arXiv subjects

Xun Jiang

Publications and source records attributed to Xun Jiang.

At least 19 recordsLinked to original sources

arXiv2026

VisualRouter: Query-Grounded Visual Sampling for Long Video Understanding

Large vision-language models (LVLMs) have achieved significant progress in video understanding, yet understanding long videos remains challenging due to the large number of visual tokens and limited context windows. Visual sampling provides a practical solution by selecting an informative subset of frames. However, existing methods typically either rely on relevance-aware sampling, leading to redundant frame selection and insufficient temporal coverage, or adopt a fixed sampling strategy regardless of query type. In this paper, we propose VisualRouter, a training-free and plug-and-play framework for query-grounded visual sampling. VisualRouter first classifies each query as either global or local and then applies the corresponding sampling strategy. For global queries, it employs a relevance-coverage hybrid strategy that preserves temporal coverage while retaining query-relevant visual evidence. For local queries, it adopts an event-aware frame selection strategy that performs event partitioning, segment-level frame allocation, and intra-event frame selection, jointly balancing relevance, coverage, and diversity with a limited number of input frames. Experiments show that VisualRouter consistently improves multiple LVLMs over uniform sampling, achieving gains of 5.2%, 7.7%, and 11.6% on Video-MME, LongVideoBench, and MLVU with Qwen2.5-VL-7B, and outperforming existing training-free visual sampling methods under the same setting.

cs.CV↗

arXiv2026

COAST: Congestion-Aware Start-Time Recommendations for Carbon-Aware HPC Jobs

High-performance computing (HPC) workloads consume substantial amounts of electricity, and their carbon emissions vary over time with the carbon intensity of grid electricity. However, uncoordinated shifting of carbon-aware HPC jobs toward low-carbon periods can concentrate recommended start times in the same time slots, creating congestion and eroding the resulting carbon benefits. This paper proposes COAST, a congestion-aware start-time recommendation mechanism that coordinates HPC jobs by balancing carbon savings against additional job delay and congestion in recommended start-time slots. COAST formulates each decision batch as an exact potential game, enabling best-response updates to converge to stable start-time recommendations. Under an idealized realization model that assumes each job can start at its recommended time, we conduct trace-driven simulations using public HPC energy data and historical grid carbon-intensity traces. The results show that COAST reduces estimated carbon emissions by 15.4\% with 1.5 hours of additional average start delay. Compared with carbon-greedy start-time recommendations, COAST reduces peak time-slot load by 23.8\% while preserving 93\% of the achievable carbon savings. These results quantify the potential benefits of congestion-aware start-time coordination for flexible, carbon-aware HPC jobs.

cs.DC↗

arXiv2026

CisTransCell: Single-Cell Perturbation Prediction via Gene Function, Regulatory Control, and Cellular Context

Predicting cellular transcriptional responses to genetic perturbations is a central problem in single-cell biology, especially in the zero-shot setting where the perturbed gene or gene combination is unseen during training. A major difficulty is that perturbation effects are not determined by expression state alone: they depend on how the perturbed gene product influences other genes and proteins, how those downstream factors act on cis-regulatory elements, and which regulatory programs are active in the current cell state. To better capture this biological complexity, we propose CisTransCell, a cell-conditioned multi-modal framework for single-cell perturbation prediction that augments each gene with two complementary priors: a regulatory-sequence prior that captures how the gene is controlled, and a coding-sequence prior that captures what the gene product does. By integrating these priors with cellular expression state, CisTransCell models perturbation response as a cascade from gene function to regulatory control to downstream transcriptional change. Experiments on benchmark single-cell perturbation datasets show that CisTransCell achieves strong performance in zero-shot perturbation prediction.

q-bio.GN↗

arXiv2026

Multimodal Learning on Low-Quality Data with Conformal Predictive Self-Calibration

Multimodal learning often grapples with the challenge of low-quality data, which predominantly manifests as two facets: modality imbalance and noisy corruption. While these issues are often studied in isolation, we argue that they share a common root in the predictive uncertainty towards the reliability of individual modalities and instances during learning. In this paper, we propose a unified framework, termed Conformal Predictive Self-Calibration (CPSC), which leverages conformal prediction to equip the model with the ability to perform self-guided calibration on-the-fly. The core of our proposed CPSC lies in a novel self-calibrating training loop that seamlessly integrates two key modules: (1) Representation Self-Calibration, which decomposes unimodal features into components, and selectively fuses the most robust ones identified by a conformal predictor to enhance feature resilience. (2) Gradient Self-Calibration, which recalibrates the gradient flow during backpropagation based on instance-wise reliability scores, steering the optimization towards more trustworthy directions. Furthermore, we also devise a self-update strategy for the conformal predictor to ensure the entire system co-evolves consistently throughout the training process. Extensive experiments on six benchmark datasets under both imbalanced and noisy settings demonstrate that our CPSC framework consistently outperforms existing state-of-the-art methods. Our code is available at https://github.com/XunCHN/CPSC.

cs.CV↗

arXiv2026

MedDialBench: Benchmarking LLM Diagnostic Robustness under Parametric Adversarial Patient Behaviors

Interactive medical dialogue benchmarks have shown that LLM diagnostic accuracy degrades significantly when interacting with non-cooperative patients, yet existing approaches either apply adversarial behaviors without graded severity or case-specific grounding, or reduce patient non-cooperation to a single ungraded axis, and none analyze cross-dimension interactions. We introduce MedDialBench, a benchmark enabling controlled, dose-response characterization of how individual patient behavior dimensions affect LLM diagnostic robustness. It decomposes patient behavior into five dimensions -- Logic Consistency, Health Cognition, Expression Style, Disclosure, and Attitude -- each with graded severity levels and case-specific behavioral scripts. This controlled factorial design enables graded sensitivity analysis, dose-response profiling, and cross-dimension interaction detection. Evaluating five frontier LLMs across 7,225 dialogues (85 cases x 17 configurations x 5 models), we find a fundamental asymmetry: information pollution (fabricating symptoms) produces 1.7-3.4x larger accuracy drops than information deficit (withholding information), and fabricating is the only configuration achieving statistical significance across all five models (McNemar p < 0.05). Among six dimension combinations, fabricating is the sole driver of super-additive interaction: all three fabricating-involving pairs produce O/E ratios of 0.70-0.81 (35-44% of eligible cases fail under the combination despite succeeding under each dimension alone), while all non-fabricating pairs show purely additive effects (O/E ~ 1.0). Inquiry strategy moderates deficit but not pollution: exhaustive questioning recovers withheld information, but cannot compensate for fabricated inputs. Models exhibit distinct vulnerability profiles, with worst-case drops ranging from 38.8 to 54.1 percentage points.

cs.CL↗

arXiv2026

ESL-Bench: An Event-Driven Synthetic Longitudinal Benchmark for Health Agents

Longitudinal health agents must reason across multi-source trajectories that combine continuous device streams, sparse clinical exams, and episodic life events - yet evaluating them is hard: real-world data cannot be released at scale, and temporally grounded attribution questions seldom admit definitive answers without structured ground truth. We present ESL-Bench, an event-driven synthesis framework and benchmark providing 100 synthetic users, each with a 1-5 year trajectory comprising a health profile, a multi-phase narrative plan, daily device measurements, periodic exam records, and an event log with explicit per-indicator impact parameters. Each indicator follows a baseline stochastic process driven by discrete events with sigmoid-onset, exponential-decay kernels under saturation and projection constraints; a hybrid pipeline delegates sparse semantic artifacts to LLM-based planning and dense indicator dynamics to algorithmic simulation with hard physiological bounds. Users are each paired with 100 evaluation queries across five dimensions - Lookup, Trend, Comparison, Anomaly, Explanation - stratified into Easy, Medium, and Hard tiers, with all ground-truth answers programmatically computable from the recorded event-indicator relationships. Evaluating 13 methods spanning LLMs with tools, DB-native agents, and memory-augmented RAG, we find that DB agents (48-58%) substantially outperform memory RAG baselines (30-38%), with the gap concentrated on Comparison and Explanation queries where multi-hop reasoning and evidence attribution are required.

cs.AI↗

arXiv2026

Modeling Heterogeneous Mediation Effects in Survival Analysis via an Interpretable M-Learner Framework

Mediation analysis is a useful tool to evaluate surrogate endpoints in clinical trials. We propose a novel method, the M-survival learner, for estimating heterogeneous indirect treatment effects in the presence of censored outcomes. The proposed approach enables the identification of interpretable patient subgroups characterized by distinct mediation pathways. To distinguish heterogeneous from homogeneous mediation effects, we introduce a new statistical criterion specifically designed for survival data. The method provides a principled framework for evaluating heterogeneity in surrogate biomarker performance across patient populations, offering evidence to support accelerated approval drug. By explicitly assessing subgroup-specific surrogate validity, the proposed approach addresses key regulatory concerns regarding the reliability of surrogate endpoints. We further establish theoretical properties of the method to justify its statistical guarantees. We apply the approach to data from a Phase III randomized clinical trial of HIV treatment, demonstrating its practical utility in real-world settings. Extensive simulation studies further evaluate and demonstrate its finite-sample performance.

stat.ME↗

arXiv2026

A Comparative Study of Traditional Machine Learning, Deep Learning, and Large Language Models for Mental Health Forecasting using Smartphone Sensing Data

Smartphone sensing offers an unobtrusive and scalable way to track daily behaviors linked to mental health, capturing changes in sleep, mobility, and phone use that often precede symptoms of stress, anxiety, or depression. While most prior studies focus on detection that responds to existing conditions, forecasting mental health enables proactive support through Just-in-Time Adaptive Interventions. In this paper, we present the first comprehensive benchmarking study comparing traditional machine learning (ML), deep learning (DL), and large language model (LLM) approaches for mental health forecasting using the College Experience Sensing (CES) dataset, the most extensive longitudinal dataset of college student mental health to date. We systematically evaluate models across temporal windows, feature granularities, personalization strategies, and class imbalance handling. Our results show that DL models, particularly Transformer (Macro-F1 = 0.58), achieve the best overall performance, while LLMs show strength in contextual reasoning but weaker temporal modeling. Personalization substantially improves forecasts of severe mental health states. By revealing how different modeling approaches interpret phone sensing behavioral data over time, this work lays the groundwork for next-generation, adaptive, and human-centered mental health technologies that can advance both research and real-world well-being.

cs.LG↗

arXiv2025

What Makes Reasoning Invalid: Echo Reflection Mitigation for Large Language Models

Large Language Models (LLMs) have demonstrated remarkable performance across a wide range of reasoning tasks. Recent methods have further improved LLM performance in complex mathematical reasoning. However, when extending these methods beyond the domain of mathematical reasoning to tasks involving complex domain-specific knowledge, we observe a consistent failure of LLMs to generate novel insights during the reflection stage. Instead of conducting genuine cognitive refinement, the model tends to mechanically reiterate earlier reasoning steps without introducing new information or perspectives, a phenomenon referred to as "Echo Reflection". We attribute this behavior to two key defects: (1) Uncontrollable information flow during response generation, which allows premature intermediate thoughts to propagate unchecked and distort final decisions; (2) Insufficient exploration of internal knowledge during reflection, leading to repeating earlier findings rather than generating new cognitive insights. Building on these findings, we proposed a novel reinforcement learning method termed Adaptive Entropy Policy Optimization (AEPO). Specifically, the AEPO framework consists of two major components: (1) Reflection-aware Information Filtration, which quantifies the cognitive information flow and prevents the final answer from being affected by earlier bad cognitive information; (2) Adaptive-Entropy Optimization, which dynamically balances exploration and exploitation across different reasoning stages, promoting both reflective diversity and answer correctness. Extensive experiments demonstrate that AEPO consistently achieves state-of-the-art performance over mainstream reinforcement learning baselines across diverse benchmarks.

cs.AI↗

arXiv2025

Relief of EGFR/FOS-downregulated miR-103a by loganin alleviates NF-kappaB-triggered inflammation and gut barrier disruption in colitis

Due to the ever-rising global incidence rate of inflammatory bowel disease (IBD) and the lack of effective clinical treatment drugs, elucidating the detailed pathogenesis, seeking novel targets, and developing promising drugs are the top priority for IBD treatment. Here, we demonstrate that the levels of microRNA (miR)-103a were significantly downregulated in the inflamed mucosa of ulcerative colitis (UC) patients, along with elevated inflammatory cytokines (IL-1beta/TNF-alpha) and reduced tight junction protein (Occludin/ZO-1) levels, as compared with healthy control objects. Consistently, miR-103a deficient intestinal epithelial cells Caco-2 showed serious inflammatory responses and increased permeability, and DSS induced more severe colitis in miR-103a-/- mice than wild-type ones. Mechanistic studies unraveled that c-FOS suppressed miR-103a transcription via binding to its promoter, then miR-103a-targeted NF-kappaB activation contributes to inflammatory responses and barrier disruption by targeting TAB2 and TAK1. Notably, the traditional Chinese medicine Cornus officinalis (CO) and its core active ingredient loganin potently mitigated inflammation and barrier disruption in UC by specifically blocking the EGFR/RAS/ERK/c-FOS signaling axis, these effects mainly attributed to modulated miR-103a levels as the therapeutic activities of them were almost completely shielded in miR-103a KO mice. Taken together, this work reveals that loganin relieves EGFR/c-FOS axis-suppressed epithelial miR-103a expression, thereby inhibiting NF-kappaB pathway activation, suppressing inflammatory responses, and preserving tight junction integrity in UC. Thus, our data enrich mechanistic insights and promising targets for UC treatment.

q-bio.BM↗

arXiv2025

Investigating Advanced Reasoning of Large Language Models via Black-Box Environment Interaction

Existing tasks fall short in evaluating reasoning ability of Large Language Models (LLMs) in an interactive, unknown environment. This deficiency leads to the isolated assessment of deductive, inductive, and abductive reasoning, neglecting the integrated reasoning process that is indispensable for human-like discovery learning. We introduce a novel evaluation paradigm, \textit{black-box environment interaction}, to tackle this challenge. A black-box environment is defined by a hidden function that maps a specific set of inputs to outputs. LLMs are required to unravel the hidden function behind the black-box environment by interacting with it in given exploration turns, and reasoning over observed input-output pairs. Leveraging this idea, we build the \textsc{Oracle} benchmark which comprises 6 types of black-box task with 96 black-box environments. 19 modern LLMs are benchmarked. o3, a leading LLM from OpenAI, ranks first in 5 of the 6 tasks, achieving over 70\% accuracy on most easy black-box environments. But it still struggles with some hard black-box tasks, where the average performance drops below 40\%. Further analysis reveals a universal difficulty among LLMs: They lack the high-level planning capability to develop efficient and adaptive exploration strategies for hypothesis refinement. Code is available in https://github.com/lemonsis/Oracle_Benchmark.

cs.AI↗

arXiv2025

AgentDistill: Training-Free Agent Distillation with Generalizable MCP Boxes

While knowledge distillation has become a mature field for compressing large language models (LLMs) into smaller ones by aligning their outputs or internal representations, the distillation of LLM-based agents, which involve planning, memory, and tool use, remains relatively underexplored. Existing agent distillation methods typically replay full teacher trajectories or imitate step-by-step teacher tool usage, but they often struggle to train student agents to dynamically plan and act in novel environments. We propose AgentDistill, a novel, training-free agent distillation framework that enables efficient and scalable knowledge transfer via direct reuse of Model-Context-Protocols (MCPs), which are structured and reusable task-solving modules autonomously generated by teacher agents. The reuse of these distilled MCPs enables student agents to generalize their capabilities across domains and solve new problems with minimal supervision or human intervention. Experiments on biomedical and mathematical benchmarks demonstrate that our distilled student agents, built on small language models, can achieve performance comparable to advanced systems using large LLMs such as OctoTools (GPT-4o), highlighting the effectiveness of our framework in building scalable and cost-efficient intelligent agents.

cs.AI↗

arXiv2025

On Path to Multimodal Historical Reasoning: HistBench and HistAgent

Recent advances in large language models (LLMs) have led to remarkable progress across domains, yet their capabilities in the humanities, particularly history, remain underexplored. Historical reasoning poses unique challenges for AI, involving multimodal source interpretation, temporal inference, and cross-linguistic analysis. While general-purpose agents perform well on many existing benchmarks, they lack the domain-specific expertise required to engage with historical materials and questions. To address this gap, we introduce HistBench, a new benchmark of 414 high-quality questions designed to evaluate AI's capacity for historical reasoning and authored by more than 40 expert contributors. The tasks span a wide range of historical problems-from factual retrieval based on primary sources to interpretive analysis of manuscripts and images, to interdisciplinary challenges involving archaeology, linguistics, or cultural history. Furthermore, the benchmark dataset spans 29 ancient and modern languages and covers a wide range of historical periods and world regions. Finding the poor performance of LLMs and other agents on HistBench, we further present HistAgent, a history-specific agent equipped with carefully designed tools for OCR, translation, archival search, and image understanding in History. On HistBench, HistAgent based on GPT-4o achieves an accuracy of 27.54% pass@1 and 36.47% pass@2, significantly outperforming LLMs with online search and generalist agents, including GPT-4o (18.60%), DeepSeek-R1(14.49%) and Open Deep Research-smolagents(20.29% pass@1 and 25.12% pass@2). These results highlight the limitations of existing LLMs and generalist agents and demonstrate the advantages of HistAgent for historical reasoning.

cs.AI↗

arXiv2025

Alita: Generalist Agent Enabling Scalable Agentic Reasoning with Minimal Predefinition and Maximal Self-Evolution

Recent advances in large language models (LLMs) have enabled agents to autonomously perform complex, open-ended tasks. However, many existing frameworks depend heavily on manually predefined tools and workflows, which hinder their adaptability, scalability, and generalization across domains. In this work, we introduce Alita--a generalist agent designed with the principle of "Simplicity is the ultimate sophistication," enabling scalable agentic reasoning through minimal predefinition and maximal self-evolution. For minimal predefinition, Alita is equipped with only one component for direct problem-solving, making it much simpler and neater than previous approaches that relied heavily on hand-crafted, elaborate tools and workflows. This clean design enhances its potential to generalize to challenging questions, without being limited by tools. For Maximal self-evolution, we enable the creativity of Alita by providing a suite of general-purpose components to autonomously construct, refine, and reuse external capabilities by generating task-related model context protocols (MCPs) from open source, which contributes to scalable agentic reasoning. Notably, Alita achieves 75.15% pass@1 and 87.27% pass@3 accuracy, which is top-ranking among general-purpose agents, on the GAIA benchmark validation dataset, 74.00% and 52.00% pass@1, respectively, on Mathvista and PathVQA, outperforming many agent systems with far greater complexity. More details will be updated at $\href{https://github.com/CharlesQ9/Alita}{https://github.com/CharlesQ9/Alita}$.

cs.AI↗

arXiv2025

Local-in-time well-posedness for the regular solution to the 2D full compressible Navier-Stokes equations with degenerate viscosities and heat conductivity

This paper considers the two-dimensional Cauchy problem of the full compressible Navier-Stokes equations with far-field vacuum in $\mathbb{R}^2$, where the viscosity and heat-conductivity coefficients depend on the absolute temperature $\theta$ in the form of $\theta^\nu$ with $\nu>0$. Due to the appearance of the vacuum, the momentum equation are both degenerate in the time evolution and spatial dissipation, which makes the study on the well-posedness challenged. By establishing some new singular-weighted (negative powers of the density $\rho$) estimates of the solution, we establish the local-in-time well-posedness of the regular solution with far-field vacuum in terms of $\rho$, the velocity $u$ and the entropy $S$.

math.AP↗

arXiv2025

Design Optimization of Flip FET Standard Cells with Dual-sided Pins for Ultimate Scaling

Recently, we proposed a novel transistor architecture for 3D stacked FETs called Flip FET (FFET), featuring N/P transistors back-to-back stacked and dual-sided interconnects. With dual-sided power rails and signal tracks, FFET can achieve an aggressive 2.5T cell height. As a tradeoff, the complex structure and limited numbers of M0 tracks could limit the standard cell design. As a solution, multiple innovations were introduced and examined in this work. Based on an advanced node design rule, several unique building blocks in FFET such as drain merge (DM), gate merge (GM), field drain merge (FDM) and buried signal track (BST) were investigated. Other key design concepts of multi-row, split gate and dummy gate insertion (DG) were also carefully studied, delivering around 35.6% area reduction compared with 3T CFET. Furthermore, the symmetric design of FFET has unique superiority over CFET thanks to the separate N/P logic on two sides of the wafer and their connections using DM and GM. New routing scheme with dual-sided output pins on both wafer frontside (FS) and backside (BS) was proposed for the first time. Finally, we conducted a comprehensive evaluation on complex cell design, taking AOI22 as an example. New strategies were proposed and examined. The FDM design is identified as the best, outperforming the BST and dummy gate design by 1.93% and 5.13% for the transition delay.

cond-mat.mes-hall↗

arXiv2025

EmoAgent: Assessing and Safeguarding Human-AI Interaction for Mental Health Safety

The rise of LLM-driven AI characters raises safety concerns, particularly for vulnerable human users with psychological disorders. To address these risks, we propose EmoAgent, a multi-agent AI framework designed to evaluate and mitigate mental health hazards in human-AI interactions. EmoAgent comprises two components: EmoEval simulates virtual users, including those portraying mentally vulnerable individuals, to assess mental health changes before and after interactions with AI characters. It uses clinically proven psychological and psychiatric assessment tools (PHQ-9, PDI, PANSS) to evaluate mental risks induced by LLM. EmoGuard serves as an intermediary, monitoring users' mental status, predicting potential harm, and providing corrective feedback to mitigate risks. Experiments conducted in popular character-based chatbots show that emotionally engaging dialogues can lead to psychological deterioration in vulnerable users, with mental state deterioration in more than 34.4% of the simulations. EmoGuard significantly reduces these deterioration rates, underscoring its role in ensuring safer AI-human interactions. Our code is available at: https://github.com/1akaman/EmoAgent

cs.AI↗

arXiv2025

A Systematic Approach for Multi-objective Double-side Clock Tree Synthesis

As the scaling of semiconductor devices nears its limits, utilizing the back-side space of silicon has emerged as a new trend for future integrated circuits. With intense interest, several works have hacked existing backend tools to explore the potential of synthesizing double-side clock trees via nano Through-Silicon-Vias (nTSVs). However, these works lack a systematic perspective on design resource allocation and multi-objective optimization. We propose a systematic approach to design clock trees with double-side metal layers, including hierarchical clock routing, concurrent buffers and nTSVs insertion, and skew refinement. Compared with the state-of-the-art (SOTA) methods, the widely-used open-source tool, our algorithm outperforms them in latency, skew, wirelength, and the number of buffers and nTSVs.

cs.AR↗