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Yifan Gu

Publications and source records attributed to Yifan Gu.

At least 19 recordsLinked to original sources

Continuum modeling of fluidic and elastic flow during growth-driven wound closure in partial-EMT cell monolayers

Large-scale circular gap closure occurs over a time scale on which cell growth and proliferation become important. Growth is the main driver of the closing process, while cell dynamics such as elongation and intercalation reflect elastic and fluidic contributions to tissue deformation. We develop a novel fluidized growth-elasticity framework as a nonlinear analogue of a Maxwell fluid with growth. The framework decomposes the experimentally observable strain rate into the additive sum of the growth, elastic, and fluidic strain rates, thus enabling the separate quantification of these contributions from tissue kinematics and allowing the roles of tissue elasticity and fluidity (the inverse of viscosity) to be characterized. We apply the model to large circular gaps ($\sim$1.7 mm in diameter) in confluent monolayers of mouse embryonic epicardial cells (MEC1) under two conditions, without and with TGF-$\beta$ treatment. We show that both tissue fluidity and the elastic properties associated with fiber reinforcement are critical for reproducing the closure kinematics. Specifically, we predict that the treated condition has lower fluidity, associated with a lower fluidic deformation rate and a higher elastic deformation rate than the untreated condition, in agreement with the experimental observations.

physics.flu-dyn

Collaborative Inference for Sparse High-Dimensional Models with Non-Shared Data

In modern data analysis, statistical efficiency improvement is expected via effective collaboration among multiple data holders with non-shared data. In this article, we propose a collaborative score-type test (CST) for testing linear hypotheses, which accommodates potentially high-dimensional nuisance parameters and a diverging number of constraints and target parameters. Through a careful decomposition of the Kiefer-Bahadur representation for the traditional score statistic, we identify and approximate the key components using aggregated local gradient information from each data source. In addition, we employ a two-stage partial penalization strategy to shrink the approximation error and mitigate the bias from the high-dimensional nuisance parameters. Unlike existing methods, the CST procedure involves constrained optimization under non-shared and high-dimensional data settings, which requires novel theoretical developments. We derive the limiting distributions for the CST statistic under the null hypothesis and the local alternatives. Besides, the CST exhibits an oracle property and achieves the global statistical efficiency. Moreover, it relaxes the stringent restrictions on the number of data sources required in the current literature. Extensive numerical studies and a real example demonstrate the effectiveness and validity of our proposed method.

stat.ME

AVP-AP: Self-supervised Automatic View Positioning in 3D cardiac CT via Atlas Prompting

Automatic view positioning is crucial for cardiac computed tomography (CT) examinations, including disease diagnosis and surgical planning. However, it is highly challenging due to individual variability and large 3D search space. Existing work needs labor-intensive and time-consuming manual annotations to train view-specific models, which are limited to predicting only a fixed set of planes. However, in real clinical scenarios, the challenge of positioning semantic 2D slices with any orientation into varying coordinate space in arbitrary 3D volume remains unsolved. We thus introduce a novel framework, AVP-AP, the first to use Atlas Prompting for self-supervised Automatic View Positioning in the 3D CT volume. Specifically, this paper first proposes an atlas prompting method, which generates a 3D canonical atlas and trains a network to map slices into their corresponding positions in the atlas space via a self-supervised manner. Then, guided by atlas prompts corresponding to the given query images in a reference CT, we identify the coarse positions of slices in the target CT volume using rigid transformation between the 3D atlas and target CT volume, effectively reducing the search space. Finally, we refine the coarse positions by maximizing the similarity between the predicted slices and the query images in the feature space of a given foundation model. Our framework is flexible and efficient compared to other methods, outperforming other methods by 19.8% average structural similarity (SSIM) in arbitrary view positioning and achieving 9% SSIM in two-chamber view compared to four radiologists. Meanwhile, experiments on a public dataset validate our framework's generalizability.

eess.IV

A comparative study of dynamic models for gravity-driven particle-laden flows

The dynamics of viscous thin-film particle-laden flows down inclined surfaces are commonly modeled with one of two approaches: a diffusive flux model or a suspension balance model. The diffusive flux model assumes that the particles migrate via a diffusive flux induced by gradients in both the particle concentration and the effective suspension viscosity. The suspension balance model introduces non-Newtonian bulk stress with shear-induced normal stresses, the gradients of which cause particle migration. Both models have appeared in the literature of particle-laden flow with virtually no comparison between the two models. For particle-laden viscous flow on an incline, in a thin-film geometry, one can use lubrication theory to derive a compact dynamic model in the form of a $2\times 2$ system of conservation laws. We can then directly compare the two theories side by side by looking at similarities and differences in the flux functions for the conservation laws, and in exact and numerical simulations of the equations. We compare the flux profiles over a range of parameters, showing fairly good agreement between the models, with the biggest difference involving the behavior at the free surface. We also consider less dense suspensions at lower inclination angles where the dynamics involve two shock waves that can be clearly measured in experiments. In this context the solutions differ by no more than about 10%, suggesting that either model could be used for this configuration.

physics.flu-dyn

The Potential of LLMs in Medical Education: Generating Questions and Answers for Qualification Exams

In this work, we leverage LLMs to produce medical qualification exam questions and the corresponding answers through few-shot prompts, investigating in-depth how LLMs meet the requirements in terms of coherence, evidence of statement, factual consistency, and professionalism etc. Utilizing a multicenter bidirectional anonymized database with respect to comorbid chronic diseases, named Elderly Comorbidity Medical Database (CECMed), we tasked LLMs with generating open-ended questions and answers based on a subset of sampled admission reports. For CECMed, the retrospective cohort includes patients enrolled from January 2010 to January 2022 while the prospective cohort from January 2023 to November 2023, with participants sourced from selected tertiary and community hospitals across the southern, northern, and central regions of China. A total of 8 widely used LLMs were used, including ERNIE 4, ChatGLM 4, Doubao, Hunyuan, Spark 4, Qwen, Conventional medical education requires sophisticated clinicians to formulate questions and answers based on prototypes from EHRs, which is heuristic and time-consuming. We found that mainstream LLMs could generate questions and answers with real-world EHRs at levels close to clinicians. Although current LLMs performed dissatisfactory in some aspects, medical students, interns and residents could reasonably make use of LLMs to facilitate understanding.

cs.CL

Graph Neural Networks for Distributed Power Allocation in Wireless Networks: Aggregation Over-the-Air

Distributed power allocation is important for interference-limited wireless networks with dense transceiver pairs. In this paper, we aim to design low signaling overhead distributed power allocation schemes by using graph neural networks (GNNs), which are scalable to the number of wireless links. We first apply the message passing neural network (MPNN), a unified framework of GNN, to solve the problem. We show that the signaling overhead grows quadratically as the network size increases. Inspired from the over-the-air computation (AirComp), we then propose an Air-MPNN framework, where the messages from neighboring nodes are represented by the transmit power of pilots and can be aggregated efficiently by evaluating the total interference power. The signaling overhead of Air-MPNN grows linearly as the network size increases, and we prove that Air-MPNN is permutation invariant. To further reduce the signaling overhead, we propose the Air message passing recurrent neural network (Air-MPRNN), where each node utilizes the graph embedding and local state in the previous frame to update the graph embedding in the current frame. Since existing communication systems send a pilot during each frame, Air-MPRNN can be integrated into the existing standards by adjusting pilot power. Simulation results validate the scalability of the proposed frameworks, and show that they outperform the existing power allocation algorithms in terms of sum-rate for various system parameters.

eess.SP

Optimizing Information Freshness in Two-Hop Status Update Systems under a Resource Constraint

In this paper, we investigate the age minimization problem for a two-hop relay system, under a resource constraint on the average number of forwarding operations at the relay. We first design an optimal policy by modelling the considered scheduling problem as a constrained Markov decision process (CMDP) problem. Based on the observed multi-threshold structure of the optimal policy, we then devise a low-complexity double threshold relaying (DTR) policy with only two thresholds, one for relay's AoI and the other one for the age gain between destination and relay. We derive approximate closed-form expressions of the average AoI at the destination, and the average number of forwarding operations at the relay for the DTR policy, by modelling the tangled evolution of age at relay and destination as a Markov chain (MC). Numerical results validate all the theoretical analysis, and show that the low-complexity DTR policy can achieve near optimal performance compared with the optimal CMDP-based policy. Moreover, the relay should always consider the threshold for its local age to maintain a low age at the destination. When the resource constraint is relatively tight, it further needs to consider the threshold on the age gain to ensure that only those packets that can decrease destination's age dramatically will be forwarded.

cs.IT

Software-Defined Radio Implementation of Age-of-Information-Oriented Random Access

More and more emerging Internet of Things (IoT) applications involve status updates, where various IoT devices monitor certain physical processes and report their latest statuses to the relevant information fusion nodes. A new performance measure, termed the age of information (AoI), has recently been proposed to quantify the information freshness in time-critical IoT applications. Due to a large number of devices in future IoT networks, the decentralized channel access protocols (e.g. random access) are preferable thanks to their low network overhead. Built on the AoI concept, some recent efforts have developed several AoI-oriented ALOHA-like random access protocols for boosting the network-wide information freshness. However, all relevant works focused on theoretical designs and analysis. The development and implementation of a working prototype to evaluate and further improve these random access protocols in practice have been largely overlooked. Motivated as such, we build a software-defined radio (SDR) prototype for testing and comparing the performance of recently proposed AoI-oriented random access protocols. To this end, we implement a time-slotted wireless system by devising a simple yet effective over-the-air time synchronization scheme, in which beacons that serve as reference timing packets are broadcast by an access point from time to time. For a complete working prototype, we also design the frame structures of various packets exchanged within the system. Finally, we design a set of experiments, implement them on our prototype and test the considered algorithms in an office environment.

cs.NI

Age-of-Information Dependent Random Access for Massive IoT Networks

As the most well-known application of the Internet of Things (IoT), remote monitoring is now pervasive. In these monitoring applications, information usually has a higher value when it is fresher. A new metric, termed the age of information (AoI), has recently been proposed to quantify the information freshness in various IoT applications. This paper concentrates on the design and analysis of age-oriented random access for massive IoT networks. Specifically, we devise a new stationary threshold-based age-dependent random access (ADRA) protocol, in which each IoT device accesses the channel with a certain probability only when its instantaneous AoI exceeds a predetermined threshold. We manage to evaluate the average AoI of the proposed ADRA protocol mathematically by decoupling the tangled AoI evolution of multiple IoT devices and modeling the decoupled AoI evolution of each device as a Discrete-Time Markov Chain. Simulation results validate our theoretical analysis and affirm the superior age performance of the proposed ADRA protocol over the state-of-the-art age-oriented random access schemes.

cs.IT

Minimizing the Age of Information of Cognitive Radio-Based IoT Systems Under A Collision Constraint

This paper considers a cognitive radio-based IoT monitoring system, consisting of an IoT device that aims to update its measurement to a destination using cognitive radio technique. Specifically, the IoT device as a secondary user (SIoT), seeks and exploits the spectrum opportunities of the licensed band vacated by its primary user (PU) to deliver status updates without causing visible effects to the licensed operation. In this context, the SIoT should carefully make use of the licensed band and schedule when to transmit to maintain the timeliness of the status update. We adopt a recent metric, Age of Information (AoI), to characterize the timeliness of the status update of the SIoT. We aim to minimize the long-term average AoI of the SIoT while satisfying the collision constraint imposed by the PU by formulating a constrained Markov decision process (CMDP) problem. We first prove the existence of optimal stationary policy of the CMDP problem. The optimal stationary policy (termed age-optimal policy) is shown to be a randomized simple policy that randomizes between two deterministic policies with a fixed probability. We prove that the two deterministic policies have a threshold structure and further derive the closed-form expression of average AoI and collision probability for the deterministic threshold-structured policy by conducting Markov Chain analysis. The analytical expression offers an efficient way to calculate the threshold and randomization probability to form the age-optimal policy. For comparison, we also consider the throughput maximization policy (termed throughput-optimal policy) and analyze the average AoI performance under the throughput-optimal policy in the considered system. Numerical simulations show the superiority of the derived age-optimal policy over the throughput-optimal policy. We also unveil the impacts of various system parameters on the corresponding optimal policy and the resultant average AoI.

cs.IT

Minimizing Age of Information in Cognitive Radio-based IoT Systems: Underlay or Overlay?

We consider a cognitive radio-based Internet-of-Things (CR-IoT) network consisting of one primary IoT (PIoT) system and one secondary IoT (SIoT) system. The IoT devices of both the PIoT and the SIoT respectively monitor one physical process and send randomly generated status updates to their associated access points (APs). The timeliness of the status updates is important as the systems are interested in the latest condition (e.g., temperature, speed and position) of the IoT device. In this context, two natural questions arise: (1) How to characterize the timeliness of the status updates in CR-IoT systems? (2) Which scheme, overlay or underlay, is better in terms of the timeliness of the status updates. To answer these two questions, we adopt a new performance metric, named the age of information (AoI). We analyze the average peak AoI of the PIoT and the SIoT for overlay and underlay schemes, respectively. Simple asymptotic expressions of the average peak AoI are also derived when the PIoT operates at high signal-to-noise ratio (SNR). Based on the asymptotic expressions, we characterize a critical generation rate of the PIoT system, which can determine the superiority of overlay and underlay schemes in terms of the average peak AoI of the SIoT. Numerical results validate the theoretical analysis and uncover that the overlay and underlay schemes can outperform each other in terms of the average peak AoI of the SIoT for different system setups.

eess.SP

On the Age of Information of Short-Packet Communications with Packet Management

In this paper, we consider a point-to-point wireless communication system. The source monitors a physical process and generates status update packets according to a Poisson process. The packets are transmitted to the destination by using finite blocklength coding to update the status (e.g., temperature, speed, position) of the monitored process. In some applications, such as real-time monitoring and tracking, the timeliness of the status updates is critical since the users are interested in the latest condition of the process. The timeliness of the status updates can be reflected by a recently proposed metric, termed the age of information (AoI). We focus on the packet management policies for the considered system. Specifically, the preemption and discard of status updates are important to decrease the AoI. For example, it is meaningless to transmit stale status updates when a new status update is generated. We propose three packet management schemes in the transmission between the source and the destination, namely non-preemption (NP), preemption (PR) and retransmission (RT) schemes. We derive closed-form expressions of the average AoI for the proposed three schemes. Based on the derived analytical expressions of the average AoI, we further minimize the average AoI by optimizing the packet blocklength for each status update. Simulation results are provided to validate our theoretical analysis, which further show that the proposed schemes can outperform each other for different system setups, and the proposed schemes considerably outperform the existing ones without packet management at medium to high generation rate.

eess.SP

Short-Packet Two-Way Amplify-and-Forward Relaying

This letter investigates an amplify-and-forward two-way relay network (TWRN) for short-packet communications. We consider a classical three-node TWRN consisting of two sources and one relay. Both two time slots (2TS) scheme and three time slots (3TS) scheme are studied under the finite blocklength regime. We derive approximate closed-form expressions of sum-block error rate (BLER) for both schemes. Simple asymptotic expressions for sum-BLER at high signal-to-noise ratio (SNR) are also derived. Based on the asymptotic expressions, we analytically compare the sum-BLER performance of 2TS and 3TS schemes, and attain an expression of critical blocklength, which can determine the performance superiority of 2TS and 3TS in terms of sum-BLER. Extensive simulations are provided to validate our theoretical analysis. Our results discover that 3TS scheme is more suitable for a system with lower relay transmission power, higher differences between the average SNR of both links and relatively lower requirements on data rate and latency.

cs.IT

Ultra-Reliable Short-Packet Communications: Half-Duplex or Full-Duplex Relaying?

This letter analyzes and compares the performance of full-duplex relaying (FDR) and half-duplex relaying (HDR) for ultra-reliable short-packet communications. Specifically, we derive both approximate and asymptotic closed-form expressions of the block error rate (BLER) for FDR and HDR using short packets with finite blocklength codes. We define and attain a closed-form expression of a critical BLER, which can be used to efficiently determine the optimal duplex mode for ultra-reliable low latency communication scenarios. Our results unveil that FDR is more appealing to the system with relatively lower transmit power constraint, less stringent BLER requirement and stronger loop interference suppression.

cs.IT

Distributed Multi-Relay Selection in Accumulate-then-Forward Energy Harvesting Relay Networks

This paper investigates a wireless-powered cooperative network (WPCN) consisting of one source-destination pair and multiple decode-and-forward (DF) relays. We develop an energy threshold based multi-relay selection (ETMRS) scheme for the considered WPCN. The proposed ETMRS scheme can be implemented in a fully distributed manner as the relays only need local information to switch between energy harvesting and information forwarding modes. By modeling the charging/discharging behaviours of the finite-capacity battery at each relay as a finite-state Markov Chain (MC), we derive an analytical expression for the system outage probability of the proposed ETMRS scheme over mixed Nakagami-$m$ and Rayleigh fading channels. Based on the derived expression, the optimal energy thresholds for all the relays corresponding to the minimum system outage probability can be obtained via an exhaustive search. However, this approach becomes computationally prohibitive when the number of relays and the associated number of battery energy levels is large. To resolve this issue, we propose a heuristic approach to optimize the energy threshold for each relay. To gain some useful insights for practical relay design, we also derive the upper bound for system outage probability corresponding to the case that all relays are equipped with infinite-capacity batteries. Numerical results validate our theoretical analysis. It is shown that the proposed heuristic approach can achieve a near-optimal system performance and our ETMRS scheme outperforms the existing single-relay selection scheme and common energy threshold scheme.

cs.IT

Exploiting Energy Accumulation Against Co-channel Interference in Wireless Energy Harvesting MIMO Relaying

This paper investigates a three-node multiple-input multiple-output relay system suffering from co-channel interference (CCI) at the multi-antenna relay. Contrary to the conventional relay networks, we consider the scenario that the relay is an energy harvesting (EH) node and has no embedded energy supply. But it is equipped with a rechargeable battery such that it can harvest and accumulate the harvested energy from RF signals sent by the source and co-channel interferers to support its operation. Leveraging the inherent feature of the considered system, we develop a novel accumulate-then-forward (ATF) protocol to eliminate the harmful effect of CCI. In the proposed ATF scheme, at the beginning of each transmission block, the relay can choose either EH operation to harvest energy from source and CCI or information decoding (ID) operation to decode and forward source's information while suffering from CCI. Specifically, ID operation is activated only when the accumulated energy at the relay can support an outage-free transmission in the second hop. Otherwise, EH operation is invoked at the relay to harvest and accumulate energy. By modeling the finite-capacity battery of relay as a finite-state Markov Chain (MC), we derive a closed-form expression for the system throughput of the proposed ATF scheme over mixed Nakagami-m and Rayleigh fading channels. Numerical results validate our theoretical analysis, and show that the proposed ATF scheme with energy accumulation significantly outperforms the existing one without energy accumulation.

cs.IT

Wireless-Powered Two-Way Relaying with Power Splitting-based Energy Accumulation

This paper investigates a wireless-powered two-way relay network (WP-TWRN), in which two sources exchange information with the aid of one amplify-and-forward (AF) relay. Contrary to the conventional two-way relay networks, we consider the scenario that the AF relay has no embedded energy supply, and it is equipped with an energy harvesting unit and rechargeable battery. As such, it can accumulate the energy harvested from both sources' signals before helping forwarding their information. In this paper, we develop a power splitting-based energy accumulation (PS-EA) scheme for the considered WP-TWRN. To determine whether the relay has accumulated sufficient energy, we set a predefined energy threshold for the relay. When the accumulated energy reaches the threshold, relay splits the received signal power into two parts, one for energy harvesting and the other for information forwarding. If the stored energy at the relay is below the threshold, all the received signal power will be accumulated at the relay's battery. By modeling the finite-capacity battery of relay as a finite-state Markov Chain (MC), we derive a closed-form expression for the system throughput of the proposed PS-EA scheme over Nakagami-m fading channels. Numerical results validate our theoretical analysis and show that the proposed PS-EA scheme outperforms the conventional time switching-based energy accumulation (TS-EA) scheme and the existing power splitting schemes without energy accumulation.

cs.IT

Accumulate then Forward: An Opportunistic Relaying Protocol for Wireless-Powered Cooperative Communications

This paper investigates a wireless-powered cooperative communication network consisting of a source, a destination and a multi-antenna decode-and-forward relay. We consider the relay as a wireless-powered node that has no external power supply; but it is equipped with an energy harvesting (EH) unit and a rechargeable battery such that it can harvest and accumulate energy from radio-frequency signals broadcast by the source. By fully incorporating the EH feature of the relay, we develop an opportunistic relaying protocol, termed accumulate-then-forward (ATF), for the considered WPCCN. We then adopt the discrete Markov chain to model the dynamic charging and discharging behaviors of the relay battery. Based on this, we derive a closed-form expression for the exact outage probability of the proposed ATF protocol. Numerical results show that the ATF scheme can outperform the direct transmission one, especially when the amount of energy consumed by relay for information forwarding is optimized.

cs.IT