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Ying Yuan

Publications and source records attributed to Ying Yuan.

At least 55 records · Page 3Linked to original sources

Lessons from Learning to Spin "Pens"

In-hand manipulation of pen-like objects is an important skill in our daily lives, as many tools such as hammers and screwdrivers are similarly shaped. However, current learning-based methods struggle with this task due to a lack of high-quality demonstrations and the significant gap between simulation and the real world. In this work, we push the boundaries of learning-based in-hand manipulation systems by demonstrating the capability to spin pen-like objects. We first use reinforcement learning to train an oracle policy with privileged information and generate a high-fidelity trajectory dataset in simulation. This serves two purposes: 1) pre-training a sensorimotor policy in simulation; 2) conducting open-loop trajectory replay in the real world. We then fine-tune the sensorimotor policy using these real-world trajectories to adapt it to the real world dynamics. With less than 50 trajectories, our policy learns to rotate more than ten pen-like objects with different physical properties for multiple revolutions. We present a comprehensive analysis of our design choices and share the lessons learned during development.

cs.RO↗

ROMI: A Randomized Two-Stage Basket Trial Design to Optimize Doses for Multiple Indications

Optimizing doses for multiple indications is challenging. The pooled approach of finding a single optimal biological dose (OBD) for all indications ignores that dose-response or dose-toxicity curves may differ between indications, resulting in varying OBDs. Conversely, indication-specific dose optimization often requires a large sample size. To address this challenge, we propose a Randomized two-stage basket trial design that Optimizes doses in Multiple Indications (ROMI). In stage 1, for each indication, response and toxicity are evaluated for a high dose, which may be a previously obtained MTD, with a rule that stops accrual to indications where the high dose is unsafe or ineffective. Indications not terminated proceed to stage 2, where patients are randomized between the high dose and a specified lower dose. A latent-cluster Bayesian hierarchical model is employed to borrow information between indications, while considering the potential heterogeneity of OBD across indications. Indication-specific utilities are used to quantify response-toxicity trade-offs. At the end of stage 2, for each indication with at least one acceptable dose, the dose with highest posterior mean utility is selected as optimal. Two versions of ROMI are presented, one using only stage 2 data for dose optimization and the other optimizing doses using data from both stages. Simulations show that both versions have desirable operating characteristics compared to designs that either ignore indications or optimize dose independently for each indication.

stat.ME↗

MPCODER: Multi-user Personalized Code Generator with Explicit and Implicit Style Representation Learning

Large Language Models (LLMs) have demonstrated great potential for assisting developers in their daily development. However, most research focuses on generating correct code, how to use LLMs to generate personalized code has seldom been investigated. To bridge this gap, we proposed MPCoder (Multi-user Personalized Code Generator) to generate personalized code for multiple users. To better learn coding style features, we utilize explicit coding style residual learning to capture the syntax code style standards and implicit style learning to capture the semantic code style conventions. We train a multi-user style adapter to better differentiate the implicit feature representations of different users through contrastive learning, ultimately enabling personalized code generation for multiple users. We further propose a novel evaluation metric for estimating similarities between codes of different coding styles. The experimental results show the effectiveness of our approach for this novel task.

cs.CL↗

First Indication of Solar $^8$B Neutrino Flux through Coherent Elastic Neutrino-Nucleus Scattering in PandaX-4T

The PandaX-4T liquid xenon detector at the China Jinping Underground Laboratory is used to measure the solar $^8$B neutrino flux by detecting neutrinos through coherent scattering with xenon nuclei. Data samples requiring the coincidence of scintillation and ionization signals (paired), as well as unpaired ionization-only signals (US2), are selected with energy threshold of approximately 1.1 keV (0.33 keV) nuclear recoil energy. Combining the commissioning run and the first science run of PandaX-4T, a total exposure of 1.20 and 1.04 tonne$\cdot$year are collected for the paired and US2, respectively. After unblinding, 3 and 332 events are observed with an expectation of 2.8$\pm$0.5 and 251$\pm$32 background events, for the paired and US2 data, respectively. A combined analysis yields a best-fit $^8$B neutrino signal of 3.5 (75) events from the paired (US2) data sample, with $\sim$37\% uncertainty, and the background-only hypothesis is disfavored at 2.64$σ$ significance. This gives a solar $^8$B neutrino flux of ($8.4\pm3.1$)$\times$10$^6$ cm$^{-2}$s$^{-1}$, consistent with the standard solar model prediction. It is also the first indication of solar $^8$B neutrino ``fog'' in a dark matter direct detection experiment.

hep-ex↗

Search for Cosmic-ray Boosted Sub-MeV Dark-Matter-Electron Scattering in PandaX-4T

We report the first search for the elastic scatterings between cosmic-ray boosted sub-MeV dark matter and electrons in the PandaX-4T liquid xenon experiment. Sub-MeV dark matter particles can be accelerated by scattering with electrons in the cosmic rays and produce detectable electron recoil signals in the detector. Using the commissioning data from PandaX-4T of 0.63~tonne$\cdot$year exposure, we set new constraints on DM-electron scattering cross sections for DM masses ranging from 10~eV/$c^2$ to 3~keV/$c^2$.

hep-ex↗

Dual-criterion Dose Finding Designs Based on Dose-Limiting Toxicity and Tolerability

The primary objective of Phase I oncology trials is to assess the safety and tolerability of novel therapeutics. Conventional dose escalation methods identify the maximum tolerated dose (MTD) based on dose-limiting toxicity (DLT). However, as cancer therapies have evolved from chemotherapy to targeted therapies, these traditional methods have become problematic. Many targeted therapies rarely produce DLT and are administered over multiple cycles, potentially resulting in the accumulation of lower-grade toxicities, which can lead to intolerance, such as dose reduction or interruption. To address this issue, we proposed dual-criterion designs that find the MTD based on both DLT and non-DLT-caused intolerance. We considered the model-based design and model-assisted design that allow real-time decision-making in the presence of pending data due to long event assessment windows. Compared to DLT-based methods, our approaches exhibit superior operating characteristics when intolerance is the primary driver for determining the MTD and comparable operating characteristics when DLT is the primary driver.

stat.ME↗

Constraints on the axial-vector and pseudo-scalar mediated WIMP-nucleus interactions from PandaX-4T experiment

We present the constraints on the axial-vector and pseudo-scalar mediated WIMP-nucleus interactions from the PandaX-4T experiment, using the data set corresponding to a total exposure of 0.63~tonne$\cdot$year. No significant signal excess is observed, and the most stringent upper limits to date on the spin-dependent WIMP-neutron scattering cross section are set at 90\% confidence level with the minimum WIMP-neutron scattering cross section of 5.8$\times 10^{-42}$\si{\cm^{2}} for WIMP mass of 40~\si{\GeV/}$c^2$. Exclusion limits on the axial-vector and pseudo-scalar simplified models are also derived.

hep-ex↗

BOP2-TE: Bayesian Optimal Phase 2 Design for Jointly Monitoring Efficacy and Toxicity with Application to Dose Optimization

We propose a Bayesian optimal phase 2 design for jointly monitoring efficacy and toxicity, referred to as BOP2-TE, to improve the operating characteristics of the BOP2 design proposed by Zhou et al. (2017). BOP2-TE utilizes a Dirichlet-multinomial model to jointly model the distribution of toxicity and efficacy endpoints, making go/no-go decisions based on the posterior probability of toxicity and futility. In comparison to the original BOP2 and other existing designs, BOP2-TE offers the advantage of providing rigorous type I error control in cases where the treatment is toxic and futile, effective but toxic, or safe but futile, while optimizing power when the treatment is effective and safe. As a result, BOP2-TE enhances trial safety and efficacy. We also explore the incorporation of BOP2-TE into multiple-dose randomized trials for dose optimization, and consider a seamless design that integrates phase I dose finding with phase II randomized dose optimization. BOP2-TE is user-friendly, as its decision boundary can be determined prior to the trial's onset. Simulations demonstrate that BOP2-TE possesses desirable operating characteristics. We have developed a user-friendly web application as part of the BOP2 app, which is freely available at www.trialdesign.org.

stat.ME↗

Robot Synesthesia: In-Hand Manipulation with Visuotactile Sensing

Executing contact-rich manipulation tasks necessitates the fusion of tactile and visual feedback. However, the distinct nature of these modalities poses significant challenges. In this paper, we introduce a system that leverages visual and tactile sensory inputs to enable dexterous in-hand manipulation. Specifically, we propose Robot Synesthesia, a novel point cloud-based tactile representation inspired by human tactile-visual synesthesia. This approach allows for the simultaneous and seamless integration of both sensory inputs, offering richer spatial information and facilitating better reasoning about robot actions. The method, trained in a simulated environment and then deployed to a real robot, is applicable to various in-hand object rotation tasks. Comprehensive ablations are performed on how the integration of vision and touch can improve reinforcement learning and Sim2Real performance. Our project page is available at https://yingyuan0414.github.io/visuotactile/ .

cs.RO↗

Measurement of Solar $pp$ Neutrino Flux using Electron Recoil Data from PandaX-4T Commissioning Run

The proton-proton ($pp$) fusion chain dominates the neutrino production from the Sun. The uncertainty of the predicted $pp$ neutrino flux is at the sub-percent level, whereas that of the best measurement is $\mathcal{O}(10\%)$. In this paper, we present the first result to measure the solar $pp$ neutrinos in the electron recoil energy range from 24 to 144 keV, using the PandaX-4T commissioning data with 0.63 tonne$\times$year exposure. The $pp$ neutrino flux is determined to be $(8.0 \pm 3.9 \,{\rm{(stat)}} \pm 10.0 \,{\rm{(syst)}} )\times 10^{10}\, $$\rm{s}^{-1} \rm{cm}^{-2}$, consistent with Standard Solar Model and existing measurements, corresponding to a flux upper limit of $23.3\times 10^{10}\, $$\rm{s}^{-1} \rm{cm}^{-2}$ at 90\% C.L..

hep-ex↗

Signal Response Model in PandaX-4T

PandaX-4T experiment is a deep-underground dark matter direct search experiment that employs a dual-phase time projection chamber with a sensitive volume containing 3.7 tonne of liquid xenon. The detector of PandaX-4T is capable of simultaneously collecting the primary scintillation and ionization signals, utilizing their ratio to discriminate dark matter signals from background sources such as gamma rays and beta particles. The signal response model plays a crucial role in interpreting the data obtained by PandaX-4T. It describes the conversion from the deposited energy by dark matter interactions to the detectable signals within the detector. The signal response model is utilized in various PandaX-4T results. This work provides a comprehensive description of the procedures involved in constructing and parameter-fitting the signal response model for the energy range of approximately 1 keV to 25 keV for electronic recoils and 6 keV to 90 keV for nuclear recoils. It also covers the signal reconstruction, selection, and correction methods, which are crucial components integrated into the signal response model.

physics.ins-det↗

Waveform Simulation in PandaX-4T

Signal reconstruction through software processing is a crucial component of the background and signal models in the PandaX-4T experiment, which is a multi-tonne dark matter direct search experiment. The accuracy of signal reconstruction is influenced by various detector artifacts, including noise, dark count of photomultiplier, impurity photoionization in the detector, and other relevant considerations. In this study, we present a detailed description of a semi-data-driven approach designed to simulate the signal waveform. This work provides a reliable model for the efficiency and bias of the signal reconstruction in the data analysis of PandaX-4T. By comparing critical variables which relate to the temporal shape and hit pattern of the signals, we demonstrate a good agreement between the simulation and data.

hep-ex↗

Searching for Two-Neutrino and Neutrinoless Double Beta Decay of $^{134}$Xe with the PandaX-4T Experiment

$^{134}$Xe is a candidate isotope for neutrinoless double beta decay~($0νββ$) search. In addition, the two-neutrino case ($2νββ$) allowed by the Standard Model of particle physics has not yet been observed. Utilizing the 10.4% of $^{134}$Xe in the natural xenon in the PandaX-4T detector and its first 94.9-day exposure, we have established the most stringent constraints on $2νββ$ and $0νββ$ of $^{134}$Xe half-lives, with limits of $2.8\times10^{22}$ yr and $3.0\times10^{23}$ yr at 90% confidence level, respectively. The $2νββ$ ($0νββ$) limit surpasses the previously reported best result by a factor of 32 (2.7), highlighting the potential of large monolithic natural xenon detectors.

nucl-ex↗

"Are Adversarial Phishing Webpages a Threat in Reality?" Understanding the Users' Perception of Adversarial Webpages

Machine learning based phishing website detectors (ML-PWD) are a critical part of today's anti-phishing solutions in operation. Unfortunately, ML-PWD are prone to adversarial evasions, evidenced by both academic studies and analyses of real-world adversarial phishing webpages. However, existing works mostly focused on assessing adversarial phishing webpages against ML-PWD, while neglecting a crucial aspect: investigating whether they can deceive the actual target of phishing -- the end users. In this paper, we fill this gap by conducting two user studies (n=470) to examine how human users perceive adversarial phishing webpages, spanning both synthetically crafted ones (which we create by evading a state-of-the-art ML-PWD) as well as real adversarial webpages (taken from the wild Web) that bypassed a production-grade ML-PWD. Our findings confirm that adversarial phishing is a threat to both users and ML-PWD, since most adversarial phishing webpages have comparable effectiveness on users w.r.t. unperturbed ones. However, not all adversarial perturbations are equally effective. For example, those with added typos are significantly more noticeable to users, who tend to overlook perturbations of higher visual magnitude (such as replacing the background). We also show that users' self-reported frequency of visiting a brand's website has a statistically negative correlation with their phishing detection accuracy, which is likely caused by overconfidence. We release our resources.

cs.CR↗

Detecting Neutrinos from Supernova Bursts in PandaX-4T

Neutrinos from core-collapse supernovae are essential for the understanding of neutrino physics and stellar evolution. The dual-phase xenon dark matter detectors can provide a way to track explosions of galactic supernovae by detecting neutrinos through coherent elastic neutrino-nucleus scatterings. In this study, a variation of progenitor masses as well as explosion models are assumed to predict the neutrino fluxes and spectra, which result in the number of expected neutrino events ranging from 6.6 to 13.7 at a distance of 10 kpc over a 10-second duration with negligible backgrounds at PandaX-4T. Two specialized triggering alarms for monitoring supernova burst neutrinos are built. The efficiency of detecting supernova explosions at various distances in the Milky Way is estimated. These alarms will be implemented in the real-time supernova monitoring system at PandaX-4T in the near future, providing the astronomical communities with supernova early warnings.

hep-ex↗

Search for Dark-Matter-Nucleon Interactions with a Dark Mediator in PandaX-4T

We report results of a search for dark-matter-nucleon interactions via a dark mediator using optimized low-energy data from the PandaX-4T liquid xenon experiment. With the ionization-signal-only data and utilizing the Migdal effect, we set the most stringent limits on the cross section for dark matter masses ranging from 30~$\rm{MeV/c^2}$ to 2~$\rm{GeV/c^2}$. Under the assumption that the dark mediator is a dark photon that decays into scalar dark matter pairs in the early Universe, we rule out significant parameter space of such thermal relic dark-matter model.

hep-ex↗

Multi-SpacePhish: Extending the Evasion-space of Adversarial Attacks against Phishing Website Detectors using Machine Learning

Existing literature on adversarial Machine Learning (ML) focuses either on showing attacks that break every ML model, or defenses that withstand most attacks. Unfortunately, little consideration is given to the actual feasibility of the attack or the defense. Moreover, adversarial samples are often crafted in the "feature-space", making the corresponding evaluations of questionable value. Simply put, the current situation does not allow to estimate the actual threat posed by adversarial attacks, leading to a lack of secure ML systems. We aim to clarify such confusion in this paper. By considering the application of ML for Phishing Website Detection (PWD), we formalize the "evasion-space" in which an adversarial perturbation can be introduced to fool a ML-PWD -- demonstrating that even perturbations in the "feature-space" are useful. Then, we propose a realistic threat model describing evasion attacks against ML-PWD that are cheap to stage, and hence intrinsically more attractive for real phishers. After that, we perform the first statistically validated assessment of state-of-the-art ML-PWD against 12 evasion attacks. Our evaluation shows (i) the true efficacy of evasion attempts that are more likely to occur; and (ii) the impact of perturbations crafted in different evasion-spaces. Our realistic evasion attempts induce a statistically significant degradation (3-10% at p<0.05), and their cheap cost makes them a subtle threat. Notably, however, some ML-PWD are immune to our most realistic attacks (p=0.22). Finally, as an additional contribution of this journal publication, we are the first to consider the intriguing case wherein an attacker introduces perturbations in multiple evasion-spaces at the same time. These new results show that simultaneously applying perturbations in the problem- and feature-space can cause a drop in the detection rate from 0.95 to 0.

cs.CR↗

Statistical and Practical Considerations in Planning and Conduct of Dose Optimization Trials

The US Food and Drug Administration launched Project Optimus with the aim of shifting the paradigm of dose-finding and selection towards identifying the optimal biological dose that offers the best balance between benefit and risk, rather than the maximum tolerated dose. However, achieving dose optimization is a challenging task that involves a variety of factors and is considerably more complicated than identifying the maximum tolerated dose, both in terms of design and implementation. This article provides a comprehensive review of various design strategies for dose optimization trials, including phase I/II and II/III designs, and highlights their respective advantages and disadvantages. Additionally, practical considerations for selecting an appropriate design and planning and executing the trial are discussed. The article also presents freely available software tools that can be utilized for designing and implementing dose optimization trials. The approaches and their implementation are illustrated through real-world examples.

stat.ME↗