arXiv subjects

Zhengming Ding

Publications and source records attributed to Zhengming Ding.

At least 37 records · Page 2Linked to original sources

arXiv2025

Enhancing Skin Disease Diagnosis: Interpretable Visual Concept Discovery with SAM

Current AI-assisted skin image diagnosis has achieved dermatologist-level performance in classifying skin cancer, driven by rapid advancements in deep learning architectures. However, unlike traditional vision tasks, skin images in general present unique challenges due to the limited availability of well-annotated datasets, complex variations in conditions, and the necessity for detailed interpretations to ensure patient safety. Previous segmentation methods have sought to reduce image noise and enhance diagnostic performance, but these techniques require fine-grained, pixel-level ground truth masks for training. In contrast, with the rise of foundation models, the Segment Anything Model (SAM) has been introduced to facilitate promptable segmentation, enabling the automation of the segmentation process with simple yet effective prompts. Efforts applying SAM predominantly focus on dermatoscopy images, which present more easily identifiable lesion boundaries than clinical photos taken with smartphones. This limitation constrains the practicality of these approaches to real-world applications. To overcome the challenges posed by noisy clinical photos acquired via non-standardized protocols and to improve diagnostic accessibility, we propose a novel Cross-Attentive Fusion framework for interpretable skin lesion diagnosis. Our method leverages SAM to generate visual concepts for skin diseases using prompts, integrating local visual concepts with global image features to enhance model performance. Extensive evaluation on two skin disease datasets demonstrates our proposed method's effectiveness on lesion diagnosis and interpretability.

cs.CV↗

arXiv2024

Exploiting Aggregation and Segregation of Representations for Domain Adaptive Human Pose Estimation

Human pose estimation (HPE) has received increasing attention recently due to its wide application in motion analysis, virtual reality, healthcare, etc. However, it suffers from the lack of labeled diverse real-world datasets due to the time- and labor-intensive annotation. To cope with the label deficiency issue, one common solution is to train the HPE models with easily available synthetic datasets (source) and apply them to real-world data (target) through domain adaptation (DA). Unfortunately, prevailing domain adaptation techniques within the HPE domain remain predominantly fixated on effecting alignment and aggregation between source and target features, often sidestepping the crucial task of excluding domain-specific representations. To rectify this, we introduce a novel framework that capitalizes on both representation aggregation and segregation for domain adaptive human pose estimation. Within this framework, we address the network architecture aspect by disentangling representations into distinct domain-invariant and domain-specific components, facilitating aggregation of domain-invariant features while simultaneously segregating domain-specific ones. Moreover, we tackle the discrepancy measurement facet by delving into various keypoint relationships and applying separate aggregation or segregation mechanisms to enhance alignment. Extensive experiments on various benchmarks, e.g., Human3.6M, LSP, H3D, and FreiHand, show that our method consistently achieves state-of-the-art performance. The project is available at \url{https://github.com/davidpengucf/EPIC}.

cs.CV↗

arXiv2024

From Majority to Minority: A Diffusion-based Augmentation for Underrepresented Groups in Skin Lesion Analysis

AI-based diagnoses have demonstrated dermatologist-level performance in classifying skin cancer. However, such systems are prone to under-performing when tested on data from minority groups that lack sufficient representation in the training sets. Although data collection and annotation offer the best means for promoting minority groups, these processes are costly and time-consuming. Prior works have suggested that data from majority groups may serve as a valuable information source to supplement the training of diagnosis tools for minority groups. In this work, we propose an effective diffusion-based augmentation framework that maximizes the use of rich information from majority groups to benefit minority groups. Using groups with different skin types as a case study, our results show that the proposed framework can generate synthetic images that improve diagnostic results for the minority groups, even when there is little or no reference data from these target groups. The practical value of our work is evident in medical imaging analysis, where under-diagnosis persists as a problem for certain groups due to insufficient representation.

cs.CV↗

arXiv2024

Adversarial Bi-Regressor Network for Domain Adaptive Regression

Domain adaptation (DA) aims to transfer the knowledge of a well-labeled source domain to facilitate unlabeled target learning. When turning to specific tasks such as indoor (Wi-Fi) localization, it is essential to learn a cross-domain regressor to mitigate the domain shift. This paper proposes a novel method Adversarial Bi-Regressor Network (ABRNet) to seek more effective cross-domain regression model. Specifically, a discrepant bi-regressor architecture is developed to maximize the difference of bi-regressor to discover uncertain target instances far from the source distribution, and then an adversarial training mechanism is adopted between feature extractor and dual regressors to produce domain-invariant representations. To further bridge the large domain gap, a domain-specific augmentation module is designed to synthesize two source-similar and target-similar intermediate domains to gradually eliminate the original domain mismatch. The empirical studies on two cross-domain regressive benchmarks illustrate the power of our method on solving the domain adaptive regression (DAR) problem.

cs.HC↗

arXiv2024

A Demographic-Conditioned Variational Autoencoder for fMRI Distribution Sampling and Removal of Confounds

Objective: fMRI and derived measures such as functional connectivity (FC) have been used to predict brain age, general fluid intelligence, psychiatric disease status, and preclinical neurodegenerative disease. However, it is not always clear that all demographic confounds, such as age, sex, and race, have been removed from fMRI data. Additionally, many fMRI datasets are restricted to authorized researchers, making dissemination of these valuable data sources challenging. Methods: We create a variational autoencoder (VAE)-based model, DemoVAE, to decorrelate fMRI features from demographics and generate high-quality synthetic fMRI data based on user-supplied demographics. We train and validate our model using two large, widely used datasets, the Philadelphia Neurodevelopmental Cohort (PNC) and Bipolar and Schizophrenia Network for Intermediate Phenotypes (BSNIP). Results: We find that DemoVAE recapitulates group differences in fMRI data while capturing the full breadth of individual variations. Significantly, we also find that most clinical and computerized battery fields that are correlated with fMRI data are not correlated with DemoVAE latents. An exception are several fields related to schizophrenia medication and symptom severity. Conclusion: Our model generates fMRI data that captures the full distribution of FC better than traditional VAE or GAN models. We also find that most prediction using fMRI data is dependent on correlation with, and prediction of, demographics. Significance: Our DemoVAE model allows for generation of high quality synthetic data conditioned on subject demographics as well as the removal of the confounding effects of demographics. We identify that FC-based prediction tasks are highly influenced by demographic confounds.

q-bio.QM↗

arXiv2024

Achieving Reliable and Fair Skin Lesion Diagnosis via Unsupervised Domain Adaptation

The development of reliable and fair diagnostic systems is often constrained by the scarcity of labeled data. To address this challenge, our work explores the feasibility of unsupervised domain adaptation (UDA) to integrate large external datasets for developing reliable classifiers. The adoption of UDA with multiple sources can simultaneously enrich the training set and bridge the domain gap between different skin lesion datasets, which vary due to distinct acquisition protocols. Particularly, UDA shows practical promise for improving diagnostic reliability when training with a custom skin lesion dataset, where only limited labeled data are available from the target domain. In this study, we investigate three UDA training schemes based on source data utilization: single-source, combined-source, and multi-source UDA. Our findings demonstrate the effectiveness of applying UDA on multiple sources for binary and multi-class classification. A strong correlation between test error and label shift in multi-class tasks has been observed in the experiment. Crucially, our study shows that UDA can effectively mitigate bias against minority groups and enhance fairness in diagnostic systems, while maintaining superior classification performance. This is achieved even without directly implementing fairness-focused techniques. This success is potentially attributed to the increased and well-adapted demographic information obtained from multiple sources.

cs.CV↗

arXiv2024

GCC: Generative Calibration Clustering

Deep clustering as an important branch of unsupervised representation learning focuses on embedding semantically similar samples into the identical feature space. This core demand inspires the exploration of contrastive learning and subspace clustering. However, these solutions always rely on the basic assumption that there are sufficient and category-balanced samples for generating valid high-level representation. This hypothesis actually is too strict to be satisfied for real-world applications. To overcome such a challenge, the natural strategy is utilizing generative models to augment considerable instances. How to use these novel samples to effectively fulfill clustering performance improvement is still difficult and under-explored. In this paper, we propose a novel Generative Calibration Clustering (GCC) method to delicately incorporate feature learning and augmentation into clustering procedure. First, we develop a discriminative feature alignment mechanism to discover intrinsic relationship across real and generated samples. Second, we design a self-supervised metric learning to generate more reliable cluster assignment to boost the conditional diffusion generation. Extensive experimental results on three benchmarks validate the effectiveness and advantage of our proposed method over the state-of-the-art methods.

cs.CV↗

arXiv2024

Sketch3D: Style-Consistent Guidance for Sketch-to-3D Generation

Recently, image-to-3D approaches have achieved significant results with a natural image as input. However, it is not always possible to access these enriched color input samples in practical applications, where only sketches are available. Existing sketch-to-3D researches suffer from limitations in broad applications due to the challenges of lacking color information and multi-view content. To overcome them, this paper proposes a novel generation paradigm Sketch3D to generate realistic 3D assets with shape aligned with the input sketch and color matching the textual description. Concretely, Sketch3D first instantiates the given sketch in the reference image through the shape-preserving generation process. Second, the reference image is leveraged to deduce a coarse 3D Gaussian prior, and multi-view style-consistent guidance images are generated based on the renderings of the 3D Gaussians. Finally, three strategies are designed to optimize 3D Gaussians, i.e., structural optimization via a distribution transfer mechanism, color optimization with a straightforward MSE loss and sketch similarity optimization with a CLIP-based geometric similarity loss. Extensive visual comparisons and quantitative analysis illustrate the advantage of our Sketch3D in generating realistic 3D assets while preserving consistency with the input.

cs.CV↗

arXiv2024

An Interpretable Cross-Attentive Multi-modal MRI Fusion Framework for Schizophrenia Diagnosis

Both functional and structural magnetic resonance imaging (fMRI and sMRI) are widely used for the diagnosis of mental disorder. However, combining complementary information from these two modalities is challenging due to their heterogeneity. Many existing methods fall short of capturing the interaction between these modalities, frequently defaulting to a simple combination of latent features. In this paper, we propose a novel Cross-Attentive Multi-modal Fusion framework (CAMF), which aims to capture both intra-modal and inter-modal relationships between fMRI and sMRI, enhancing multi-modal data representation. Specifically, our CAMF framework employs self-attention modules to identify interactions within each modality while cross-attention modules identify interactions between modalities. Subsequently, our approach optimizes the integration of latent features from both modalities. This approach significantly improves classification accuracy, as demonstrated by our evaluations on two extensive multi-modal brain imaging datasets, where CAMF consistently outperforms existing methods. Furthermore, the gradient-guided Score-CAM is applied to interpret critical functional networks and brain regions involved in schizophrenia. The bio-markers identified by CAMF align with established research, potentially offering new insights into the diagnosis and pathological endophenotypes of schizophrenia.

eess.IV↗

arXiv2024

Exploring General Intelligence via Gated Graph Transformer in Functional Connectivity Studies

Functional connectivity (FC) as derived from fMRI has emerged as a pivotal tool in elucidating the intricacies of various psychiatric disorders and delineating the neural pathways that underpin cognitive and behavioral dynamics inherent to the human brain. While Graph Neural Networks (GNNs) offer a structured approach to represent neuroimaging data, they are limited by their need for a predefined graph structure to depict associations between brain regions, a detail not solely provided by FCs. To bridge this gap, we introduce the Gated Graph Transformer (GGT) framework, designed to predict cognitive metrics based on FCs. Empirical validation on the Philadelphia Neurodevelopmental Cohort (PNC) underscores the superior predictive prowess of our model, further accentuating its potential in identifying pivotal neural connectivities that correlate with human cognitive processes.

q-bio.NC↗

arXiv2023

Mining Label Distribution Drift in Unsupervised Domain Adaptation

Unsupervised domain adaptation targets to transfer task-related knowledge from labeled source domain to unlabeled target domain. Although tremendous efforts have been made to minimize domain divergence, most existing methods only partially manage by aligning feature representations from diverse domains. Beyond the discrepancy in data distribution, the gap between source and target label distribution, recognized as label distribution drift, is another crucial factor raising domain divergence, and has been under insufficient exploration. From this perspective, we first reveal how label distribution drift brings negative influence. Next, we propose Label distribution Matching Domain Adversarial Network (LMDAN) to handle data distribution shift and label distribution drift jointly. In LMDAN, label distribution drift is addressed by a source sample weighting strategy, which selects samples that contribute to positive adaptation and avoid adverse effects brought by the mismatched samples. Experiments show that LMDAN delivers superior performance under considerable label distribution drift.

cs.CV↗

arXiv2023

Create Your World: Lifelong Text-to-Image Diffusion

Text-to-image generative models can produce diverse high-quality images of concepts with a text prompt, which have demonstrated excellent ability in image generation, image translation, etc. We in this work study the problem of synthesizing instantiations of a use's own concepts in a never-ending manner, i.e., create your world, where the new concepts from user are quickly learned with a few examples. To achieve this goal, we propose a Lifelong text-to-image Diffusion Model (L2DM), which intends to overcome knowledge "catastrophic forgetting" for the past encountered concepts, and semantic "catastrophic neglecting" for one or more concepts in the text prompt. In respect of knowledge "catastrophic forgetting", our L2DM framework devises a task-aware memory enhancement module and a elastic-concept distillation module, which could respectively safeguard the knowledge of both prior concepts and each past personalized concept. When generating images with a user text prompt, the solution to semantic "catastrophic neglecting" is that a concept attention artist module can alleviate the semantic neglecting from concept aspect, and an orthogonal attention module can reduce the semantic binding from attribute aspect. To the end, our model can generate more faithful image across a range of continual text prompts in terms of both qualitative and quantitative metrics, when comparing with the related state-of-the-art models. The code will be released at https://wenqiliang.github.io/.

cs.CV↗

arXiv2023

iBARLE: imBalance-Aware Room Layout Estimation

Room layout estimation predicts layouts from a single panorama. It requires datasets with large-scale and diverse room shapes to train the models. However, there are significant imbalances in real-world datasets including the dimensions of layout complexity, camera locations, and variation in scene appearance. These issues considerably influence the model training performance. In this work, we propose the imBalance-Aware Room Layout Estimation (iBARLE) framework to address these issues. iBARLE consists of (1) Appearance Variation Generation (AVG) module, which promotes visual appearance domain generalization, (2) Complex Structure Mix-up (CSMix) module, which enhances generalizability w.r.t. room structure, and (3) a gradient-based layout objective function, which allows more effective accounting for occlusions in complex layouts. All modules are jointly trained and help each other to achieve the best performance. Experiments and ablation studies based on ZInD~\cite{cruz2021zillow} dataset illustrate that iBARLE has state-of-the-art performance compared with other layout estimation baselines.

cs.CV↗

arXiv2023

RAIN: RegulArization on Input and Network for Black-Box Domain Adaptation

Source-Free domain adaptation transits the source-trained model towards target domain without exposing the source data, trying to dispel these concerns about data privacy and security. However, this paradigm is still at risk of data leakage due to adversarial attacks on the source model. Hence, the Black-Box setting only allows to use the outputs of source model, but still suffers from overfitting on the source domain more severely due to source model's unseen weights. In this paper, we propose a novel approach named RAIN (RegulArization on Input and Network) for Black-Box domain adaptation from both input-level and network-level regularization. For the input-level, we design a new data augmentation technique as Phase MixUp, which highlights task-relevant objects in the interpolations, thus enhancing input-level regularization and class consistency for target models. For network-level, we develop a Subnetwork Distillation mechanism to transfer knowledge from the target subnetwork to the full target network via knowledge distillation, which thus alleviates overfitting on the source domain by learning diverse target representations. Extensive experiments show that our method achieves state-of-the-art performance on several cross-domain benchmarks under both single- and multi-source black-box domain adaptation.

cs.CV↗

arXiv2023

Angle Basis: a Generative Model and Decomposition for Functional Connectivity

Functional connectivity (FC) is one of the most common inputs to fMRI-based predictive models, due to a combination of its simplicity and robustness. However, there may be a lack of theoretical models for the generation of FC. In this work, we present a straightforward decomposition of FC into a set of basis states of sine waves with an additional jitter component. We show that the decomposition matches the predictive ability of FC after including 5-10 bases. We also find that both the decomposition and its residual have approximately equal predictive value, and when combined into an ensemble, exceed the AUC of FC-based prediction by up to 5%. Additionally, we find the residual can be used for subject fingerprinting, with 97.3% same-subject, different-scan identifiability, compared to 62.5% for FC. Unlike PCA or Factor Analysis methods, our method does not require knowledge of a population to perform its decomposition; a single subject is enough. Our decomposition of FC into two equally-predictive components may lead to a novel appreciation of group differences in patient populations. Additionally, we generate synthetic patient FC based on user-specified characteristics such as age, sex, and disease diagnosis. By creating synthetic datasets or augmentations we may reduce the high financial burden associated with fMRI data acquisition.

q-bio.NC↗

arXiv2023

CLCLSA: Cross-omics Linked embedding with Contrastive Learning and Self Attention for multi-omics integration with incomplete multi-omics data

Integration of heterogeneous and high-dimensional multi-omics data is becoming increasingly important in understanding genetic data. Each omics technique only provides a limited view of the underlying biological process and integrating heterogeneous omics layers simultaneously would lead to a more comprehensive and detailed understanding of diseases and phenotypes. However, one obstacle faced when performing multi-omics data integration is the existence of unpaired multi-omics data due to instrument sensitivity and cost. Studies may fail if certain aspects of the subjects are missing or incomplete. In this paper, we propose a deep learning method for multi-omics integration with incomplete data by Cross-omics Linked unified embedding with Contrastive Learning and Self Attention (CLCLSA). Utilizing complete multi-omics data as supervision, the model employs cross-omics autoencoders to learn the feature representation across different types of biological data. The multi-omics contrastive learning, which is used to maximize the mutual information between different types of omics, is employed before latent feature concatenation. In addition, the feature-level self-attention and omics-level self-attention are employed to dynamically identify the most informative features for multi-omics data integration. Extensive experiments were conducted on four public multi-omics datasets. The experimental results indicated that the proposed CLCLSA outperformed the state-of-the-art approaches for multi-omics data classification using incomplete multi-omics data.

cs.LG↗

arXiv2023

Polyline Generative Navigable Space Segmentation for Autonomous Visual Navigation

Detecting navigable space is a fundamental capability for mobile robots navigating in unknown or unmapped environments. In this work, we treat visual navigable space segmentation as a scene decomposition problem and propose Polyline Segmentation Variational autoencoder Network (PSV-Net), a representation learning-based framework for learning the navigable space segmentation in a self-supervised manner. Current segmentation techniques heavily rely on fully-supervised learning strategies which demand a large amount of pixel-level annotated images. In this work, we propose a framework leveraging a Variational AutoEncoder (VAE) and an AutoEncoder (AE) to learn a polyline representation that compactly outlines the desired navigable space boundary. Through extensive experiments, we validate that the proposed PSV-Net can learn the visual navigable space with no or few labels, producing an accuracy comparable to fully-supervised state-of-the-art methods that use all available labels. In addition, we show that integrating the proposed navigable space segmentation model with a visual planner can achieve efficient mapless navigation in real environments.

cs.CV↗

arXiv2023

IDA: Informed Domain Adaptive Semantic Segmentation

Mixup-based data augmentation has been validated to be a critical stage in the self-training framework for unsupervised domain adaptive semantic segmentation (UDA-SS), which aims to transfer knowledge from a well-annotated (source) domain to an unlabeled (target) domain. Existing self-training methods usually adopt the popular region-based mixup techniques with a random sampling strategy, which unfortunately ignores the dynamic evolution of different semantics across various domains as training proceeds. To improve the UDA-SS performance, we propose an Informed Domain Adaptation (IDA) model, a self-training framework that mixes the data based on class-level segmentation performance, which aims to emphasize small-region semantics during mixup. In our IDA model, the class-level performance is tracked by an expected confidence score (ECS). We then use a dynamic schedule to determine the mixing ratio for data in different domains. Extensive experimental results reveal that our proposed method is able to outperform the state-of-the-art UDA-SS method by a margin of 1.1 mIoU in the adaptation of GTA-V to Cityscapes and of 0.9 mIoU in the adaptation of SYNTHIA to Cityscapes.

cs.CV↗