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Ying Yuan

Publications and source records attributed to Ying Yuan.

At least 37 records · Page 2Linked to original sources

Tomographic beta-gamma spectroscopy of nuclear beta decay

Nuclear $β$ decay, a sensitive probe of nuclear structure and weak interactions, has become a precision test bed for physics beyond the Standard Model, driven by recent advances in spectrometric techniques. Here we introduce tomographic $β$-$γ$ spectroscopy (TBGS) of nuclear $β$ decay, a method that detects the energies of $β$, $γ$, and internal conversion electrons while simultaneously reconstructing the energy deposition vertices. Using the PandaX-4T detector operated as a TBGS, we obtain a precise and unbiased decay scheme of $^{214}$Pb, a key background isotope in searches for dark matter and Majorana neutrinos. For the first time, transitions of $^{214}$Pb to both the ground and excited states of $^{214}$Bi are measured concurrently, revealing discrepancies in branching ratios of up to 4.7$σ$ relative to previous evaluations. Combined with state-of-the-art theoretical spectral-shape calculations, these results establish a new benchmark for background modelling in rare-event searches and highlight the potential of TBGS as a versatile tool for fundamental physics and nuclear applications.

nucl-ex↗

Kinetic Freeze-Out Properties from Transverse Momentum Spectra of kaon, Pion, and (anti-)proton production in U+U collisions at $\sqrt{s_{NN}}$ = 193 GeV

In the framework of the multi-source thermal model employing the Tsallis distribution, the transverse momentum distributions of kaon, pion, and (anti -)proton production in U+U collisions at $\sqrt{s_{NN}}$ = 193 GeV with varying centrality are investigated. The transverse momentum spectra are appropriately characterized. The dependencies of parameters (average transverse momenta, effective temperature, and entropy index) on event centrality are determined. It is observed that the q parameters increase as the average number of particles participating in the collisions rises, which implies that the nuclear stopping degree elevates with the increase of collision centrality. The T value remains fundamentally consistent for the same particle under different collision parameters, suggesting that the kinetic freezing temperature of particle ejection in this collision system is independent of the collision parameters.

hep-ph↗

BE-BOIN: A Dose Optimization Design Accommodating Backfill and Late-Onset Toxicity

The US Food and Drug Administration (FDA) launched Project Optimus and issued guidance to reform dose-finding and selection trials, shifting the paradigm from identifying the maximum tolerable dose (MTD) to determining the optimal biological dose (OBD), which optimizes the risk and benefit of treatments. The FDA's guidance emphasizes the importance of collecting sufficient toxicity and efficacy data across multiple doses and considering late-onset cumulative toxicity that often results in tolerability issues. To address these challenges, we propose the BE-BOIN (Backfill time-to-Event Bayesian Optimal INterval) design, which allows backfilling patients into safe and effective doses during dose escalation and accommodates late-onset toxicities. BE-BOIN enables the collection of additional safety and efficacy data to enhance the accuracy and reliability of OBD selection and supports real-time dose decisions for new patients. Our simulation studies show that BE-BOIN accurately identifies the MTD and OBD while significantly reducing trial duration.

stat.ME↗

HypoGeneAgent: A Hypothesis Language Agent for Gene-Set Cluster Resolution Selection Using Perturb-seq Datasets

Large-scale single-cell and Perturb-seq investigations routinely involve clustering cells and subsequently annotating each cluster with Gene-Ontology (GO) terms to elucidate the underlying biological programs. However, both stages, resolution selection and functional annotation, are inherently subjective, relying on heuristics and expert curation. We present HYPOGENEAGENT, a large language model (LLM)-driven framework, transforming cluster annotation into a quantitatively optimizable task. Initially, an LLM functioning as a gene-set analyst analyzes the content of each gene program or perturbation module and generates a ranked list of GO-based hypotheses, accompanied by calibrated confidence scores. Subsequently, we embed every predicted description with a sentence-embedding model, compute pair-wise cosine similarities, and let the agent referee panel score (i) the internal consistency of the predictions, high average similarity within the same cluster, termed intra-cluster agreement (ii) their external distinctiveness, low similarity between clusters, termed inter-cluster separation. These two quantities are combined to produce an agent-derived resolution score, which is maximized when clusters exhibit simultaneous coherence and mutual exclusivity. When applied to a public K562 CRISPRi Perturb-seq dataset as a preliminary test, our Resolution Score selects clustering granularities that exhibit alignment with known pathway compared to classical metrics such silhouette score, modularity score for gene functional enrichment summary. These findings establish LLM agents as objective adjudicators of cluster resolution and functional annotation, thereby paving the way for fully automated, context-aware interpretation pipelines in single-cell multi-omics studies.

q-bio.QM↗

Generalizable Humanoid Manipulation with 3D Diffusion Policies

Humanoid robots capable of autonomous operation in diverse environments have long been a goal for roboticists. However, autonomous manipulation by humanoid robots has largely been restricted to one specific scene, primarily due to the difficulty of acquiring generalizable skills and the expensiveness of in-the-wild humanoid robot data. In this work, we build a real-world robotic system to address this challenging problem. Our system is mainly an integration of 1) a whole-upper-body robotic teleoperation system to acquire human-like robot data, 2) a 25-DoF humanoid robot platform with a height-adjustable cart and a 3D LiDAR sensor, and 3) an improved 3D Diffusion Policy learning algorithm for humanoid robots to learn from noisy human data. We run more than 2000 episodes of policy rollouts on the real robot for rigorous policy evaluation. Empowered by this system, we show that using only data collected in one single scene and with only onboard computing, a full-sized humanoid robot can autonomously perform skills in diverse real-world scenarios. Videos are available at https://humanoid-manipulation.github.io .

cs.RO↗

ROSE: Randomized Optimal Selection Design for Dose Optimization

The U.S. Food and Drug Administration (FDA) launched Project Optimus to shift the objective of dose selection from the maximum tolerated dose to the optimal biological dose (OBD), optimizing the benefit-risk tradeoff. One approach recommended by the FDA's guidance is to conduct randomized trials comparing multiple doses. In this paper, using the selection design framework (Simon et al., 1985), we propose a randomized optimal selection (ROSE) design, which minimizes sample size while ensuring the probability of correct selection of the OBD at prespecified accuracy levels. The ROSE design is simple to implement, involving a straightforward comparison of the difference in response rates between two dose arms against a predetermined decision boundary. We further consider a two-stage ROSE design that allows for early selection of the OBD at the interim when there is sufficient evidence, further reducing the sample size. Simulation studies demonstrate that the ROSE design exhibits desirable operating characteristics in correctly identifying the OBD. A sample size of 15 to 40 patients per dosage arm typically results in a percentage of correct selection of the optimal dose ranging from 60% to 70%.

stat.ME↗

Precise Measurement of $^{216}$Po Half-life with Exact Parent-daughter Pairing in PandaX-4T

We report a precise measurement of $^{216}\rm Po$ half-life using the PandaX-4T liquid xenon time projection chamber (TPC). $^{220}\rm Rn $, emanating from a $^{228}\rm Th $ calibration source, is injected to the detector and undergoes successive $α$ decays, first to $^{216}\rm Po$ and then to $^{212}\rm Pb$. PandaX-4T detector measures the 5-dimensional (5D) information of each decay, including time, energy, and 3-dimensional positions. Therefore, we can identify the $^{220}\rm Rn $ and $^{216}\rm Po$ decay events and pair them exactly to extract the lifetime of each $^{216}\rm Po$. With a large data set and high-precision $^{220}\rm $Rn-$^{216}\rm $Po pairing technique, we measure the $^{216}\rm Po$ half-life to be $143.7\pm0.5$ ms, which is the most precise result to date and agrees with previously published values. The leading precision of this measurement demonstrates the power of 5D calorimeter and the potential of exact parent-daughter pairing in the xenon TPC.

nucl-ex↗

Simple is what you need for efficient and accurate medical image segmentation

While modern segmentation models often prioritize performance over practicality, we advocate a design philosophy prioritizing simplicity and efficiency, and attempted high performance segmentation model design. This paper presents SimpleUNet, a scalable ultra-lightweight medical image segmentation model with three key innovations: (1) A partial feature selection mechanism in skip connections for redundancy reduction while enhancing segmentation performance; (2) A fixed-width architecture that prevents exponential parameter growth across network stages; (3) An adaptive feature fusion module achieving enhanced representation with minimal computational overhead. With a record-breaking 16 KB parameter configuration, SimpleUNet outperforms LBUNet and other lightweight benchmarks across multiple public datasets. The 0.67 MB variant achieves superior efficiency (8.60 GFLOPs) and accuracy, attaining a mean DSC/IoU of 85.76%/75.60% on multi-center breast lesion datasets, surpassing both U-Net and TransUNet. Evaluations on skin lesion datasets (ISIC 2017/2018: mDice 84.86%/88.77%) and endoscopic polyp segmentation (KVASIR-SEG: 86.46%/76.48% mDice/mIoU) confirm consistent dominance over state-of-the-art models. This work demonstrates that extreme model compression need not compromise performance, providing new insights for efficient and accurate medical image segmentation. Codes can be found at https://github.com/Frankyu5666666/SimpleUNet.

eess.IV↗

Measurement of two-neutrino double electron capture half-life of $^{124}$Xe with PandaX-4T

Detailed studies of two-neutrino double electron capture (2$ν$DEC) is a crucial step towards searching for the neutrino-less mode to explore the Majorana nature of neutrinos. We have measured precisely the half-life of the 2$ν$DEC process in $^{124}$Xe, utilizing a total exposure of 1.73 tonne$\cdot$year from the commissioning run and the first science run of the PandaX-4T experiment. A time-dependent background model in the $\mathcal{O}$(10 keV) energy is constructed for the first time in PandaX-4T data. With an unbinned maximum likelihood fit, we determine the half-life of the 2$ν$DEC process to be $(1.03\pm0.15_{\rm stat}\pm0.08_{\rm sys})\times 10^{22}$$\,$yr. Furthermore, we have evaluated the branching ratio for both electrons captured from the $K$ shell ($KK$) to be $(65\pm5)\%$, which aligns with the $^{124}$Xe nuclear model calculations within 1.8$\,$$σ$.

nucl-ex↗

Search for Solar Boosted Dark Matter Particles at the PandaX-4T Experiment

We present a novel constraint on light dark matter utilizing $1.54$ tonne$\cdot$year of data acquired from the PandaX-4T dual-phase xenon time projection chamber. This constraint is derived through detecting electronic recoil signals resulting from the interaction with solar-enhanced dark matter flux. Low-mass dark matter particles, lighter than a few MeV/$c^2$, can scatter with the thermal electrons in the Sun. Consequently, with higher kinetic energy, the boosted dark matter component becomes detectable via contact scattering with xenon electrons, resulting in a few keV energy deposition that exceeds the threshold of PandaX-4T. We calculate the expected recoil energy in PandaX-4T considering the Sun's acceleration and the detection capabilities of the xenon detector. The first experimental search results using the xenon detector yield the most stringent cross-section of $3.51 \times 10^{-39}~\mathrm{cm}^2$ at $0.08~\mathrm{MeV}$/$c^2$ for a solar boosted dark matter mass ranging from $0.02$ to $10~ \mathrm{MeV}$/$c^2$, achieving a 23 fold improvement compared with earlier experimental studies.

hep-ex↗

Search for Double Beta Decay of $^{136}$Xe to the $0^+_1$ Excited State of $^{136}$Ba with PandaX-4T

We perform a search of double beta decay of $^{136}$Xe to the excited state, $0^+_1$, of $^{136}$Ba (2$νββ$-0$_1^+$), using the dual-phase xenon detector of PandaX-4T with the first 94.9-day commissioning data. The multi-site events are reconstructed up to the MeV energy scale, which helps to improve the background model significantly. The background contribution from the stainless steel platform outside PandaX-4T cryostat is evaluated for the first time. No significant evidence for 2$νββ$-$0_1^+$ is observed, resulting in a lower limit on half-life of $7.5 \times 10^{22}$ yr at the 90% confidence level. This is the first experimental limit on such a rare decay in a natural xenon-based detector.

nucl-ex↗

Search for MeV-Scale Axionlike Particles and Dark Photons with PandaX-4T

Axionlike particles (ALPs) and dark photons (DPs) are viable dark matter particle candidates. We have searched for possible ALP/DP signals in the PandaX-4T liquid xenon detector using 440 kg$\cdot$yr of data. A binned likelihood fit is constructed to search for possible mono-energetic peaks induced by the absorption processes between ALPs/DPs and atomic electrons of xenon. A detailed temporal model of decays associated with xenon isotopes is introduced to constrain the number of background events. No signal excess over background expectations is observed, and we have established the most stringent exclusion limits for most ALP/DP masses across the range of 150 keV/$c^2$ to 1 MeV/$c^2$. The improvement is particularly significant within the mass range of \text{150-400}~keV/$c^2$, with the average factor of 3.5 compared to previous results.

hep-ex↗

Position reconstruction and surface background model for the PandaX-4T detector

We report the position reconstruction methods and surface background model for the PandaX-4T dark matter direct search experiment. This work develops two position reconstruction algorithms: template matching (TM) method and photon acceptance function (PAF) method. Both methods determine the horizontal position of events based on the light pattern of secondary scintillation collected by the light sensors. After a comprehensive evaluation of resolution, uniformity, and robustness, the PAF method was selected for position reconstruction, while the TM method was employed for verification. The PAF method achieves a bulk event resolution of 1.0 mm and a surface event resolution of 4.4 mm for a typical $S2$ signal with a bottom charge of 1500 PE (about 14 keV). The uniformity is around 20\%. Robustness studies reveal average deviations of 5.1 mm and 8.8 mm for the commissioning run (Run0) and the first science run (Run1), respectively, due to the deactivation of certain PMTs. A data-driven surface background model is developed based on the PAF method. The surface background is estimated to be $0.09 \pm 0.06$ events for Run0 (0.54 tonne$\cdot$year) and $0.17 \pm 0.11$ events for Run1 (1.00 tonne$\cdot$year).

physics.ins-det↗

Dark Matter Search Results from 1.54 Tonne$\cdot$Year Exposure of PandaX-4T

In this letter, we report the dark matter search results from the commissioning run and the first science run of the PandaX-4T experiment. A blind analysis is carried out on the entire data set. The data processing is improved compared to previous work, unifying the low-level signal reconstruction in a wide energy range up to 120 keV. With a total exposure of 1.54 tonne$\cdot$year, no significant excess of nuclear recoil events is found. The lowest 90% confidence level exclusion on the spin-independent cross section is $1.6 \times 10^{-47}\,\mathrm{cm}^2$ at a dark matter mass of 40 GeV$/c^2$. Our results represent the most stringent constraint for a dark matter mass above 100 GeV$/c^2$.

hep-ex↗

Exploring New Physics with PandaX-4T Low Energy Electronic Recoil Data

New particles beyond the standard model of particle physics, such as axions, can be effectively searched through their interactions with electrons. We use the large liquid xenon detector PandaX-4T to search for novel electronic recoil signals induced by solar axions, neutrinos with anomalous magnetic moment, axionlike particles, dark photons, and light fermionic dark matter. A detailed background model is established using the latest datasets with 1.54 $\rm ton \cdot yr$ exposure. No significant excess above the background has been observed, and we have obtained competitive constraints for axion couplings, neutrino magnetic moment, and fermionic dark matter interactions.

hep-ex↗

Searching for Neutrinoless Double-Beta Decay of $^{136}$Xe with PandaX-4T

We report the search for neutrinoless double-beta decay of $^{136}$Xe from the PandaX-4T experiment with a 3.7-tonne natural xenon target. The data reconstruction and the background modeling are optimized in the MeV energy region. A blind analysis is performed with data from the commissioning run and the first science run. No significant excess of signal over the background is observed. A lower limit on the half-life of $^{136}$Xe neutrinoless double-beta decay is established to be $2.1 \times 10^{24}$~yr at the 90\% confidence level, with a $^{136}$Xe exposure of 44.6~kg$\cdot$year. Our result represents the most stringent constraint from a natural xenon detector to date.

nucl-ex↗

PandaX-xT: a Multi-ten-tonne Liquid Xenon Observatory at the China Jinping Underground Laboratory

We propose a major upgrade to the existing PandaX-4T experiment in the China Jinping Underground Laboratory. The new experiment, PandaX-xT, will be a multi-ten-tonne liquid xenon, ultra-low background, and general-purpose observatory. The full-scaled PandaX-xT contains a 43-tonne liquid xenon active target. Such an experiment will significantly advance our fundamental understanding of particle physics and astrophysics. The sensitivity of dark matter direct detection will be improved by nearly two orders of magnitude compared to the current best limits, approaching the so-called "neutrino floor" for a dark matter mass above 10 GeV/$c^2$, providing a decisive test to the Weakly Interacting Massive Particle paradigm. By searching for the neutrinoless double beta decay of $^{136}$Xe isotope in the detector, the effective Majorana neutrino mass can be measured to a [10 -- 41] meV/$c^2$ sensitivity, providing a key test to the Dirac/Majorana nature of neutrino s. Astrophysical neutrinos and other ultra-rare interactions can also be measured and searched for with an unprecedented background level, opening up new windows of discovery. Depending on the findings, PandaX-xT will seek the next stage upgrade utilizing isotopic separation on natural xenon.

hep-ex↗

BARD: A seamless two-stage dose optimization design integrating backfill and adaptive randomization

One common approach for dose optimization is a two-stage design, which initially conducts dose escalation to identify the maximum tolerated dose (MTD), followed by a randomization stage where patients are assigned to two or more doses to further assess and compare their risk-benefit profiles to identify the optimal dose. A limitation of this approach is its requirement for a relatively large sample size. To address this challenge, we propose a seamless two-stage design, BARD (Backfill and Adaptive Randomization for Dose Optimization), which incorporates two key features to reduce sample size and shorten trial duration. The first feature is the integration of backfilling into the stage 1 dose escalation, enhancing patient enrollment and data generation without prolonging the trial. The second feature involves seamlessly combining patients treated in stage 1 with those in stage 2, enabled by covariate-adaptive randomization, to inform the optimal dose and thereby reduce the sample size. Our simulation study demonstrates that BARD reduces the sample size, improves the accuracy of identifying the optimal dose, and maintains covariate balance in randomization, allowing for unbiased comparisons between doses. BARD designs offer an efficient solution to meet the dose optimization requirements set by Project Optimus, with software freely available at www.trialdesign.org.

stat.ME↗