic platform by exploiting algorithm-hardware co-designs and proved that the model can fully utilize neuromorphic many-core architecture to develop hybrid computation paradigm.

cs.NE↗

arXiv2020

Adversarial symmetric GANs: bridging adversarial samples and adversarial networks

Generative adversarial networks have achieved remarkable performance on various tasks but suffer from training instability. Despite many training strategies proposed to improve training stability, this issue remains as a challenge. In this paper, we investigate the training instability from the perspective of adversarial samples and reveal that adversarial training on fake samples is implemented in vanilla GANs, but adversarial training on real samples has long been overlooked. Consequently, the discriminator is extremely vulnerable to adversarial perturbation and the gradient given by the discriminator contains non-informative adversarial noises, which hinders the generator from catching the pattern of real samples. Here, we develop adversarial symmetric GANs (AS-GANs) that incorporate adversarial training of the discriminator on real samples into vanilla GANs, making adversarial training symmetrical. The discriminator is therefore more robust and provides more informative gradient with less adversarial noise, thereby stabilizing training and accelerating convergence. The effectiveness of the AS-GANs is verified on image generation on CIFAR-10 , CelebA, and LSUN with varied network architectures. Not only the training is more stabilized, but the FID scores of generated samples are consistently improved by a large margin compared to the baseline. The bridging of adversarial samples and adversarial networks provides a new approach to further develop adversarial networks.

cs.CV↗

arXiv2020

Bigeminal Priors Variational auto-encoder

Variational auto-encoders (VAEs) are an influential and generally-used class of likelihood-based generative models in unsupervised learning. The likelihood-based generative models have been reported to be highly robust to the out-of-distribution (OOD) inputs and can be a detector by assuming that the model assigns higher likelihoods to the samples from the in-distribution (ID) dataset than an OOD dataset. However, recent works reported a phenomenon that VAE recognizes some OOD samples as ID by assigning a higher likelihood to the OOD inputs compared to the one from ID. In this work, we introduce a new model, namely Bigeminal Priors Variational auto-encoder (BPVAE), to address this phenomenon. The BPVAE aims to enhance the robustness of the VAEs by combing the power of VAE with the two independent priors that belong to the training dataset and simple dataset, which complexity is lower than the training dataset, respectively. BPVAE learns two datasets'features, assigning a higher likelihood for the training dataset than the simple dataset. In this way, we can use BPVAE's density estimate for detecting the OOD samples. Quantitative experimental results suggest that our model has better generalization capability and stronger robustness than the standard VAEs, proving the effectiveness of the proposed approach of hybrid learning by collaborative priors. Overall, this work paves a new avenue to potentially overcome the OOD problem via multiple latent priors modeling.

cs.LG↗