arXiv subjects

Pieter Kruizinga

Publications and source records attributed to Pieter Kruizinga.

7 recordsLinked to original sources

arXiv2026

ffdas: Volumetric ultrasound reconstruction at warp speed

Volumetric ultrafast ultrasound imaging demands reconstruction of images with millions of voxels thousands of times per second, creating computational challenges that limit both real-time feedback and easy offline analysis. Graphics processing units (GPUs) are well suited to this workload, yet we show that standard delay-and-sum implementations underutilize GPU resources through fragmented memory access patterns, even when sufficient computational capacity is available. Three optimization strategies address this: aligning memory access with GPU transfer granularity, halving memory traffic through mixed-precision storage, and exploiting spatial locality to utilize tensor core arithmetic. Together, these achieve kilohertz frame rates for $128^3$-voxel grids with 1024-element arrays, substantially outperforming existing implementations while maintaining image quality. This enables real-time volumetric imaging at scales previously restricted to offline processing, supporting applications such as intraoperative brain imaging and brain-computer interfaces where immediate feedback is essential. We release our implementation as part of the open-source \texttt{ffdas} library.

physics.med-ph↗

arXiv2025

4D Computational Ultrasound Imaging of Carotid Artery Flow

Computational ultrasound imaging (cUSi) with few elements and spatial field encoding can provide high-resolution volumetric B-mode imaging. In this work, we extend its application to 4D carotid artery (CA) flow imaging using a custom large-aperture 240-element matrix probe. We implemented a frequency band-based matched filtering strategy that balances resolution and contrast. The system's inherent imaging capabilities were evaluated and validated in flow phantom and human CA experiments. In the phantom study, 3D/4D power Doppler image and speckle-tracking analyses confirmed the system's ability to resolve flow structures and hemodynamics. In the human study, the CA bifurcation flow structure and its local pulsatile flow dynamics were successfully reconstructed. These results demonstrate the feasibility of using a large-footprint, few-element cUSi system for 4D CA flow assessment.

physics.med-ph↗

arXiv2025

A 240 Elements Matrix Probe with Aberration Mask for 4D Carotid Artery Computational Ultrasound Imaging

Three-dimensional (3D) ultrasound provides enhanced visualization of the carotid artery (CA) anatomy and volumetric flow, offering improved accuracy for cardiovascular diagnosis and monitoring. However, fully populated matrix transducers with large apertures are complex and costly to implement. Computational ultrasound imaging (cUSi) offers a promising alternative by enabling simplified hardware design through model-based reconstruction and spatial field encoding. In this work, we present a 3D cUSi system tailored for CA imaging, consisting of a 240-element matrix probe with a 40 x 24 mm$^2$ large aperture and a spatial encoding mask. We describe the system's design, characterization, and image reconstruction. Phantom experiments show that computational reconstruction using matched filtering (MF) significantly improves volumetric image quality over delay-and-sum (DAS), with spatial encoding enhancing lateral resolution at the cost of reduced contrast ratio. LSQR-based reconstruction was demonstrated to further improve resolution and suppress artifacts. Using both Hadamard and 16-angle plane wave transmission schemes, the system achieved high-resolution images with reasonable contrast, supporting the feasibility of 4D CA imaging applications.

physics.med-ph↗

arXiv2025

The Tensor-Core Beamformer: A High-Speed Signal-Processing Library for Multidisciplinary Use

Beamforming is a well-known technique to combine signals from multiple sensors. It has a wide range of application domains. This paper introduces the Tensor-Core Beamformer: a generic, optimized beamformer library that harnesses the computational power of GPU tensor cores to accelerate beamforming computations. The library hides the complexity of tensor cores from the user, and supports 16-bit and 1-bit precision. An extensive performance evaluation on NVIDIA and AMD GPUs shows that the library outperforms traditional beamforming on regular GPU cores by a wide margin, at much higher energy efficiency. In the 16-bit mode, it achieves over 600 TeraOps/s on an AMD MI300X GPU, while approaching 1 TeraOp/J. In the 1-bit mode, it breaks the 3 PetaOps/s barrier and achieves over 10 TeraOps/J on an NVIDIA A100 GPU. The beamforming library can be easily integrated into existing pipelines. We demonstrate its use for medical ultrasound and radio-astronomical instruments.

cs.DC↗

arXiv2023

Four-Dimensional Computational Ultrasound Imaging of Brain Haemodynamics

Four-dimensional ultrasound imaging of complex biological systems such as the brain is technically challenging because of the spatiotemporal sampling requirements. We present computational ultrasound imaging (cUSi), a new imaging method that uses complex ultrasound fields that can be generated with simple hardware and a physical wave prediction model to alleviate the sampling constraints. cUSi allows for high-resolution four-dimensional imaging of brain haemodynamics in awake and anesthetized mice.

physics.med-ph↗

arXiv2022

Deconvolution of the Functional Ultrasound Response in the Mouse Visual Pathway Using Block-Term Decomposition

Functional ultrasound (fUS) indirectly measures brain activity by recording changes in cerebral blood volume and flow in response to neural activation. Conventional approaches model such functional neuroimaging data as the convolution between an impulse response, known as the hemodynamic response function (HRF), and a binarized representation of the input (i.e., source) signal based on the stimulus onsets, the so-called experimental paradigm (EP). However, the EP may not be enough to characterize the whole complexity of the underlying source signals that evoke the hemodynamic changes, such as in the case of spontaneous resting state activity. Furthermore, the HRF varies across brain areas and stimuli. To achieve an adaptable framework that can capture such dynamics and unknowns of the brain function, we propose a deconvolution method for multivariate fUS time-series that reveals both the region-specific HRFs, and the source signals that induce the hemodynamic responses in the studied regions. We start by modeling the fUS time-series as convolutive mixtures and use a tensor-based approach for deconvolution based on two assumptions: (1) HRFs are parametrizable, and (2) source signals are uncorrelated. We test our approach on fUS data acquired during a visual experiment on a mouse subject, focusing on three regions within the mouse brain's colliculo-cortical, image-forming pathway: the lateral geniculate nucleus, superior colliculus and visual cortex. The estimated HRFs in each region are in agreement with prior works, whereas the estimated source signal is observed to closely follow the EP. Yet, we note a few deviations from the EP in the estimated source signal that most likely arise due to the trial-by-trial variability of the neural response across different repetitions of the stimulus observed in the selected regions.

eess.SP↗

arXiv2018

Monodisperse versus polydisperse ultrasound contrast agents: nonlinear response, sensitivity, and deep tissue imaging potential

Monodisperse microbubble ultrasound contrast agents have been proposed to further increase the signal-to-noise-ratio of contrast enhanced ultrasound imaging. Here, the sensitivity of a polydisperse preclinical agent was compared experimentally to that of its size- and acoustically-sorted derivatives by using narrowband pressure- and frequency-dependent scattering and attenuation measurements. The sorted monodisperse agents showed up to a two orders of magnitude increase in sensitivity, i.e. in the average scattering cross-section per bubble. Moreover, we demonstrate here, for the first time, that the highly nonlinear response of acoustically sorted microbubbles can be exploited to confine scattering and attenuation to the focal region of ultrasound fields used in clinical imaging. This property is a result of minimal prefocal scattering and attenuation and can be used to minimize shadowing effects in deep tissue imaging. Moreover, it potentially allows for more localized therapy using microbubbles through the spatial control of resonant microbubble oscillations.

physics.med-ph↗