arXiv subjects

Panagiotis Charalampopoulos

Publications and source records attributed to Panagiotis Charalampopoulos.

41 records · Page 3Linked to original sources

arXiv2017

How to answer a small batch of RMQs or LCA queries in practice

In the Range Minimum Query (RMQ) problem, we are given an array $A$ of $n$ numbers and we are asked to answer queries of the following type: for indices $i$ and $j$ between $0$ and $n-1$, query $\text{RMQ}_A(i,j)$ returns the index of a minimum element in the subarray $A[i..j]$. Answering a small batch of RMQs is a core computational task in many real-world applications, in particular due to the connection with the Lowest Common Ancestor (LCA) problem. With small batch, we mean that the number $q$ of queries is $o(n)$ and we have them all at hand. It is therefore not relevant to build an $Ω(n)$-sized data structure or spend $Ω(n)$ time to build a more succinct one. It is well-known, among practitioners and elsewhere, that these data structures for online querying carry high constants in their pre-processing and querying time. We would thus like to answer this batch efficiently in practice. With efficiently in practice, we mean that we (ultimately) want to spend $n + \mathcal{O}(q)$ time and $\mathcal{O}(q)$ space. We write $n$ to stress that the number of operations per entry of $A$ should be a very small constant. Here we show how existing algorithms can be easily modified to satisfy these conditions. The presented experimental results highlight the practicality of this new scheme. The most significant improvement obtained is for answering a small batch of LCA queries. A library implementation of the presented algorithms is made available.

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arXiv2017

Faster algorithms for 1-mappability of a sequence

In the k-mappability problem, we are given a string x of length n and integers m and k, and we are asked to count, for each length-m factor y of x, the number of other factors of length m of x that are at Hamming distance at most k from y. We focus here on the version of the problem where k = 1. The fastest known algorithm for k = 1 requires time O(mn log n/ log log n) and space O(n). We present two algorithms that require worst-case time O(mn) and O(n log^2 n), respectively, and space O(n), thus greatly improving the state of the art. Moreover, we present an algorithm that requires average-case time and space O(n) for integer alphabets if m = Ω(log n/ log σ), where σ is the alphabet size.

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arXiv2017

Optimal Computation of Overabundant Words

The observed frequency of the longest proper prefix, the longest proper suffix, and the longest infix of a word $w$ in a given sequence $x$ can be used for classifying $w$ as avoided or overabundant. The definitions used for the expectation and deviation of $w$ in this statistical model were described and biologically justified by Brendel et al. (J Biomol Struct Dyn 1986). We have very recently introduced a time-optimal algorithm for computing all avoided words of a given sequence over an integer alphabet (Algorithms Mol Biol 2017). In this article, we extend this study by presenting an $\mathcal{O}(n)$-time and $\mathcal{O}(n)$-space algorithm for computing all overabundant words in a sequence $x$ of length $n$ over an integer alphabet. Our main result is based on a new non-trivial combinatorial property of the suffix tree $\mathcal{T}$ of $x$: the number of distinct factors of $x$ whose longest infix is the label of an explicit node of $\mathcal{T}$ is no more than $3n-4$. We further show that the presented algorithm is time-optimal by proving that $\mathcal{O}(n)$ is a tight upper bound for the number of overabundant words. Finally, we present experimental results, using both synthetic and real data, which justify the effectiveness and efficiency of our approach in practical terms.

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arXiv2017

Palindromic Decompositions with Gaps and Errors

Identifying palindromes in sequences has been an interesting line of research in combinatorics on words and also in computational biology, after the discovery of the relation of palindromes in the DNA sequence with the HIV virus. Efficient algorithms for the factorization of sequences into palindromes and maximal palindromes have been devised in recent years. We extend these studies by allowing gaps in decompositions and errors in palindromes, and also imposing a lower bound to the length of acceptable palindromes. We first present an algorithm for obtaining a palindromic decomposition of a string of length n with the minimal total gap length in time O(n log n * g) and space O(n g), where g is the number of allowed gaps in the decomposition. We then consider a decomposition of the string in maximal δ-palindromes (i.e. palindromes with δerrors under the edit or Hamming distance) and g allowed gaps. We present an algorithm to obtain such a decomposition with the minimal total gap length in time O(n (g + δ)) and space O(n g).

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arXiv2016

Optimal Computation of Avoided Words

The deviation of the observed frequency of a word $w$ from its expected frequency in a given sequence $x$ is used to determine whether or not the word is avoided. This concept is particularly useful in DNA linguistic analysis. The value of the standard deviation of $w$, denoted by $std(w)$, effectively characterises the extent of a word by its edge contrast in the context in which it occurs. A word $w$ of length $k>2$ is a $ρ$-avoided word in $x$ if $std(w) \leq ρ$, for a given threshold $ρ< 0$. Notice that such a word may be completely absent from $x$. Hence computing all such words na\"ıvely can be a very time-consuming procedure, in particular for large $k$. In this article, we propose an $O(n)$-time and $O(n)$-space algorithm to compute all $ρ$-avoided words of length $k$ in a given sequence $x$ of length $n$ over a fixed-sized alphabet. We also present a time-optimal $O(σn)$-time and $O(σn)$-space algorithm to compute all $ρ$-avoided words (of any length) in a sequence of length $n$ over an alphabet of size $σ$. Furthermore, we provide a tight asymptotic upper bound for the number of $ρ$-avoided words and the expected length of the longest one. We make available an open-source implementation of our algorithm. Experimental results, using both real and synthetic data, show the efficiency of our implementation.

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