arXiv subjects

Zheng Chen

Publications and source records attributed to Zheng Chen.

At least 109 records · Page 6Linked to original sources

arXiv2025

MLOmics: Cancer Multi-Omics Database for Machine Learning

Framing the investigation of diverse cancers as a machine learning problem has recently shown significant potential in multi-omics analysis and cancer research. Empowering these successful machine learning models are the high-quality training datasets with sufficient data volume and adequate preprocessing. However, while there exist several public data portals, including The Cancer Genome Atlas (TCGA) multi-omics initiative or open-bases such as the LinkedOmics, these databases are not off-the-shelf for existing machine learning models. In this paper, we introduce MLOmics, an open cancer multi-omics database aiming at serving better the development and evaluation of bioinformatics and machine learning models. MLOmics contains 8,314 patient samples covering all 32 cancer types with four omics types, stratified features, and extensive baselines. Complementary support for downstream analysis and bio-knowledge linking are also included to support interdisciplinary analysis.

q-bio.GN↗

arXiv2025

OSDFace: One-Step Diffusion Model for Face Restoration

Diffusion models have demonstrated impressive performance in face restoration. Yet, their multi-step inference process remains computationally intensive, limiting their applicability in real-world scenarios. Moreover, existing methods often struggle to generate face images that are harmonious, realistic, and consistent with the subject's identity. In this work, we propose OSDFace, a novel one-step diffusion model for face restoration. Specifically, we propose a visual representation embedder (VRE) to better capture prior information and understand the input face. In VRE, low-quality faces are processed by a visual tokenizer and subsequently embedded with a vector-quantized dictionary to generate visual prompts. Additionally, we incorporate a facial identity loss derived from face recognition to further ensure identity consistency. We further employ a generative adversarial network (GAN) as a guidance model to encourage distribution alignment between the restored face and the ground truth. Experimental results demonstrate that OSDFace surpasses current state-of-the-art (SOTA) methods in both visual quality and quantitative metrics, generating high-fidelity, natural face images with high identity consistency. The code and model will be released at https://github.com/jkwang28/OSDFace.

cs.CV↗

arXiv2025

SkyReels-V2: Infinite-length Film Generative Model

Recent advances in video generation have been driven by diffusion models and autoregressive frameworks, yet critical challenges persist in harmonizing prompt adherence, visual quality, motion dynamics, and duration: compromises in motion dynamics to enhance temporal visual quality, constrained video duration (5-10 seconds) to prioritize resolution, and inadequate shot-aware generation stemming from general-purpose MLLMs' inability to interpret cinematic grammar, such as shot composition, actor expressions, and camera motions. These intertwined limitations hinder realistic long-form synthesis and professional film-style generation. To address these limitations, we propose SkyReels-V2, an Infinite-length Film Generative Model, that synergizes Multi-modal Large Language Model (MLLM), Multi-stage Pretraining, Reinforcement Learning, and Diffusion Forcing Framework. Firstly, we design a comprehensive structural representation of video that combines the general descriptions by the Multi-modal LLM and the detailed shot language by sub-expert models. Aided with human annotation, we then train a unified Video Captioner, named SkyCaptioner-V1, to efficiently label the video data. Secondly, we establish progressive-resolution pretraining for the fundamental video generation, followed by a four-stage post-training enhancement: Initial concept-balanced Supervised Fine-Tuning (SFT) improves baseline quality; Motion-specific Reinforcement Learning (RL) training with human-annotated and synthetic distortion data addresses dynamic artifacts; Our diffusion forcing framework with non-decreasing noise schedules enables long-video synthesis in an efficient search space; Final high-quality SFT refines visual fidelity. All the code and models are available at https://github.com/SkyworkAI/SkyReels-V2.

cs.CV↗

arXiv2025

NTIRE 2025 Challenge on Real-World Face Restoration: Methods and Results

This paper provides a review of the NTIRE 2025 challenge on real-world face restoration, highlighting the proposed solutions and the resulting outcomes. The challenge focuses on generating natural, realistic outputs while maintaining identity consistency. Its goal is to advance state-of-the-art solutions for perceptual quality and realism, without imposing constraints on computational resources or training data. The track of the challenge evaluates performance using a weighted image quality assessment (IQA) score and employs the AdaFace model as an identity checker. The competition attracted 141 registrants, with 13 teams submitting valid models, and ultimately, 10 teams achieved a valid score in the final ranking. This collaborative effort advances the performance of real-world face restoration while offering an in-depth overview of the latest trends in the field.

cs.CV↗

arXiv2025

Nonlinear Optimal Guidance for Intercepting Moving Targets

This paper introduces a nonlinear optimal guidance framework for guiding a pursuer to intercept a moving target, with an emphasis on real-time generation of optimal feedback control for a nonlinear optimal control problem. Initially, considering the target moves without maneuvering, we derive the necessary optimality conditions using Pontryagin's Maximum Principle. These conditions reveal that each extremal trajectory is uniquely determined by two scalar parameters. Analyzing the geometric property of the parameterized extremal trajectories not only leads to an additional necessary condition but also allows to establish a sufficient condition for local optimality. This enables the generation of a dataset containing at least locally optimal trajectories. By studying the properties of the optimal feedback control, the size of the dataset is reduced significantly, allowing training a lightweight neural network to predict the optimal guidance command in real time. Furthermore, the performance of the neural network is enhanced by incorporating the target's acceleration, making it suitable for intercepting both uniformly moving and maneuvering targets. Finally, numerical simulations validate the proposed nonlinear optimal guidance framework, demonstrating its better performance over existing guidance laws.

math.OC↗

arXiv2025

Can Large Language Models Replace Data Scientists in Biomedical Research?

Data science plays a critical role in biomedical research, but it requires professionals with expertise in coding and medical data analysis. Large language models (LLMs) have shown great potential in supporting medical tasks and performing well in general coding tests. However, existing evaluations fail to assess their capability in biomedical data science, particularly in handling diverse data types such as genomics and clinical datasets. To address this gap, we developed a benchmark of data science coding tasks derived from the analyses of 39 published studies. This benchmark comprises 293 coding tasks (128 in Python and 165 in R) performed on real-world TCGA-type genomics and clinical data. Our findings reveal that the vanilla prompting of LLMs yields suboptimal performances due to drawbacks in following input instructions, understanding target data, and adhering to standard analysis practices. Next, we benchmarked six cutting-edge LLMs and advanced adaptation methods, finding two methods to be particularly effective: chain-of-thought prompting, which provides a step-by-step plan for data analysis, which led to a 21% code accuracy improvement (56.6% versus 35.3%); and self-reflection, enabling LLMs to refine the buggy code iteratively, yielding an 11% code accuracy improvement (45.5% versus 34.3%). Building on these insights, we developed a platform that integrates LLMs into the data science workflow for medical professionals. In a user study with five medical professionals, we found that while LLMs cannot fully automate programming tasks, they significantly streamline the programming process. We found that 80% of their submitted code solutions were incorporated from LLM-generated code, with up to 96% reuse in some cases. Our analysis highlights the potential of LLMs to enhance data science efficiency in biomedical research when integrated into expert workflows.

cs.AI↗

arXiv2025

Robust and Efficient Average Consensus with Non-Coherent Over-the-Air Aggregation

Non-coherent over-the-air (OTA) computation has garnered increasing attention for its advantages in facilitating information aggregation among distributed agents in resource-constrained networks without requiring precise channel estimation. A promising application scenario of this method is distributed average consensus in wireless multi-agent systems. However, in such scenario, non-coherent interference from concurrent OTA transmissions can introduce bias in the consensus value. To address this issue, we develop a robust distributed average consensus algorithm by formulating the consensus problem as a distributed optimization problem. Using decentralized projected gradient descent (D-PGD), our proposed algorithm can achieve unbiased mean square average consensus even in the presence of non-coherent interference and noise. Additionally, we implement transmit power control and receive scaling mechanisms to further accelerate convergence. Simulation results demonstrate that our method can significantly enhance the convergence speed of the D-PGD algorithm for OTA average consensus without compromising accuracy.

cs.IT↗

arXiv2025

PAFFA: Premeditated Actions For Fast Agents

Modern AI assistants have made significant progress in natural language understanding and tool-use, with emerging efforts to interact with Web interfaces. However, current approaches that heavily rely on repeated LLM-driven HTML parsing are computationally expensive and error-prone, particularly when handling dynamic web interfaces and multi-step tasks. We introduce PAFFA (Premeditated Actions For Fast Agents), a method that makes LLMs faster and more accurate in completing tasks on the internet using a novel inference-time technique that requires no task-specific training. PAFFA constructs an 'Action Library', leveraging the parametric knowledge of the base LLM to pre-compute browser interaction patterns that generalize across tasks. By strategically re-using LLM inference across tasks - either via 'Dist-Map' for task-agnostic identification of key interactive web elements, or 'Unravel' for first-encounter, stateful exploration of novel tasks/sites) - PAFFA drastically reduces inference time tokens by 87% while maintaining robust performance (achieving 0.57 vs. 0.50 step accuracy compared to baseline). Further, Unravel's ability to update its action library based on explorations allows generalization and adaptation to unseen websites. In sum, this work exhibits that LLM reasoning sequences can generalize across prompts, offering a way to scale inference-time techniques for internet-scale data with sublinear token count.

cs.AI↗

arXiv2025

Nonlinear Optimal Guidance for Impact Time Control with Field-of-View Constraint

An optimal guidance law for impact time control with field-of-view constraint is presented. The guidance law is derived by first converting the inequality-constrained nonlinear optimal control problem into an equality-constrained one through a saturation function. Based on Pontryagin's maximum principle, a parameterized system satisfying the necessary optimality conditions is established. By propagating this system, a large number of extremal trajectories can be efficiently generated. These trajectories are then used to train a neural network that maps the current state and time-to-go to the optimal guidance command. The trained neural network can generate optimal commands within 0.1 milliseconds while satisfying the field-of-view constraint. Numerical simulations demonstrate that the proposed guidance law outperforms existing methods and achieves nearly optimal performance in terms of control effort.

math.OC↗

arXiv2025

Image Super-Resolution with Text Prompt Diffusion

Image super-resolution (SR) methods typically model degradation to improve reconstruction accuracy in complex and unknown degradation scenarios. However, extracting degradation information from low-resolution images is challenging, which limits the model performance. To boost image SR performance, one feasible approach is to introduce additional priors. Inspired by advancements in multi-modal methods and text prompt image processing, we introduce text prompts to image SR to provide degradation priors. Specifically, we first design a text-image generation pipeline to integrate text into the SR dataset through the text degradation representation and degradation model. By adopting a discrete design, the text representation is flexible and user-friendly. Meanwhile, we propose the PromptSR to realize the text prompt SR. The PromptSR leverages the latest multi-modal large language model (MLLM) to generate prompts from low-resolution images. It also utilizes the pre-trained language model (e.g., T5 or CLIP) to enhance text comprehension. We train the PromptSR on the text-image dataset. Extensive experiments indicate that introducing text prompts into SR, yields impressive results on both synthetic and real-world images. Code: https://github.com/zhengchen1999/PromptSR.

cs.CV↗

arXiv2025

Contrast: A Hybrid Architecture of Transformers and State Space Models for Low-Level Vision

Transformers have become increasingly popular for image super-resolution (SR) tasks due to their strong global context modeling capabilities. However, their quadratic computational complexity necessitates the use of window-based attention mechanisms, which restricts the receptive field and limits effective context expansion. Recently, the Mamba architecture has emerged as a promising alternative with linear computational complexity, allowing it to avoid window mechanisms and maintain a large receptive field. Nevertheless, Mamba faces challenges in handling long-context dependencies when high pixel-level precision is required, as in SR tasks. This is due to its hidden state mechanism, which can compress and store a substantial amount of context but only in an approximate manner, leading to inaccuracies that transformers do not suffer from. In this paper, we propose \textbf{Contrast}, a hybrid SR model that combines \textbf{Con}volutional, \textbf{Tra}nsformer, and \textbf{St}ate Space components, effectively blending the strengths of transformers and Mamba to address their individual limitations. By integrating transformer and state space mechanisms, \textbf{Contrast} compensates for the shortcomings of each approach, enhancing both global context modeling and pixel-level accuracy. We demonstrate that combining these two architectures allows us to mitigate the problems inherent in each, resulting in improved performance on image super-resolution tasks.

cs.CV↗

arXiv2025

One-Step Diffusion Model for Image Motion-Deblurring

Currently, methods for single-image deblurring based on CNNs and transformers have demonstrated promising performance. However, these methods often suffer from perceptual limitations, poor generalization ability, and struggle with heavy or complex blur. While diffusion-based methods can partially address these shortcomings, their multi-step denoising process limits their practical usage. In this paper, we conduct an in-depth exploration of diffusion models in deblurring and propose a one-step diffusion model for deblurring (OSDD), a novel framework that reduces the denoising process to a single step, significantly improving inference efficiency while maintaining high fidelity. To tackle fidelity loss in diffusion models, we introduce an enhanced variational autoencoder (eVAE), which improves structural restoration. Additionally, we construct a high-quality synthetic deblurring dataset to mitigate perceptual collapse and design a dynamic dual-adapter (DDA) to enhance perceptual quality while preserving fidelity. Extensive experiments demonstrate that our method achieves strong performance on both full and no-reference metrics. Our code and pre-trained model will be publicly available at https://github.com/xyLiu339/OSDD.

cs.CV↗

arXiv2025

PlanarNeRF: Online Learning of Planar Primitives with Neural Radiance Fields

Identifying spatially complete planar primitives from visual data is a crucial task in computer vision. Prior methods are largely restricted to either 2D segment recovery or simplifying 3D structures, even with extensive plane annotations. We present PlanarNeRF, a novel framework capable of detecting dense 3D planes through online learning. Drawing upon the neural field representation, PlanarNeRF brings three major contributions. First, it enhances 3D plane detection with concurrent appearance and geometry knowledge. Second, a lightweight plane fitting module is proposed to estimate plane parameters. Third, a novel global memory bank structure with an update mechanism is introduced, ensuring consistent cross-frame correspondence. The flexible architecture of PlanarNeRF allows it to function in both 2D-supervised and self-supervised solutions, in each of which it can effectively learn from sparse training signals, significantly improving training efficiency. Through extensive experiments, we demonstrate the effectiveness of PlanarNeRF in various scenarios and remarkable improvement over existing works.

cs.CV↗

arXiv2025

Long-Term EEG Partitioning for Seizure Onset Detection

Deep learning models have recently shown great success in classifying epileptic patients using EEG recordings. Unfortunately, classification-based methods lack a sound mechanism to detect the onset of seizure events. In this work, we propose a two-stage framework, SODor, that explicitly models seizure onset through a novel task formulation of subsequence clustering. Given an EEG sequence, the framework first learns a set of second-level embeddings with label supervision. It then employs model-based clustering to explicitly capture long-term temporal dependencies in EEG sequences and identify meaningful subsequences. Epochs within a subsequence share a common cluster assignment (normal or seizure), with cluster or state transitions representing successful onset detections. Extensive experiments on three datasets demonstrate that our method can correct misclassifications, achieving 5\%-11\% classification improvements over other baselines and accurately detecting seizure onsets.

cs.LG↗

arXiv2025

Prior-guided Hierarchical Harmonization Network for Efficient Image Dehazing

Image dehazing is a crucial task that involves the enhancement of degraded images to recover their sharpness and textures. While vision Transformers have exhibited impressive results in diverse dehazing tasks, their quadratic complexity and lack of dehazing priors pose significant drawbacks for real-world applications. In this paper, guided by triple priors, Bright Channel Prior (BCP), Dark Channel Prior (DCP), and Histogram Equalization (HE), we propose a \textit{P}rior-\textit{g}uided Hierarchical \textit{H}armonization Network (PGH$^2$Net) for image dehazing. PGH$^2$Net is built upon the UNet-like architecture with an efficient encoder and decoder, consisting of two module types: (1) Prior aggregation module that injects B/DCP and selects diverse contexts with gating attention. (2) Feature harmonization modules that subtract low-frequency components from spatial and channel aspects and learn more informative feature distributions to equalize the feature maps.

cs.CV↗

arXiv2025

Dual-branch Graph Feature Learning for NLOS Imaging

The domain of non-line-of-sight (NLOS) imaging is advancing rapidly, offering the capability to reveal occluded scenes that are not directly visible. However, contemporary NLOS systems face several significant challenges: (1) The computational and storage requirements are profound due to the inherent three-dimensional grid data structure, which restricts practical application. (2) The simultaneous reconstruction of albedo and depth information requires a delicate balance using hyperparameters in the loss function, rendering the concurrent reconstruction of texture and depth information difficult. This paper introduces the innovative methodology, \xnet, which integrates an albedo-focused reconstruction branch dedicated to albedo information recovery and a depth-focused reconstruction branch that extracts geometrical structure, to overcome these obstacles. The dual-branch framework segregates content delivery to the respective reconstructions, thereby enhancing the quality of the retrieved data. To our knowledge, we are the first to employ the GNN as a fundamental component to transform dense NLOS grid data into sparse structural features for efficient reconstruction. Comprehensive experiments demonstrate that our method attains the highest level of performance among existing methods across synthetic and real data. https://github.com/Nicholassu/DG-NLOS.

eess.IV↗

arXiv2025

GeSubNet: Gene Interaction Inference for Disease Subtype Network Generation

Retrieving gene functional networks from knowledge databases presents a challenge due to the mismatch between disease networks and subtype-specific variations. Current solutions, including statistical and deep learning methods, often fail to effectively integrate gene interaction knowledge from databases or explicitly learn subtype-specific interactions. To address this mismatch, we propose GeSubNet, which learns a unified representation capable of predicting gene interactions while distinguishing between different disease subtypes. Graphs generated by such representations can be considered subtype-specific networks. GeSubNet is a multi-step representation learning framework with three modules: First, a deep generative model learns distinct disease subtypes from patient gene expression profiles. Second, a graph neural network captures representations of prior gene networks from knowledge databases, ensuring accurate physical gene interactions. Finally, we integrate these two representations using an inference loss that leverages graph generation capabilities, conditioned on the patient separation loss, to refine subtype-specific information in the learned representation. GeSubNet consistently outperforms traditional methods, with average improvements of 30.6%, 21.0%, 20.1%, and 56.6% across four graph evaluation metrics, averaged over four cancer datasets. Particularly, we conduct a biological simulation experiment to assess how the behavior of selected genes from over 11,000 candidates affects subtypes or patient distributions. The results show that the generated network has the potential to identify subtype-specific genes with an 83% likelihood of impacting patient distribution shifts.

cs.LG↗

arXiv2025

CondiQuant: Condition Number Based Low-Bit Quantization for Image Super-Resolution

Low-bit model quantization for image super-resolution (SR) is a longstanding task that is renowned for its surprising compression and acceleration ability. However, accuracy degradation is inevitable when compressing the full-precision (FP) model to ultra-low bit widths (2~4 bits). Experimentally, we observe that the degradation of quantization is mainly attributed to the quantization of activation instead of model weights. In numerical analysis, the condition number of weights could measure how much the output value can change for a small change in the input argument, inherently reflecting the quantization error. Therefore, we propose CondiQuant, a condition number based low-bit post-training quantization for image super-resolution. Specifically, we formulate the quantization error as the condition number of weight metrics. By decoupling the representation ability and the quantization sensitivity, we design an efficient proximal gradient descent algorithm to iteratively minimize the condition number and maintain the output still. With comprehensive experiments, we demonstrate that CondiQuant outperforms existing state-of-the-art post-training quantization methods in accuracy without computation overhead and gains the theoretically optimal compression ratio in model parameters. Our code and model are released at https://github.com/Kai-Liu001/CondiQuant.

cs.CV↗