arXiv subjects

Xinyue Hu

Publications and source records attributed to Xinyue Hu.

At least 19 recordsLinked to original sources

arXiv2026

Multipath Adaptive Video Streaming with Multiple Description Neural Video Codec over 5G Networks

5G networks employ multiple radio channels to meet growing demands for bandwidth and high-resolution video streaming for emerging applications. However, existing multipath video systems are largely designed around monolithic codecs, which require sufficiently complete chunk delivery, or layered codecs, which depend on timely base-layer delivery. Under fast-varying 5G conditions with blockage, handovers, and heterogeneous path capacities, we observe that decoding dependencies in existing codecs make multipath delivery fragile: transient under-delivery of critical video data can directly trigger stalls and degrade QoE. This paper proposes NeuralMDC, a neural multiple-description video codec co-designed with multipath streaming for dynamic 5G networks. NeuralMDC encodes each video chunk into independently decodable and mutually refinable description streams, each spanning the full chunk. This design changes the multipath delivery unit from dependent packets or layers to independent chunk-level streams, so missing streams primarily reduce quality rather than making the chunk undecodable. Built on NeuralMDC, we develop a user-space multipath streaming system that maps description streams to heterogeneous 5G paths with simple yet effective scheduling logic. Across trace-driven emulation and operational 5G experiments, NeuralMDC improves QoE by 26%-44% over existing monolithic, layered, and neural streaming systems, improves video quality by up to 41.8%, and keeps stall ratios below 0.32%.

cs.NI↗

arXiv2026

Continual-Learning Physics-Informed Neural Networks for Parameterized Partial Differential Equations

Physics-informed neural networks (PINNs) incorporate governing equations into neural-network training and can approximate PDE solutions without requiring large observational datasets. Parameterized PINNs (ParamPINNs) further take physical parameters as inputs, allowing a single model to represent a family of PDE solutions over a parameter domain. Existing ParamPINNs, however, still face inefficient training, uneven accuracy across parameters, and overfitting to a limited set of sampled parameter tasks, which can impair generalization to unsampled parameters. To address these issues, we propose a continual-learning physics-informed neural network (CL-PINN), which treats PDE instances at different parameter values as related tasks and learns them sequentially. CL-PINN combines Bayesian-optimization-based active parameter selection, task-wise dynamic loss weighting, sparse physics-constrained replay, and an optional parameter subnetwork to improve task allocation and knowledge retention under bounded active-task capacity. It requires no observational data and is designed to solve parameterized PDEs over relatively broad parameter domains under limited computational resources. Multi-seed evaluations on five benchmarks, including one continuous function and four parameterized PDEs, show that Bayesian selection substantially reduces objective-loss queries relative to grid-greedy search, while sparse replay mitigates forgetting of earlier tasks. Under the prescribed within-case resource protocols, CL-PINN generally provides higher and more balanced solution accuracy than fixed-sampling and grid-greedy baselines. CL-PINN offers a practical route toward learning PDE solutions that generalize across physical parameters and has the potential to support reusable physics-informed surrogates for large-scale engineering parameter studies.

cs.LG↗

arXiv2026

Curriculum Learning of Physics-Informed Neural Networks based on Spatial Correlation

Physics-Informed Neural Networks (PINNs) combine deep learning with physical constraints for solving partial differential equations (PDEs), and are widely applied in fluid mechanics, heat transfer, and solid mechanics. However, PINN training still suffers from high-dimensional non-convex loss landscapes, imbalanced multiobjective constraints, and ineffective information propagation. Existing curriculum learning and causality-guided strategies improve training stability, but mainly focus on temporal or parametric progression, lacking explicit treatment of spatial information propagation and inter-region consistency. Moreover, they are not directly applicable to boundary value problems (BVPs) with strong spatial coupling. To address this issue, we propose a spatially correlated curriculum learning framework for PINNs. To the best of our knowledge, this is the first work to address PINN training difficulties from the perspective of spatial coupling among subregions. First, spatial causal weights guide information from near-boundary regions inward, reducing optimization failures and spurious convergence. Second, a low-frequency information bridge enforces pseudo-label-based consistency across spatially separated regions, suppressing global low-frequency drift. Third, a region-adaptive reweighting strategy adjusts subregion losses to reduce local residuals and recover high-frequency details. Experiments on PDE benchmarks show that, under comparable computational cost, the proposed method alleviates training failures and improves solution accuracy. The code is available at https://github.com/pigofmomo/CurriculumLearningPINN.

cs.LG↗

arXiv2026

Strategic Shaping of Human Prosociality: A Latent-State POMDP Framework

We propose a decision-theoretic framework in which a robot strategically can shape inferred human's prosocial state during repeated interactions. Modeling the human's prosociality as a latent state that evolves over time, the robot learns to infer and influence this state through its own actions, including helping and signaling. We formalize this as a latent-state POMDP with limited observations and learn the transition and observation dynamics using expectation maximization. The resulting belief-based policy balances task and social objectives, selecting actions that maximize long-term cooperative outcomes. We evaluate the model using data from user studies and show that the learned policy outperforms baseline strategies in both team performance and increasing observed human cooperative behavior.

cs.HC↗

arXiv2026

EMAD: Evidence-Centric Grounded Multimodal Diagnosis for Alzheimer's Disease

Deep learning models for medical image analysis often act as black boxes, seldom aligning with clinical guidelines or explicitly linking decisions to supporting evidence. This is especially critical in Alzheimer's disease (AD), where predictions should be grounded in both anatomical and clinical findings. We present EMAD, a vision-language framework that generates structured AD diagnostic reports in which each claim is explicitly grounded in multimodal evidence. EMAD uses a hierarchical Sentence-Evidence-Anatomy (SEA) grounding mechanism: (i) sentence-to-evidence grounding links generated sentences to clinical evidence phrases, and (ii) evidence-to-anatomy grounding localizes corresponding structures on 3D brain MRI. To reduce dense annotation requirements, we propose GTX-Distill, which transfers grounding behavior from a teacher trained with limited supervision to a student operating on model-generated reports. We further introduce Executable-Rule GRPO, a reinforcement fine-tuning scheme with verifiable rewards that enforces clinical consistency, protocol adherence, and reasoning-diagnosis coherence. On the AD-MultiSense dataset, EMAD achieves state-of-the-art diagnostic accuracy and produces more transparent, anatomically faithful reports than existing methods. We will release code and grounding annotations to support future research in trustworthy medical vision-language models.

cs.CV↗

arXiv2025

AD-CDO: A Lightweight Ontology for Representing Eligibility Criteria in Alzheimer's Disease Clinical Trials

Objective This study introduces the Alzheimer's Disease Common Data Element Ontology for Clinical Trials (AD-CDO), a lightweight, semantically enriched ontology designed to represent and standardize key eligibility criteria concepts in Alzheimer's disease (AD) clinical trials. Materials and Methods We extracted high-frequency concepts from more than 1,500 AD clinical trials on ClinicalTrials.gov and organized them into seven semantic categories: Disease, Medication, Diagnostic Test, Procedure, Social Determinants of Health, Rating Criteria, and Fertility. Each concept was annotated with standard biomedical vocabularies, including the UMLS, OMOP Standardized Vocabularies, DrugBank, NDC, and NLM VSAC value sets. To balance coverage and manageability, we applied the Jenks Natural Breaks method to identify an optimal set of representative concepts. Results The optimized AD-CDO achieved over 63% coverage of extracted trial concepts while maintaining interpretability and compactness. The ontology effectively captured the most frequent and clinically meaningful entities used in AD eligibility criteria. We demonstrated AD-CDO's practical utility through two use cases: (a) an ontology-driven trial simulation system for formal modeling and virtual execution of clinical trials, and (b) an entity normalization task mapping raw clinical text to ontology-aligned terms, enabling consistency and integration with EHR data. Discussion AD-CDO bridges the gap between broad biomedical ontologies and task-specific trial modeling needs. It supports multiple downstream applications, including phenotyping algorithm development, cohort identification, and structured data integration. Conclusion By harmonizing essential eligibility entities and aligning them with standardized vocabularies, AD-CDO provides a versatile foundation for ontology-driven AD clinical trial research.

cs.CL↗

arXiv2025

Early GVHD Prediction in Liver Transplantation via Multi-Modal Deep Learning on Imbalanced EHR Data

Graft-versus-host disease (GVHD) is a rare but often fatal complication in liver transplantation, with a very high mortality rate. By harnessing multi-modal deep learning methods to integrate heterogeneous and imbalanced electronic health records (EHR), we aim to advance early prediction of GVHD, paving the way for timely intervention and improved patient outcomes. In this study, we analyzed pre-transplant electronic health records (EHR) spanning the period before surgery for 2,100 liver transplantation patients, including 42 cases of graft-versus-host disease (GVHD), from a cohort treated at Mayo Clinic between 1992 and 2025. The dataset comprised four major modalities: patient demographics, laboratory tests, diagnoses, and medications. We developed a multi-modal deep learning framework that dynamically fuses these modalities, handles irregular records with missing values, and addresses extreme class imbalance through AUC-based optimization. The developed framework outperforms all single-modal and multi-modal machine learning baselines, achieving an AUC of 0.836, an AUPRC of 0.157, a recall of 0.768, and a specificity of 0.803. It also demonstrates the effectiveness of our approach in capturing complementary information from different modalities, leading to improved performance. Our multi-modal deep learning framework substantially improves existing approaches for early GVHD prediction. By effectively addressing the challenges of heterogeneity and extreme class imbalance in real-world EHR, it achieves accurate early prediction. Our proposed multi-modal deep learning method demonstrates promising results for early prediction of a GVHD in liver transplantation, despite the challenge of extremely imbalanced EHR data.

cs.LG↗

arXiv2025

Enhancing Uncertainty Estimation and Interpretability via Bayesian Non-negative Decision Layer

Although deep neural networks have demonstrated significant success due to their powerful expressiveness, most models struggle to meet practical requirements for uncertainty estimation. Concurrently, the entangled nature of deep neural networks leads to a multifaceted problem, where various localized explanation techniques reveal that multiple unrelated features influence the decisions, thereby undermining interpretability. To address these challenges, we develop a Bayesian Non-negative Decision Layer (BNDL), which reformulates deep neural networks as a conditional Bayesian non-negative factor analysis. By leveraging stochastic latent variables, the BNDL can model complex dependencies and provide robust uncertainty estimation. Moreover, the sparsity and non-negativity of the latent variables encourage the model to learn disentangled representations and decision layers, thereby improving interpretability. We also offer theoretical guarantees that BNDL can achieve effective disentangled learning. In addition, we developed a corresponding variational inference method utilizing a Weibull variational inference network to approximate the posterior distribution of the latent variables. Our experimental results demonstrate that with enhanced disentanglement capabilities, BNDL not only improves the model's accuracy but also provides reliable uncertainty estimation and improved interpretability.

cs.LG↗

arXiv2025

Launching Insights: A Pilot Study on Leveraging Real-World Observational Data from the Mayo Clinic Platform to Advance Clinical Research

Backgrounds: Artificial intelligence (AI) is transforming healthcare, yet translating AI models from theoretical frameworks to real-world clinical applications remains challenging. The Mayo Clinic Platform (MCP) was established to address these challenges by providing a scalable ecosystem that integrates real-world multiple modalities data from multiple institutions, advanced analytical tools, and secure computing environments to support clinical research and AI development. Methods: In this study, we conducted four research projects leveraging MCP's data infrastructure and analytical capabilities to demonstrate its potential in facilitating real-world evidence generation and AI-driven clinical insights. Utilizing MCP's tools and environment, we facilitated efficient cohort identification, data extraction, and subsequent statistical or AI-powered analyses. Results: The results underscore MCP's role in accelerating translational research by offering de-identified, standardized real-world data and facilitating AI model validation across diverse healthcare settings. Compared to Mayo's internal Electronic Health Record (EHR) data, MCP provides broader accessibility, enhanced data standardization, and multi-institutional integration, making it a valuable resource for both internal and external researchers. Conclusion: Looking ahead, MCP is well-positioned to transform clinical research through its scalable ecosystem, effectively bridging the divide between AI innovation and clinical deployment. Future investigations will build upon this foundation, further exploring MCP's capacity to advance precision medicine and enhance patient outcomes.

cs.CY↗

arXiv2025

Generative Active Adaptation for Drifting and Imbalanced Network Intrusion Detection

Machine learning has shown promise in network intrusion detection systems, yet its performance often degrades due to concept drift and imbalanced data. These challenges are compounded by the labor-intensive process of labeling network traffic, especially when dealing with evolving and rare attack types, which makes preparing the right data for adaptation difficult. To address these issues, we propose a generative active adaptation framework that minimizes labeling effort while enhancing model robustness. Our approach employs density-aware dataset prior selection to identify the most informative samples for annotation, and leverages deep generative models to conditionally synthesize diverse samples, thereby augmenting the training set and mitigating the effects of concept drift. We evaluate our end-to-end framework \NetGuard on both simulated IDS data and a real-world ISP dataset, demonstrating significant improvements in intrusion detection performance. Our method boosts the overall F1-score from 0.60 (without adaptation) to 0.86. Rare attacks such as Infiltration, Web Attack, and FTP-BruteForce, which originally achieved F1 scores of 0.001, 0.04, and 0.00, improve to 0.30, 0.50, and 0.71, respectively, with generative active adaptation in the CIC-IDS 2018 dataset. Our framework effectively enhances rare attack detection while reducing labeling costs, making it a scalable and practical solution for intrusion detection.

cs.NI↗

arXiv2024

Robust Multiple Description Neural Video Codec with Masked Transformer for Dynamic and Noisy Networks

Multiple Description Coding (MDC) is a promising error-resilient source coding method that is particularly suitable for dynamic networks with multiple (yet noisy and unreliable) paths. However, conventional MDC video codecs suffer from cumbersome architectures, poor scalability, limited loss resilience, and lower compression efficiency. As a result, MDC has never been widely adopted. Inspired by the potential of neural video codecs, this paper rethinks MDC design. We propose a novel MDC video codec, NeuralMDC, demonstrating how bidirectional transformers trained for masked token prediction can vastly simplify the design of MDC video codec. To compress a video, NeuralMDC starts by tokenizing each frame into its latent representation and then splits the latent tokens to create multiple descriptions containing correlated information. Instead of using motion prediction and warping operations, NeuralMDC trains a bidirectional masked transformer to model the spatial-temporal dependencies of latent representations and predict the distribution of the current representation based on the past. The predicted distribution is used to independently entropy code each description and infer any potentially lost tokens. Extensive experiments demonstrate NeuralMDC achieves state-of-the-art loss resilience with minimal sacrifices in compression efficiency, significantly outperforming the best existing residual-coding-based error-resilient neural video codec.

cs.CV↗

arXiv2024

Disentangled Generative Graph Representation Learning

Recently, generative graph models have shown promising results in learning graph representations through self-supervised methods. However, most existing generative graph representation learning (GRL) approaches rely on random masking across the entire graph, which overlooks the entanglement of learned representations. This oversight results in non-robustness and a lack of explainability. Furthermore, disentangling the learned representations remains a significant challenge and has not been sufficiently explored in GRL research. Based on these insights, this paper introduces DiGGR (Disentangled Generative Graph Representation Learning), a self-supervised learning framework. DiGGR aims to learn latent disentangled factors and utilizes them to guide graph mask modeling, thereby enhancing the disentanglement of learned representations and enabling end-to-end joint learning. Extensive experiments on 11 public datasets for two different graph learning tasks demonstrate that DiGGR consistently outperforms many previous self-supervised methods, verifying the effectiveness of the proposed approach.

cs.LG↗

arXiv2024

MAC: A Benchmark for Multiple Attributes Compositional Zero-Shot Learning

Compositional Zero-Shot Learning (CZSL) aims to learn semantic primitives (attributes and objects) from seen compositions and recognize unseen attribute-object compositions. Existing CZSL datasets focus on single attributes, neglecting the fact that objects naturally exhibit multiple interrelated attributes. Their narrow attribute scope and single attribute labeling introduce annotation biases, misleading the learning of attributes and causing inaccurate evaluation. To address these issues, we introduce the Multi-Attribute Composition (MAC) dataset, encompassing 22,838 images and 17,627 compositions with comprehensive and representative attribute annotations. MAC shows complex relationship between attributes and objects, with each attribute type linked to an average of 82.2 object types, and each object type associated with 31.4 attribute types. Based on MAC, we propose multi-attribute compositional zero-shot learning that requires deeper semantic understanding and advanced attribute associations, establishing a more realistic and challenging benchmark for CZSL. We also propose Multi-attribute Visual-Primitive Integrator (MVP-Integrator), a robust baseline for multi-attribute CZSL, which disentangles semantic primitives and performs effective visual-primitive association. Experimental results demonstrate that MVP-Integrator significantly outperforms existing CZSL methods on MAC with improved inference efficiency.

cs.CV↗

arXiv2024

What Large Language Models Know and What People Think They Know

As artificial intelligence (AI) systems, particularly large language models (LLMs), become increasingly integrated into decision-making processes, the ability to trust their outputs is crucial. To earn human trust, LLMs must be well calibrated such that they can accurately assess and communicate the likelihood of their predictions being correct. Whereas recent work has focused on LLMs' internal confidence, less is understood about how effectively they convey uncertainty to users. Here we explore the calibration gap, which refers to the difference between human confidence in LLM-generated answers and the models' actual confidence, and the discrimination gap, which reflects how well humans and models can distinguish between correct and incorrect answers. Our experiments with multiple-choice and short-answer questions reveal that users tend to overestimate the accuracy of LLM responses when provided with default explanations. Moreover, longer explanations increased user confidence, even when the extra length did not improve answer accuracy. By adjusting LLM explanations to better reflect the models' internal confidence, both the calibration gap and the discrimination gap narrowed, significantly improving user perception of LLM accuracy. These findings underscore the importance of accurate uncertainty communication and highlight the effect of explanation length in influencing user trust in AI-assisted decision-making environments. Code and Data can be found at https://osf.io/y7pr6/ . Journal publication can be found on Nature Machine Intelligence at https://www.nature.com/articles/s42256-024-00976-7 .

cs.LG↗

arXiv2023

Volumetric Medical Image Segmentation via Scribble Annotations and Shape Priors

Recently, weakly-supervised image segmentation using weak annotations like scribbles has gained great attention in computer vision and medical image analysis, since such annotations are much easier to obtain compared to time-consuming and labor-intensive labeling at the pixel/voxel level. However, due to a lack of structure supervision on regions of interest (ROIs), existing scribble-based methods suffer from poor boundary localization. Furthermore, most current methods are designed for 2D image segmentation, which do not fully leverage the volumetric information if directly applied to each image slice. In this paper, we propose a scribble-based volumetric image segmentation, Scribble2D5, which tackles 3D anisotropic image segmentation and aims to its improve boundary prediction. To achieve this, we augment a 2.5D attention UNet with a proposed label propagation module to extend semantic information from scribbles and use a combination of static and active boundary prediction to learn ROI's boundary and regularize its shape. Also, we propose an optional add-on component, which incorporates the shape prior information from unpaired segmentation masks to further improve model accuracy. Extensive experiments on three public datasets and one private dataset demonstrate our Scribble2D5 achieves state-of-the-art performance on volumetric image segmentation using scribbles and shape prior if available.

cs.CV↗

arXiv2023

Self-explainable Graph Neural Network for Alzheimer's Disease And Related Dementias Risk Prediction

Background: Alzheimer's disease and related dementias (ADRD) ranks as the sixth leading cause of death in the US, underlining the importance of accurate ADRD risk prediction. While recent advancement in ADRD risk prediction have primarily relied on imaging analysis, yet not all patients undergo medical imaging before an ADRD diagnosis. Merging machine learning with claims data can reveal additional risk factors and uncover interconnections among diverse medical codes. Objective: Our goal is to utilize Graph Neural Networks (GNNs) with claims data for ADRD risk prediction. Addressing the lack of human-interpretable reasons behind these predictions, we introduce an innovative method to evaluate relationship importance and its influence on ADRD risk prediction, ensuring comprehensive interpretation. Methods: We employed Variationally Regularized Encoder-decoder Graph Neural Network (VGNN) for estimating ADRD likelihood. We created three scenarios to assess the model's efficiency, using Random Forest and Light Gradient Boost Machine as baselines. We further used our relation importance method to clarify the key relationships for ADRD risk prediction. Results: VGNN surpassed other baseline models by 10% in the area under the receiver operating characteristic. The integration of the GNN model and relation importance interpretation could potentially play an essential role in providing valuable insight into factors that may contribute to or delay ADRD progression. Conclusions: Employing a GNN approach with claims data enhances ADRD risk prediction and provides insights into the impact of interconnected medical code relationships. This methodology not only enables ADRD risk modeling but also shows potential for other image analysis predictions using claims data.

cs.LG↗

arXiv2023

Expert Uncertainty and Severity Aware Chest X-Ray Classification by Multi-Relationship Graph Learning

Patients undergoing chest X-rays (CXR) often endure multiple lung diseases. When evaluating a patient's condition, due to the complex pathologies, subtle texture changes of different lung lesions in images, and patient condition differences, radiologists may make uncertain even when they have experienced long-term clinical training and professional guidance, which makes much noise in extracting disease labels based on CXR reports. In this paper, we re-extract disease labels from CXR reports to make them more realistic by considering disease severity and uncertainty in classification. Our contributions are as follows: 1. We re-extracted the disease labels with severity and uncertainty by a rule-based approach with keywords discussed with clinical experts. 2. To further improve the explainability of chest X-ray diagnosis, we designed a multi-relationship graph learning method with an expert uncertainty-aware loss function. 3. Our multi-relationship graph learning method can also interpret the disease classification results. Our experimental results show that models considering disease severity and uncertainty outperform previous state-of-the-art methods.

cs.CV↗

arXiv2023

Expert Knowledge-Aware Image Difference Graph Representation Learning for Difference-Aware Medical Visual Question Answering

To contribute to automating the medical vision-language model, we propose a novel Chest-Xray Difference Visual Question Answering (VQA) task. Given a pair of main and reference images, this task attempts to answer several questions on both diseases and, more importantly, the differences between them. This is consistent with the radiologist's diagnosis practice that compares the current image with the reference before concluding the report. We collect a new dataset, namely MIMIC-Diff-VQA, including 700,703 QA pairs from 164,324 pairs of main and reference images. Compared to existing medical VQA datasets, our questions are tailored to the Assessment-Diagnosis-Intervention-Evaluation treatment procedure used by clinical professionals. Meanwhile, we also propose a novel expert knowledge-aware graph representation learning model to address this task. The proposed baseline model leverages expert knowledge such as anatomical structure prior, semantic, and spatial knowledge to construct a multi-relationship graph, representing the image differences between two images for the image difference VQA task. The dataset and code can be found at https://github.com/Holipori/MIMIC-Diff-VQA. We believe this work would further push forward the medical vision language model.

cs.CV↗