arXiv subjects

Zhengming Ding

Publications and source records attributed to Zhengming Ding.

At least 19 recordsLinked to original sources

arXiv2026

Long-Range Indirect Control-Flow Prediction in Stripped Binaries via Dual Virtual Hubs and Multi-Task Graph Learning

Recovering indirect control-flow (ICF) edges is fundamental to binary security analysis, yet existing methods struggle with long-range dependencies, isolate different ICF types, and are often evaluated under protocols vulnerable to label noise and data leakage. We present ICFlowNet, a unified framework for long-range ICF prediction in stripped binaries. ICFlowNet introduces candidate-aware Dual Virtual Hubs, a Global Code Hub and a Global Data Hub, to create short routing paths between distant code and data evidence, and combines them with multi-task graph learning to jointly model indirect calls, indirect tail calls, jump tables, and returns. To enable credible evaluation, we further develop a leakage-aware, noise-controlled pipeline with package-level splits, function-level mnemonic-hash deduplication, and a clean test protocol built from dynamic positives and absolute negatives. Using this pipeline, we construct a dataset of 15,901 unique stripped x86-64 binaries, including 1,351 with dynamic ground truth. Experiments show that simply scaling static supervision yields only marginal gains, whereas our structural and multi-task designs are essential: Dual Virtual Hubs improve long-range F1 by up to 9.13 points, multi-task learning adds up to 5.81 points, and the final model outperforms prior baselines by more than 13 F1 points on long-range indirect calls while adding only 11.44 percent topological overhead.

cs.CR↗

arXiv2026

Structure-Regularized Interpretable TCR-Epitope Prediction

T cell receptor (TCR)-epitope binding prediction is essential for understanding adaptive immunity and developing immunotherapies. Existing sequence- and structure-based models often generalize poorly to unseen epitopes and provide limited interpretability. Furthermore, the impact of generated structures on model learning remains unclear. We present TCR-SRIM, a structure-regularized interpretable-by-design model that combines protein language model embeddings with interpretable contact prototypes to capture residue-level TCR-epitope interactions. TCR-SRIM achieves state-of-the-art predictive performance and improved interpretation quality on the TCR-XAI benchmark. Using its inherent interpretability, we further evaluate the effect of generated structures on model learning. While structures predicted by AlphaFold3, TCRModel2, and tFold-TCR yield competitive performance, they lead to less accurate interaction patterns and reduced binding-site diversity than experimentally-resolved structures. Our results highlight limitations of current structure prediction models for TCR-epitope learning and demonstrate the value of interpretable-by-design models for studying generated biological structures.

q-bio.BM↗

arXiv2026

Why Does It Look There? Structured Explanations for Image Classification

Deep learning models achieve remarkable predictive performance, yet their black-box nature limits transparency and trustworthiness. Although numerous explainable artificial intelligence (XAI) methods have been proposed, they primarily provide saliency maps or concepts (i.e., unstructured interpretability). Existing approaches often rely on auxiliary models (\eg, GPT, CLIP) to describe model behavior, thereby compromising faithfulness to the original models. We propose Interpretability to Explainability (I2X), a framework that builds structured explanations directly from unstructured interpretability by quantifying progress at selected checkpoints during training using prototypes extracted from post-hoc XAI methods (e.g., GradCAM). I2X answers the question of "why does it look there" by providing a structured view of both intra- and inter-class decision making during training. Experiments on MNIST and CIFAR10 demonstrate effectiveness of I2X to reveal prototype-based inference process of various image classification models. Moreover, we demonstrate that I2X can be used to improve predictions across different model architectures and datasets: we can identify uncertain prototypes recognized by I2X and then use targeted perturbation of samples that allows fine-tuning to ultimately improve accuracy. Thus, I2X not only faithfully explains model behavior but also provides a practical approach to guide optimization toward desired targets.

cs.CV↗

arXiv2026

MixerCSeg: An Efficient Mixer Architecture for Crack Segmentation via Decoupled Mamba Attention

Feature encoders play a key role in pixel-level crack segmentation by shaping the representation of fine textures and thin structures. Existing CNN-, Transformer-, and Mamba-based models each capture only part of the required spatial or structural information, leaving clear gaps in modeling complex crack patterns. To address this, we present MixerCSeg, a mixer architecture designed like a coordinated team of specialists, where CNN-like pathways focus on local textures, Transformer-style paths capture global dependencies, and Mamba-inspired flows model sequential context within a single encoder. At the core of MixerCSeg is the TransMixer, which explores Mamba's latent attention behavior while establishing dedicated pathways that naturally express both locality and global awareness. To further enhance structural fidelity, we introduce a spatial block processing strategy and a Direction-guided Edge Gated Convolution (DEGConv) that strengthens edge sensitivity under irregular crack geometries with minimal computational overhead. A Spatial Refinement Multi-Level Fusion (SRF) module is then employed to refine multi-scale details without increasing complexity. Extensive experiments on multiple crack segmentation benchmarks show that MixerCSeg achieves state-of-the-art performance with only 2.05 GFLOPs and 2.54 M parameters, demonstrating both efficiency and strong representational capability. The code is available at https://github.com/spiderforest/MixerCSeg.

cs.CV↗

arXiv2026

Seeing Clearly, Reasoning Confidently: Plug-and-Play Remedies for Vision Language Model Blindness

Vision language models (VLMs) have achieved remarkable success in broad visual understanding, yet they remain challenged by object-centric reasoning on rare objects due to the scarcity of such instances in pretraining data. While prior efforts alleviate this issue by retrieving additional data or introducing stronger vision encoders, these methods are still computationally intensive during finetuning VLMs and don't fully exploit the original training data. In this paper, we introduce an efficient plug-and-play module that substantially improves VLMs' reasoning over rare objects by refining visual tokens and enriching input text prompts, without VLMs finetuning. Specifically, we propose to learn multi-modal class embeddings for rare objects by leveraging prior knowledge from vision foundation models and synonym-augmented text descriptions, compensating for limited training examples. These embeddings refine the visual tokens in VLMs through a lightweight attention-based enhancement module that improves fine-grained object details. In addition, we use the learned embeddings as object-aware detectors to generate informative hints, which are injected into the text prompts to help guide the VLM's attention toward relevant image regions. Experiments on two benchmarks show consistent and substantial gains for pretrained VLMs in rare object recognition and reasoning. Further analysis reveals how our method strengthens the VLM's ability to focus on and reason about rare objects.

cs.CV↗

arXiv2025

VLMs Guided Interpretable Decision Making for Autonomous Driving

Recent advancements in autonomous driving (AD) have explored the use of vision-language models (VLMs) within visual question answering (VQA) frameworks for direct driving decision-making. However, these approaches often depend on handcrafted prompts and suffer from inconsistent performance, limiting their robustness and generalization in real-world scenarios. In this work, we evaluate state-of-the-art open-source VLMs on high-level decision-making tasks using ego-view visual inputs and identify critical limitations in their ability to deliver reliable, context-aware decisions. Motivated by these observations, we propose a new approach that shifts the role of VLMs from direct decision generators to semantic enhancers. Specifically, we leverage their strong general scene understanding to enrich existing vision-based benchmarks with structured, linguistically rich scene descriptions. Building on this enriched representation, we introduce a multi-modal interactive architecture that fuses visual and linguistic features for more accurate decision-making and interpretable textual explanations. Furthermore, we design a post-hoc refinement module that utilizes VLMs to enhance prediction reliability. Extensive experiments on two autonomous driving benchmarks demonstrate that our approach achieves state-of-the-art performance, offering a promising direction for integrating VLMs into reliable and interpretable AD systems.

cs.CV↗

arXiv2025

Diffusion Guided Adversarial State Perturbations in Reinforcement Learning

Reinforcement learning (RL) systems, while achieving remarkable success across various domains, are vulnerable to adversarial attacks. This is especially a concern in vision-based environments where minor manipulations of high-dimensional image inputs can easily mislead the agent's behavior. To this end, various defenses have been proposed recently, with state-of-the-art approaches achieving robust performance even under large state perturbations. However, after closer investigation, we found that the effectiveness of the current defenses is due to a fundamental weakness of the existing $l_p$ norm-constrained attacks, which can barely alter the semantics of image input even under a relatively large perturbation budget. In this work, we propose SHIFT, a novel policy-agnostic diffusion-based state perturbation attack to go beyond this limitation. Our attack is able to generate perturbed states that are semantically different from the true states while remaining realistic and history-aligned to avoid detection. Evaluations show that our attack effectively breaks existing defenses, including the most sophisticated ones, significantly outperforming existing attacks while being more perceptually stealthy. The results highlight the vulnerability of RL agents to semantics-aware adversarial perturbations, indicating the importance of developing more robust policies.

cs.LG↗

arXiv2025

TCR-EML: Explainable Model Layers for TCR-pMHC Prediction

T cell receptor (TCR) recognition of peptide-MHC (pMHC) complexes is a central component of adaptive immunity, with implications for vaccine design, cancer immunotherapy, and autoimmune disease. While recent advances in machine learning have improved prediction of TCR-pMHC binding, the most effective approaches are black-box transformer models that cannot provide a rationale for predictions. Post-hoc explanation methods can provide insight with respect to the input but do not explicitly model biochemical mechanisms (e.g. known binding regions), as in TCR-pMHC binding. ``Explain-by-design'' models (i.e., with architectural components that can be examined directly after training) have been explored in other domains, but have not been used for TCR-pMHC binding. We propose explainable model layers (TCR-EML) that can be incorporated into protein-language model backbones for TCR-pMHC modeling. Our approach uses prototype layers for amino acid residue contacts drawn from known TCR-pMHC binding mechanisms, enabling high-quality explanations for predicted TCR-pMHC binding. Experiments of our proposed method on large-scale datasets demonstrate competitive predictive accuracy and generalization, and evaluation on the TCR-XAI benchmark demonstrates improved explainability compared with existing approaches.

q-bio.QM↗

arXiv2025

Quantum Probabilistic Label Refining: Enhancing Label Quality for Robust Image Classification

Learning with softmax cross-entropy on one-hot labels often leads to overconfident predictions and poor robustness under noise or perturbations. Label smoothing mitigates this by redistributing some confidence uniformly, but treats all samples equally, ignoring intra-class variability. We propose a hybrid quantum-classical framework that leverages quantum non-determinism to refine data labels into probabilistic ones, offering more nuanced, human-like uncertainty representations than label smoothing or Bayesian approaches. A variational quantum circuit (VQC) encodes inputs into multi-qubit quantum states, using entanglement and superposition to capture subtle feature correlations. Measurement via the Born rule extracts probabilistic soft labels that reflect input-specific uncertainty. These labels are then used to train a classical convolutional neural network (CNN) with soft-target cross-entropy loss. On MNIST and Fashion-MNIST, our method improves robustness, achieving up to 50% higher accuracy under noise while maintaining competitive accuracy on clean data. It also enhances model calibration and interpretability, as CNN outputs better reflect quantum-derived uncertainty. This work introduces Quantum Probabilistic Label Refining, bridging quantum measurement and classical deep learning for robust training via refined, correlation-aware labels without architectural changes or adversarial techniques.

quant-ph↗

arXiv2025

Rational Multi-Modal Transformers for TCR-pMHC Prediction

T cell receptor (TCR) recognition of peptide-MHC (pMHC) complexes is fundamental to adaptive immunity and central to the development of T cell-based immunotherapies. While transformer-based models have shown promise in predicting TCR-pMHC interactions, most lack a systematic and explainable approach to architecture design. We present an approach that uses a new post-hoc explainability method to inform the construction of a novel encoder-decoder transformer model. By identifying the most informative combinations of TCR and epitope sequence inputs, we optimize cross-attention strategies, incorporate auxiliary training objectives, and introduce a novel early-stopping criterion based on explanation quality. Our framework achieves state-of-the-art predictive performance while simultaneously improving explainability, robustness, and generalization. This work establishes a principled, explanation-driven strategy for modeling TCR-pMHC binding and offers mechanistic insights into sequence-level binding behavior through the lens of deep learning.

cs.CE↗

arXiv2025

$i$MIND: Insightful Multi-subject Invariant Neural Decoding

Decoding visual signals holds the tantalizing potential to unravel the complexities of cognition and perception. While recent studies have focused on reconstructing visual stimuli from neural recordings to bridge brain activity with visual imagery, existing methods offer limited insights into the underlying mechanisms of visual processing in the brain. To mitigate this gap, we present an \textit{i}nsightful \textbf{M}ulti-subject \textbf{I}nvariant \textbf{N}eural \textbf{D}ecoding ($i$MIND) model, which employs a novel dual-decoding framework--both biometric and semantic decoding--to offer neural interpretability in a data-driven manner and deepen our understanding of brain-based visual functionalities. Our $i$MIND model operates through three core steps: establishing a shared neural representation space across subjects using a ViT-based masked autoencoder, disentangling neural features into complementary subject-specific and object-specific components, and performing dual decoding to support both biometric and semantic classification tasks. Experimental results demonstrate that $i$MIND achieves state-of-the-art decoding performance with minimal scalability limitations. Furthermore, $i$MIND empirically generates voxel-object activation fingerprints that reveal object-specific neural patterns and enable investigation of subject-specific variations in attention to identical stimuli. These findings provide a foundation for more interpretable and generalizable subject-invariant neural decoding, advancing our understanding of the voxel semantic selectivity as well as the neural vision processing dynamics.

cs.CE↗

arXiv2025

eSkinHealth: A Multimodal Dataset for Neglected Tropical Skin Diseases

Skin Neglected Tropical Diseases (NTDs) impose severe health and socioeconomic burdens in impoverished tropical communities. Yet, advancements in AI-driven diagnostic support are hindered by data scarcity, particularly for underrepresented populations and rare manifestations of NTDs. Existing dermatological datasets often lack the demographic and disease spectrum crucial for developing reliable recognition models of NTDs. To address this, we introduce eSkinHealth, a novel dermatological dataset collected on-site in C\^ote d'Ivoire and Ghana. Specifically, eSkinHealth contains 5,623 images from 1,639 cases and encompasses 47 skin diseases, focusing uniquely on skin NTDs and rare conditions among West African populations. We further propose an AI-expert collaboration paradigm to implement foundation language and segmentation models for efficient generation of multimodal annotations, under dermatologists' guidance. In addition to patient metadata and diagnosis labels, eSkinHealth also includes semantic lesion masks, instance-specific visual captions, and clinical concepts. Overall, our work provides a valuable new resource and a scalable annotation framework, aiming to catalyze the development of more equitable, accurate, and interpretable AI tools for global dermatology.

cs.AI↗

arXiv2025

Quantifying Cross-Attention Interaction in Transformers for Interpreting TCR-pMHC Binding

CD8+ "killer" T cells and CD4+ "helper" T cells play a central role in the adaptive immune system by recognizing antigens presented by Major Histocompatibility Complex (pMHC) molecules via T Cell Receptors (TCRs). Modeling binding between T cells and the pMHC complex is fundamental to understanding basic mechanisms of human immune response as well as in developing therapies. While transformer-based models such as TULIP have achieved impressive performance in this domain, their black-box nature precludes interpretability and thus limits a deeper mechanistic understanding of T cell response. Most existing post-hoc explainable AI (XAI) methods are confined to encoder-only, co-attention, or model-specific architectures and cannot handle encoder-decoder transformers used in TCR-pMHC modeling. To address this gap, we propose Quantifying Cross-Attention Interaction (QCAI), a new post-hoc method designed to interpret the cross-attention mechanisms in transformer decoders. Quantitative evaluation is a challenge for XAI methods; we have compiled TCR-XAI, a benchmark consisting of 274 experimentally determined TCR-pMHC structures to serve as ground truth for binding. Using these structures we compute physical distances between relevant amino acid residues in the TCR-pMHC interaction region and evaluate how well our method and others estimate the importance of residues in this region across the dataset. We show that QCAI achieves state-of-the-art performance on both interpretability and prediction accuracy under the TCR-XAI benchmark.

cs.CE↗

arXiv2025

Doctor Approved: Generating Medically Accurate Skin Disease Images through AI-Expert Feedback

Paucity of medical data severely limits the generalizability of diagnostic ML models, as the full spectrum of disease variability can not be represented by a small clinical dataset. To address this, diffusion models (DMs) have been considered as a promising avenue for synthetic image generation and augmentation. However, they frequently produce medically inaccurate images, deteriorating the model performance. Expert domain knowledge is critical for synthesizing images that correctly encode clinical information, especially when data is scarce and quality outweighs quantity. Existing approaches for incorporating human feedback, such as reinforcement learning (RL) and Direct Preference Optimization (DPO), rely on robust reward functions or demand labor-intensive expert evaluations. Recent progress in Multimodal Large Language Models (MLLMs) reveals their strong visual reasoning capabilities, making them adept candidates as evaluators. In this work, we propose a novel framework, coined MAGIC (Medically Accurate Generation of Images through AI-Expert Collaboration), that synthesizes clinically accurate skin disease images for data augmentation. Our method creatively translates expert-defined criteria into actionable feedback for image synthesis of DMs, significantly improving clinical accuracy while reducing the direct human workload. Experiments demonstrate that our method greatly improves the clinical quality of synthesized skin disease images, with outputs aligning with dermatologist assessments. Additionally, augmenting training data with these synthesized images improves diagnostic accuracy by +9.02% on a challenging 20-condition skin disease classification task, and by +13.89% in the few-shot setting.

cs.CV↗

arXiv2024

Exploiting Aggregation and Segregation of Representations for Domain Adaptive Human Pose Estimation

Human pose estimation (HPE) has received increasing attention recently due to its wide application in motion analysis, virtual reality, healthcare, etc. However, it suffers from the lack of labeled diverse real-world datasets due to the time- and labor-intensive annotation. To cope with the label deficiency issue, one common solution is to train the HPE models with easily available synthetic datasets (source) and apply them to real-world data (target) through domain adaptation (DA). Unfortunately, prevailing domain adaptation techniques within the HPE domain remain predominantly fixated on effecting alignment and aggregation between source and target features, often sidestepping the crucial task of excluding domain-specific representations. To rectify this, we introduce a novel framework that capitalizes on both representation aggregation and segregation for domain adaptive human pose estimation. Within this framework, we address the network architecture aspect by disentangling representations into distinct domain-invariant and domain-specific components, facilitating aggregation of domain-invariant features while simultaneously segregating domain-specific ones. Moreover, we tackle the discrepancy measurement facet by delving into various keypoint relationships and applying separate aggregation or segregation mechanisms to enhance alignment. Extensive experiments on various benchmarks, e.g., Human3.6M, LSP, H3D, and FreiHand, show that our method consistently achieves state-of-the-art performance. The project is available at \url{https://github.com/davidpengucf/EPIC}.

cs.CV↗

arXiv2024

Enhancing Skin Disease Diagnosis: Interpretable Visual Concept Discovery with SAM

Current AI-assisted skin image diagnosis has achieved dermatologist-level performance in classifying skin cancer, driven by rapid advancements in deep learning architectures. However, unlike traditional vision tasks, skin images in general present unique challenges due to the limited availability of well-annotated datasets, complex variations in conditions, and the necessity for detailed interpretations to ensure patient safety. Previous segmentation methods have sought to reduce image noise and enhance diagnostic performance, but these techniques require fine-grained, pixel-level ground truth masks for training. In contrast, with the rise of foundation models, the Segment Anything Model (SAM) has been introduced to facilitate promptable segmentation, enabling the automation of the segmentation process with simple yet effective prompts. Efforts applying SAM predominantly focus on dermatoscopy images, which present more easily identifiable lesion boundaries than clinical photos taken with smartphones. This limitation constrains the practicality of these approaches to real-world applications. To overcome the challenges posed by noisy clinical photos acquired via non-standardized protocols and to improve diagnostic accessibility, we propose a novel Cross-Attentive Fusion framework for interpretable skin lesion diagnosis. Our method leverages SAM to generate visual concepts for skin diseases using prompts, integrating local visual concepts with global image features to enhance model performance. Extensive evaluation on two skin disease datasets demonstrates our proposed method's effectiveness on lesion diagnosis and interpretability.

cs.CV↗

arXiv2024

From Majority to Minority: A Diffusion-based Augmentation for Underrepresented Groups in Skin Lesion Analysis

AI-based diagnoses have demonstrated dermatologist-level performance in classifying skin cancer. However, such systems are prone to under-performing when tested on data from minority groups that lack sufficient representation in the training sets. Although data collection and annotation offer the best means for promoting minority groups, these processes are costly and time-consuming. Prior works have suggested that data from majority groups may serve as a valuable information source to supplement the training of diagnosis tools for minority groups. In this work, we propose an effective diffusion-based augmentation framework that maximizes the use of rich information from majority groups to benefit minority groups. Using groups with different skin types as a case study, our results show that the proposed framework can generate synthetic images that improve diagnostic results for the minority groups, even when there is little or no reference data from these target groups. The practical value of our work is evident in medical imaging analysis, where under-diagnosis persists as a problem for certain groups due to insufficient representation.

cs.CV↗

arXiv2024

Adversarial Bi-Regressor Network for Domain Adaptive Regression

Domain adaptation (DA) aims to transfer the knowledge of a well-labeled source domain to facilitate unlabeled target learning. When turning to specific tasks such as indoor (Wi-Fi) localization, it is essential to learn a cross-domain regressor to mitigate the domain shift. This paper proposes a novel method Adversarial Bi-Regressor Network (ABRNet) to seek more effective cross-domain regression model. Specifically, a discrepant bi-regressor architecture is developed to maximize the difference of bi-regressor to discover uncertain target instances far from the source distribution, and then an adversarial training mechanism is adopted between feature extractor and dual regressors to produce domain-invariant representations. To further bridge the large domain gap, a domain-specific augmentation module is designed to synthesize two source-similar and target-similar intermediate domains to gradually eliminate the original domain mismatch. The empirical studies on two cross-domain regressive benchmarks illustrate the power of our method on solving the domain adaptive regression (DAR) problem.

cs.HC↗