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Virgilio Gómez-Rubio

Publications and source records attributed to Virgilio Gómez-Rubio.

At least 19 recordsLinked to original sources

Efficient model exploration with the integrated nested Laplace approximation

Model and variable selection are important topics in Bayesian inference. In particular, the selection of different fixed, random effects and hyperparameters in hierarchical models can be difficult because of their complex structure. In this paper, we introduce the use of approximate Bayesian inference for model and variable selection for hierarchical Bayesian models. The approach is based on the application of Markov chain Monte Carlo methods on the model space. In particular, the Metropolis-Hastings algorithm is used to sample from the set of model indices. In this way, the marginal likelihood is used to compute the acceptance probability so that it is not required to estimate the parameter models directly. For this, the integrated nested Laplace approximation (INLA) is used because it provides accurate estimates of the marginal likelihood and it can also provide estimates of the posterior marginal of the model parameters. This method can be applied not only to variable selection but to a wide range of problems subject to model uncertainty. To illustrate the potential of this approach, examples on variable selection, changepoint models and log-Gaussian Cox processes are developed.

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Longitudinal Bayesian networks for assessing team performance in the National Basketball Association

Assessing the performance of a basketball team requires the consideration of multiple sources of information. In recent years, the volume and the quality of data generated in sport has increased considerably, particularly in basketball. In this work, we propose a Bayesian graphical modelling framework for the longitudinal analysis of basketball team performance. The framework is based on Bayesian networks that explicitly represent the nodes, that is, the random variables of interest, as longitudinal stochastic processes. We propose three baseline longitudinal models: a static Bayesian network, a dynamic Bayesian network with an autoregressive structure between successive games, and a dynamic Bayesian network based on a hidden Markov structure. We illustrate the proposed framework through a real-world sports analytics case study involving the Philadelphia 76ers of the National Basketball Association (NBA) during the 2005--06 season. The analysis includes player participation, minutes played, fouls drawn, and one-, two-, and three-point shots attempted and made.

stat.AP↗

Mixture model fitting using conditional models and modal Gibbs sampling

Mixture models are a convenient way of modeling data using a convex combination of different parametric distributions. A new algorithm based on Gibbs sampling is used to approximate the posterior distribution of the auxiliary variables, that assign each observation to a group in the mixture, without sampling any other parameter in the model. In particular, the modes of an approximation to the full conditional distributions of the parameters of the densities in the mixture are computed using the Integrated Nested Laplace Approximation. These are plugged-in to the full conditional distribution of the auxiliary variables to draw samples. The posterior distributions of the remainder of the parameters in the mixture are obtained by averaging over their conditional posterior marginals on the auxiliary variables using Bayesian model averaging. This approximation, 'modal' Gibbs sampling, reduces the computational burden in the Gibbs sampling algorithm and provides very good estimates of the posterior distribution of the auxiliary variables. A simulation study supports the validity of 'modal' Gibbs sampling and two examples on well-known datasets are discussed using a mixture of Gaussian and Poisson distributions, respectively.

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Bayesian network approach to building an affective module for a driver behavioural model

This paper focuses on the affective component of a driver behavioural model (DBM). This component specifically models some drivers' mental states such as mental load and active fatigue, which may affect driving performance. We have used Bayesian networks (BNs) to explore the dependencies between various relevant random variables and assess the probability that a driver is in a particular mental state based on their physiological and demographic conditions. Through this approach, our goal is to improve our understanding of driver behaviour in dynamic environments, with potential applications in traffic safety and autonomous vehicle technologies.

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Bayesian inference for case-control point pattern data in spatial epidemiology with the \texttt{inlabru} R package

The analysis of case-control point pattern data is an important problem in spatial epidemiology. The spatial variation of cases if often compared to that of a set of controls to assess spatial risk variation as well as the detection of risk factors and exposure to putative pollution sources using spatial regression models. The intensities of the point patterns of cases and controls are estimated using log-Gaussian Cox models, so that fixed and spatial random effects can be included. Bayesian inference is conducted via the integrated Nested Laplace approximation (INLA) method using the inlabru R package. In this way, potential risk factors can be assessed by including them as fixed effects while residual spatial variation is considered as a Gaussian process with Matérn covariance. In addition, exposure to pollution sources is modeled using different smooth terms. The proposed methods have been applied to the Chorley-Ribble dataset, that records the locations of lung and larynx cancer cases as well as the location of an disused old incinerator in the area of Lancashire (England, United Kingdom). Taking the locations of lung cancer as controls, the spatial variation of both types of cases has been estimated and the increase of larynx cases in the vicinity of the incinerator has been assessed. The results are similar to those found in the literature. In a nutshell, a framework for Bayesian analysis of multivariate case-control point patterns within an epidemiological framework has been presented. Models to assess spatial variation and the effect of risk factors and pollution sources can be fit with ease with the inlabru R package.

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Bayesian network approach to building an affective module for a driver behavioural model

This paper focuses on the affective component of a Driver Behavioural Model (DBM), specifically modelling some driver's mental states, such as mental load and active fatigue, which may affect driving performance. We used Bayesian networks (BNs) to explore the dependencies between various relevant variables and estimate the probability that a driver was in a particular mental state based on their physiological and demographic conditions. Through this approach, our goal is to improve our understanding of driver behaviour in dynamic environments, with potential applications in traffic safety and autonomous vehicle technologies.

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Bayesian Multilevel Bivariate Spatial Modelling of Italian School Data

This paper studies the relationship between the student's abilities in the second year of high school and the infrastructural endowment in all Italian municipalities, using spatial Bayesian modelling. Municipal student scores are obtained by averaging standardized and spatially homogeneous indicators of student outcomes provided by the Invalsi Institute for two subjects, Italian and Mathematics. Given the nature of the data, we employ a multilevel regression model assuming a bivariate Intrinsic Conditionally Autoregressive (ICAR) latent effect to explain the spatial variability and account for the correlation between the two subjects. Bayesian model estimation is obtained by the Integrated Nested Laplace Approximation (INLA), implemented in the \texttt{R-INLA} package. We find that alongside a significant association with the current state of school infrastructure and facilities, spatially structured latent effects are still necessary to explain the different student outcomes across municipalities.

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Spatial similarity index for scouting in football

Finding players with similar profiles is an important problem in sports such as football. Scouting for new players requires a wealth of information about the available players so that similar profiles to that of a target player can be identified. However, information about the position of the players in the field is seldom used. For this reason, a novel approach based on spatial data analysis is introduced to produce a spatial similarity index that can help to identify similar players. The use of this new spatial similarity index is illustrated to identify similar players using spatial data from the Spanish competition "La Liga", season 2019-2020.

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Comparative analysis of the yields of dicentrics and chromosomal translocations

Purpose: Chromosomal dicentrics and translocations are commonly employed as biomarkers to estimate radiation doses. The main goal of this article is to perform a comparative analysis of yields of both types of aberrations. The objective is to determine if there are relevant distinctions between both yields, allowing for a comprehensive assessment of their respective suitability and accuracy in the estimation of radiation doses. Materials and Methods: The analysis involved data from a partial-radiation simulation study with the calibration data obtained through two scoring methods: conventional and PAINT modified. Subsequently, a Bayesian bivariate zero-inflated Poisson model was employed to compare the posterior marginal density of the mean of dicentrics and translocations and assess the differences between them. Results: When employing the conventional method of scoring, the findings indicate that there is no notable disparity between the yield of observed translocations and dicentrics. However, when utilizing the PAINT modified method, a notable discrepancy is observed for higher doses, indicating a relevant difference in the mean number of the two types aberrations. Conclusions: The choice of scoring method significantly influences the analysis of radiation-induced aberrations, especially when distinguishing between complex and simple chromosomal formations. Further research and analysis are necessary to gain a deeper understanding of the factors and mechanisms impacting the formation of dicentrics and translocations.

physics.med-ph↗

A framework for estimating and visualising excess mortality during the COVID-19 pandemic

COVID-19 related deaths underestimate the pandemic burden on mortality because they suffer from completeness and accuracy issues. Excess mortality is a popular alternative, as it compares observed with expected deaths based on the assumption that the pandemic did not occur. Expected deaths had the pandemic not occurred depend on population trends, temperature, and spatio-temporal patterns. In addition to this, high geographical resolution is required to examine within country trends and the effectiveness of the different public health policies. In this tutorial, we propose a framework using R to estimate and visualise excess mortality at high geographical resolution. We show a case study estimating excess deaths during 2020 in Italy. The proposed framework is fast to implement and allows combining different models and presenting the results in any age, sex, spatial and temporal aggregation desired. This makes it particularly powerful and appealing for online monitoring of the pandemic burden and timely policy making.

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Bayesian Inference for Multivariate Spatial Models with R-INLA

Bayesian methods and software for spatial data analysis are generally now well established in the scientific community. Despite the wide application of spatial models, the analysis of multivariate spatial data using R-INLA has not been widely described in the existing literature. Therefore, the main objective of this article is to demonstrate that R-INLA is a convenient toolbox to analyse different types of multivariate spatial datasets. Additionally, this will be illustrated by analysing three datasets which are publicly available. Furthermore, the details and the R code of these analyses are provided to exemplify how to adjust multivariate spatial datasets with R-INLA.

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Improving radiation dose estimation using the gamma-H2AX biomarker

To predict the health effects of accidental or therapeutic radiation exposure, one must estimate the radiation dose that person received. A well-known ionising radiation biomarker, phosphorylated gamma-H2AX protein, is used to evaluate cell damage and is thus suitable for the dose estimation process. In this paper, we present new Bayesian methods that, in contrast to approaches where estimation is carried out at predetermined post-irradiation times, allow for uncertainty regarding the time since radiation exposure and, as a result, produce more precise results. We also use the Laplace approximation method, which drastically cuts down on the time needed to get results. Real data are used to illustrate the methods, and analyses indicate that the models might be a practical choice for the gamma-H2AX biomarker dose estimation process.

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Fitting Double Hierarchical Models with the Integrated Nested Laplace Approximation

Double hierarchical generalized linear models (DHGLM) are a family of models that are flexible enough as to model hierarchically the mean and scale parameters. In a Bayesian framework, fitting highly parameterized hierarchical models is challenging when this problem is addressed using typical Markov chain Monte Carlo (MCMC) methods due to the potential high correlation between different parameters and effects in the model. The integrated nested Laplace approximation (INLA) could be considered instead to avoid dealing with these problems. However, DHGLM do not fit within the latent Gaussian Markov random field (GMRF) models that INLA can fit. In this paper we show how to fit DHGLM with INLA by combining INLA and importance sampling (IS) algorithms. In particular, we will illustrate how to split DHGLM into submodels that can be fitted with INLA so that the remainder of the parameters are fit using adaptive multiple IS (AMIS) with the aid of the graphical representation of the hierarchical model. This is illustrated using a simulation study on three different types of models and two real data examples.

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Bayesian hierarchical nonlinear modelling of intra-abdominal volume during pneumoperitoneum for laparoscopic surgery

Laparoscopy is an operation carried out in the abdomen or pelvis through small incisions with external visual control by a camera. This technique needs the abdomen to be insufflated with carbon dioxide to obtain a working space for surgical instruments' manipulation. Identifying the critical point at which insufflation should be limited is crucial to maximizing surgical working space and minimizing injurious effects. Bayesian nonlinear growth mixed-effects models are applied to data coming from a repeated measures design. This study allows to assess the relationship between the insufflation pressure and the intra--abdominal volume.

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Importance Sampling with the Integrated Nested Laplace Approximation

The Integrated Nested Laplace Approximation (INLA) is a deterministic approach to Bayesian inference on latent Gaussian models (LGMs) and focuses on fast and accurate approximation of posterior marginals for the parameters in the models. Recently, methods have been developed to extend this class of models to those that can be expressed as conditional LGMs by fixing some of the parameters in the models to descriptive values. These methods differ in the manner descriptive values are chosen. This paper proposes to combine importance sampling with INLA (IS-INLA), and extends this approach with the more robust adaptive multiple importance sampling algorithm combined with INLA (AMIS-INLA). This paper gives a comparison between these approaches and existing methods on a series of applications with simulated and observed datasets and evaluates their performance based on accuracy, efficiency, and robustness. The approaches are validated by exact posteriors in a simple bivariate linear model; then, they are applied to a Bayesian lasso model, a Bayesian imputation of missing covariate values, and lastly, in parametric Bayesian quantile regression. The applications show that the AMIS-INLA approach, in general, outperforms the other methods, but the IS-INLA algorithm could be considered for faster inference when good proposals are available.

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Bayesian analysis of population health data

The analysis of population-wide datasets can provide insight on the health status of large populations so that public health officials can make data-driven decisions. The analysis of such datasets often requires highly parameterized models with different types of fixed and randoms effects to account for risk factors, spatial and temporal variations, multilevel effects and other sources on uncertainty. To illustrate the potential of Bayesian hierarchical models, a dataset of about 500 000 inhabitants released by the Polish National Health Fund containing information about ischemic stroke incidence for a 2-year period is analyzed using different types of models. Spatial logistic regression and survival models are considered for analyzing the individual probabilities of stroke and the times to the occurrence of an ischemic stroke event. Demographic and socioeconomic variables as well as drug prescription information are available at an individual level. Spatial variation is considered by means of region-level random effects.

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Bayesian survival analysis with BUGS

Survival analysis is one of the most important fields of statistics in medicine and the biological sciences. In addition, the computational advances in the last decades have favoured the use of Bayesian methods in this context, providing a flexible and powerful alternative to the traditional frequentist approach. The objective of this paper is to summarise some of the most popular Bayesian survival models, such as accelerated failure time, proportional hazards, mixture cure, competing risks, frailty, and joint models of longitudinal and survival data. Moreover, an implementation of each presented model is provided using a BUGS syntax that can be run with JAGS from the R programming language. Reference to other Bayesian R-packages are also discussed.

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A Bayesian Multilevel Random-Effects Model for Estimating Noise in Image Sensors

Sensor noise sources cause differences in the signal recorded across pixels in a single image and across multiple images. This paper presents a Bayesian approach to decomposing and characterizing the sensor noise sources involved in imaging with digital cameras. A Bayesian probabilistic model based on the (theoretical) model for noise sources in image sensing is fitted to a set of a time-series of images with different reflectance and wavelengths under controlled lighting conditions. The image sensing model is a complex model, with several interacting components dependent on reflectance and wavelength. The properties of the Bayesian approach of defining conditional dependencies among parameters in a fully probabilistic model, propagating all sources of uncertainty in inference, makes the Bayesian modeling framework more attractive and powerful than classical methods for approaching the image sensing model. A feasible correspondence of noise parameters to their expected theoretical behaviors and well calibrated posterior predictive distributions with a small root mean square error for model predictions have been achieved in this study, thus showing that the proposed model accurately approximates the image sensing model. The Bayesian approach could be extended to formulate further components aimed at identifying even more specific parameters of the imaging process.

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