arXiv subjects

Niccole Ranaei-Zamani

Publications and source records attributed to Niccole Ranaei-Zamani.

4 recordsLinked to original sources

arXiv2026

The FetalSenseM V2: a wearable and wireless, multi-wavelength NIRS device for continuous monitoring of placental oxygenation and metabolism

We present here the FetalSenseM V2 (FSM V2), a wireless and wearable, multi-wavelength, NIRS device, based on LED illumination at six NIR wavelengths (782, 800, 818, 830, 848 and 888 nm). It utilises two sources located on the flexible wings of the sensor body, and three photodiodes placed symmetrically in its centre at 1 cm from each other. The configuration provides two sets of three source-to-detector distances (SDS) at 3, 4 and 5 cm. FSM V2 allows estimation of dynamic, relative changes in placental concentrations of HbO2, HHb and oxCCO. At the same time, the dual set of SDS also enables the use of multi-distance algorithms, such as spatially-resolved spectroscopy (SRS) and Dual Slope (DS), for estimating placental oxygen saturation (PlO2). FSM V2 is the first example of a new generation of wearable NIRS devices, paving the way for smart and advanced monitoring of placental health at bedside. The FSM V2 was successfully validated on a bench-testing, metrological platform based on optical phantoms, as well as against a gold-standard, time-domain (TD) NIRS system, before moving to preliminary examples of clinical application and usability on pregnancy monitoring trials at University College Lon-don Hospital (UCLH), conducted as part of an in vivo proof-of-concept study.

physics.med-ph↗

arXiv2026

OptoCENTAL: a standardised, bench-testing platform based on phantoms for validating optical systems aimed at clinical monitoring of the placenta

Optical imaging and spectroscopy solutions, such as near-infrared spectroscopy (NIRS) and diffuse optical tomography (DOT), have the potential to provide compact, bedside monitoring of the placenta in the clinic, thanks to recent advancements in miniaturisation and wireless wearability. This would provide neonatologist with continuous assessment of the pregnancy status in real-time, as well as tools to possibly predict delivery outcomes. We present here OptoCENTAL, a standardized platform based on multiple optical phantoms, from digital, through solid to liquid, for a comprehensive bench-testing, characterisation and validation of any photonics solution and instrumentation that aims at in vivo, clinical monitoring of the human placenta. Results: Exemplary applications of the OptoCENTAL platform on different types of optical systems, from wearable, continuous-wave devices to broadband and time-domain NIRS systems, demonstrate the flexibility of its procedures to be implemented with any setup, allowing users to compare performances across different solutions. The results also show the capability of OptoCENTAL to provide quantitative assessment of the major features required by any photonic solution for providing effective and efficient monitoring of the placenta, including basic instrument performances, quantification of monitoring accuracy, as well as depth sensitivity. OptoCENTAL represent the first-of-a-kind effort in standardising bench-testing and validation of optical imaging and spectroscopy methods in the framework of placental clinical applications, further advancing the translation of such modalities into the hospitals, as well as towards future certification and commercialisation of such technologies.

physics.med-ph↗

arXiv2025

Optimization of continuous-wave NIRS devices for placental monitoring. A simulation study

Near infrared spectroscopy (NIRS) is an optical technique that is widely used to monitor tissue oxygenation. These devices take advantage of the near infrared light to monitor deep tissues like brain, muscle or placenta. In this study, we developed a Monte Carlo framework to evaluate the sensitivity of continuous-wave (CW) NIRS devices for monitoring the placenta which a deep layer in the maternal abdomen. This framework can be used to optimize CW-NIRS acquisition parameters (integration time, source detector separation) before going into clinical applications.

physics.med-ph↗

arXiv2024

A Novel Portable and Wearable Broadband Near-Infrared Spectroscopy Device for In-Vivo Oxygenation and Metabolism Measurements

Broadband NIRS (bNIRS) is an extension of fNIRS that provides the same assessment of oxygenation biomarkers along with a valuable marker for oxygen metabolism at a cellular level, the oxidation state of cytochrome-c-oxidase (oxCCO). bNIRS implements many (100s) NIR wavelengths in the full NIR spectrum to address this and provide insight to tissue energetics. To supply these many wavelengths of light, broadband sources are required, and spectrometers are employed to distinguish power per wavelength. Current multi-channel bNIRS instruments are bulky and only semi-portable due to technological limitations. We propose a design for a bNIRS device that has been miniaturized to allow for portable use. This design leverages the innovations in photonic devices that have created a new line of microspectrometers and broadband NIR high-power LEDs; the Hamamatsu SMD-type spectrometer C14384MA and the Ushio SMBBIR45-1100 LED. This first-of-itskind device, referred to as microCYRIL (after its two predecessors CYRIL and miniCYRIL), has been developed for oxygenation and metabolism measurements with dual channel operation. To verify functionality, concentration changes in oxygenated (HbO2) and deoxygenated (HHb) haemoglobin and oxCCO were successfully tracked during a cuff-induced venous and arterial occlusion.

physics.med-ph↗