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Ying Yan

Publications and source records attributed to Ying Yan.

At least 37 records · Page 2Linked to original sources

Multicategory Matched Learning for Estimating Optimal Individualized Treatment Rules in Observational Studies with Application to a Hepatocellular Carcinoma Study

One primary goal of precision medicine is to estimate the individualized treatment rules (ITRs) that optimize patients' health outcomes based on individual characteristics. Health studies with multiple treatments are commonly seen in practice. However, most existing ITR estimation methods were developed for the studies with binary treatments. Many require that the outcomes are fully observed. In this paper, we propose a matching-based machine learning method to estimate the optimal ITRs in observational studies with multiple treatments when the outcomes are fully observed or right-censored. We establish theoretical property for the proposed method. It is compared with the existing competitive methods in simulation studies and a hepatocellular carcinoma study.

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Symmetry breaking of large-amplitude parametric oscillations in few-layer graphene nanomechanical resonators

Graphene nanomechanical resonators are well suited for the study of parametric oscillations. Their large frequency tunability and their pronounced nonlinearities enable an efficient modulation of their resonant frequencies. Here, we present measurements of the response of few-layer graphene nanomechanical resonators, each driven by a large parametric pump at frequency $2ω$ and a weak external drive at $ω$, where $ω$ is set near the mechanical resonant frequency $ω_0$. The pump actuates the resonator beyond the threshold for large-amplitude parametric oscillations, while the drive breaks the symmetry between the parametric phase states. By increasing and decreasing a gate voltage to detune $ω_0$ in the presence of the pump and the drive, we observe a double hysteresis in the response. The double hysteresis reveals the existence of two possible large-amplitude vibrational states whose phase difference is nearly $π$ radians. We deterministically prepare the resonator in either one of these states by cycling the gate voltage. We measure the stationary occupation probabilities of the two states in the presence of a white Gaussian force noise, and find that they strongly depend on the amplitude and on the phase of the external drive. The phase states of parametric oscillations with broken amplitude symmetry can be mapped to biased bi-modal degrees of freedom, such as Ising spins in an external magnetic field. Therefore, they hold promise as units of binary information.

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Hysteretic responses of nanomechanical resonators based on crumpled few-layer graphene

Manipulating two-dimensional materials occasionally results in crumpled membranes. Their complicated morphologies feature an abundance of folds, creases and wrinkles that make each crumpled membrane unique. Here, we prepare four nanomechanical resonators based on crumpled membranes of few-layer graphene and measure their static response and the spectrum of their dynamic response. We tune both responses with a dc voltage applied between the membrane and an underlying gate electrode. Surprisingly, we find that all four resonators exhibit hysteretic responses as the gate voltage is increased and then decreased. Concomitant discontinuities in the static response and in the vibrational resonant frequencies indicate a sudden change in the shape and in the tensile strain of the membranes. We also find that the hystereses can be removed and regular responses can be restored by annealing the resonators. We hypothesize that the hysteretic nature of the responses may originate from an interplay between the rugged morphology of the membranes and adsorbates trapped within the confine of the folds.

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A few-layer graphene nanomechanical resonator driven by digitally modulated video signals

Nanomechanical resonators driven by multifrequency signals combine the physics of mesoscopic vibrations and the technologies of radio communication. Their simplest property stems from their resonant response: they behave as filters, responding only to driving signals whose frequency range is contained within that of the mechanical response. While the response is routinely probed with a single tone drive, a multifrequency drive offers the possibility of inducing richer vibrational dynamics. In this case, all the frequency components of the drive are simultaneously transduced into vibrations with different amplitudes and phases that superimpose and interfere. Here, we employ a few-layer graphene nanomechanical resonator as a filter for broadband, digitally modulated video signals. We transduce the modulated drive into modulated vibrations, which we demodulate into a nanomechanical video. Our work reveals distinctive features in vibrations driven by a coherent, multifrequency drive unseen in vibrations actuated by single tone drives or by a force noise.

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Matching-Based Policy Learning

The beneficial effects of treatments vary across individuals in most studies. Treatment heterogeneity motivates practitioners to search for the optimal policy based on personal characteristics. A long-standing common practice in policy learning has been estimating and maximizing the value function using weighting techniques. Matching is widely used in many applied disciplines to infer causal effects, which is intuitively appealing because the observed covariates are directly balanced across different treatment groups. Nevertheless, matching is rarely explored in policy learning. In this work, we propose a matching-based policy learning framework. We adapt standard and bias-corrected matching methods to estimate an alternative form of the value function: the advantage function, which can be interpreted as the expected improvement achieved by implementing a given policy compared to the equiprobable random policy. We then learn the optimal policy over a restricted policy class by maximizing the matching estimator of the advantage function. We derive a non-asymptotic high probability bound for the regret of the learned optimal policy. Moreover, we show that the learned policy is almost rate-optimal. The competitive finite sample performance of the proposed method compared to weighting-based and outcome modeling-based learning methods is demonstrated in extensive simulation studies and a real data application.

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SCKF-LSTM Based Trajectory Tracking for Electricity-Gas Integrated Energy System

This paper introduces a novel approach for tracking the dynamic trajectories of integrated natural gas and power systems, leveraging a Kalman filter-based structure. To predict the states of the system, the Holt's exponential smoothing techniques and nonlinear dynamic equations of gas pipelines are applied to establish the power and gas system equations, respectively. The square-root cubature Kalman filter algorithm is utilized to address the numerical challenges posed by the strongly nonlinear system equations. The boundary conditions in the gas system include the flow balances at sink nodes, and the mass flow rates of loads have to be predicted at each computation step. For the prediction of load mass flows, the long short-term memory network is employed, known for its effectiveness in time series prediction. Consequently, a combined method based on the square-root cubature Kalman filter and the long short-term memory network is proposed for tracking integrated gas and power systems. To evaluate the tracking performances of the proposed method, the IEEE-39 bus power system and GasLib-40 node gas system are used to form the testing system. Simulation results demonstrate high precision in tracking the dynamic states of power and gas systems. Two indexes are introduced for a numerical analysis of the tracking results, indicating that the accuracy of this method surpasses that of traditional measurements.

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Tailoring the light-matter interaction for high-fidelity holonomic gate operations in multiple systems

Realization of quantum computing requires the development of high-fidelity quantum gates that are resilient to decoherence, control errors, and environmental noise. While non-adiabatic holonomic quantum computation (NHQC) offers a promising approach, it often necessitates system-specific adjustments. This work presents a versatile scheme for implementing NHQC gates across multiple qubit systems by optimizing multiple degrees of freedom using a genetic algorithm. The scheme is applied to three qubit systems: ensemble rare-earth ion (REI) qubits, single REI qubits, and superconducting transmon qubits. Numerical simulations demonstrate that the optimized gate operations are robust against frequency detuning and induce low off-resonant excitations, making the scheme effective for advancing fault-tolerant quantum computation across various platforms.

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Covariate balancing with measurement error

In recent years, there is a growing body of causal inference literature focusing on covariate balancing methods. These methods eliminate observed confounding by equalizing covariate moments between the treated and control groups. The validity of covariate balancing relies on an implicit assumption that all covariates are accurately measured, which is frequently violated in observational studies. Nevertheless, the impact of measurement error on covariate balancing is unclear, and there is no existing work on balancing mismeasured covariates adequately. In this article, we show that naively ignoring measurement error reversely increases the magnitude of covariate imbalance and induces bias to treatment effect estimation. We then propose a class of measurement error correction strategies for the existing covariate balancing methods. Theoretically, we show that these strategies successfully recover balance for all covariates, and eliminate bias of treatment effect estimation. We assess the proposed correction methods in simulation studies and real data analysis.

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FreeV: Free Lunch For Vocoders Through Pseudo Inversed Mel Filter

Vocoders reconstruct speech waveforms from acoustic features and play a pivotal role in modern TTS systems. Frequent-domain GAN vocoders like Vocos and APNet2 have recently seen rapid advancements, outperforming time-domain models in inference speed while achieving comparable audio quality. However, these frequency-domain vocoders suffer from large parameter sizes, thus introducing extra memory burden. Inspired by PriorGrad and SpecGrad, we employ pseudo-inverse to estimate the amplitude spectrum as the initialization roughly. This simple initialization significantly mitigates the parameter demand for vocoder. Based on APNet2 and our streamlined Amplitude prediction branch, we propose our FreeV, compared with its counterpart APNet2, our FreeV achieves 1.8 times inference speed improvement with nearly half parameters. Meanwhile, our FreeV outperforms APNet2 in resynthesis quality, marking a step forward in pursuing real-time, high-fidelity speech synthesis. Code and checkpoints is available at: https://github.com/BakerBunker/FreeV

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Mahalanobis balancing: a multivariate perspective on approximate covariate balancing

In the past decade, various exact balancing-based weighting methods were introduced to the causal inference literature. Exact balancing alleviates the extreme weight and model misspecification issues that may incur when one implements inverse probability weighting. It eliminates covariate imbalance by imposing balancing constraints in an optimization problem. The optimization problem can nevertheless be infeasible when there is bad overlap between the covariate distributions in the treated and control groups or when the covariates are high-dimensional. Recently, approximate balancing was proposed as an alternative balancing framework, which resolves the feasibility issue by using inequality moment constraints instead. However, it can be difficult to select the threshold parameters when the number of constraints is large. Moreover, moment constraints may not fully capture the discrepancy of covariate distributions. In this paper, we propose Mahalanobis balancing, which approximately balances covariate distributions from a multivariate perspective. We use a quadratic constraint to control overall imbalance with a single threshold parameter, which can be tuned by a simple selection procedure. We show that the dual problem of Mahalanobis balancing is an l_2 norm-based regularized regression problem, and establish interesting connection to propensity score models. We further generalize Mahalanobis balancing to the high-dimensional scenario. We derive asymptotic properties and make extensive comparisons with existing balancing methods in the numerical studies.

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Fast Evolution of Single Qubit Gate in Non-Adiabatic Geometric Quantum Computing

We implemented arbitrary single qubit gates of geometric quantum computing for a three-level system in a single-shot manner. The evolution time of the gate has been minimized by considering the shortest trajectory of the state on the Bloch sphere. The duration of gates grows from zero with the rotation angle $γ$, and the tested T gate time can be reduced to $\sim$40\% of those in the traditional orange-sliced-shaped path non-adiabatic holonomic quantum computing (NHQC) scheme by the parametrization of Rabi frequency. We also demonstrated that certain pulses are robust against static detuning errors and Rabi errors. The time-dependent detuning and Rabi frequency are found to be proportional to each other by a constant which is determined by the geometric phase. In this way, some previous NHQC schemes can be treated as special cases in our generalized model.

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Parallel measurements of vibrational modes in a few-layer graphene nanomechanical resonator using software-defined radio dongles

Software-defined radio dongles are small and inexpensive receivers well known to amateur radio enthusiasts. When connected to an antenna, they enable monitoring of a wide range of the radio spectrum by conditioning the input signal and transferring a downconverted version of it to a personal computer for software processing. Here, we employ a composite of two such dongles, interfaced with codes written in MATLAB and GNU Radio, as a measuring instrument to study the flexural vibrations of a few-layer graphene nanomechanical resonator. Instead of an antenna, we connect the dongles to the split output of a photodetector used to detect vibrations optically. We first perform a quantitative analysis of the dynamics of the first vibrational mode. We then measure the response of the first two vibrational modes in parallel. To illustrate our technique, we detect changes in the vibrational amplitude of both modes induced by periodic strain modulation with a delay of $\approx1$ ms between measurements. Last, we show that our software-based instrument can be employed to demodulate human voice encoded in the vibrations of our resonator. For parallel measurements of several frequency channels, and provided that the input signal is not too weak, our composite system may offer an alternative to the use of multiple lock-in amplifiers or multiple spectrum analyzers, with the distinct advantage of being cost-effective per frequency channel.

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IQDUBBING: Prosody modeling based on discrete self-supervised speech representation for expressive voice conversion

Prosody modeling is important, but still challenging in expressive voice conversion. As prosody is difficult to model, and other factors, e.g., speaker, environment and content, which are entangled with prosody in speech, should be removed in prosody modeling. In this paper, we present IQDubbing to solve this problem for expressive voice conversion. To model prosody, we leverage the recent advances in discrete self-supervised speech representation (DSSR). Specifically, prosody vector is first extracted from pre-trained VQ-Wav2Vec model, where rich prosody information is embedded while most speaker and environment information are removed effectively by quantization. To further filter out the redundant information except prosody, such as content and partial speaker information, we propose two kinds of prosody filters to sample prosody from the prosody vector. Experiments show that IQDubbing is superior to baseline and comparison systems in terms of speech quality while maintaining prosody consistency and speaker similarity.

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Experimental implementation of precisely tailored light-matter interaction via inverse engineering

Accurate and efficient quantum control in the presence of constraints and decoherence is a requirement and a challenge in quantum information processing. Shortcuts to adiabaticity, originally proposed to speed up slow adiabatic process, have nowadays become versatile toolboxes for preparing states or controlling the quantum dynamics. Unique shortcut designs are required for each quantum system with intrinsic physical constraints, imperfections, and noises. Here, we implement fast and robust control for the state preparation and state engineering in a rare-earth ions system. Specifically, the interacting pulses are inversely engineered and further optimized with respect to inhomogeneities of the ensemble and the unwanted interaction with other qubits. We demonstrate that our protocols surpass the conventional adiabatic schemes, by reducing the decoherence from the excited state decay and inhomogeneous broadening. The results presented here are applicable to other noisy intermediate scale quantum systems.

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Engineering of the qubit initialization in an imperfect physical system

We proposed a method to engineer the light matter interaction while initializing a qubit in presence of physical constraints utilizing the inverse engineering. Combining the multiple degrees of freedom in the pulse parameters with the perturbation theory, we developed pulses to initialize the qubit within a tightly packed frequency interval to an arbitrary superposition state with high fidelity. Importantly, the initialization induces low off-resonant excitations to the neighboring qubits, and it is robust against the spatial inhomogeneity in the laser intensity. We applied the method to the ensemble rare-earth ions system, and simulations show that the initialization is more robust against the variations in laser intensity than the previous pulses, and reduces the time that ions spend in the intermediate excited state by a factor of 17. The method is applicable to any systems addressed in frequency such as NV centers, superconducting qubits, quantum dots, and molecular qubit systems.

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Kernel-Distance-Based Covariate Balancing

A common concern in observational studies focuses on properly evaluating the causal effect, which usually refers to the average treatment effect or the average treatment effect on the treated. In this paper, we propose a data preprocessing method, the Kernel-distance-based covariate balancing, for observational studies with binary treatments. This proposed method yields a set of unit weights for the treatment and control groups, respectively, such that the reweighted covariate distributions can satisfy a set of pre-specified balance conditions. This preprocessing methodology can effectively reduce confounding bias of subsequent estimation of causal effects. We demonstrate the implementation and performance of Kernel-distance-based covariate balancing with Monte Carlo simulation experiments and a real data analysis.

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Empirical Likelihood-Based Estimation and Inference in Randomized Controlled Trials with High-Dimensional Covariates

In this paper, we propose a data-adaptive empirical likelihood-based approach for treatment effect estimation and inference, which overcomes the obstacle of the traditional empirical likelihood-based approaches in the high-dimensional setting by adopting penalized regression and machine learning methods to model the covariate-outcome relationship. In particular, we show that our procedure successfully recovers the true variance of Zhang's treatment effect estimator (Zhang, 2018) by utilizing a data-splitting technique. Our proposed estimator is proved to be asymptotically normal and semiparametric efficient under mild regularity conditions. Simulation studies indicate that our estimator is more efficient than the estimator proposed by Wager et al. (2016) when random forests are employed to model the covariate-outcome relationship. Moreover, when multiple machine learning models are imposed, our estimator is at least as efficient as any regular estimator with a single machine learning model. We compare our method to existing ones using the ACTG175 data and the GSE118657 data, and confirm the outstanding performance of our approach.

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Empirical Likelihood Weighted Estimation of Average Treatment Effects

There has been growing attention on how to effectively and objectively use covariate information when the primary goal is to estimate the average treatment effect (ATE) in randomized clinical trials (RCTs). In this paper, we propose an effective weighting approach to extract covariate information based on the empirical likelihood (EL) method. The resulting two-sample empirical likelihood weighted (ELW) estimator includes two classes of weights, which are obtained from a constrained empirical likelihood estimation procedure, where the covariate information is effectively incorporated into the form of general estimating equations. Furthermore, this ELW approach separates the estimation of ATE from the analysis of the covariate-outcome relationship, which implies that our approach maintains objectivity. In theory, we show that the proposed ELW estimator is semiparametric efficient. We extend our estimator to tackle the scenarios where the outcomes are missing at random (MAR), and prove the double robustness and multiple robustness properties of our estimator. Furthermore, we derive the semiparametric efficiency bound of all regular and asymptotically linear semiparametric ATE estimators under MAR mechanism and prove that our proposed estimator attains this bound. We conduct simulations to make comparisons with other existing estimators, which confirm the efficiency and multiple robustness property of our proposed ELW estimator. An application to the AIDS Clinical Trials Group Protocol 175 (ACTG 175) data is conducted.

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