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Petar Sirkovic

Publications and source records attributed to Petar Sirkovic.

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Extremal Chowla sets and their linear analogues: A human-AI mathematical investigation using Co-Scientist

We introduce an extremal invariant associated with Chowla-type order conditions in finite groups. A nonempty subset $S$ of a finite group $G$ is called a Chowla set if every element of $S$ has order greater than $|S|$, and we write $C(G)$ for the maximum cardinality of such a set. We first show that $C(G)$ is determined by the distribution of element orders in $G$. For cyclic groups, we derive an exact divisor formula and characterize the integers $n$ for which $C(\mathbb{Z}/n\mathbb{Z})=\varphi(n)$. We prove that $\liminf_{n\to\infty}C(\mathbb{Z}/n\mathbb{Z})/\varphi(n)=1$, whereas $\limsup_{n\to\infty}C(\mathbb{Z}/n\mathbb{Z})/\varphi(n)=\infty$, and we determine the corresponding lower and upper limits under normalization by $n$. For finite abelian groups, we obtain an explicit formula in terms of the invariant-factor decomposition, together with a closed formula for finite abelian $p$-groups. We then develop a linear analogue for finite field extensions. A nonzero $K$-subspace $A$ of an extension $L/K$ is called a Chowla subspace if $[K(a):K]>\dim_K A$ for every nonzero $a\in A$. Since this condition depends on $\dim_K A$, it does not generally require every nonzero element of $A$ to generate $L$ over $K$. Nevertheless, when $L/K$ is finite and separable, we prove the exact formula $C(L/K)=[L:K]-d_{\max}(L/K)$, where $d_{\max}(L/K)$ is the largest degree over $K$ of a proper intermediate field. For finite fields, we give a direct proof in every degree using a normal-basis construction. This work was developed through an expert-guided human-AI collaboration. A reasoning-focused configuration of Co-Scientist was used to explore examples and potential proof strategies. The authors formulated the problem, independently verified and completed all arguments, and wrote the final proofs.

math.NT

An AI Co-Data-Scientist for Prioritizing Candidate Biomarkers from Wearable Sensor Data

Wearable devices generate continuous physiological and behavioral data, but converting these signals into clinically reviewable biomarker hypotheses remains labor-intensive. We introduce CoDaS, an AI co-data-scientist that integrates multi-agent hypothesis generation, deterministic statistical analysis, adversarial validation and literature-grounded interpretation under human oversight. Across three wearable cohorts comprising 9,279 participant-observations, CoDaS prioritized candidate associations for mental-health and metabolic endpoints after internal checks for replication, stability, robustness and leakage. The system identified related circadian-instability signals associated with depression, including sleep-duration variability in DWB ($\rho$ = 0.252, $p$ < 0.001) and sleep-onset variability in GLOBEM ($\rho$ = 0.126, $p$ < 0.001), and derived a wearable cardiovascular-fitness index associated with insulin resistance (steps/resting heart rate; $\rho$ = -0.374, $p$ < 0.001). Adding these features to demographic models produced modest gains ($\Delta R^2$ = 0.040 for depression, 0.021 for insulin resistance). In a 12-clinician review totaling approximately 25 active hours, clinician validity judgments aligned with CoDaS confidence tiers ($\rho$ = 0.67, $p$ = 0.005), whereas added clinical value and confidence to act were rated lower. CoDaS supports traceable, hypothesis-generating prioritization of wearable candidate biomarkers.

cs.AI

A prospective clinical feasibility study of a conversational diagnostic AI in an ambulatory primary care clinic

Large language model (LLM)-based AI systems have shown promise for patient-facing diagnostic and management conversations in simulated settings. Translating these systems into clinical practice requires assessment in real-world workflows with rigorous safety oversight. We report a prospective, single-arm feasibility study of an LLM-based conversational AI, the Articulate Medical Intelligence Explorer (AMIE), conducting clinical history taking and presentation of potential diagnoses for patients to discuss with their provider at urgent care appointments at a leading academic medical center. 100 adult patients completed an AMIE text-chat interaction up to 5 days before their appointment. We sought to assess the conversational safety and quality, patient and clinician experience, and clinical reasoning capabilities compared to primary care providers (PCPs). Human safety supervisors monitored all patient-AMIE interactions in real time and did not need to intervene to stop any consultations based on pre-defined criteria. Patients reported high satisfaction and their attitudes towards AI improved after interacting with AMIE (p < 0.001). PCPs found AMIE's output useful with a positive impact on preparedness. AMIE's differential diagnosis (DDx) included the final diagnosis, per chart review 8 weeks post-encounter, in 90% of cases, with 75% top-3 accuracy. Blinded assessment of AMIE and PCP DDx and management (Mx) plans suggested similar overall DDx and Mx plan quality, without significant differences for DDx (p = 0.6) and appropriateness and safety of Mx (p = 0.1 and 1.0, respectively). PCPs outperformed AMIE in the practicality (p = 0.003) and cost effectiveness (p = 0.004) of Mx. While further research is needed, this study demonstrates the initial feasibility, safety, and user acceptance of conversational AI in a real-world setting, representing crucial steps towards clinical translation.

cs.HC

Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilities

In this report, we introduce the Gemini 2.X model family: Gemini 2.5 Pro and Gemini 2.5 Flash, as well as our earlier Gemini 2.0 Flash and Flash-Lite models. Gemini 2.5 Pro is our most capable model yet, achieving SoTA performance on frontier coding and reasoning benchmarks. In addition to its incredible coding and reasoning skills, Gemini 2.5 Pro is a thinking model that excels at multimodal understanding and it is now able to process up to 3 hours of video content. Its unique combination of long context, multimodal and reasoning capabilities can be combined to unlock new agentic workflows. Gemini 2.5 Flash provides excellent reasoning abilities at a fraction of the compute and latency requirements and Gemini 2.0 Flash and Flash-Lite provide high performance at low latency and cost. Taken together, the Gemini 2.X model generation spans the full Pareto frontier of model capability vs cost, allowing users to explore the boundaries of what is possible with complex agentic problem solving.

cs.CL

Accelerating scientific discovery with Co-Scientist

Scientific discovery is driven by scientists generating novel hypotheses for complex problems that undergo rigorous experimental validation. To augment this process, we introduce Co-Scientist, a multi-agent AI system built on Gemini for structured scientific thinking and hypothesis generation. Co-Scientist aims to help scientists discover new original knowledge. Conditioned on their research objectives and prior scientific evidence, it formulates demonstrably novel research hypotheses for experimental verification. The system's design involves agents continuously generating, critiquing and refining hypotheses accelerated by scaling test-time compute. Key contributions include: (1) a multi-agent architecture with an asynchronous task execution framework for flexible compute scaling; (2) a tournament evolution process for self-improving hypotheses generation. Automated evaluations show continued benefits of test-time compute scaling, improving hypothesis quality over time. While general purpose, we focus the validation in three biomedical applications: drug repurposing, novel target discovery, and explaining mechanisms of anti-microbial resistance. Specifically, Co-Scientist helped identify new drug repurposing candidates and synergistic combination therapies for acute myeloid leukemia, which were validated through in vitro experiments. These real-world validations demonstrate the potential of Co-Scientist to accelerate scientific discovery and usher in an era of AI empowered scientists.

cs.AI