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Yuxi Zhou

Publications and source records attributed to Yuxi Zhou.

At least 19 recordsLinked to original sources
arXiv2026

ReplayFactor: Replay-Aware Dual-Attribute Learning for Practical Speech Deepfake Detection

Advances in synthesis techniques have made deepfake speech increasingly realistic, amplifying voice security threats, including unauthorized voice cloning and impersonation. Although existing deepfake detectors perform well on digitally generated speech, their performance often degrades on physically replayed deepfakes, which constitute a low-cost and practical threat to real-world systems. Existing research focuses primarily on dataset construction and evaluation, while available dataset diversity and replay-aware detector design remain limited. We propose ReplayFactor, a dual-attribute framework that enhances replay evidence by fusing self-supervised learning (SSL) representations with an acoustic prior, while leveraging multi-task learning and supervised contrastive learning to promote robust, generalizable representations. We also construct ReplayFake-CN, a large-scale, multi-device Chinese dataset comprising approximately 185k replayed synthetic utterances to complement public benchmarks. Our framework improves macro-F1 from 60.99% to 76.44% and reduces EER from 11.86% to 3.05% on the EchoFake open set over the baseline, demonstrating strong potential for practical replayed deepfake detection.

cs.SD↗
arXiv2026

ECG2Gene: Deep Learning-Based Germline Tumor Susceptibility Gene Risk Assessment Using Electrocardiograms

Electrocardiograms (ECGs) may contain physiological information related to hereditary cancer susceptibility, but its relationship with future cancer risk remains unclear. Here, we present ECG2Gene, a two-stage deep-learning framework that derives digital phenotypes related to germline tumor susceptibility from routine 12-lead ECGs and predicts future cancer risk. In Stage 1, carrier status for pathogenic or likely pathogenic variants in ATM, BRIP1, CHEK2, PALB2, BRCA1, and BRCA2 supervises a multitask model that generates six continuous ECG-derived gene scores. In Stage 2, XGBoost integrates these scores with clinical variables to predict subsequent breast and ovarian cancer in women and prostate cancer in men. We also introduce ECG-Wide Association Analysis (EWAS) to characterize associations between ECG-derived gene scores and ECG waveforms. Across the clinical feature combinations evaluated in UK Biobank, the best-performing sex-specific models achieve AUROCs of 0.683, 0.633, and 0.660 for breast, ovarian, and prostate cancer, respectively. In external evaluations, models combining ECG-derived gene scores with age achieve prostate cancer AUROCs of 0.709 and 0.579 among men in the overall China Kadoorie Biobank and MIMIC-IV-ECG cohorts, respectively. ECG2Gene links genetically supervised ECG phenotyping and waveform association analysis to future cancer outcomes, demonstrating the potential of routine ECGs combined with clinical information for non-invasive, opportunistic cancer risk assessment.

cs.LG↗
arXiv2026

When Does Better Acceptance Pay? A Controlled Study of Speculative Decoding

The throughput gains of speculative decoding depend on the trade-off between acceptance length and execution latency. We ask when additional acceptance is worth the cost of obtaining it. We establish a comparison protocol spanning training, inference, and evaluation, remeasuring released checkpoints and retraining six drafter recipes on shared target-generated data across ten benchmarks and two target models. Alignment changes the picture: gaps that appear large in published comparisons shrink substantially under shared training and inference conditions. This narrowing motivates two deeper questions: how is acceptance improved at different costs, and when do these gains improve throughput? We find that acceptance can be improved through nearly free objective and context changes or more expensive token-to-token conditioning, which pays off most clearly under sampled drafting. DCore illustrates the former route as a strong baseline with little additional measured drafting overhead. The payoff is conditional: task uncertainty and serving conditions affect acceptance returns, execution costs, and the preferred drafter and budget. These findings inform future drafter design and deployment choices.

cs.CL↗
arXiv2026

ECG-SDI: Single-lead Electrocardiogram Enables Continuous Sleep Depth Index Profiling and Scalable Digital Biomarkers for Sleep Health

Conventional sleep staging provides a coarse-grained representation that obscures within-stage depth variation. We developed ECG-SDI, a single-lead electrocardiography (ECG) framework for continuous sleep-depth profiling and digital biomarker extraction. Using 12,392 overnight polysomnographic recordings, we trained and validated a two-stage deep learning model supervised by conventional sleep-stage labels. Correlations with ordered stages excluding rapid eye movement (REM) sleep were 0.828 in the pooled internal test set and 0.848 in the external Cleveland Family Study; corresponding REM classification AUROCs were 0.954 and 0.977. Overnight trajectories captured within-stage variation. Biomarker-based phenotyping identified a disturbed subtype associated with poorer subjective sleep quality and higher all-cause mortality in the Sleep Heart Health Study (adjusted hazard ratio, 1.20; 95% CI, 1.05-1.38). Among 507 participants with paired recordings before and after continuous positive airway pressure (CPAP), normalized sleep-depth area increased by 6.1% and shallow-sleep burden below 0.3 decreased by 16.0%. Exploratory analyses linked reductions in approximate entropy and depth variability to reduced oxygen desaturation and increased sleep efficiency, respectively (Spearman rho = 0.24 and 0.12); both associations remained positive after covariate adjustment. Mean ECG-SDI within N2 increased by 0.017 (95% CI, 0.004-0.030). A wearable proof-of-concept illustrated the acquisition-to-report workflow. These findings support ECG-based sleep phenotyping and further evaluation of CPAP response monitoring at home.

eess.SP↗
arXiv2026

Separating Expert Retention from Autonomous Source Inference in Raw-ECG-Replay-Free Continual ECG Deployment

In multi-source ECG deployment, new sources may arrive when earlier raw ECGs cannot be retained or replayed. Isolating source-specific classifiers on a frozen backbone prevents parameter interference, but source-unknown inference still requires selecting an appropriate expert. We study this distinction with IRFE-ECG, a controlled continual-deployment framework built on frozen 1024-dimensional ECGFounder features. Each arriving source adds an isolated Balanced-Softmax linear expert, while a lightweight router is re-fitted using retained frozen training features and source labels from previously observed sources. Rather than proposing a new routing architecture, the main contribution is to separate preserved expert performance from autonomous source inference and quantify the resulting deployment gap. Across CPSC, PTB-XL, Georgia, and Chapman-Shaoxing, source-aware expert selection reaches $0.7915 \pm 0.0036$ Macro-F1, close to a matched offline independent-head reference at $0.7885 \pm 0.0009$. Without source IDs, an MLP router reaches $0.7756 \pm 0.0027$, while top-2 margin fusion reaches $0.7782 \pm 0.0022$. The top-2 improvement is small (+0.0026) and not statistically significant under paired bootstrap. Across three domain orders, the top-2-to-oracle gap remains 0.0111-0.0133, indicating a persistent source-inference gap within this protocol. The results are record-level because reliable patient identifiers were unavailable. The method replays no raw ECGs, but it retains frozen feature vectors for router updates and is therefore raw-ECG-replay-free rather than memory-free. Code is publicly available at https://github.com/yufanlu221/IRFE-ECG.

cs.AI↗
arXiv2026

Improving Fairness of Large Language Model-Based ICU Mortality Prediction via Case-Based Prompting

Accurately predicting mortality risk in intensive care unit (ICU) patients is critical for clinical decision-making. Large language models (LLMs) are increasingly explored for clinical prediction using structured medical data, but their outputs may exhibit demographic disparities. Mitigating such disparities without degrading predictive performance remains challenging. We systematically investigate demographic bias in LLM-based ICU mortality prediction and propose Case-Based Prompting (CAP), a training-free framework designed to improve the empirical balance between predictive performance and subgroup fairness. CAP retrieves clinically similar historical misprediction and demographic-sensitive cases with known outcomes and incorporates them as case-level contextual evidence. We further evaluate model discrimination, subgroup fairness, and feature-dependence consistency. On MIMIC-IV, CAP improved AUROC from 0.806 to 0.873 and AUPRC from 0.497 to 0.694 compared with the Baseline Prompt. CAP also reduced several subgroup disparities, particularly for sex and White-Black comparisons, although age-related disparities remained non-negligible. Controlled demographic-information ablations showed that removing demographic information did not uniformly improve both predictive performance and subgroup fairness, indicating distinct performance-fairness patterns rather than a uniform benefit from demographic suppression. Feature-dependence analysis showed generally consistent expressed clinical factor patterns across demographic subgroups. These findings suggest that CAP is a promising inference-time strategy for LLM-based clinical prediction under the evaluated retrospective setting. Further validation across additional LLMs, external datasets, and prospective clinical scenarios is required before deployment.

cs.LG↗
arXiv2026

NeuroECG: ECGFounder-Based Deep ECG Representation for EEG-Free Neurological Prognostication After Cardiac Arrest

Neurological prognostication after cardiac arrest commonly relies on electroencephalography (EEG). However, EEG demands high clinical resources. Bedside electrocardiography (ECG) is standard and low-cost. Yet, its value for predicting neurological outcomes remains underexplored. In this study, we propose NeuroECG, an ECGFounder-based deep representation framework for EEG-free auxiliary prognostication. NeuroECG adapts a pretrained ECG foundation model via task-specific fine-tuning. We implement a gradual unfreezing strategy on single-channel bedside monitoring ECG. Multiple ECG segments per patient are encoded into segment-level deep features. These embeddings are aggregated via quantile pooling (q = 0.24) and compressed using principal component analysis (PCA). Experiments on 412 ECG-available patients from the multicenter I-CARE database show that the adapted ECGFounder backbone achieves the best performance among ECG-only backbone baselines, with a test AUROC of 0.7333. We further combine the learned deep ECG representation with static clinical covariates. The proposed NeuroECG model achieves a test AUROC of 0.8077 and an AUPRC of 0.8970. These results support deep bedside ECG representations as a useful source of auxiliary prognostic information. Their integration with static clinical covariates improves prediction in an EEG-free setting. The source code is available at https://github.com/goddream66/NeuroECG

cs.LG↗
arXiv2026

Aortic Valve Disease Screening from PPG via Physiology-Guided Self-Supervised Learning

Aortic valve disease (AVD) represents a major public health burden, while its diagnosis relies on echocardiography, which is limited by cost and specialist expertise, restricting scalable screening and risk stratification. Existing portable sensing modalities are constrained by indirect representations or acquisition dependencies. In this context, photoplethysmography (PPG), a widely available optical signal capturing peripheral hemodynamic dynamics, provides a scalable physiological measurement. However, the scarcity of clinically labeled PPG data severely constrains the development of effective data-driven models. To address this limitation, we propose Physiology-Guided Self-Supervised Learning (PG-SSL), leveraging approximately 170,000 unlabeled UK Biobank PPG recordings. PG-SSL constructs physiologically derived pseudo-labels based on clinically motivated waveform phenotypes associated with aortic stenosis (AS) and aortic regurgitation (AR), enabling large-scale pretraining without AVD-specific labels. Following fine-tuning on a small labeled cohort, the model achieved AUROCs of 0.8025 for AS and 0.7669 for AR. Further analyses demonstrated robustness under clinical confounding and covariate-balanced evaluation, as well as significant longitudinal associations with incident AVD events. This study demonstrates the feasibility of PG-SSL for leveraging large-scale unlabeled physiological signals under clinically labeled data-scarce conditions. The proposed approach provides a useful strategy for improving low-cost PPG-based screening and risk enrichment for clinically recognized AVD.

eess.SP↗
arXiv2026

LSTrans: Efficient Knowledge Transfer for Lightweight and Automated ECG Classification

Deploying deep learning models for automated electrocardiogram classification on resource-constrained wearable devices remains challenging due to high computational costs. To address this, we propose LSTrans, a lightweight hybrid model designed for efficient and sensitive ECG analysis. LSTrans introduces a specialized 1D convolutional backbone with an interleaved layer architecture to capture both macroscopic rhythmic trends and microscopic morphological variations. This backbone is cascaded with a Transformer encoder to model long-range temporal dependencies, incorporating Low-Rank Adaptation across critical layers to compress the model and reduce the trainable parameter space. We further employ homogeneous and heterogeneous knowledge distillation to transfer diagnostic expertise from high-capacity teacher models to the student. Experimental results on multiple benchmark datasets demonstrate that LSTrans achieves a competitive balance between diagnostic sensitivity and resource efficiency, substantially reducing peak memory footprints and training latency during downstream adaptation. The source code is available for review at https://github.com/zyee00128/LSTrans4BIBM.

cs.LG↗
arXiv2026

Frequency-Enhanced Diffusion Models: Curriculum-Guided Semantic Alignment for Zero-Shot Skeleton Action Recognition

Human action recognition is pivotal in computer vision, with applications ranging from surveillance to human-robot interaction. Despite the effectiveness of supervised skeleton-based methods, their reliance on exhaustive annotation limits generalization to novel actions. Zero-Shot Skeleton Action Recognition (ZSAR) emerges as a promising paradigm, yet it faces challenges due to the spectral bias of diffusion models, which oversmooth high-frequency dynamics. Here, we propose Frequency-Aware Diffusion for Skeleton-Text Matching (FDSM), integrating a Semantic-Guided Spectral Residual Module, a Timestep-Adaptive Spectral Loss, and Curriculum-based Semantic Abstraction to address these challenges. Our approach effectively recovers fine-grained motion details, achieving state-of-the-art performance on NTU RGB+D, PKU-MMD, and Kinetics-skeleton datasets. Code has been made available at https://github.com/yuzhi535/FDSM. Project homepage: https://yuzhi535.github.io/FDSM.github.io/

cs.CV↗
arXiv2026

Aligned but Fragile: Enhancing LLM Safety Robustness via Zeroth-Order Optimization

Safety alignment for large language models (LLMs) aims to reduce harmful or unsafe behavior while preserving general utility. However, recent findings reveal that alignment effects can be fragile: lightweight post-alignment manipulations, such as parameter noise, activation noise, or quantization, can easily weaken the intended safety behavior. Prior efforts to improve robustness have primarily focused on data curation, modified alignment objectives, and safety-critical parameter identification, leaving the role of the optimizer itself largely unexplored. In this paper, we are the first to study the robustness of safety alignment from the perspective of the base optimizer. This optimizer-centric view naturally points to zeroth-order optimization, which provides a robustness-oriented signal by evaluating safety alignment under perturbations. Based on this insight, we propose a hybrid framework that first performs standard first-order safety alignment and then applies zeroth-order refinement to improve robustness. Both theoretically and empirically, we show that only a few zeroth-order refinement steps can enhance robustness while preserving safety alignment. We further improve the efficiency of zeroth-order refinement by exploiting its inherent perturbation-based evaluations to estimate layer-wise robustness sensitivity, enabling the refinement process to concentrate updates on robustness-critical layers with modest training overhead.

cs.AI↗
arXiv2026

Towards Cross-lingual Values Judgment: A Consensus-Pluralism Perspective

As large language models (LLMs) are employed worldwide, existing evaluation paradigms for their multilingual capabilities primarily focus on factual task performance, neglecting the ability to judge content's deep-level values across multiple languages. To bridge this gap, we first reveal two primary challenges in constructing values judgment benchmarks, cultural diversity and disciplinary complexity, and propose a novel two-stage human-AI collaborative annotation framework to alleviate them. This framework identifies the issue scope and nature, establishes specific annotation criteria, and utilizes multiple LLMs for final review. Building upon this framework, we introduce \textbf{X-Value}, the first \textit{Cross-lingual Values Judgment Benchmark} designed to evaluate the capability of LLMs in judging deep-level values of content. X-Value comprises 4,750 Question-Answer pairs across 14 languages, covering 7 major global issue categories, and provides 12 granular annotation metadata to facilitate a rigorous evaluation of model performance. Systematic evaluations of X-Value are conducted across 17 LLMs using distinct prompting strategies. Multi-dimensional analysis of accuracy and F1-scores reveals their limitations in cross-lingual values judgment and indicates performance disparities across categories and languages. This work highlights the urgent need to improve the underlying, values-aware content judgment capability of LLMs.\footnote{Samples of X-Value are available at https://huggingface.co/datasets/Whitolf/X-Value.}

cs.CL↗
arXiv2026

Masked Training for Robust Arrhythmia Detection from Digitalized Multiple Layout ECG Images

Background: Electrocardiograms are indispensable for diagnosing cardiovascular diseases, yet in many settings they exist only as paper printouts stored in multiple recording layouts. Converting these images into digital signals introduces two key challenges: temporal asynchrony among leads and partial blackout missing, where contiguous signal segments become entirely unavailable. Existing models cannot adequately handle these concurrent problems while maintaining interpretability. Methods: We propose PatchECG, combining an adaptive variable block count missing learning mechanism with a masked training strategy. The model segments each lead into fixed-length patches, discards entirely missing patches, and encodes the remainder via a pluggable patch encoder. A disordered patch attention mechanism with patch-level temporal and lead embeddings captures cross-lead and temporal dependencies without interpolation. PatchECG was trained on PTB-XL and evaluated under seven simulated layout conditions, with external validation on 400 real ECG images from Chaoyang Hospital across three clinical layouts. Results: PatchECG achieves an average AUROC of approximately 0.835 across all simulated layouts. On the Chaoyang cohort, the model attains an overall AUROC of 0.778 for atrial fibrillation detection, rising to 0.893 on the 12x1 subset -- surpassing the pre-trained baseline by 0.111 and 0.190, respectively. Model attention aligns with cardiologist annotations at a rate approaching inter-clinician agreement. Conclusions: PatchECG provides a robust, interpolation-free, and interpretable solution for arrhythmia detection from digitized ECG images across diverse layouts. Its direct modeling of asynchronous and partially missing signals, combined with clinically aligned attention, positions it as a practical tool for cardiac diagnostics from legacy ECG archives in real-world clinical environments.

cs.LG↗
arXiv2026

Holter-to-Sleep: AI-Enabled Repurposing of Single-Lead ECG for Sleep Phenotyping

Sleep disturbances are tightly linked to cardiovascular risk, yet polysomnography (PSG)-the clinical reference standard-remains resource-intensive and poorly suited for multi-night, home-based, and large-scale screening. Single-lead electrocardiography (ECG), already ubiquitous in Holter and patch-based devices, enables comfortable long-term acquisition and encodes sleep-relevant physiology through autonomic modulation and cardiorespiratory coupling. Here, we present a proof-of-concept Holter-to-Sleep framework that, using single-lead ECG as the sole input, jointly supports overnight sleep phenotyping and Holter-grade cardiac phenotyping within the same recording, and further provides an explicit analytic pathway for scalable cardio-sleep association studies. The framework is developed and validated on a pooled multi-center PSG sample of 10,439 studies spanning four public cohorts, with independent external evaluation to assess cross-cohort generalizability, and additional real-world feasibility assessment using overnight patch-ECG recordings via objective-subjective consistency analysis. This integrated design enables robust extraction of clinically meaningful overnight sleep phenotypes under heterogeneous populations and acquisition conditions, and facilitates systematic linkage between ECG-derived sleep metrics and arrhythmia-related Holter phenotypes. Collectively, the Holter-to-Sleep paradigm offers a practical foundation for low-burden, home-deployable, and scalable cardio-sleep monitoring and research beyond traditional PSG-centric workflows.

eess.SP↗
arXiv2026

SpiroLLM: Finetuning Pretrained LLMs to Understand Spirogram Time Series with Clinical Validation in COPD Reporting

Chronic Obstructive Pulmonary Disease (COPD), a major chronic respiratory disease with persistent airflow limitation, is a leading global cause of disability and mortality. Respiratory spirogram time series, routinely collected during pulmonary function tests (PFTs), play a critical role in the early detection of respiratory diseases and in monitoring lung function over time. However, most current AI models for COPD diagnosis are limited to outputting classification results without providing a rationale for their diagnostic process, while current Large Language Models (LLMs) cannot understand spirograms yet, which severely limits their clinical trust and adoption. To tackle this challenge, we leverage a cohort of 234,028 individuals from the UK Biobank (UKB) to propose SpiroLLM, the first multimodal large language model that can understand spirogram. The model extracts morphological features from respiratory curves via a SpiroEncoder and aligns them with PFT numerical values in a unified latent space using a SpiroProjector, ultimately empowering a large language model to generate a comprehensive diagnostic report. Experimental results confirm that SpiroLLM achieved a diagnostic AUROC of 0.8977 (95% CI: 0.88-0.91). In a robustness test with missing core data, it maintained a 100% valid response rate, far surpassing the 13.4% of a text-only model and showcasing the superiority of its multimodal design. This work demonstrates the substantial potential of deeply fusing physiological signals with large language models, establishing a new paradigm for the next generation of interpretable and reliable clinical decision support tools.

cs.AI↗
arXiv2026

Copy-Paste to Mitigate Large Language Model Hallucinations

While Retrieval-Augmented Generation (RAG) enables large language models (LLMs) to generate contextually grounded responses, contextual faithfulness remains challenging as LLMs may not consistently trust provided context, leading to hallucinations that undermine reliability. We observe an inverse correlation between response copying degree and context-unfaithful hallucinations on RAGTruth, suggesting that higher copying degrees reduce hallucinations by fostering genuine contextual belief. We propose CopyPasteLLM, obtained through two-stage high-copying response preference training. We design three prompting methods to enhance copying degree, demonstrating that high-copying responses achieve superior contextual faithfulness and hallucination control. These approaches enable a fully automated pipeline that transforms generated responses into high-copying preference data for training CopyPasteLLM. On FaithEval, ConFiQA and PubMedQA, CopyPasteLLM achieves best performance in both counterfactual and original contexts, remarkably with 12.2% to 24.5% accuracy improvements on FaithEval over the best baseline, while requiring only 365 training samples -- 1/50th of baseline data. To elucidate CopyPasteLLM's effectiveness, we propose the Context-Parameter Copying Capturing algorithm. Interestingly, this reveals that CopyPasteLLM recalibrates reliance on internal parametric knowledge rather than external knowledge during generation. All codes are available at https://github.com/longyongchao/CopyPasteLLM

cs.CL↗
arXiv2026

Instance Temperature Knowledge Distillation

Knowledge distillation (KD) enhances the performance of a student network by allowing it to learn the knowledge transferred from a teacher network incrementally. Existing methods dynamically adjust the temperature to enable the student network to adapt to the varying learning difficulties at different learning stages of KD. KD is a continuous process, but when adjusting the temperature, these methods consider only the immediate benefits of the operation in the current learning phase and fail to take into account its future returns. To address this issue, we formulate the adjustment of temperature as a sequential decision-making task and propose a method based on reinforcement learning, termed RLKD. Importantly, we design a novel state representation to enable the agent to make more informed action (i.e. instance temperature adjustment). To handle the problem of delayed rewards in our method due to the KD setting, we explore an instance reward calibration approach. In addition,we devise an efficient exploration strategy that enables the agent to learn valuable instance temperature adjustment policy more efficiently. Our framework can serve as a plug-and-play technique to be inserted into various KD methods easily, and we validate its effectiveness on both image classification and object detection tasks. Our project is at https://itkd123.github.io/ITKD.github.io/.

cs.LG↗
arXiv2026

From Reasoning LLMs to BERT: A Two-Stage Distillation Framework for Search Relevance

Query-service relevance prediction in e-commerce search systems faces strict latency requirements that prevent the direct application of Large Language Models (LLMs). To bridge this gap, we propose a two-stage reasoning distillation framework to transfer reasoning capabilities from a powerful teacher LLM to a lightweight, deployment-friendly student model. In the first stage, we address the limitations of general-purpose LLMs by constructing a domain-adapted teacher model. This is achieved through a three-step process: domain-adaptive pre-training to inject platform knowledge, supervised fine-tuning to elicit reasoning skills, and preference optimization with a multi-dimensional reward model to ensure the generation of reliable and preference-aligned reasoning paths. This teacher can then automatically annotate massive query-service pairs from search logs with both relevance labels and reasoning chains. In the second stage, to address the challenges of architectural heterogeneity in standard distillation, we introduce Contrastive Reasoning Self-Distillation (CRSD). By modeling the behavior of the same student model under ``standard'' and ``reasoning-augmented'' inputs as a teacher-student relationship, CRSD enables the lightweight model to internalize the teacher's complex decision-making mechanisms without needing the explicit reasoning path at inference. Offline evaluations and online A/B testing in the Meituan search advertising system demonstrate that our framework achieves significant improvements across multiple metrics, validating its effectiveness and practical value.

cs.IR↗