Mind the Gap: Mesh-Guided Repair of Broken Vessels
Vessel segmentation is commonly optimized as voxel-wise classification, but small local errors can strongly disrupt vascular connectivity while having little effect on overlap scores. This is particularly problematic for downstream analyses that rely on centerlines, branches, connected components, or graph structure. We propose a mesh-guided post-processing framework for repairing broken vessel segmentations produced by nnU-Net. For each predicted binary mask, a deformable template mesh is fitted to the mask surface in physical space and used as a case-specific geometric scaffold. The fitted mesh is not voxelized as the final segmentation; instead, it guides conservative reconnection of disconnected components by proposing or validating thin bridge candidates under foreground-growth constraints. We evaluated this approach in three vascular anatomies using AortaSeg24 and SEGA for the aorta, TopCoW for the Circle of Willis, and PARSE for the pulmonary arteries. Performance is measured using Dice, connected-component Dice (ccDice), and the Betti-0 number. Across these datasets, repair substantially improved connectivity while preserving overlap: Dice remained nearly unchanged, whereas ccDice increased from 0.596 to 0.992 for aorta, from 0.722 to 0.835 for TopCoW, and from 0.028 to 0.862 for PARSE. The FOMAML meta-initialization further accelerated the fitting per-case, supporting practical mesh-based repair of the vascular topology. These results suggest that explicit mesh representations can provide a useful geometric prior for correcting topological failures in otherwise accurate voxel segmentations.