arXiv subjects

Yunlong Zhao

Publications and source records attributed to Yunlong Zhao.

At least 19 recordsLinked to original sources

arXiv2026

RareDxR1: Autonomous Medical Reasoning for Rare Disease Diagnosis Beyond Human Annotation

Rare disease differential diagnosis is a critical yet arduous clinical task, requiring physicians to identify precise phenotypes from complex, unstructured patient symptoms and execute intricate reasoning within a vast search space. However, existing AI approaches typically rely on pipeline-based phenotype extraction or retrieval-augmented generation, which suffer from critical information loss due to predefined ontologies, retrieval bottlenecks, and a lack of diagnostic logic. To address these challenges, we introduce RareDxR1, an end-to-end reasoning-centric large language model designed for open-domain rare disease diagnosis directly from unstructured clinical notes. We design a progressive end-to-end training framework by synergizing knowledge internalization with autonomous evolutionary learning, thereby bypassing reliance on structured phenotypes and closed-set decision-making. To overcome the limitations of RAG and phenotype restriction, we enabled the deep internalization of fragmented rare-disease knowledge directly into the model's parameters. Moreover, to bridge the gap between model generation and expert reasoning, we propose Reflection-Enhanced Reasoning Sampling (RERS), a strategy that synthesizes expert-level diagnostic trajectories by learning from failures without human annotation. Additionally, we propose a dual-level curriculum reinforcement learning approach for gradually mastering rare disease diagnosis. Experimental results demonstrate that RareDxR1 achieves state-of-the-art accuracy across different benchmarks, marking a significant breakthrough in open-domain rare disease diagnosis. Our code and dataset will be publicly available.

cs.AI↗

arXiv2026

Model-Building Implications from Light Magnetic Monopoles: A Case Study of Flavour Deconstruction

We highlight a generic connection between extensions of the Standard Model featuring low-scale semi-simple embeddings of $\rm{U}(1)_{\rm EM}$ and the phenomenology of light magnetic monopoles in the early Universe. Combining cosmological, astrophysical, and direct-search constraints, we show that magnetic monopoles with masses far below the scale of Grand Unified Theories are generically excluded and require low-scale inflation to dilute their abundance, followed by reheating below the monopole-production scale. These constraints are particularly relevant for flavour non-universal models, which provide a well-motivated framework to address the hierarchical structure of Yukawa couplings while allowing new dynamics close to the TeV scale compatible with experimental bounds. In many of these constructions, the sequential breaking of semi-simple gauge groups through intermediate stages containing a $\rm{U}(1)$ factor generically leads to the production of light magnetic monopoles. We show that the parameter region naturally predicted by these models implies low-scale inflation, with reheating temperature as low as $10^{3}\text{--}10^4 \,\mathrm{TeV}$. These results significantly reduce the otherwise large allowed inflationary window and establish a direct connection between flavour physics and the thermal history of the early Universe: future evidence for a low-scale semi-simple embedding of $\rm U(1)_{\rm EM}$, in particular through flavour non-universal interactions, would point towards low-scale reheating, while probes of primordial gravitational waves could directly constrain the scale at which low-scale semi-simple groups can appear.

hep-ph↗

arXiv2026

GeoTopoDiff: Learning Geometry--Topology Graph Priors through Boundary-Constrained Mixed Diffusion for Sparse-Slice 3D Porous Reconstruction

Diffusion-based voxel prior modelling is challenging for the reconstruction of large-scale 3D porous microstructures. Due to the demanding requirements for simultaneously modelling both the continuous pore morphology and the discrete pore-throat topology, the diffusion models require fully observed CT scans to provide topology-faithful priors, which results in an inherent trade-off among throughput, topological fidelity, and field of view in practical industrial applications. We propose GeoTopoDiff, a graph diffusion-based framework for reconstructing 3D porous microstructures from sparse CT slices. GeoTopoDiff transfers the learning of diffusion priors from a voxel-based space to a mixed graph state space, which simultaneously encompasses continuous pore geometry and discrete pore-throat topology. A topology-aware partial graph prior from sparsely observed CT slices is introduced to constrain the reverse denoising process. Experiments on anisotropic PTFE and Fontainebleau sandstone show that GeoTopoDiff reduces morphology-related errors by 19.8% and topology-sensitive transport errors by 36.5% on average. Our findings suggest that the mixed graph state space promotes the diffusion denoising process to reduce posterior uncertainty under a sparse observations. All models and code have been made publicly available to facilitate the exploration of diffusion models in the field of 3D porous microstructures simulation.

cs.CV↗

arXiv2026

YCDa: YCbCr Decoupled Attention for Real-time Realistic Camouflaged Object Detection

Human vision exhibits remarkable adaptability in perceiving objects under camouflage. When color cues become unreliable, the visual system instinctively shifts its reliance from chrominance (color) to luminance (brightness and texture), enabling more robust perception in visually confusing environments. Drawing inspiration from this biological mechanism, we propose YCDa, an efficient early-stage feature processing strategy that embeds this "chrominance-luminance decoupling and dynamic attention" principle into modern real-time detectors. Specifically, YCDa separates color and luminance information in the input stage and dynamically allocates attention across channels to amplify discriminative cues while suppressing misleading color noise. The strategy is plug-and-play and can be integrated into existing detectors by simply replacing the first downsampling layer. Extensive experiments on multiple baselines demonstrate that YCDa consistently improves performance with negligible overhead as shown in Fig. Notably, YCDa-YOLO12s achieves a 112% improvement in mAP over the baseline on COD10K-D and sets new state-of-the-art results for real-time camouflaged object detection across COD-D datasets.

cs.CV↗

arXiv2025

Speech-Aware Long Context Pruning and Integration for Contextualized Automatic Speech Recognition

Automatic speech recognition (ASR) systems have achieved remarkable performance in common conditions but often struggle to leverage long-context information in contextualized scenarios that require domain-specific knowledge, such as conference presentations. This challenge arises primarily due to constrained model context windows and the sparsity of relevant information within extensive contextual noise. To solve this, we propose the SAP$^{2}$ method, a novel framework that dynamically prunes and integrates relevant contextual keywords in two stages. Specifically, each stage leverages our proposed Speech-Driven Attention-based Pooling mechanism, enabling efficient compression of context embeddings while preserving speech-salient information. Experimental results demonstrate state-of-the-art performance of SAP$^{2}$ on the SlideSpeech and LibriSpeech datasets, achieving word error rates (WER) of 7.71% and 1.12%, respectively. On SlideSpeech, our method notably reduces biased keyword error rates (B-WER) by 41.1% compared to non-contextual baselines. SAP$^{2}$ also exhibits robust scalability, consistently maintaining performance under extensive contextual input conditions on both datasets.

cs.CL↗

arXiv2025

PRNet: Original Information Is All You Have

Small object detection in aerial images suffers from severe information degradation during feature extraction due to limited pixel representations, where shallow spatial details fail to align effectively with semantic information, leading to frequent misses and false positives. Existing FPN-based methods attempt to mitigate these losses through post-processing enhancements, but the reconstructed details often deviate from the original image information, impeding their fusion with semantic content. To address this limitation, we propose PRNet, a real-time detection framework that prioritizes the preservation and efficient utilization of primitive shallow spatial features to enhance small object representations. PRNet achieves this via two modules:the Progressive Refinement Neck (PRN) for spatial-semantic alignment through backbone reuse and iterative refinement, and the Enhanced SliceSamp (ESSamp) for preserving shallow information during downsampling via optimized rearrangement and convolution. Extensive experiments on the VisDrone, AI-TOD, and UAVDT datasets demonstrate that PRNet outperforms state-of-the-art methods under comparable computational constraints, achieving superior accuracy-efficiency trade-offs.

cs.CV↗

arXiv2025

DPMT: Dual Process Multi-scale Theory of Mind Framework for Real-time Human-AI Collaboration

Real-time human-artificial intelligence (AI) collaboration is crucial yet challenging, especially when AI agents must adapt to diverse and unseen human behaviors in dynamic scenarios. Existing large language model (LLM) agents often fail to accurately model the complex human mental characteristics such as domain intentions, especially in the absence of direct communication. To address this limitation, we propose a novel dual process multi-scale theory of mind (DPMT) framework, drawing inspiration from cognitive science dual process theory. Our DPMT framework incorporates a multi-scale theory of mind (ToM) module to facilitate robust human partner modeling through mental characteristic reasoning. Experimental results demonstrate that DPMT significantly enhances human-AI collaboration, and ablation studies further validate the contributions of our multi-scale ToM in the slow system.

cs.LG↗

arXiv2025

LVC: A Lightweight Compression Framework for Enhancing VLMs in Long Video Understanding

Long video understanding is a complex task that requires both spatial detail and temporal awareness. While Vision-Language Models (VLMs) obtain frame-level understanding capabilities through multi-frame input, they suffer from information loss due to the sparse sampling strategy. In contrast, Video Large Language Models (Video-LLMs) capture temporal relationships within visual features but are limited by the scarcity of high-quality video-text datasets. To transfer long video understanding capabilities to VLMs with minimal data and computational cost, we propose Lightweight Video Compression (LVC), a novel method featuring the Query-Attention Video Compression mechanism, which effectively tackles the sparse sampling problem in VLMs. By training only the alignment layer with 10k short video-text pairs, LVC significantly enhances the temporal reasoning abilities of VLMs. Extensive experiments show that LVC provides consistent performance improvements across various models, including the InternVL2 series and Phi-3.5-Vision. Notably, the InternVL2-40B-LVC achieves scores of 68.2 and 65.9 on the long video understanding benchmarks MLVU and Video-MME, respectively, with relative improvements of 14.6% and 7.7%. The enhanced models and code will be publicly available soon.

cs.CV↗

arXiv2025

GP-GS: Gaussian Processes Densification for 3D Gaussian Splatting

3D Gaussian Splatting (3DGS) enables photorealistic rendering but suffers from artefacts due to sparse Structure-from-Motion (SfM) initialisation. To address this limitation, we propose GP-GS, a Gaussian Process (GP) based densification framework for 3DGS optimisation. GP-GS formulates point cloud densification as a continuous regression problem, where a GP learns a local mapping from 2D pixel coordinates to 3D position and colour attributes. An adaptive neighbourhood-based sampling strategy generates candidate pixels for inference, while GP-predicted uncertainty is used to filter unreliable predictions, reducing noise and preserving geometric structure. Extensive experiments on synthetic and real-world benchmarks demonstrate that GP-GS consistently improves reconstruction quality and rendering fidelity, achieving up to 1.12 dB PSNR improvement over strong baselines.

cs.CV↗

arXiv2024

Grid: Omni Visual Generation

Visual generation has witnessed remarkable progress in single-image tasks, yet extending these capabilities to temporal sequences remains challenging. Current approaches either build specialized video models from scratch with enormous computational costs or add separate motion modules to image generators, both requiring learning temporal dynamics anew. We observe that modern image generation models possess underutilized potential in handling structured layouts with implicit temporal understanding. Building on this insight, we introduce GRID, which reformulates temporal sequences as grid layouts, enabling holistic processing of visual sequences while leveraging existing model capabilities. Through a parallel flow-matching training strategy with coarse-to-fine scheduling, our approach achieves up to 67 faster inference speeds while using <1/1000 of the computational resources compared to specialized models. Extensive experiments demonstrate that GRID not only excels in temporal tasks from Text-to-Video to 3D Editing but also preserves strong performance in image generation, establishing itself as an efficient and versatile omni-solution for visual generation.

cs.CV↗

arXiv2024

MetaDD: Boosting Dataset Distillation with Neural Network Architecture-Invariant Generalization

Dataset distillation (DD) entails creating a refined, compact distilled dataset from a large-scale dataset to facilitate efficient training. A significant challenge in DD is the dependency between the distilled dataset and the neural network (NN) architecture used. Training a different NN architecture with a distilled dataset distilled using a specific architecture often results in diminished trainning performance for other architectures. This paper introduces MetaDD, designed to enhance the generalizability of DD across various NN architectures. Specifically, MetaDD partitions distilled data into meta features (i.e., the data's common characteristics that remain consistent across different NN architectures) and heterogeneous features (i.e., the data's unique feature to each NN architecture). Then, MetaDD employs an architecture-invariant loss function for multi-architecture feature alignment, which increases meta features and reduces heterogeneous features in distilled data. As a low-memory consumption component, MetaDD can be seamlessly integrated into any DD methodology. Experimental results demonstrate that MetaDD significantly improves performance across various DD methods. On the Distilled Tiny-Imagenet with Sre2L (50 IPC), MetaDD achieves cross-architecture NN accuracy of up to 30.1\%, surpassing the second-best method (GLaD) by 1.7\%.

cs.CV↗

arXiv2024

Directional WPT Charging for Routing-Asymmetric WRSNs with a Mobile Charger

Mobile Charge Scheduling for wirelessly charging nodes in Wireless Rechargeable Sensor Networks (WRSNs) is a promising but still evolving research area. Existing research mostly assumes a symmetric environment, where the routing costs in opposite directions between two locations are considered identical. However, various factors such as terrain restrictions and wind or water flows may invalidate the routing-symmetric assumption in practical environments, thereby significantly limiting the performance of these solutions in routing-asymmetric WRSNs (RA-WRSNs). To address the routing-asymmetric challenges in mobile charge scheduling for WRSNs, this paper systematically investigates the underlying Asymmetric Directional Mobile Charger (DMC) Charge Scheduling (ADMCCS) problem, aiming to minimize energy loss while satisfying the charging demands of the network nodes. The DMC model is assumed because its results can be easily applied to the specialized case of an Omnidirectional Mobile Charger (OMC). To solve the ADMCCS problem, we propose a four-step framework. First, a minimum-size efficient charging position set is selected using our designed K-means-based Charging Position Generation (KCPG) algorithm, addressing the challenge of the unlimited charging position selection space. Next, minimum-size functional-equivalent direction sets at these positions are determined using an optimal algorithm, tackling the challenge of infinite charging directions. Subsequently, the optimal energy transmission time lengths for all directions at the positions are obtained by formulating and solving a Nonlinear Program (NLP) problem. Finally, the Lin-Kernighan Heuristic (LKH) algorithm for the Asymmetric Traveling Salesman Problem is adapted to obtain a highly probable optimal loop tour, addressing the routing-asymmetric challenge.

cs.NI↗

arXiv2024

Games for Artificial Intelligence Research: A Review and Perspectives

Games have been the perfect test-beds for artificial intelligence research for the characteristics that widely exist in real-world scenarios. Learning and optimisation, decision making in dynamic and uncertain environments, game theory, planning and scheduling, design and education are common research areas shared between games and real-world problems. Numerous open-source games or game-based environments have been implemented for studying artificial intelligence. In addition to single- or multi-player, collaborative or adversarial games, there has also been growing interest in implementing platforms for creative design in recent years. Those platforms provide ideal benchmarks for exploring and comparing artificial intelligence ideas and techniques. This paper reviews the games and game-based platforms for artificial intelligence research, provides guidance on matching particular types of artificial intelligence with suitable games for testing and matching particular needs in games with suitable artificial intelligence techniques, discusses the research trend induced by the evolution of those games and platforms, and gives an outlook.

cs.AI↗

arXiv2024

Game Generation via Large Language Models

Recently, the emergence of large language models (LLMs) has unlocked new opportunities for procedural content generation. However, recent attempts mainly focus on level generation for specific games with defined game rules such as Super Mario Bros. and Zelda. This paper investigates the game generation via LLMs. Based on video game description language, this paper proposes an LLM-based framework to generate game rules and levels simultaneously. Experiments demonstrate how the framework works with prompts considering different combinations of context. Our findings extend the current applications of LLMs and offer new insights for generating new games in the area of procedural content generation.

cs.AI↗

arXiv2024

Fully Exploiting Every Real Sample: SuperPixel Sample Gradient Model Stealing

Model stealing (MS) involves querying and observing the output of a machine learning model to steal its capabilities. The quality of queried data is crucial, yet obtaining a large amount of real data for MS is often challenging. Recent works have reduced reliance on real data by using generative models. However, when high-dimensional query data is required, these methods are impractical due to the high costs of querying and the risk of model collapse. In this work, we propose using sample gradients (SG) to enhance the utility of each real sample, as SG provides crucial guidance on the decision boundaries of the victim model. However, utilizing SG in the model stealing scenario faces two challenges: 1. Pixel-level gradient estimation requires extensive query volume and is susceptible to defenses. 2. The estimation of sample gradients has a significant variance. This paper proposes Superpixel Sample Gradient stealing (SPSG) for model stealing under the constraint of limited real samples. With the basic idea of imitating the victim model's low-variance patch-level gradients instead of pixel-level gradients, SPSG achieves efficient sample gradient estimation through two steps. First, we perform patch-wise perturbations on query images to estimate the average gradient in different regions of the image. Then, we filter the gradients through a threshold strategy to reduce variance. Exhaustive experiments demonstrate that, with the same number of real samples, SPSG achieves accuracy, agreements, and adversarial success rate significantly surpassing the current state-of-the-art MS methods. Codes are available at https://github.com/zyl123456aB/SPSG_attack.

cs.CV↗

arXiv2024

Generative Enzyme Design Guided by Functionally Important Sites and Small-Molecule Substrates

Enzymes are genetically encoded biocatalysts capable of accelerating chemical reactions. How can we automatically design functional enzymes? In this paper, we propose EnzyGen, an approach to learn a unified model to design enzymes across all functional families. Our key idea is to generate an enzyme's amino acid sequence and their three-dimensional (3D) coordinates based on functionally important sites and substrates corresponding to a desired catalytic function. These sites are automatically mined from enzyme databases. EnzyGen consists of a novel interleaving network of attention and neighborhood equivariant layers, which captures both long-range correlation in an entire protein sequence and local influence from nearest amino acids in 3D space. To learn the generative model, we devise a joint training objective, including a sequence generation loss, a position prediction loss and an enzyme-substrate interaction loss. We further construct EnzyBench, a dataset with 3157 enzyme families, covering all available enzymes within the protein data bank (PDB). Experimental results show that our EnzyGen consistently achieves the best performance across all 323 testing families, surpassing the best baseline by 10.79% in terms of substrate binding affinity. These findings demonstrate EnzyGen's superior capability in designing well-folded and effective enzymes binding to specific substrates with high affinities.

cs.LG↗

arXiv2024

Functional Geometry Guided Protein Sequence and Backbone Structure Co-Design

Proteins are macromolecules responsible for essential functions in almost all living organisms. Designing reasonable proteins with desired functions is crucial. A protein's sequence and structure are strongly correlated and they together determine its function. In this paper, we propose NAEPro, a model to jointly design Protein sequence and structure based on automatically detected functional sites. NAEPro is powered by an interleaving network of attention and equivariant layers, which can capture global correlation in a whole sequence and local influence from nearest amino acids in three dimensional (3D) space. Such an architecture facilitates effective yet economic message passing at two levels. We evaluate our model and several strong baselines on two protein datasets, $β$-lactamase and myoglobin. Experimental results show that our model consistently achieves the highest amino acid recovery rate, TM-score, and the lowest RMSD among all competitors. These findings prove the capability of our model to design protein sequences and structures that closely resemble their natural counterparts. Furthermore, in-depth analysis further confirms our model's ability to generate highly effective proteins capable of binding to their target metallocofactors. We provide code, data and models in Github.

cs.LG↗

arXiv2023

Joint Design of Protein Sequence and Structure based on Motifs

Designing novel proteins with desired functions is crucial in biology and chemistry. However, most existing work focus on protein sequence design, leaving protein sequence and structure co-design underexplored. In this paper, we propose GeoPro, a method to design protein backbone structure and sequence jointly. Our motivation is that protein sequence and its backbone structure constrain each other, and thus joint design of both can not only avoid nonfolding and misfolding but also produce more diverse candidates with desired functions. To this end, GeoPro is powered by an equivariant encoder for three-dimensional (3D) backbone structure and a protein sequence decoder guided by 3D geometry. Experimental results on two biologically significant metalloprotein datasets, including $β$-lactamases and myoglobins, show that our proposed GeoPro outperforms several strong baselines on most metrics. Remarkably, our method discovers novel $β$-lactamases and myoglobins which are not present in protein data bank (PDB) and UniProt. These proteins exhibit stable folding and active site environments reminiscent of those of natural proteins, demonstrating their excellent potential to be biologically functional.

cs.LG↗