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Tianbin Li

Publications and source records attributed to Tianbin Li.

At least 19 recordsLinked to original sources

EvoGraph-R1: Self-Evolving Multimodal Knowledge Hypergraphs for Agentic Retrieval

Retrieval-augmented generation (RAG) has emerged as a critical paradigm for grounding Multimodal Large Language Models (MLLMs) in external knowledge. Recent GraphRAG methods introduce structured entity-relation graphs to improve retrieval and reasoning. However, they remain limited by treating knowledge graphs as static data structures built offline and queried in a single pass. This static paradigm misaligns with the interactive, iterative nature of knowledge-intensive reasoning, creating three bottlenecks: (i) text-centric fragmentation that impedes cross-modal reasoning, (ii) frozen structures unable to incorporate new evidence or correct errors, and (iii) rigid single-pass retrieval without adaptive refinement. To overcome these limitations, we introduce EvoGraph-R1, a self-evolving GraphRAG framework that reconceptualizes knowledge graphs as dynamic environments shaped through agent interactions. We formulate retrieval as a Markov Decision Process (MDP) where the agent observes the graph state and executes actions to query (GraphRetrieve), expand (WebSearch), refine (GraphEdit), or terminate (Answer) the reasoning. These actions reshape the hypergraph structure and generate feedback signals that guide subsequent evolution. Through this closed loop, the hypergraph evolves by integrating new evidence, correcting errors, and refining structure to support multi-hop reasoning. Experiments on multimodal VQA and text QA benchmarks demonstrate substantial improvements over existing RAG baselines in accuracy, coverage, and traceability, establishing self-evolving knowledge graphs as a fundamental paradigm across modalities.

cs.CV

A First-Principles Derivation of LLM Policy Optimization: From Expected Reward to GRPO and Its Structural Extensions

Policy gradient algorithms for language models optimize the same objective $J(\theta) = \mathbb{E}*{\tau \sim p*\theta(\tau)}[R(\tau)]$, which has exactly two factors: the trajectory probability $p_\theta(\tau)$ and the reward $R(\tau)$. Every method from REINFORCE to PPO to GRPO and their descendants modifies one or both factors to address a specific failure in the preceding formulation. Existing surveys organize these methods by domain or chronology, which obscures the rationale behind each design choice and the precise location of its intervention within the gradient estimator. This survey revisits the landscape of LLM policy optimization from $J(\theta)$ on first principles and uses the trajectory side, induced by $p_\theta(\tau)$, and the reward side, induced by $R(\tau)$, as the two axes along which methods are located. It covers the path from REINFORCE and PPO to GRPO, as well as post-GRPO variants, Agentic RL, and GRPO-OPD. The resulting framework is unified, diagnostic, and extensible: it analyzes methods from a shared objective, identifies which side each method modifies and why, and applies the same trajectory and reward axes across these settings. Across these settings, the framework also exposes compound failures that no single-side fix resolves and that therefore require joint design of the trajectory side and the reward side. The boundary cases and coupled failures identified by this map mark where existing solutions run out and provide a principled starting point for designing the next generation of LLM policy optimization algorithms.

cs.AI

SafeMed-R1: Clinician-Audited Safety and Ethics Alignment for Medical Large Language Models

Large language models(LLMs) increasingly match expert performance on licensing examinations, yet routine clinical use remains limited because governance requires auditable reasoning, safety and ethics alignment, and resilience to adversarial misuse. Here we present SafeMed-R1, trained with a traceable Clinical Trust Signals(CTS) pipeline that links each reasoning instance to clinician rubric scores and edit histories, and aligned through safety and ethics supervision and red team stress testing. SafeMed-R1 attains a macro-averaged accuracy of 79.6% across clinical benchmarks. Under adversarial safety testing, it shows the lowest aggregated risk and reduces unsafe outputs by about 3 to 5% relative to its baseline. In a paired expert study of 30 medication safety vignettes, SafeMed-R1 matches PGY1 and PGY2 residents on medical correctness and scores higher for medication safety, guideline consistency, and clinical usefulness. Collectively, these results suggest that clinician-audited supervision provenance, together with domain-tailored safety and ethics alignment, can strengthen governance-relevant evidence without relying on inference-time retrieval or citation grounding.

cs.AI

MedProbeBench: Systematic Benchmarking at Deep Evidence Integration for Expert-level Medical Guideline

Recent advances in deep research systems enable large language models to retrieve, synthesize, and reason over large-scale external knowledge. In medicine, developing clinical guidelines critically depends on such deep evidence integration. However, existing benchmarks fail to evaluate this capability in realistic workflows requiring multi-step evidence integration and expert-level judgment. To address this gap, we introduce MedProbeBench, the first benchmark leveraging high-quality clinical guidelines as expert-level references. Medical guidelines, with their rigorous standards in neutrality and verifiability, represent the pinnacle of medical expertise and pose substantial challenges for deep research agents. For evaluation, we propose MedProbe-Eval, a comprehensive evaluation framework featuring: (1) Holistic Rubrics with 1,200+ task-adaptive rubric criteria for comprehensive quality assessment, and (2) Fine-grained Evidence Verification for rigorous validation of evidence precision, grounded in 5,130+ atomic claims. Evaluation of 17 LLMs and deep research agents reveals critical gaps in evidence integration and guideline generation, underscoring the substantial distance between current capabilities and expert-level clinical guideline development. Project: https://github.com/uni-medical/MedProbeBench

cs.CV

MMRareBench: A Rare-Disease Multimodal and Multi-Image Medical Benchmark

Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing them to rely strictly on case-level evidence for clinical judgments. Existing benchmarks predominantly evaluate common-condition, single-image settings, leaving multimodal and multi-image evidence integration under rare-disease data scarcity systematically unevaluated. We introduce MMRareBench, to our knowledge the first rare-disease benchmark jointly evaluating multimodal and multi-image clinical capability across four workflow-aligned tracks: diagnosis, treatment planning, cross-image evidence alignment, and examination suggestion. The benchmark comprises 1,756 question-answer pairs with 7,958 associated medical images curated from PMC case reports, with Orphanet-anchored ontology alignment, track-specific leakage control, evidence-grounded annotations, and a two-level evaluation protocol. A systematic evaluation of 23 MLLMs reveals fragmented capability profiles and universally low treatment-planning performance, with medical-domain models trailing general-purpose MLLMs substantially on multi-image tracks despite competitive diagnostic scores. These patterns are consistent with a capacity dilution effect: medical fine-tuning can narrow the diagnostic gap but may erode the compositional multi-image capability that rare-disease evidence integration demands.

cs.CV

Project Imaging-X: A Survey of 1000+ Open-Access Medical Imaging Datasets for Foundation Model Development

Foundation models have demonstrated remarkable success across diverse domains and tasks, primarily due to the thrive of large-scale, diverse, and high-quality datasets. However, in the field of medical imaging, the curation and assembling of such medical datasets are highly challenging due to the reliance on clinical expertise and strict ethical and privacy constraints, resulting in a scarcity of large-scale unified medical datasets and hindering the development of powerful medical foundation models. In this work, we present the largest survey to date of medical image datasets, covering over 1,000 open-access datasets with a systematic catalog of their modalities, tasks, anatomies, annotations, limitations, and potential for integration. Our analysis exposes a landscape that is modest in scale, fragmented across narrowly scoped tasks, and unevenly distributed across organs and modalities, which in turn limits the utility of existing medical image datasets for developing versatile and robust medical foundation models. To turn fragmentation into scale, we propose a metadata-driven fusion paradigm (MDFP) that integrates public datasets with shared modalities or tasks, thereby transforming multiple small data silos into larger, more coherent resources. Building on MDFP, we release an interactive discovery portal that enables end-to-end, automated medical image dataset integration, and compile all surveyed datasets into a unified, structured table that clearly summarizes their key characteristics and provides reference links, offering the community an accessible and comprehensive repository. By charting the current terrain and offering a principled path to dataset consolidation, our survey provides a practical roadmap for scaling medical imaging corpora, supporting faster data discovery, more principled dataset creation, and more capable medical foundation models.

cs.CV

MedQ-Deg: A Multidimensional Benchmark for Evaluating MLLMs Across Medical Image Quality Degradations

Despite impressive performance on standard benchmarks, multimodal large language models (MLLMs) face critical challenges in real-world clinical environments where medical images inevitably suffer various quality degradations. Existing benchmarks exhibit two key limitations: (1) absence of large-scale, multidimensional assessment across medical image quality gradients and (2) no systematic confidence calibration analysis. To address these gaps, we present MedQ-Deg, a comprehensive benchmark for evaluating medical MLLMs under image quality degradations. MedQ-Deg provides multi-dimensional evaluation spanning 18 distinct degradation types, 30 fine-grained capability dimensions, and 7 imaging modalities, with 24,894 question-answer pairs. Each degradation is implemented at 3 severity degrees, calibrated by expert radiologists. We further introduce Calibration Shift metric, which quantifies the gap between a model's perceived confidence and actual performance to assess metacognitive reliability under degradation. Our comprehensive evaluation of 40 mainstream MLLMs reveals several critical findings: (1) overall model performance degrades systematically as degradation severity increases, (2) models universally exhibit the AI Dunning-Kruger Effect, maintaining inappropriately high confidence despite severe accuracy collapse, and (3) models display markedly differentiated behavioral patterns across capability dimensions, imaging modalities, and degradation types. We hope MedQ-Deg drives progress toward medical MLLMs that are robust and trustworthy in real clinical practice.

cs.CV

HSD: Training-Free Acceleration for Document Parsing Vision-Language Models with Hierarchical Speculative Decoding

Document parsing is a fundamental task in multimodal understanding, supporting a wide range of downstream applications such as information extraction and intelligent document analysis. Benefiting from strong semantic modeling and robust generalization, VLM-based end-to-end approaches have emerged as the mainstream paradigm in recent years. However, these models often suffer from substantial inference latency, as they must autoregressively generate long, full-page sequences when processing long-form documents. While recent hybrid methods mitigate this issue via region-level parallel decoding with VLMs, independent region decoding loses full-page context and might weaken global coherence. To address this issue, we propose Hierarchical Speculative Decoding (HSD), a two-stage local-to-global framework for document parsing. HSD first employs a lightweight pipeline drafter to predict region partitions and generate coarse drafts for each region. The first stage verifies the generated region-level drafts in parallel for efficiency, while the second stage further performs page-level verification on these refined outputs to preserve full-page coherence. Experimental results show that HSD achieves a near-lossless 2.7x speedup with HunyuanOCR on OmniDocBench v1.5 and up to 7.04x speedup on long-document parsing tasks, demonstrating the effectiveness of the proposed method. The code is available at https://github.com/whlscut/HSD.

cs.CV

Evaluating the Ability of Large Language Models to Identify Adherence to CONSORT Reporting Guidelines in Randomized Controlled Trials: A Methodological Evaluation Study

The Consolidated Standards of Reporting Trials statement is the global benchmark for transparent and high-quality reporting of randomized controlled trials. Manual verification of CONSORT adherence is a laborious, time-intensive process that constitutes a significant bottleneck in peer review and evidence synthesis. This study aimed to systematically evaluate the accuracy and reliability of contemporary LLMs in identifying the adherence of published RCTs to the CONSORT 2010 statement under a zero-shot setting. We constructed a golden standard dataset of 150 published RCTs spanning diverse medical specialties. The primary outcome was the macro-averaged F1-score for the three-class classification task, supplemented by item-wise performance metrics and qualitative error analysis. Overall model performance was modest. The top-performing models, Gemini-2.5-Flash and DeepSeek-R1, achieved nearly identical macro F1 scores of 0.634 and Cohen's Kappa coefficients of 0.280 and 0.282, respectively, indicating only fair agreement with expert consensus. A striking performance disparity was observed across classes: while most models could identify compliant items with high accuracy (F1 score > 0.850), they struggled profoundly with identifying non-compliant and not applicable items, where F1 scores rarely exceeded 0.400. Notably, some high-profile models like GPT-4o underperformed, achieving a macro F1-score of only 0.521. LLMs show potential as preliminary screening assistants for CONSORT checks, capably identifying well-reported items. However, their current inability to reliably detect reporting omissions or methodological flaws makes them unsuitable for replacing human expertise in the critical appraisal of trial quality.

cs.CL

TCM-5CEval: Extended Deep Evaluation Benchmark for LLM's Comprehensive Clinical Research Competence in Traditional Chinese Medicine

Large language models (LLMs) have demonstrated exceptional capabilities in general domains, yet their application in highly specialized and culturally-rich fields like Traditional Chinese Medicine (TCM) requires rigorous and nuanced evaluation. Building upon prior foundational work such as TCM-3CEval, which highlighted systemic knowledge gaps and the importance of cultural-contextual alignment, we introduce TCM-5CEval, a more granular and comprehensive benchmark. TCM-5CEval is designed to assess LLMs across five critical dimensions: (1) Core Knowledge (TCM-Exam), (2) Classical Literacy (TCM-LitQA), (3) Clinical Decision-making (TCM-MRCD), (4) Chinese Materia Medica (TCM-CMM), and (5) Clinical Non-pharmacological Therapy (TCM-ClinNPT). We conducted a thorough evaluation of fifteen prominent LLMs, revealing significant performance disparities and identifying top-performing models like deepseek\_r1 and gemini\_2\_5\_pro. Our findings show that while models exhibit proficiency in recalling foundational knowledge, they struggle with the interpretative complexities of classical texts. Critically, permutation-based consistency testing reveals widespread fragilities in model inference. All evaluated models, including the highest-scoring ones, displayed a substantial performance degradation when faced with varied question option ordering, indicating a pervasive sensitivity to positional bias and a lack of robust understanding. TCM-5CEval not only provides a more detailed diagnostic tool for LLM capabilities in TCM but aldso exposes fundamental weaknesses in their reasoning stability. To promote further research and standardized comparison, TCM-5CEval has been uploaded to the Medbench platform, joining its predecessor in the "In-depth Challenge for Comprehensive TCM Abilities" special track.

cs.CL

Can Large Language Models Function as Qualified Pediatricians? A Systematic Evaluation in Real-World Clinical Contexts

With the rapid rise of large language models (LLMs) in medicine, a key question is whether they can function as competent pediatricians in real-world clinical settings. We developed PEDIASBench, a systematic evaluation framework centered on a knowledge-system framework and tailored to realistic clinical environments. PEDIASBench assesses LLMs across three dimensions: application of basic knowledge, dynamic diagnosis and treatment capability, and pediatric medical safety and medical ethics. We evaluated 12 representative models released over the past two years, including GPT-4o, Qwen3-235B-A22B, and DeepSeek-V3, covering 19 pediatric subspecialties and 211 prototypical diseases. State-of-the-art models performed well on foundational knowledge, with Qwen3-235B-A22B achieving over 90% accuracy on licensing-level questions, but performance declined ~15% as task complexity increased, revealing limitations in complex reasoning. Multiple-choice assessments highlighted weaknesses in integrative reasoning and knowledge recall. In dynamic diagnosis and treatment scenarios, DeepSeek-R1 scored highest in case reasoning (mean 0.58), yet most models struggled to adapt to real-time patient changes. On pediatric medical ethics and safety tasks, Qwen2.5-72B performed best (accuracy 92.05%), though humanistic sensitivity remained limited. These findings indicate that pediatric LLMs are constrained by limited dynamic decision-making and underdeveloped humanistic care. Future development should focus on multimodal integration and a clinical feedback-model iteration loop to enhance safety, interpretability, and human-AI collaboration. While current LLMs cannot independently perform pediatric care, they hold promise for decision support, medical education, and patient communication, laying the groundwork for a safe, trustworthy, and collaborative intelligent pediatric healthcare system.

cs.CL

Human-Level and Beyond: Benchmarking Large Language Models Against Clinical Pharmacists in Prescription Review

The rapid advancement of large language models (LLMs) has accelerated their integration into clinical decision support, particularly in prescription review. To enable systematic and fine-grained evaluation, we developed RxBench, a comprehensive benchmark that covers common prescription review categories and consolidates 14 frequent types of prescription errors drawn from authoritative pharmacy references. RxBench consists of 1,150 single-choice, 230 multiple-choice, and 879 short-answer items, all reviewed by experienced clinical pharmacists. We benchmarked 18 state-of-the-art LLMs and identified clear stratification of performance across tasks. Notably, Gemini-2.5-pro-preview-05-06, Grok-4-0709, and DeepSeek-R1-0528 consistently formed the first tier, outperforming other models in both accuracy and robustness. Comparisons with licensed pharmacists indicated that leading LLMs can match or exceed human performance in certain tasks. Furthermore, building on insights from our benchmark evaluation, we performed targeted fine-tuning on a mid-tier model, resulting in a specialized model that rivals leading general-purpose LLMs in performance on short-answer question tasks. The main contribution of RxBench lies in establishing a standardized, error-type-oriented framework that not only reveals the capabilities and limitations of frontier LLMs in prescription review but also provides a foundational resource for building more reliable and specialized clinical tools.

cs.CL

UniMedVL: Unifying Medical Multimodal Understanding and Generation through Observation-Knowledge-Analysis

Medical workflows routinely combine reading images with producing visual and textual outputs, making both image understanding and generation central to medical AI. Most existing systems, however, address these abilities in isolated models, losing the shared knowledge that a unified architecture could exploit. To bridge this gap, we present UniMedVL, the first unified medical model that seamlessly integrates multimodal understanding and generation capabilities within a single model without switching weights. We achieve this via a tailored progressive training pipeline where understanding and generation mutually reinforce each other. To effectively train UniMedVL, we curate UniMedVL-5M, the first large-scale medical dataset comprising over 5.6M instances across 8 medical imaging modalities, tailored for multimodal input-output tasks in unified medical understanding and generation. Experimental results demonstrate that UniMedVL achieves competitive performance on five medical understanding benchmarks. Crucially, UniMedVL natively supports diverse interleaved generation tasks, e.g., virtual staining, super-resolution, cross-modal synthesis, essential for complex medical workflows. Our code and dataset are publicly available.

cs.CV

Lumina-DiMOO: An Omni Diffusion Large Language Model for Multi-Modal Generation and Understanding

We introduce Lumina-DiMOO, an open-source foundational model for seamless multi-modal generation and understanding. Lumina-DiMOO sets itself apart from prior unified models by utilizing a fully discrete diffusion modeling to handle inputs and outputs across various modalities. This innovative approach allows Lumina-DiMOO to achieve higher sampling efficiency compared to previous autoregressive (AR) or hybrid AR-Diffusion paradigms and adeptly support a broad spectrum of multi-modal tasks, including text-to-image generation, image-to-image generation (e.g., image editing, subject-driven generation, and image inpainting, etc.), as well as image understanding. Lumina-DiMOO achieves state-of-the-art performance on multiple benchmarks, surpassing existing open-source unified multi-modal models. To foster further advancements in multi-modal and discrete diffusion model research, we release our code and checkpoints to the community. Project Page: https://synbol.github.io/Lumina-DiMOO.

cs.CV

A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers

Scientific Large Language Models (Sci-LLMs) are transforming how knowledge is represented, integrated, and applied in scientific research, yet their progress is shaped by the complex nature of scientific data. This survey presents a comprehensive, data-centric synthesis that reframes the development of Sci-LLMs as a co-evolution between models and their underlying data substrate. We formulate a unified taxonomy of scientific data and a hierarchical model of scientific knowledge, emphasizing the multimodal, cross-scale, and domain-specific challenges that differentiate scientific corpora from general natural language processing datasets. We systematically review recent Sci-LLMs, from general-purpose foundations to specialized models across diverse scientific disciplines, alongside an extensive analysis of over 270 pre-/post-training datasets, showing why Sci-LLMs pose distinct demands -- heterogeneous, multi-scale, uncertainty-laden corpora that require representations preserving domain invariance and enabling cross-modal reasoning. On evaluation, we examine over 190 benchmark datasets and trace a shift from static exams toward process- and discovery-oriented assessments with advanced evaluation protocols. These data-centric analyses highlight persistent issues in scientific data development and discuss emerging solutions involving semi-automated annotation pipelines and expert validation. Finally, we outline a paradigm shift toward closed-loop systems where autonomous agents based on Sci-LLMs actively experiment, validate, and contribute to a living, evolving knowledge base. Collectively, this work provides a roadmap for building trustworthy, continually evolving artificial intelligence (AI) systems that function as a true partner in accelerating scientific discovery.

cs.CL

Intern-S1: A Scientific Multimodal Foundation Model

In recent years, a plethora of open-source foundation models have emerged, achieving remarkable progress in some widely attended fields, with performance being quite close to that of closed-source models. However, in high-value but more challenging scientific professional fields, either the fields still rely on expert models, or the progress of general foundation models lags significantly compared to those in popular areas, far from sufficient for transforming scientific research and leaving substantial gap between open-source models and closed-source models in these scientific domains. To mitigate this gap and explore a step further toward Artificial General Intelligence (AGI), we introduce Intern-S1, a specialized generalist equipped with general understanding and reasoning capabilities with expertise to analyze multiple science modal data. Intern-S1 is a multimodal Mixture-of-Experts (MoE) model with 28 billion activated parameters and 241 billion total parameters, continually pre-trained on 5T tokens, including over 2.5T tokens from scientific domains. In the post-training stage, Intern-S1 undergoes offline and then online reinforcement learning (RL) in InternBootCamp, where we propose Mixture-of-Rewards (MoR) to synergize the RL training on more than 1000 tasks simultaneously. Through integrated innovations in algorithms, data, and training systems, Intern-S1 achieved top-tier performance in online RL training. On comprehensive evaluation benchmarks, Intern-S1 demonstrates competitive performance on general reasoning tasks among open-source models and significantly outperforms open-source models in scientific domains, surpassing closed-source state-of-the-art models in professional tasks, such as molecular synthesis planning, reaction condition prediction, predicting thermodynamic stabilities for crystals. Our models are available at https://huggingface.co/internlm/Intern-S1.

cs.LG

S2-UniSeg: Fast Universal Agglomerative Pooling for Scalable Segment Anything without Supervision

Recent self-supervised image segmentation models have achieved promising performance on semantic segmentation and class-agnostic instance segmentation. However, their pretraining schedule is multi-stage, requiring a time-consuming pseudo-masks generation process between each training epoch. This time-consuming offline process not only makes it difficult to scale with training dataset size, but also leads to sub-optimal solutions due to its discontinuous optimization routine. To solve these, we first present a novel pseudo-mask algorithm, Fast Universal Agglomerative Pooling (UniAP). Each layer of UniAP can identify groups of similar nodes in parallel, allowing to generate both semantic-level and instance-level and multi-granular pseudo-masks within ens of milliseconds for one image. Based on the fast UniAP, we propose the Scalable Self-Supervised Universal Segmentation (S2-UniSeg), which employs a student and a momentum teacher for continuous pretraining. A novel segmentation-oriented pretext task, Query-wise Self-Distillation (QuerySD), is proposed to pretrain S2-UniSeg to learn the local-to-global correspondences. Under the same setting, S2-UniSeg outperforms the SOTA UnSAM model, achieving notable improvements of AP+6.9 on COCO, AR+11.1 on UVO, PixelAcc+4.5 on COCOStuff-27, RQ+8.0 on Cityscapes. After scaling up to a larger 2M-image subset of SA-1B, S2-UniSeg further achieves performance gains on all four benchmarks. Our code and pretrained models are available at https://github.com/bio-mlhui/S2-UniSeg

cs.CV

Unified Medical Image Tokenizer for Autoregressive Synthesis and Understanding

Autoregressive modeling has driven major advances in multimodal AI, yet its application to medical imaging remains constrained by the absence of a unified image tokenizer that simultaneously preserves fine-grained anatomical structures and rich clinical semantics across heterogeneous modalities. Existing approaches jointly optimize image reconstruction and textual semantic objectives, relying on large-scale image-caption pairs and are prone to gradient interference. This is ill-suited for the medical domain where paired data are scarce and abundant unpaired images remain unexploited. This work identifies these issues in building unified medical image tokenizers, and introduces a principled two-stage training framework using visual representation as a bridge to address them. The propose visual representation alignment stage enables the utilization of large-scale unpaired medical images to ensure reconstruction fidelity and establish foundational semantics, alleviating the interference and better preparing for the second stage where fine-grained textual semantics are injected using image-text pairs. The resulting tokenizer, MedITok, is trained on over 33 million medical images spanning 9 modalities and 2 million image-text pairs. MedITok achieves state-of-the-art performance on 30+ benchmarks spanning 9 imaging modalities and 4 task families. It further enables autoregressive modeling for diagnostic and generative applications, serving as a scalable component for future multimodal models with unified synthesis and understanding capabilities in the medical domain. Project page: https://github.com/Masaaki-75/meditok

eess.IV