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Xiaofeng Yang

Publications and source records attributed to Xiaofeng Yang.

At least 37 records · Page 2Linked to original sources
arXiv2026

A Digital Twin Framework for Adaptive Treatment Planning in Radiotherapy

The development of a digital twin (DT) framework for fast online adaptive proton therapy planning in prostate stereotactic body radiation therapy (SBRT) with dominant intraprostatic lesion (DIL) boost represents a significant advancement in personalized radiotherapy. This framework integrates deep learning-based multi-atlas deformable image registration, daily patient anatomy updates via cone-beam CT (CBCT), and knowledge-based plan quality evaluation using the ProKnow scoring system to achieve clinical-equivalent plan quality with substantially reduced reoptimization times compared to traditional clinical workflows. Drawing on a database of 43 prior prostate SBRT cases, the DT framework predicts interfractional anatomical variations for new patients and pre-generates multiple probabilistic treatment plans. Upon acquiring daily CBCT, it enables rapid plan reoptimization, achieving an average reoptimization time of 5.5 [2.8, 8.2] minutes, compared to 19.8 [7.9, 31.7] minutes for clinical plans. The DT-based plans yielded a plan quality score of 157.2 [151.6, 162.8], surpassing or matching clinical plans, with superior dose coverage for the DIL (V100: 99.5%) and clinical target volume (CTV V100: 99.8%). Additionally, the framework minimized doses to organs at risk (OARs), achieving bladder V20.8Gy of 11.4 [7.2, 15.6] cc, rectum V23Gy of 0.7 [0.3, 1.1] cc, and urethra D10 of 90.9% [88.6%, 93.2%], aligning with clinical standards. By addressing interfractional variations efficiently, the DT framework enhances treatment precision, reduces OAR toxicity, and supports real-time adaptive radiotherapy. This transformative approach not only streamlines the planning process but also improves clinical outcomes, offering a scalable solution for prostate SBRT with DIL boost and paving the way for broader applications in adaptive proton therapy.

physics.med-ph↗
arXiv2026

Testing Cosmic Distance Duality Relation and Transparency with DESI DR2

The Cosmic Distance Duality Relation (CDDR) is a fundamental principle of standard cosmology, linking luminosity (LD) and angular diameter distances (ADD). This work investigates the validity of the CDDR and cosmic transparency by combining the latest Baryon Acoustic Oscillations (BAO) data from DESI DR2, Type Ia Supernovae from Pantheon+, and cosmic chronometers. To address the redshift mismatch between datasets, two distinct reconstruction techniques are employed: Gaussian Process Regression (GPR) and the Free-Knots Method (FKM). The analysis performs null tests on the CDDR under different cosmological priors, finding that the null hypothesis holds and the CDDR is valid within statistical uncertainties. Although mild deviations are observed from the local distance ladder prior, internal consistency calibration indicates that these discrepancies and the Hubble tension may share a common origin, possibly related to systematic effects or new physics. Using multiple phenomenological parameterizations, the deviation parameter is also found to be statistically consistent with zero (e.g., $η_1 = 0.023 \pm 0.027$ for the linear model under Planck priors). Furthermore, the study finds no statistically significant evidence for cosmic opacity. The average of the opacity derivative is compatible with zero ($\langle dτ/dz \rangle = 0.0409 \pm 0.1024$ for GPR and $0.0730 \pm 0.1607$ for FKM). Based on these null results, stringent constraints are placed on the parameter space of Axion-Like Particles (ALPs) and Mini-Charged Particles (MCPs).

astro-ph.CO↗
arXiv2026

Reconstructing Barrow Holographic Dark Energy in $f(Q,T)$ Gravity and Cosmic Constraint

In this work, we reconstruct the cosmological evolution of Barrow Holographic Dark Energy (BHDE) within the framework of modified gravity $f(Q,T)$. Working in the coincident gauge, we incorporate the holographic principle into non-metric gravity with non-minimal matter coupling. To address the dynamical complexity, we adopt a reconstruction approach, deriving the matter density evolution from the modified field equations rather than imposing a conserved fluid a priori. We perform parameter estimation using the latest observational data, including Type Ia supernovae, BAO, and direct Hubble parameter measurements. Our results show that the model provides a theoretical framework to describe late-time cosmic evolution and the universe's accelerated expansion. Despite the additional complexity introduced, the model offers an alternative approach for investigating dark energy within modified gravity theories.

astro-ph.CO↗
arXiv2026

Holographic dark energy in a coasting cosmology

Coasting cosmology offers an intriguing and straightforward framework for understanding the universe. In this work, we employ the Trans-Planckian Censorship Criterion (TCC) conjecture to test the viability of the coasting cosmology and propose an entropic dark energy (EDE) model within this framework. By applying the holographic principle to constrain the dark energy density and adopting the Bekenstein entropy and Tsallis entropy as the constraining entropies of the system, we find that, in a holographic coasting cosmological framework where dark energy and dark matter evolve independently, the Tsallis entropy satisfies certain general assumptions better than the Bekenstein entropy. Thus, there may be a fundamental relationship between Tsallis entropy and dark energy. We utilize observational data from Type Ia Supernovae (SNIa), Baryon Acoustic Oscillations (BAO), and Cosmic Chronometers (CC) to constrain EDE model. The optimal Tsallis parameter obtained aligns well with theoretical expectations. To evaluate the model's fit to the observed data, we calculate the Akaike Information Criterion (AIC), Bayesian Information Criterion (BIC), and Kullback Information Criterion (KIC), and compare these metrics with those derived from $Λ$CDM, under which the model shows some improvement. Overall, this model provides a novel and simple on the evolution of the universe.

astro-ph.CO↗
arXiv2026

Testing the cosmological principle with quasars

The inferred velocity is consistent at the 1.56 σ level with the value of 370 km/s from a purely kinematic interpretation of the CMB dipole. Based on the motion direction component analysis, we have not found any significant deviation from cosmological principle in current released quasars data. The cosmological principle posits that the universe is homogeneous and isotropic on the large scales. In history, the cosmological principle was confirmed by various cosmological observations from CMB to large scale structure. However, several new challenges to the cosmological principle were reported in recent years, particularly in radio observations from overdispersed radio source counts to quasars. Here, we firstly present studies on the peculiar velocity of large-scale anisotropy by measuring the dipole signal from the DESI DR1 catalogue with a sample of 1,176,570 quasars (0.8 < z < 3.0). Our analysis reveals the peculiar velocity of $|v| = 443.8 \pm 204.1$ km/s towards $(l, b) = (107.4^\circ \pm 86.8^\circ, 28.4^\circ \pm 45.2^\circ)$ in Galactic coordinates.The motion direction deviates from the CMB dipole (264.02$^\circ$, 48.253$^\circ$). The inferred velocity is consistent at the 1.56 $σ$ level with the value of 370 km/s from a purely kinematic interpretation of the CMB dipole. Based on the motion direction component analysis, we have not found any significant deviation from cosmological principle in current released quasars data.

astro-ph.CO↗
arXiv2026

Explainable Cross-Disease Reasoning for Cardiovascular Risk Assessment from Low-Dose Computed Tomography

Low-dose chest computed tomography (LDCT) captures pulmonary and cardiac structures in a single scan, enabling joint assessment of lung and cardiovascular health. Existing approaches typically model these domains independently and do not explicitly represent their physiological interactions. We propose an Explainable Cross-Disease Reasoning Framework for cardiovascular risk assessment from LDCT. The framework follows a constrained clinical-information pathway: it extracts pulmonary findings, grounds cross-organ mechanisms in medical knowledge, and produces a cardiovascular prediction with a natural-language rationale. It combines four components: a frozen lung-risk prior, a pulmonary perception module, an agentic reasoning module, and a cardiac subvolume feature extractor. Their outputs are fused to integrate localized cardiac evidence with mechanism-level pulmonary context. On the National Lung Screening Trial cohort, the framework achieves an AUC of 0.919 for CVD screening and up to 0.838 for CVD mortality prediction, outperforming cardiac-specific, single-disease, and foundation-model baselines. Targeted controls indicate that the gains are not explained by additional thoracic visual features alone, fixed rule propagation, or a single reasoning backend. The proposed framework thus provides an auditable approach to cross-disease cardiovascular risk assessment from LDCT.

cs.CV↗
arXiv2026

Universal CT Representations from Anatomy to Disease Phenotype through Agglomerative Pretraining

Computed tomography (CT) is a central to three-dimensional medical imaging, yet CT-based artificial intelligence remains fragmented across task-specific models for segmentation, classification, registration, and report analysis. Here we present FlexiCT, a family of CT foundation models trained by agglomerative continual pretraining on 266,227 CT volumes from 56 publicly available datasets, forming a large-scale public resource for CT representation learning. FlexiCT uses agglomerative pretraining across three stages: two-dimensional axial pretraining, three-dimensional anatomical pretraining and report-guided semantic alignment. This training strategy supports slice-level, volume-level and vision-language analysis. Across five downstream task families (segmentation, classification, registration, vision-language understanding and clinical retrieval), FlexiCT matches or exceeds prior task-specific approaches on multiple benchmarks. Its embeddings further organize CT scans along gradients associated with various tumor stages, suggesting that CT foundation models can capture imaging features relevant to disease phenotype characterization. Project page and code are available at: https://ricklisz.github.io/flexict.github.io and https://github.com/ricklisz/FlexiCT.

cs.CV↗
arXiv2026

Are Video Models Emerging as Zero-Shot Learners and Reasoners in Medical Imaging?

Recent advances in large generative models have shown that simple autoregressive formulations, when scaled appropriately, can exhibit strong zero-shot generalization across domains. Motivated by this trend, we investigate whether autoregressive video modeling principles can be directly applied to medical imaging tasks, despite the model never being trained on medical data. Specifically, we evaluate a large vision model (LVM) in a zero-shot setting across four representative tasks: organ segmentation, denoising, super-resolution, and motion prediction. Remarkably, even without domain-specific fine-tuning, the LVM can delineate anatomical structures in CT scans and achieve competitive performance on segmentation, denoising, and super-resolution. Most notably, in radiotherapy motion prediction, the model forecasts future 3D CT phases directly from prior phases of a 4D CT scan, producing anatomically consistent predictions that capture patient-specific respiratory dynamics with realistic temporal coherence. We evaluate the LVM on 4D CT data from 122 patients, totaling over 1,820 3D CT volumes. Despite no prior exposure to medical data, the model achieves strong performance across all tasks and surpasses specialized DVF-based and generative baselines in motion prediction, achieving state-of-the-art spatial accuracy. These findings reveal the emergence of zero-shot capabilities in medical video modeling and highlight the potential of general-purpose video models to serve as unified learners and reasoners laying the groundwork for future medical foundation models built on video models.

cs.CV↗
arXiv2026

Distilling Photon-Counting CT into Routine Chest CT through Clinically Validated Degradation Modeling

Photon-counting CT (PCCT) provides superior image quality with higher spatial resolution and lower noise compared to conventional energy-integrating CT (EICT), but its limited clinical availability restricts large-scale research and clinical deployment. To bridge this gap, we propose SUMI, a simulated degradation-to-enhancement method that learns to reverse realistic acquisition artifacts in low-quality EICT by leveraging high-quality PCCT as reference. Our central insight is to explicitly model realistic acquisition degradations, transforming PCCT into clinically plausible lower-quality counterparts and learning to invert this process. The simulated degradations were validated for clinical realism by board-certified radiologists, enabling faithful supervision without requiring paired acquisitions at scale. As outcomes of this technical contribution, we: (1) train a latent diffusion model on 1,046 PCCTs, using an autoencoder first pre-trained on both these PCCTs and 405,379 EICTs from 145 hospitals to extract general CT latent features that we release for reuse in other generative medical imaging tasks; (2) construct a large-scale dataset of over 17,316 publicly available EICTs enhanced to PCCT-like quality, with radiologist-validated voxel-wise annotations of airway trees, arteries, veins, lungs, and lobes; and (3) demonstrate substantial improvements: across external data, SUMI outperforms state-of-the-art image translation methods by 15% in SSIM and 20% in PSNR, improves radiologist-rated clinical utility in reader studies, and enhances downstream top-ranking lesion detection performance, increasing sensitivity by up to 15% and F1 score by up to 10%. Our results suggest that emerging imaging advances can be systematically distilled into routine EICT using limited high-quality scans as reference.

cs.CV↗
arXiv2026

Efficient Vision Mamba for MRI Super-Resolution via Hybrid Selective Scanning

Background: High-resolution MRI is critical for diagnosis, but long acquisition times limit clinical use. Super-resolution (SR) can enhance resolution post-scan, yet existing deep learning methods face fidelity-efficiency trade-offs. Purpose: To develop a computationally efficient and accurate deep learning framework for MRI SR that preserves anatomical detail for clinical integration. Materials and Methods: We propose a novel SR framework combining multi-head selective state-space models (MHSSM) with a lightweight channel MLP. The model uses 2D patch extraction with hybrid scanning to capture long-range dependencies. Each MambaFormer block integrates MHSSM, depthwise convolutions, and gated channel mixing. Evaluation used 7T brain T1 MP2RAGE maps (n=142) and 1.5T prostate T2w MRI (n=334). Comparisons included Bicubic interpolation, GANs (CycleGAN, Pix2pix, SPSR), transformers (SwinIR), Mamba (MambaIR), and diffusion models (I2SB, Res-SRDiff). Results: Our model achieved superior performance with exceptional efficiency. For 7T brain data: SSIM=0.951+-0.021, PSNR=26.90+-1.41 dB, LPIPS=0.076+-0.022, GMSD=0.083+-0.017, significantly outperforming all baselines (p<0.001). For prostate data: SSIM=0.770+-0.049, PSNR=27.15+-2.19 dB, LPIPS=0.190+-0.095, GMSD=0.087+-0.013. The framework used only 0.9M parameters and 57 GFLOPs, reducing parameters by 99.8% and computation by 97.5% versus Res-SRDiff, while outperforming SwinIR and MambaIR in accuracy and efficiency. Conclusion: The proposed framework provides an efficient, accurate MRI SR solution, delivering enhanced anatomical detail across datasets. Its low computational demand and state-of-the-art performance show strong potential for clinical translation.

cs.CV↗
arXiv2026

CBCT-Based Synthetic CT Generation Using Conditional Flow Matching Model

Daily or weekly cone-beam computed tomography (CBCT) is employed in image-guided radiotherapy (IGRT) for precise patient alignment. However, its clinical utility in quantitative tasks is hindered by severe artifacts and inaccurate Hounsfeld unit (HU). It is essential to enhance CBCT image quality to a level comparable with that of conventional CT scans. This study proposed a conditional flow matching model that gradually transforms a sample from normal distribution to the corresponding CT sample conditioned on the input CBCT image. The proposed model was trained using CBCT and deformed planning CT (dpCT) image pairs in a supervised learning scheme. The feasibility of the conditional flow matching model was verified using studies of brain, head-and-neck (HN), and lung patients. The quantitative performance was evaluated using three metrics, including mean absolute error (MAE), peak signal-to-noise ratio (PSNR), and normalized cross-correlation (NCC). The proposed flow matching model was also compared to other flow matching and diffusion-based generative models for sCT generation. The proposed flow matching model effectively reduced multiple types of artifacts on CBCT images in all the studies. In the study of brain patient, the MAE, PSNR, and NCC of the sCT were improved to 26.02 HU, 32.35 dB, and 0.99, respectively, from 40.63 HU, 27.87 dB, and 0.98 on the CBCT images. In the study of HN patient, the metrics were improved to 33.17 HU, 28.68 dB, 0.98 from 38.99 HU, 27.00 dB, 0.98. In the lung patient study, the metrics were 25.09 HU, 32.81 dB, 0.99 and 32.90 HU, 30.48 dB, 0.98 for sCT and CBCT, respectively. The proposed conditional flow matching model effectively synthesizes high-quality CT-like images from CBCT, achieving accurate HU representation and artifact reduction. This enables more reliable organ segmentation and dose calculation in CBCT-guided online ART workflows.

physics.med-ph↗
arXiv2026

Evaluating GPT-5 as a Multimodal Clinical Reasoner: A Landscape Commentary

The transition from task-specific artificial intelligence toward general-purpose foundation models raises fundamental questions about their capacity to support the integrated reasoning required in clinical medicine, where diagnosis demands synthesis of ambiguous patient narratives, laboratory data, and multimodal imaging. This landscape commentary provides the first controlled, cross-sectional evaluation of the GPT-5 family (GPT-5, GPT-5 Mini, GPT-5 Nano) against its predecessor GPT-4o across a diverse spectrum of clinically grounded tasks, including medical education examinations, text-based reasoning benchmarks, and visual question-answering in neuroradiology, digital pathology, and mammography using a standardized zero-shot chain-of-thought protocol. GPT-5 demonstrated substantial gains in expert-level textual reasoning, with absolute improvements exceeding 25 percentage-points on MedXpertQA. When tasked with multimodal synthesis, GPT-5 effectively leveraged this enhanced reasoning capacity to ground uncertain clinical narratives in concrete imaging evidence, achieving state-of-the-art or competitive performance across most VQA benchmarks and outperforming GPT-4o by margins of 10-40% in mammography tasks requiring fine-grained lesion characterization. However, performance remained moderate in neuroradiology (44% macro-average accuracy) and lagged behind domain-specific models in mammography, where specialized systems exceed 80% accuracy compared to GPT-5's 52-64%. These findings indicate that while GPT-5 represents a meaningful advance toward integrated multimodal clinical reasoning, mirroring the clinician's cognitive process of biasing uncertain information with objective findings, generalist models are not yet substitutes for purpose-built systems in highly specialized, perception-critical tasks.

cs.CV↗
arXiv2026

IPEC: Test-Time Incremental Prototype Enhancement Classifier for Few-Shot Learning

Metric-based few-shot approaches have gained significant popularity due to their relatively straightforward implementation, high interpret ability, and computational efficiency. However, stemming from the batch-independence assumption during testing, which prevents the model from leveraging valuable knowledge accumulated from previous batches. To address these challenges, we propose a novel test-time method called Incremental Prototype Enhancement Classifier (IPEC), a test-time method that optimizes prototype estimation by leveraging information from previous query samples. IPEC maintains a dynamic auxiliary set by selectively incorporating query samples that are classified with high confidence. To ensure sample quality, we design a robust dual-filtering mechanism that assesses each query sample based on both global prediction confidence and local discriminative ability. By aggregating this auxiliary set with the support set in subsequent tasks, IPEC builds progressively more stable and representative prototypes, effectively reducing its reliance on the initial support set. We ground this approach in a Bayesian interpretation, conceptualizing the support set as a prior and the auxiliary set as a data-driven posterior, which in turn motivates the design of a practical "warm-up and test" two-stage inference protocol. Extensive empirical results validate the superior performance of our proposed method across multiple few-shot classification tasks.

cs.LG↗
arXiv2026

EfficientFSL: Enhancing Few-Shot Classification via Query-Only Tuning in Vision Transformers

Large models such as Vision Transformers (ViTs) have demonstrated remarkable superiority over smaller architectures like ResNet in few-shot classification, owing to their powerful representational capacity. However, fine-tuning such large models demands extensive GPU memory and prolonged training time, making them impractical for many real-world low-resource scenarios. To bridge this gap, we propose EfficientFSL, a query-only fine-tuning framework tailored specifically for few-shot classification with ViT, which achieves competitive performance while significantly reducing computational overhead. EfficientFSL fully leverages the knowledge embedded in the pre-trained model and its strong comprehension ability, achieving high classification accuracy with an extremely small number of tunable parameters. Specifically, we introduce a lightweight trainable Forward Block to synthesize task-specific queries that extract informative features from the intermediate representations of the pre-trained model in a query-only manner. We further propose a Combine Block to fuse multi-layer outputs, enhancing the depth and robustness of feature representations. Finally, a Support-Query Attention Block mitigates distribution shift by adjusting prototypes to align with the query set distribution. With minimal trainable parameters, EfficientFSL achieves state-of-the-art performance on four in-domain few-shot datasets and six cross-domain datasets, demonstrating its effectiveness in real-world applications.

cs.CV↗
arXiv2026

InfoSculpt: Sculpting the Latent Space for Generalized Category Discovery

Generalized Category Discovery (GCD) aims to classify instances from both known and novel categories within a large-scale unlabeled dataset, a critical yet challenging task for real-world, open-world applications. However, existing methods often rely on pseudo-labeling, or two-stage clustering, which lack a principled mechanism to explicitly disentangle essential, category-defining signals from instance-specific noise. In this paper, we address this fundamental limitation by re-framing GCD from an information-theoretic perspective, grounded in the Information Bottleneck (IB) principle. We introduce InfoSculpt, a novel framework that systematically sculpts the representation space by minimizing a dual Conditional Mutual Information (CMI) objective. InfoSculpt uniquely combines a Category-Level CMI on labeled data to learn compact and discriminative representations for known classes, and a complementary Instance-Level CMI on all data to distill invariant features by compressing augmentation-induced noise. These two objectives work synergistically at different scales to produce a disentangled and robust latent space where categorical information is preserved while noisy, instance-specific details are discarded. Extensive experiments on 8 benchmarks demonstrate that InfoSculpt validating the effectiveness of our information-theoretic approach.

cs.CV↗
arXiv2026

Enhancing Visual In-Context Learning by Multi-Faceted Fusion

Visual In-Context Learning (VICL) has emerged as a powerful paradigm, enabling models to perform novel visual tasks by learning from in-context examples. The dominant "retrieve-then-prompt" approach typically relies on selecting the single best visual prompt, a practice that often discards valuable contextual information from other suitable candidates. While recent work has explored fusing the top-K prompts into a single, enhanced representation, this still simply collapses multiple rich signals into one, limiting the model's reasoning capability. We argue that a more multi-faceted, collaborative fusion is required to unlock the full potential of these diverse contexts. To address this limitation, we introduce a novel framework that moves beyond single-prompt fusion towards an multi-combination collaborative fusion. Instead of collapsing multiple prompts into one, our method generates three contextual representation branches, each formed by integrating information from different combinations of top-quality prompts. These complementary guidance signals are then fed into proposed MULTI-VQGAN architecture, which is designed to jointly interpret and utilize collaborative information from multiple sources. Extensive experiments on diverse tasks, including foreground segmentation, single-object detection, and image colorization, highlight its strong cross-task generalization, effective contextual fusion, and ability to produce more robust and accurate predictions than existing methods.

cs.CV↗
arXiv2026

Beyond Single Prompts: Synergistic Fusion and Arrangement for VICL

Vision In-Context Learning (VICL) enables inpainting models to quickly adapt to new visual tasks from only a few prompts. However, existing methods suffer from two key issues: (1) selecting only the most similar prompt discards complementary cues from other high-quality prompts; and (2) failing to exploit the structured information implied by different prompt arrangements. We propose an end-to-end VICL framework to overcome these limitations. Firstly, an adaptive Fusion Module aggregates critical patterns and annotations from multiple prompts to form more precise contextual prompts. Secondly, we introduce arrangement-specific lightweight MLPs to decouple layout priors from the core model, while minimally affecting the overall model. In addition, an bidirectional fine-tuning mechanism swaps the roles of query and prompt, encouraging the model to reconstruct the original prompt from fused context and thus enhancing collaboration between the fusion module and the inpainting model. Experiments on foreground segmentation, single-object detection, and image colorization demonstrate superior results and strong cross-task generalization of our method.

cs.CV↗
arXiv2025

RefLSM: Linearized Structural-Prior Reflectance Model for Medical Image Segmentation and Bias-Field Correction

Medical image segmentation remains challenging due to intensity inhomogeneity, noise, blurred boundaries, and irregular structures. Traditional level set methods, while effective in certain cases, often depend on approximate bias field estimations and therefore struggle under severe non-uniform imaging conditions. To address these limitations, we propose a novel variational Reflectance-based Level Set Model (RefLSM), which explicitly integrates Retinex-inspired reflectance decomposition into the segmentation framework. By decomposing the observed image into reflectance and bias field components, RefLSM directly segments the reflectance, which is invariant to illumination and preserves fine structural details. Building on this foundation, we introduce two key innovations for enhanced precision and robustness. First, a linear structural prior steers the smoothed reflectance gradients toward a data-driven reference, providing reliable geometric guidance in noisy or low-contrast scenes. Second, a relaxed binary level-set is embedded in RefLSM and enforced via convex relaxation and sign projection, yielding stable evolution and avoiding reinitialization-induced diffusion. The resulting variational problem is solved efficiently using an ADMM-based optimization scheme. Extensive experiments on multiple medical imaging datasets demonstrate that RefLSM achieves superior segmentation accuracy, robustness, and computational efficiency compared to state-of-the-art level set methods.

cs.CV↗