arXiv subjects

Siddharth Parashari

Publications and source records attributed to Siddharth Parashari.

7 recordsLinked to original sources

arXiv2026

Roadmap Towards Quantum Entanglement Positron Emission Tomography (QE-PET)

Annihilation photons are quantum entangled in their polarization, a property that is not accessible in state-of-the-art clinical Positron Emission Tomography (PET). This roadmap describes the current status of research in the emerging field of quantum entanglement applications involving these photons for medical diagnosis. It outlines the underlying physics phenomena and the development of detector systems that can serve as a foundation for future Quantum Entanglement PET (QE-PET) scanners. These scanners will be capable of utilizing the entanglement between annihilation photons by measuring their Compton scattering on electrons. This roadmap comprises up-to-date experimental results on the study of quantum entanglement and the decoherence of annihilation photons, alongside the current theoretical understanding of these phenomena. The methods and detector technologies described herein are being developed (i) in order to enhance standard PET imaging by suppressing random coincidences in the reconstruction of annihilation site density distributions, (ii) in order to establish the degree of quantum entanglement as a diagnostic biomarker for tissue pathology and oxygenation, and (iii) in order to elaborate a method for pH imaging. Whether entanglement-based imaging and pH mapping can be successfully translated into clinical practice remains an open question and a subject of exciting ongoing research. This roadmap serves as an invitation to the scientific community to join this burgeoning field.

physics.med-ph↗

arXiv2026

Positron Emission Tomography with quantum-entangled Compton events: first imaging results at clinically relevant activities

In Positron Emission Tomography, a potential, yet unutilized enhancement, may come from exploiting the quantum entanglement of the annihilation quanta, inscribed in the correlation of their polarizations. To investigate this, we built a PET demonstrator capable of measuring polarization correlations of annihilation quanta by their Compton scattering, based on single-layer scintillator polarimeters. We present a detailed study of the imaging of two $^{68}$Ge line sources, 45 MBq each, to extract the spatial resolution and assess image quality. The results show that a spatial resolution of 2.5$\pm$0.1 mm is obtained using single-pixel events, while resolutions obtained with polarization-correlated Compton events range from 3.6$\pm$0.3 mm to 4.9$\pm$0.3 mm, depending on data selection criteria. We also found that the polarization-correlated Compton events exhibit up to 20% higher average signal to random background ratio compared to the single-pixel events. We also present the first imaging of the NEMA NU-4 phantom filled with a $^{68}$Ga solution of 378 MBq initial activity, successfully combining polarization-correlated events with conventional single-pixel event selection. Based on the extracted spatial resolution, signal-to-background, signal-to-noise, contrast, and contrast-to-noise ratio, we estimate that up to 10% sensitivity increase may be attained by exploiting the polarization-correlated events, while preserving a high image quality.

physics.ins-det↗

arXiv2026

Impact of Shape Coexistence on Nuclear Stability

Nuclear decay properties are conventionally predicted assuming nuclei decay from their ground-state configurations. However, this often neglects a fundamental structural complexity which is the phenomenon of shape coexistence, where nuclei possess multiple competing configurations at nearly degenerate energies. When both parent and daughter nuclei can exist in different energy minima, multiple decay pathways become possible. We systematically investigate how shape coexistence influences nuclear decay for approximately 1500 even-even nuclei ($8 \leq Z \leq 118$, $8 \leq N \leq 184$) using the Nilsson-Strutinsky method and relativistic mean-field calculations with NL3$^*$, DD-ME2, and DD-PC1 functionals. We identify around 400 nuclei exhibiting competing energy minima separated by less than 1 MeV. For these shape-coexisting nuclei, we calculate $\alpha$, $\beta^+$ and $\beta^-$ decay half-lives considering all possible transition pathways between the competing minima. Our results demonstrate that shape coexistence substantially impacts decay predictions, with half-lives showing variations up to nearly one logarithmic unit depending on which configurations participate in the transition. Comparison with experimental data from NUBASE2020 shows that pathways involving the second minimum sometimes reproduce measured lifetimes more closely than conventional ground-state to ground-state assumptions. Branching ratios exhibit even stronger sensitivity, with certain nuclei displaying complete inversions of the dominant decay mode depending on configuration choice. These pathway-dependent variations are not due to model uncertainties but reflect inherent structural effects. The correlation between the shape dynamics and nuclear stability establishes the shape coexistence as an essential component in predictive nuclear structure and astrophysics studies.

nucl-th↗

arXiv2025

Towards polarization-enhanced PET: Study of random background in polarization-correlated Compton events

Positron Emission Tomography (PET) is a medical imaging modality that utilizes positron-emitting isotopes, such as Ga-68 and F-18, for many diagnostic purposes. The positron annihilates with an electron from the surrounding area, creating two photons of 511 keV energy and opposite momenta, entangled in their orthogonal polarizations. When each photon undergoes a Compton scattering process, the difference of their azimuthal scattering angles reflects the initial orthogonality of their polarizations, peaking at $\pm$90$^{\circ}$. This type of correlation is not yet utilized in conventional PET scanners, but could potentially offer an energy-independent method for background reduction. Measurements of these kinds of correlations can be achieved using Compton polarimeters, built from a single layer of segmented scintillating crystals such as Gadolinium Aluminium Gallium Garnet doped with Cerium (GAGG:Ce), read out by silicon photomultipliers (SiPMs). In this paper, we study the signal-to-random background ratios in measurements of these correlated annihilation photons from coincidence time spectra across clinically relevant source activities, from $\sim$200 MBq to $\sim$378 MBq. These are then compared to the standard single-pixel (photoelectric) measurements. We find that the signal-to-random background ratios (SBRs) obtained from the polarization-correlated events for Compton scattering angles $\theta_{1,2}\in[72^{\circ}, 90^{\circ}]$ and azimuthal angle difference $\Delta\phi=90^{\circ}\pm20^{\circ}$ are consistently higher than those from single-pixel events, with the ratio of their SBR values of 1.23. The SBR of the selected events also increases with the polarimetric modulation factor $\mu$, gaining $\sim$50\% in value during the experiment.

physics.ins-det↗

arXiv2024

Investigation of the spatial resolution of PET imaging system measuring polarization-correlated Compton events

Recent studies of positron emission tomography (PET) devices have shown that the detection of polarization-correlated annihilation quanta can potentially reduce the background and creation of false lines of response (LORs) leading to improved image quality. We developed a novel PET demonstrator system, capable of measuring correlated gamma photons with single-layer Compton polarimeters to explore the potential of the method. We tested the system using sources with clinically relevant activities at the University Hospital Centre Zagreb. Here we present, for the first time, the images of two Ge-68 line sources, reconstructed solely from the correlated annihilation events. The spatial resolution at two different diameters is determined and compared to the one obtained from events with photoelectric interaction.

physics.ins-det↗

arXiv2023

Closing the Door on the "Puzzle of Decoherence'' of Annihilation Quanta

In para-positronium annihilation, exploration of the polarization correlations of the emerging gamma quanta has gained interest, since it offers a possibility to improve signal-to-background in medical imaging using positron emission tomography. The annihilation quanta, which are predicted to be in an entangled state, have orthogonal polarizations and this property may be exploited to discriminate them from two uncorrelated gamma photons contributing to the background. Recent experimental studies of polarization correlations of the annihilation quanta after a decoherence process induced by a prior Compton scattering of one of them, had rather different conclusions regarding the strength of the correlation after the decoherence, showing its puzzling nature. In the present work, we perform for the first time, a study of the polarization correlations of annihilation quanta after decoherence via Compton scattering in the angular range $0^\circ-50^\circ$ using single-layer gamma ray polarimeters. In addition, we compare the measured polarization correlations after Compton scattering at $30^\circ$ with an active and a passive scatterer element. The results indicate that the correlation, expressed in terms of the polarimetric modulation factor, shows no significant difference at small scattering angles ($0^\circ-30^\circ$) compared to the correlation measured for direct photons, while lower modulation was observed for $50^\circ$ scattering angle.

quant-ph↗

arXiv2022

Optimization of detector modules for measuring gamma-ray polarization in Positron Emission Tomography

Detection of $γ$-ray polarization in Positron Emission Tomography (PET) is as yet an unexploited feature that could be used as an additional handle to improve signal-to-background ratio in this imaging modality. The $γ$ polarization is related to the azimuthal angle in the Compton scattering process, so the initial correlation of polarizations of the annihilation quanta translates to the correlation of the azimuthal angles in events where both annihilation photons undergo Compton scattering. This results in a modulated distribution of the azimuthal angle difference for true events, while this modulation is lacking for the background events. We present a comprehensive experimental study of five detector configurations based on scintillator matrices and silicon photomultipliers, suitable for measuring the azimuthal modulation. The modules consist of either GaGG:Ce or LYSO:Ce pixels with sizes varying from 1.9x1.9x20 $\mathrm{mm^3}$ to 3x3x20 $\mathrm{mm^3}$. The distinctive feature of the modules is that they can reconstruct the Compton scattering by detecting the recoil electron and the scattered gamma in a single detector layer, which simplifies extension to larger systems. The amplitude modulation of the azimuthal angles' difference is clearly observable in all configurations ranging from $0.26\pm0.01$ to $0.34\pm 0.02$ depending on the event selection criteria. The results suggest that finer detector segmentation plays a leading role in achieving higher modulation factors.

physics.ins-det↗