arXiv subjects

Wenxiang Cong

Publications and source records attributed to Wenxiang Cong.

At least 19 recordsLinked to original sources

arXiv2024

Image Reconstruction Using a Mixture Score Function (MSF)

Computed tomography (CT) reconstructs volumetric images using X-ray projection data acquired from multiple angles around an object. For low-dose or sparse-view CT scans, the classic image reconstruction algorithms often produce severe noise and artifacts. To address this issue, we develop a novel iterative image reconstruction method based on maximum a posteriori (MAP) estimation. In the MAP framework, the score function, i.e., the gradient of the logarithmic probability density distribution, plays a crucial role as an image prior in the iterative image reconstruction process. By leveraging the Gaussian mixture model, we derive a novel score matching formula to establish an advanced score function (ADSF) through deep learning. Integrating the new ADSF into the image reconstruction process, a new ADSF iterative reconstruction method is developed to improve image reconstruction quality. The convergence of the ADSF iterative reconstruction algorithm is proven through mathematical analysis. The performance of the ADSF reconstruction method is also evaluated on both public medical image datasets and clinical raw CT datasets. Our results show that the ADSF reconstruction method can achieve better denoising and deblurring effects than the state-of-the-art reconstruction methods, showing excellent generalizability and stability.

physics.med-ph↗

arXiv2024

Parallel Diffusion Model-based Sparse-view Cone-beam Breast CT

Breast cancer is the most prevalent cancer among women worldwide, and early detection is crucial for reducing its mortality rate and improving quality of life. Dedicated breast computed tomography (CT) scanners offer better image quality than mammography and tomosynthesis in general but at higher radiation dose. To enable breast CT for cancer screening, the challenge is to minimize the radiation dose without compromising image quality, according to the ALARA principle (as low as reasonably achievable). Over the past years, deep learning has shown remarkable successes in various tasks, including low-dose CT especially few-view CT. Currently, the diffusion model presents the state of the art for CT reconstruction. To develop the first diffusion model-based breast CT reconstruction method, here we report innovations to address the large memory requirement for breast cone-beam CT reconstruction and high computational cost of the diffusion model. Specifically, in this study we transform the cutting-edge Denoising Diffusion Probabilistic Model (DDPM) into a parallel framework for sub-volume-based sparse-view breast CT image reconstruction in projection and image domains. This novel approach involves the concurrent training of two distinct DDPM models dedicated to processing projection and image data synergistically in the dual domains. Our experimental findings reveal that this method delivers competitive reconstruction performance at half to one-third of the standard radiation doses. This advancement demonstrates an exciting potential of diffusion-type models for volumetric breast reconstruction at high-resolution with much-reduced radiation dose and as such hopefully redefines breast cancer screening and diagnosis.

eess.IV↗

arXiv2023

Diffusion Prior Regularized Iterative Reconstruction for Low-dose CT

Computed tomography (CT) involves a patient's exposure to ionizing radiation. To reduce the radiation dose, we can either lower the X-ray photon count or down-sample projection views. However, either of the ways often compromises image quality. To address this challenge, here we introduce an iterative reconstruction algorithm regularized by a diffusion prior. Drawing on the exceptional imaging prowess of the denoising diffusion probabilistic model (DDPM), we merge it with a reconstruction procedure that prioritizes data fidelity. This fusion capitalizes on the merits of both techniques, delivering exceptional reconstruction results in an unsupervised framework. To further enhance the efficiency of the reconstruction process, we incorporate the Nesterov momentum acceleration technique. This enhancement facilitates superior diffusion sampling in fewer steps. As demonstrated in our experiments, our method offers a potential pathway to high-definition CT image reconstruction with minimized radiation.

eess.IV↗

arXiv2023

Fluorescence Molecular Tomography for Quantum Yield and Lifetime

Fluorescence molecular tomography (FMT) is a promising modality for non-invasive imaging of internal fluorescence agents in biological tissues especially in small animal models, with applications in diagnosis, therapy, and drug design. In this paper, we present a new fluorescent reconstruction algorithm that combines time-resolved fluorescence imaging data with photon-counting micro-CT (PCMCT) images to estimate the quantum yield and lifetime of fluorescent markers in a mouse model. By incorporating PCMCT images, a permissible region of interest of fluorescence yield and lifetime can be roughly estimated as prior knowledge, reducing the number of unknown variables in the inverse problem and improving image reconstruction stability. Our numerical simulation results demonstrate the accuracy and stability of this method in the presence of data noise, with an average relative error of 18% in fluorescent yield and lifetime reconstruction.

physics.optics↗

arXiv2022

Patch-Based Denoising Diffusion Probabilistic Model for Sparse-View CT Reconstruction

Sparse-view computed tomography (CT) can be used to reduce radiation dose greatly but is suffers from severe image artifacts. Recently, the deep learning based method for sparse-view CT reconstruction has attracted a major attention. However, neural networks often have a limited ability to remove the artifacts when they only work in the image domain. Deep learning-based sinogram processing can achieve a better anti-artifact performance, but it inevitably requires feature maps of the whole image in a video memory, which makes handling large-scale or three-dimensional (3D) images rather challenging. In this paper, we propose a patch-based denoising diffusion probabilistic model (DDPM) for sparse-view CT reconstruction. A DDPM network based on patches extracted from fully sampled projection data is trained and then used to inpaint down-sampled projection data. The network does not require paired full-sampled and down-sampled data, enabling unsupervised learning. Since the data processing is patch-based, the deep learning workflow can be distributed in parallel, overcoming the memory problem of large-scale data. Our experiments show that the proposed method can effectively suppress few-view artifacts while faithfully preserving textural details.

eess.IV↗

arXiv2021

Phase function estimation from a diffuse optical image via deep learning

The phase function is a key element of a light propagation model for Monte Carlo (MC) simulation, which is usually fitted with an analytic function with associated parameters. In recent years, machine learning methods were reported to estimate the parameters of the phase function of a particular form such as the Henyey-Greenstein phase function but, to our knowledge, no studies have been performed to determine the form of the phase function. Here we design a convolutional neural network to estimate the phase function from a diffuse optical image without any explicit assumption on the form of the phase function. Specifically, we use a Gaussian mixture model as an example to represent the phase function generally and learn the model parameters accurately. The Gaussian mixture model is selected because it provides the analytic expression of phase function to facilitate deflection angle sampling in MC simulation, and does not significantly increase the number of free parameters. Our proposed method is validated on MC-simulated reflectance images of typical biological tissues using the Henyey-Greenstein phase function with different anisotropy factors. The effects of field of view (FOV) and spatial resolution on the errors are analyzed to optimize the estimation method. The mean squared error of the phase function is 0.01 and the relative error of the anisotropy factor is 3.28%.

cs.LG↗

arXiv2021

Stabilizing Deep Tomographic Reconstruction

Tomographic image reconstruction with deep learning is an emerging field, but a recent landmark study reveals that several deep reconstruction networks are unstable for computed tomography (CT) and magnetic resonance imaging (MRI). Specifically, three kinds of instabilities were reported: (1) strong image artefacts from tiny perturbations, (2) small features missing in a deeply reconstructed image, and (3) decreased imaging performance with increased input data. On the other hand, compressed sensing (CS) inspired reconstruction methods do not suffer from these instabilities because of their built-in kernel awareness. For deep reconstruction to realize its full potential and become a mainstream approach for tomographic imaging, it is thus critically important to meet this challenge by stabilizing deep reconstruction networks. Here we propose an Analytic Compressed Iterative Deep (ACID) framework to address this challenge. ACID synergizes a deep reconstruction network trained on big data, kernel awareness from CS-inspired processing, and iterative refinement to minimize the data residual relative to real measurement. Our study demonstrates that the deep reconstruction using ACID is accurate and stable, and sheds light on the converging mechanism of the ACID iteration under a Bounded Relative Error Norm (BREN) condition. In particular, the study shows that ACID-based reconstruction is resilient against adversarial attacks, superior to classic sparsity-regularized reconstruction alone, and eliminates the three kinds of instabilities. We anticipate that this integrative data-driven approach will help promote development and translation of deep tomographic image reconstruction networks into clinical applications.

eess.IV↗

arXiv2020

Deep Interactive Denoiser (DID) for X-Ray Computed Tomography

Low dose computed tomography (LDCT) is desirable for both diagnostic imaging and image guided interventions. Denoisers are openly used to improve the quality of LDCT. Deep learning (DL)-based denoisers have shown state-of-the-art performance and are becoming one of the mainstream methods. However, there exists two challenges regarding the DL-based denoisers: 1) a trained model typically does not generate different image candidates with different noise-resolution tradeoffs which sometimes are needed for different clinical tasks; 2) the model generalizability might be an issue when the noise level in the testing images is different from that in the training dataset. To address these two challenges, in this work, we introduce a lightweight optimization process at the testing phase on top of any existing DL-based denoisers to generate multiple image candidates with different noise-resolution tradeoffs suitable for different clinical tasks in real-time. Consequently, our method allows the users to interact with the denoiser to efficiently review various image candidates and quickly pick up the desired one, and thereby was termed as deep interactive denoiser (DID). Experimental results demonstrated that DID can deliver multiple image candidates with different noise-resolution tradeoffs, and shows great generalizability regarding various network architectures, as well as training and testing datasets with various noise levels.

eess.IV↗

arXiv2020

Clinical Micro-CT Empowered by Interior Tomography, Robotic Scanning, and Deep Learning

While micro-CT systems are instrumental in preclinical research, clinical micro-CT imaging has long been desired with cochlear implantation as a primary example. The structural details of the cochlear implant and the temporal bone require a significantly higher image resolution than that (about 0.2 mm) provided by current medical CT scanners. In this paper, we propose a clinical micro-CT (CMCT) system design integrating conventional spiral cone-beam CT, contemporary interior tomography, deep learning techniques, and technologies of micro-focus X-ray source, photon-counting detector (PCD), and robotic arms for ultrahigh resolution localized tomography of a freely-selected volume of interest (VOI) at a minimized radiation dose level. The whole system consists of a standard CT scanner for a clinical CT exam and VOI specification, and a robotic-arm based micro-CT scanner for a local scan at much higher spatial and spectral resolution as well as much reduced radiation dose. The prior information from global scan is also fully utilized for background compensation to improve interior tomography from local data for accurate and stable VOI reconstruction. Our results and analysis show that the proposed hybrid reconstruction algorithm delivers superior local reconstruction, being insensitive to the misalignment of the isocenter position and initial view angle in the data/image registration while the attenuation error caused by scale mismatch can be effectively addressed with bias correction. These findings demonstrate the feasibility of our system design. We envision that deep learning techniques can be leveraged for optimized imaging performance. With high resolution imaging, high dose efficiency and low system cost synergistically, our proposed CMCT system has great potentials in temporal bone imaging as well as various other clinical applications.

physics.med-ph↗

arXiv2020

Deep Efficient End-to-end Reconstruction (DEER) Network for Few-view Breast CT Image Reconstruction

Breast CT provides image volumes with isotropic resolution in high contrast, enabling detection of small calcification (down to a few hundred microns in size) and subtle density differences. Since breast is sensitive to x-ray radiation, dose reduction of breast CT is an important topic, and for this purpose, few-view scanning is a main approach. In this article, we propose a Deep Efficient End-to-end Reconstruction (DEER) network for few-view breast CT image reconstruction. The major merits of our network include high dose efficiency, excellent image quality, and low model complexity. By the design, the proposed network can learn the reconstruction process with as few as O(N) parameters, where N is the side length of an image to be reconstructed, which represents orders of magnitude improvements relative to the state-of-the-art deep-learning-based reconstruction methods that map raw data to tomographic images directly. Also, validated on a cone-beam breast CT dataset prepared by Koning Corporation on a commercial scanner, our method demonstrates a competitive performance over the state-of-the-art reconstruction networks in terms of image quality. The source code of this paper is available at: https://github.com/HuidongXie/DEER.

eess.IV↗

arXiv2020

Low-dimensional Manifold Constrained Disentanglement Network for Metal Artifact Reduction

Deep neural network based methods have achieved promising results for CT metal artifact reduction (MAR), most of which use many synthesized paired images for training. As synthesized metal artifacts in CT images may not accurately reflect the clinical counterparts, an artifact disentanglement network (ADN) was proposed with unpaired clinical images directly, producing promising results on clinical datasets. However, without sufficient supervision, it is difficult for ADN to recover structural details of artifact-affected CT images based on adversarial losses only. To overcome these problems, here we propose a low-dimensional manifold (LDM) constrained disentanglement network (DN), leveraging the image characteristics that the patch manifold is generally low-dimensional. Specifically, we design an LDM-DN learning algorithm to empower the disentanglement network through optimizing the synergistic network loss functions while constraining the recovered images to be on a low-dimensional patch manifold. Moreover, learning from both paired and unpaired data, an efficient hybrid optimization scheme is proposed to further improve the MAR performance on clinical datasets. Extensive experiments demonstrate that the proposed LDM-DN approach can consistently improve the MAR performance in paired and/or unpaired learning settings, outperforming competing methods on synthesized and clinical datasets.

eess.IV↗

arXiv2020

X-ray Monochromatic Imaging from Single-spectrum CT via Machine Learning

In clinical CT system, the x-ray tube emits polychromatic x-rays, and the x-ray detectors operate in the current-integrating mode. This physical process is accurately described by an energy-dependent non-linear integral equation. However, the non-linear model is not invertible with a computationally efficient solution, and is often approximated as a linear integral model in the form of the Radon transform. Such approximation basically ignores energy-dependent information and would generate beam hardening artifacts. Dual-energy CT (DECT) scans one object using two different x-ray energy spectra for the acquisition of two spectrally distinct projection datasets to improve imaging performance. Thus, DECT can reconstruct energy and material-selective images, realizing monochromatic imaging and material decomposition. Nevertheless, DECT would increase radiation dose, system complexity, and equipment cost relative to single-spectrum CT. In this paper, a machine-learning-based CT reconstruction method is proposed to perform monochromatic image reconstruction using a single-spectrum CT scanner. Specifically, a residual neural network (ResNet) model is adapted to map a CT image to a monochromatic counterpart at a pre-specified energy level. This ResNet is trained on clinical dual-energy data, showing an excellent convergence to a minimal loss. The trained network produces high-quality monochromatic images on testing data, with a relative error of less than 0.2%. This work has great potential in clinical DECT applications such as tissue characterization, beam hardening correction and proton therapy planning.

physics.med-ph↗

arXiv2019

Deep-learning-based Breast CT for Radiation Dose Reduction

Cone-beam breast computed tomography (CT) provides true 3D breast images with isotropic resolution and high-contrast information, detecting calcifications as small as a few hundred microns and revealing subtle tissue differences. However, breast is highly sensitive to x-ray radiation. It is critically important for healthcare to reduce radiation dose. Few-view cone-beam CT only uses a fraction of x-ray projection data acquired by standard cone-beam breast CT, enabling significant reduction of the radiation dose. However, insufficient sampling data would cause severe streak artifacts in CT images reconstructed using conventional methods. In this study, we propose a deep-learning-based method to establish a residual neural network model for the image reconstruction, which is applied for few-view breast CT to produce high quality breast CT images. We respectively evaluate the deep-learning-based image reconstruction using one third and one quarter of x-ray projection views of the standard cone-beam breast CT. Based on clinical breast imaging dataset, we perform a supervised learning to train the neural network from few-view CT images to corresponding full-view CT images. Experimental results show that the deep learning-based image reconstruction method allows few-view breast CT to achieve a radiation dose <6 mGy per cone-beam CT scan, which is a threshold set by FDA for mammographic screening.

physics.med-ph↗

arXiv2019

Dual Network Architecture for Few-view CT -- Trained on ImageNet Data and Transferred for Medical Imaging

X-ray computed tomography (CT) reconstructs cross-sectional images from projection data. However, ionizing X-ray radiation associated with CT scanning might induce cancer and genetic damage. Therefore, the reduction of radiation dose has attracted major attention. Few-view CT image reconstruction is an important topic to reduce the radiation dose. Recently, data-driven algorithms have shown great potential to solve the few-view CT problem. In this paper, we develop a dual network architecture (DNA) for reconstructing images directly from sinograms. In the proposed DNA method, a point-based fully-connected layer learns the backprojection process requesting significantly less memory than the prior arts do. Proposed method uses O(C*N*N_c) parameters where N and N_c denote the dimension of reconstructed images and number of projections respectively. C is an adjustable parameter that can be set as low as 1. Our experimental results demonstrate that DNA produces a competitive performance over the other state-of-the-art methods. Interestingly, natural images can be used to pre-train DNA to avoid overfitting when the amount of real patient images is limited.

eess.IV↗

arXiv2018

CT Super-resolution GAN Constrained by the Identical, Residual, and Cycle Learning Ensemble(GAN-CIRCLE)

Computed tomography (CT) is widely used in screening, diagnosis, and image-guided therapy for both clinical and research purposes. Since CT involves ionizing radiation, an overarching thrust of related technical research is development of novel methods enabling ultrahigh quality imaging with fine structural details while reducing the X-ray radiation. In this paper, we present a semi-supervised deep learning approach to accurately recover high-resolution (HR) CT images from low-resolution (LR) counterparts. Specifically, with the generative adversarial network (GAN) as the building block, we enforce the cycle-consistency in terms of the Wasserstein distance to establish a nonlinear end-to-end mapping from noisy LR input images to denoised and deblurred HR outputs. We also include the joint constraints in the loss function to facilitate structural preservation. In this deep imaging process, we incorporate deep convolutional neural network (CNN), residual learning, and network in network techniques for feature extraction and restoration. In contrast to the current trend of increasing network depth and complexity to boost the CT imaging performance, which limit its real-world applications by imposing considerable computational and memory overheads, we apply a parallel $1\times1$ CNN to compress the output of the hidden layer and optimize the number of layers and the number of filters for each convolutional layer. Quantitative and qualitative evaluations demonstrate that our proposed model is accurate, efficient and robust for super-resolution (SR) image restoration from noisy LR input images. In particular, we validate our composite SR networks on three large-scale CT datasets, and obtain promising results as compared to the other state-of-the-art methods.

eess.IV↗

arXiv2018

Structure-sensitive Multi-scale Deep Neural Network for Low-Dose CT Denoising

Computed tomography (CT) is a popular medical imaging modality in clinical applications. At the same time, the x-ray radiation dose associated with CT scans raises public concerns due to its potential risks to the patients. Over the past years, major efforts have been dedicated to the development of Low-Dose CT (LDCT) methods. However, the radiation dose reduction compromises the signal-to-noise ratio (SNR), leading to strong noise and artifacts that down-grade CT image quality. In this paper, we propose a novel 3D noise reduction method, called Structure-sensitive Multi-scale Generative Adversarial Net (SMGAN), to improve the LDCT image quality. Specifically, we incorporate three-dimensional (3D) volumetric information to improve the image quality. Also, different loss functions for training denoising models are investigated. Experiments show that the proposed method can effectively preserve structural and texture information from normal-dose CT (NDCT) images, and significantly suppress noise and artifacts. Qualitative visual assessments by three experienced radiologists demonstrate that the proposed method retrieves more detailed information, and outperforms competing methods.

cs.CV↗

arXiv2018

Projection Decomposition for Dual-energy Computed Tomography

Dual-energy computed tomography (CT) is to reconstruct images of an object from two projection datasets generated from two distinct x-ray source energy spectra. It can provide more accurate attenuation quantification than conventional CT with a single x-ray energy spectrum. In the diagnostic energy range, x-ray energy-dependent attenuation can be approximated as a linear combination of photoelectric absorption and Compton scattering. Hence, two physical components of x-ray attenuation can be determined from two spectral informative projection datasets to achieve monochromatic imaging and material decomposition. In this paper, a projection decomposition method is proposed for the image reconstruction in dual-energy CT. This method combines both an analytical algorithm and a single-variable optimization method to solve the non-linear polychromatic x-ray integral model, allowing accurate quantification of photoelectric absorption and Compton scattering components. Numerical tests are performed to illustrate the merit of the proposed method by comparing with classical projection decomposition methods.

physics.med-ph↗

arXiv2018

3D Convolutional Encoder-Decoder Network for Low-Dose CT via Transfer Learning from a 2D Trained Network

Low-dose computed tomography (CT) has attracted a major attention in the medical imaging field, since CT-associated x-ray radiation carries health risks for patients. The reduction of CT radiation dose, however, compromises the signal-to-noise ratio, and may compromise the image quality and the diagnostic performance. Recently, deep-learning-based algorithms have achieved promising results in low-dose CT denoising, especially convolutional neural network (CNN) and generative adversarial network (GAN). This article introduces a Contracting Path-based Convolutional Encoder-decoder (CPCE) network in 2D and 3D configurations within the GAN framework for low-dose CT denoising. A novel feature of our approach is that an initial 3D CPCE denoising model can be directly obtained by extending a trained 2D CNN and then fine-tuned to incorporate 3D spatial information from adjacent slices. Based on the transfer learning from 2D to 3D, the 3D network converges faster and achieves a better denoising performance than that trained from scratch. By comparing the CPCE with recently published methods based on the simulated Mayo dataset and the real MGH dataset, we demonstrate that the 3D CPCE denoising model has a better performance, suppressing image noise and preserving subtle structures.

cs.CV↗