arXiv subjects

Xiaofan Zhang

Publications and source records attributed to Xiaofan Zhang.

At least 37 records · Page 2Linked to original sources

arXiv2026

LesionDiffusion: Towards Text-controlled General Lesion Synthesis

Fully-supervised lesion recognition methods in medical imaging face challenges due to the reliance on large annotated datasets, which are expensive and difficult to collect. To address this, synthetic lesion generation has become a promising approach. However, existing models struggle with scalability, fine-grained control over lesion attributes, and the generation of complex structures. We propose LesionDiffusion, a text-controllable lesion synthesis framework for 3D CT imaging that generates both lesions and corresponding masks. By utilizing a structured lesion report template, our model provides greater control over lesion attributes and supports a wider variety of lesion types. We introduce a dataset of 1,505 annotated CT scans with paired lesion masks and structured reports, covering 14 lesion types across 8 organs. LesionDiffusion consists of two components: a lesion mask synthesis network (LMNet) and a lesion inpainting network (LINet), both guided by lesion attributes and image features. Extensive experiments demonstrate that LesionDiffusion significantly improves segmentation performance, with strong generalization to unseen lesion types and organs, outperforming current state-of-the-art models. Code is available at https://github.com/HengruiTianSJTU/LesionDiffusion.

eess.IV↗

arXiv2026

CT Synthesis with Conditional Diffusion Models for Abdominal Lymph Node Segmentation

Despite the significant success achieved by deep learning methods in medical image segmentation, researchers still struggle in the computer-aided diagnosis of abdominal lymph nodes due to the complex abdominal environment, small and indistinguishable lesions, and limited annotated data. To address these problems, we present a pipeline that integrates the conditional diffusion model for lymph node generation and the nnU-Net model for lymph node segmentation to improve the segmentation performance of abdominal lymph nodes through synthesizing a diversity of realistic abdominal lymph node data. We propose LN-DDPM, a conditional denoising diffusion probabilistic model (DDPM) for lymph node (LN) generation. LN-DDPM utilizes lymph node masks and anatomical structure masks as model conditions. These conditions work in two conditioning mechanisms: global structure conditioning and local detail conditioning, to distinguish between lymph nodes and their surroundings and better capture lymph node characteristics. The obtained paired abdominal lymph node images and masks are used for the downstream segmentation task. Experimental results on the abdominal lymph node datasets demonstrate that LN-DDPM outperforms other generative methods in the abdominal lymph node image synthesis and better assists the downstream abdominal lymph node segmentation task.

eess.IV↗

arXiv2026

Optically locked low-noise photonic microwave oscillator

The next-generation sensing and communication applications rely on high-frequency microwave generation with low-noise. The microwave photonic technology is promising by the practical application is limited by its complex architecture so far. Here, we demonstrate an optically locked low-noise photonic microwave oscillator, so that all the optical components are packaged within a small module of 166 mL, and low noise microwave generation is achieved at 10.4 GHz with single-sideband phase noise of -54 dBc/Hz at 10 Hz, -141 dBc/Hz at 10 kHz, and -162 dBc/Hz at 10 MHz offset. Above performance arises from a dual-laser self-injection-locking scheme to a single Fabry-Perot cavity with high Q exceeding 10^8, with over 20 dB common-mode noise suppression. The low-noise nature of such reference is coherently transferred to the X-band through a high-performance TFLN electro-optic comb chip, thereby overcoming long-standing barriers in photonic microwave integration to enable truly field-deployable low-noise microwave generation.

physics.optics↗

arXiv2026

EHRWorld: A Patient-Centric Medical World Model for Long-Horizon Clinical Trajectories

World models offer a principled framework for simulating future states under interventions, but realizing such models in complex, high-stakes domains like medicine remains challenging. Recent large language models (LLMs) have achieved strong performance on static medical reasoning tasks, raising the question of whether they can function as dynamic medical world models capable of simulating disease progression and treatment outcomes over time. In this work, we show that LLMs only incorporating medical knowledge struggle to maintain consistent patient states under sequential interventions, leading to error accumulation in long-horizon clinical simulation. To address this limitation, we introduce EHRWorld, a patient-centric medical world model trained under a causal sequential paradigm, together with EHRWorld-110K, a large-scale longitudinal clinical dataset derived from real-world electronic health records. Extensive evaluations demonstrate that EHRWorld significantly outperforms naive LLM-based baselines, achieving more stable long-horizon simulation, improved modeling of clinically sensitive events, and favorable reasoning efficiency, highlighting the necessity of training on causally grounded, temporally evolving clinical data for reliable and robust medical world modeling.

cs.AI↗

arXiv2026

Concepts from Representations: Post-hoc Concept Bottleneck Models via Sparse Decomposition of Visual Representations

Deep learning has achieved remarkable success in image recognition, yet their inherent opacity poses challenges for deployment in critical domains. Concept-based interpretations aim to address this by explaining model reasoning through human-understandable concepts. However, existing post-hoc methods and ante-hoc concept bottleneck models (CBMs), suffer from limitations such as unreliable concept relevance, non-visual or labor-intensive concept definitions, and model or data-agnostic assumptions. This paper introduces Post-hoc Concept Bottleneck Model via Representation Decomposition (PCBM-ReD), a novel pipeline that retrofits interpretability onto pretrained opaque models. PCBM-ReD automatically extracts visual concepts from a pre-trained encoder, employs multimodal large language models (MLLMs) to label and filter concepts based on visual identifiability and task relevance, and selects an independent subset via reconstruction-guided optimization. Leveraging CLIP's visual-text alignment, it decomposes image representations into linear combination of concept embeddings to fit into the CBMs abstraction. Extensive experiments across 11 image classification tasks show PCBM-ReD achieves state-of-the-art accuracy, narrows the performance gap with end-to-end models, and exhibits better interpretability.

cs.CV↗

arXiv2025

PathFound: An Agentic Multimodal Model Activating Evidence-seeking Pathological Diagnosis

Recent pathological foundation models have substantially advanced visual representation learning and multimodal interaction. However, most models still rely on a static inference paradigm in which whole-slide images are processed once to produce predictions, without reassessment or targeted evidence acquisition under ambiguous diagnoses. This contrasts with clinical diagnostic workflows that refine hypotheses through repeated slide observations and further examination requests. We propose PathFound, an agentic multimodal model designed to support evidence-seeking inference in pathological diagnosis. PathFound integrates the power of pathological visual foundation models, vision-language models, and reasoning models trained with reinforcement learning to perform proactive information acquisition and diagnosis refinement by progressing through the initial diagnosis, evidence-seeking, and final decision stages. Across several large multimodal models, adopting this strategy consistently improves diagnostic accuracy, indicating the effectiveness of evidence-seeking workflows in computational pathology. Among these models, PathFound achieves state-of-the-art diagnostic performance across diverse clinical scenarios and demonstrates strong potential to discover subtle details, such as nuclear features and local invasions.

cs.CV↗

arXiv2025

MedCEG: Reinforcing Verifiable Medical Reasoning with Critical Evidence Graph

Large language models with reasoning capabilities have demonstrated impressive performance across a wide range of domains. In clinical applications, a transparent, step-by-step reasoning process provides physicians with strong evidence to support decision-making. While reinforcement learning has effectively enhanced reasoning performance in medical contexts, the clinical reliability of these reasoning processes remains limited because their accuracy and validity are often overlooked during training. To address this gap, we propose MedCEG, a framework that augments medical language models with clinically valid reasoning pathways by explicitly supervising the reasoning process through a Critical Evidence Graph (CEG). We curate a dataset of challenging clinical cases and algorithmically construct a CEG for each sample to represent a high-quality verifiable reasoning pathway. To guide the reasoning process, we introduce a Clinical Reasoning Procedure Reward, which evaluates Node Coverage, Structural Correctness, and Chain Completeness, thereby providing a holistic assessment of reasoning quality. Experimental results show that MedCEG surpasses existing methods in performance while producing clinically valid reasoning chains, representing a solid advancement in reliable medical AI reasoning. The code and models are available at https://github.com/LinjieMu/MedCEG.

cs.AI↗

arXiv2025

CP-Env: Evaluating Large Language Models on Clinical Pathways in a Controllable Hospital Environment

Medical care follows complex clinical pathways that extend beyond isolated physician-patient encounters, emphasizing decision-making and transitions between different stages. Current benchmarks focusing on static exams or isolated dialogues inadequately evaluate large language models (LLMs) in dynamic clinical scenarios. We introduce CP-Env, a controllable agentic hospital environment designed to evaluate LLMs across end-to-end clinical pathways. CP-Env simulates a hospital ecosystem with patient and physician agents, constructing scenarios ranging from triage and specialist consultation to diagnostic testing and multidisciplinary team meetings for agent interaction. Following real hospital adaptive flow of healthcare, it enables branching, long-horizon task execution. We propose a three-tiered evaluation framework encompassing Clinical Efficacy, Process Competency, and Professional Ethics. Results reveal that most models struggle with pathway complexity, exhibiting hallucinations and losing critical diagnostic details. Interestingly, excessive reasoning steps can sometimes prove counterproductive, while top models tend to exhibit reduced tool dependency through internalized knowledge. CP-Env advances medical AI agents development through comprehensive end-to-end clinical evaluation. We provide the benchmark and evaluation tools for further research and development at https://github.com/SPIRAL-MED/CP_ENV.

cs.AI↗

arXiv2025

MedDiff-FM: A Diffusion-based Foundation Model for Versatile Medical Image Applications

Diffusion models have achieved significant success in both natural image and medical image domains, encompassing a wide range of applications. Previous investigations in medical images have often been constrained to specific anatomical regions, particular applications, and limited datasets, resulting in isolated diffusion models. This paper introduces a diffusion-based foundation model to address a diverse range of medical image tasks, namely MedDiff-FM. MedDiff-FM leverages 3D CT images from multiple publicly available datasets, covering anatomical regions from head to abdomen, to pre-train a diffusion foundation model, and explores the capabilities of the diffusion foundation model across a variety of application scenarios. The diffusion foundation model handles multi-level integrated image processing both at the image-level and patch-level, utilizes position embedding to establish multi-level spatial relationships, and leverages region classes and anatomical structures to capture certain anatomical regions. MedDiff-FM manages several downstream tasks seamlessly, including image denoising, anomaly detection, and image synthesis. MedDiff-FM is also capable of performing super-resolution, lesion generation, and lesion inpainting by rapidly fine-tuning the diffusion foundation model using ControlNet with task-specific conditions. The experimental results demonstrate the effectiveness of MedDiff-FM in addressing diverse downstream medical image tasks.

cs.CV↗

arXiv2025

UCAgents: Unidirectional Convergence for Visual Evidence Anchored Multi-Agent Medical Decision-Making

Vision-Language Models (VLMs) show promise in medical diagnosis, yet suffer from reasoning detachment, where linguistically fluent explanations drift from verifiable image evidence, undermining clinical trust. Recent multi-agent frameworks simulate Multidisciplinary Team (MDT) debates to mitigate single-model bias, but open-ended discussions amplify textual noise and computational cost while failing to anchor reasoning to visual evidence, the cornerstone of medical decision-making. We propose UCAgents, a hierarchical multi-agent framework enforcing unidirectional convergence through structured evidence auditing. Inspired by clinical workflows, UCAgents forbids position changes and limits agent interactions to targeted evidence verification, suppressing rhetorical drift while amplifying visual signal extraction. In UCAgents, a one-round inquiry discussion is introduced to uncover potential risks of visual-textual misalignment. This design jointly constrains visual ambiguity and textual noise, a dual-noise bottleneck that we formalize via information theory. Extensive experiments on four medical VQA benchmarks show UCAgents achieves superior accuracy (71.3% on PathVQA, +6.0% over state-of-the-art) with 87.7% lower token cost, the evaluation results further confirm that UCAgents strikes a balance between uncovering more visual evidence and avoiding confusing textual interference. These results demonstrate that UCAgents exhibits both diagnostic reliability and computational efficiency critical for real-world clinical deployment. Code is available at https://github.com/fqhank/UCAgents.

cs.CV↗

arXiv2025

GuideGen: A Text-Guided Framework for Paired Full-torso Anatomy and CT Volume Generation

The recently emerging conditional diffusion models seem promising for mitigating the labor and expenses in building large 3D medical imaging datasets. However, previous studies on 3D CT generation primarily focus on specific organs characterized by a local structure and fixed contrast and have yet to fully capitalize on the benefits of both semantic and textual conditions. In this paper, we present GuideGen, a controllable framework based on easily-acquired text prompts to generate anatomical masks and corresponding CT volumes for the entire torso-from chest to pelvis. Our approach includes three core components: a text-conditional semantic synthesizer for creating realistic full-torso anatomies; an anatomy-aware high-dynamic-range (HDR) autoencoder for high-fidelity feature extraction across varying intensity levels; and a latent feature generator that ensures alignment between CT images, anatomical semantics and input prompts. Combined, these components enable data synthesis for segmentation tasks from only textual instructions. To train and evaluate GuideGen, we compile a multi-modality cancer imaging dataset with paired CT and clinical descriptions from 12 public TCIA datasets and one private real-world dataset. Comprehensive evaluations across generation quality, cross-modality alignment, and data usability on multi-organ and tumor segmentation tasks demonstrate GuideGen's superiority over existing CT generation methods. Relevant materials are available at https://github.com/OvO1111/GuideGen.

eess.IV↗

arXiv2025

Echo-N1: Affective RL Frontier

The LLM field has spent a year perfecting RL for tasks machines already excel at, math, code, and deterministic reasoning, while completely sidestepping the domain that actually defines human intelligence: subjective, emotionally grounded, personality sensitive conversation. This space has often been regarded as inherently subjective and challenging to formalize, making it appear unsuitable for conventional RL pipelines. We show that it is not only possible and it is a solvable and transformative RL problem. We propose the first framework that infers user personality on the fly and optimizes model behavior toward personalized conversational preferences. Contrary to the widespread belief that RL collapses in non-verifiable settings, our method produces consistent, robust, and dramatic improvements in humanlike interaction quality. We also introduce the first dynamic emotional intelligence evaluation suite to quantify these gains. Our model, which is introduced as Echo-N1, behaves far above its base version and outperforming the proprietary Doubao 1.5 Character. This work establishes a new frontier for RL: optimizing models for the deeply subjective, deeply human dimensions of conversation.

cs.AI↗

arXiv2025

QDM: Quadtree-Based Region-Adaptive Sparse Diffusion Models for Efficient Image Super-Resolution

Deep learning-based super-resolution (SR) methods often perform pixel-wise computations uniformly across entire images, even in homogeneous regions where high-resolution refinement is redundant. We propose the Quadtree Diffusion Model (QDM), a region-adaptive diffusion framework that leverages a quadtree structure to selectively enhance detail-rich regions while reducing computations in homogeneous areas. By guiding the diffusion with a quadtree derived from the low-quality input, QDM identifies key regions-represented by leaf nodes-where fine detail is essential and applies minimal refinement elsewhere. This mask-guided, two-stream architecture adaptively balances quality and efficiency, producing high-fidelity outputs with low computational redundancy. Experiments demonstrate QDM's effectiveness in high-resolution SR tasks across diverse image types, particularly in medical imaging (e.g., CT scans), where large homogeneous regions are prevalent. Furthermore, QDM outperforms or is comparable to state-of-the-art SR methods on standard benchmarks while significantly reducing computational costs, highlighting its efficiency and suitability for resource-limited environments. Our code is available at https://github.com/linYDTHU/QDM.

cs.CV↗

arXiv2025

ASAP: an Agentic Solution to Auto-optimize Performance of Large-Scale LLM Training

Optimizing large-language model (LLM) training on distributed domain-specific accelerator systems presents significant challenges due to its complex optimization space. Existing optimization methods, however, rely on time-consuming manual tuning or resource-intensive black-box searches, which struggle to keep pace with the rapidly evolving LLM domain, leading to slow development and underutilized resources. To address this, we introduce ASAP, an Agentic Solution to Auto-optimize Performance of Large-Scale LLM Training. It is a multi-agent system, featuring Coordinator, Analyzer, and Proposal agents, which integrates LLM reasoning with insights from performance profiling tools, roofline analysis, and a knowledge base of best practices and successful past optimizations from human experts. Our proposed design can automate the diagnosis of performance bottlenecks and recommend optimized sharding configurations with reasoning, thus effectively improving the efficiency of distributed LLM training. Experiments have shown that the ASAP-generated sharding configurations can contribute up to 28% training step time reduction and 1.43 times throughput improvement. When combined with additional optimization from human experts, throughput can be further increased to 2.58 times. The proposed ASAP promises to provide a scalable and explainable methodology for AI-assisted performance engineering in large-scale LLM training.

cs.MA↗

arXiv2025

Elicit and Enhance: Advancing Multimodal Reasoning in Medical Scenarios

Effective clinical decision-making depends on iterative, multimodal reasoning across diverse sources of evidence. The recent emergence of multimodal reasoning models has significantly transformed the landscape of solving complex tasks. Although such models have achieved notable success in mathematics and science, their application to medical domains remains underexplored. In this work, we propose \textit{MedE$^2$}, a two-stage post-training pipeline that elicits and then enhances multimodal reasoning for medical domains. In Stage-I, we fine-tune models using 2,000 text-only data samples containing precisely orchestrated reasoning demonstrations to elicit reasoning behaviors. In Stage-II, we further enhance the model's reasoning capabilities using 1,500 rigorously curated multimodal medical cases, aligning model reasoning outputs with our proposed multimodal medical reasoning preference. Extensive experiments demonstrate the efficacy and reliability of \textit{MedE$^2$} in improving the reasoning performance of medical multimodal models. Notably, models trained with \textit{MedE$^2$} consistently outperform baselines across multiple medical multimodal benchmarks. Additional validation on larger models and under inference-time scaling further confirms the robustness and practical utility of our approach.

cs.CL↗

arXiv2025

Towards Generalist Intelligence in Dentistry: Vision Foundation Models for Oral and Maxillofacial Radiology

Oral and maxillofacial radiology plays a vital role in dental healthcare, but radiographic image interpretation is limited by a shortage of trained professionals. While AI approaches have shown promise, existing dental AI systems are restricted by their single-modality focus, task-specific design, and reliance on costly labeled data, hindering their generalization across diverse clinical scenarios. To address these challenges, we introduce DentVFM, the first family of vision foundation models (VFMs) designed for dentistry. DentVFM generates task-agnostic visual representations for a wide range of dental applications and uses self-supervised learning on DentVista, a large curated dental imaging dataset with approximately 1.6 million multi-modal radiographic images from various medical centers. DentVFM includes 2D and 3D variants based on the Vision Transformer (ViT) architecture. To address gaps in dental intelligence assessment and benchmarks, we introduce DentBench, a comprehensive benchmark covering eight dental subspecialties, more diseases, imaging modalities, and a wide geographical distribution. DentVFM shows impressive generalist intelligence, demonstrating robust generalization to diverse dental tasks, such as disease diagnosis, treatment analysis, biomarker identification, and anatomical landmark detection and segmentation. Experimental results indicate DentVFM significantly outperforms supervised, self-supervised, and weakly supervised baselines, offering superior generalization, label efficiency, and scalability. Additionally, DentVFM enables cross-modality diagnostics, providing more reliable results than experienced dentists in situations where conventional imaging is unavailable. DentVFM sets a new paradigm for dental AI, offering a scalable, adaptable, and label-efficient model to improve intelligent dental healthcare and address critical gaps in global oral healthcare.

cs.CV↗

arXiv2025

Rethinking RoPE Scaling in Quantized LLM: Theory, Outlier, and Channel-Band Analysis with Weight Rescaling

Extending the context window support of large language models (LLMs) is crucial for tasks with long-distance dependencies. RoPE-based interpolation and extrapolation methods, such as linear scaling and frequency-aware schemes, enable longer input length support without retraining, while post-training quantization (PTQ) makes deployment practical. However, we show that combining RoPE position interpolation (PI) with PTQ degrades accuracy due to coupled effects including long-context aliasing, dynamic-range dilation, anisotropy from axis-aligned quantizers vs. rotated RoPE pairs, and outlier shifting that produces position-dependent logit noise. We provide, to the best of our knowledge, the first systematic analysis of the PI+PTQ approach and introduce two practical diagnostics: interpolation pressure (per-band sensitivity to phase scaling) and tail-inflation ratios (outlier shift from short to long contexts). Following the analysis results, we propose Q-ROAR (Quantization, RoPE-interpolation, and Outlier Aware Rescaling), a weight-only, interpolation-aware stabilization of PI for quantized LLMs. Q-ROAR groups RoPE dimensions into a small number of frequency bands and performs a lightweight search over per-band scales for Key and Query weights (with an optional symmetric variant to preserve logit scale). The search is guided by our diagnostics and uses a tiny long-context development dataset, requiring no fine-tuning to the model, no architecture or kernel changes, and no additional deployment overhead. Empirically, Q-ROAR reduces the model's perplexity on long-context workloads by more than 14%, while preserving short-context performance, inference throughput, and compatibility with existing LLM system stacks.

cs.LG↗

arXiv2025

Reconfigurable Stream Network Architecture

As AI systems grow increasingly specialized and complex, managing hardware heterogeneity becomes a pressing challenge. How can we efficiently coordinate and synchronize heterogeneous hardware resources to achieve high utilization? How can we minimize the friction of transitioning between diverse computation phases, reducing costly stalls from initialization, pipeline setup, or drain? Our insight is that a network abstraction at the ISA level naturally unifies heterogeneous resource orchestration and phase transitions. This paper presents a Reconfigurable Stream Network Architecture (RSN), a novel ISA abstraction designed for the DNN domain. RSN models the datapath as a circuit-switched network with stateful functional units as nodes and data streaming on the edges. Programming a computation corresponds to triggering a path. Software is explicitly exposed to the compute and communication latency of each functional unit, enabling precise control over data movement for optimizations such as compute-communication overlap and layer fusion. As nodes in a network naturally differ, the RSN abstraction can efficiently virtualize heterogeneous hardware resources by separating control from the data plane, enabling low instruction-level intervention. We build a proof-of-concept design RSN-XNN on VCK190, a heterogeneous platform with FPGA fabric and AI engines. Compared to the SOTA solution on this platform, it reduces latency by 6.1x and improves throughput by 2.4x-3.2x. Compared to the T4 GPU with the same FP32 performance, it matches latency with only 18% of the memory bandwidth. Compared to the A100 GPU at the same 7nm process node, it achieves 2.1x higher energy efficiency in FP32.

cs.AR↗