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arXiv · 1502.02775

Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm

Shuo Diao·Jeffrey L. Blackburn·Guosong Hong·Alexander L. Antaris·Junlei Chang·Justin Z. Wu·Bo Zhang·Kai Cheng·Calvin J. Kuo·Hongjie Dai
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Abstract

Compared to imaging in the visible and near-infrared regions below 900 nm, imaging in the second near-infrared window (NIR-II, 1000-1700 nm) is a promising method for deep-tissue high-resolution optical imaging in vivo mainly due to the reduced scattering of photons traversing through biological tissues. Herein, semiconducting single-walled carbon nanotubes with large diameters were used for in vivo fluorescence imaging in the long-wavelength NIR region (1500-1700 nm, NIR-IIb). With this imaging agent, 3-4 um wide capillary blood vessels at a depth of about 3 mm could be resolved. Meanwhile, the blood-flow speeds in multiple individual vessels could be mapped simultaneously. Furthermore, NIR-IIb tumor imaging of a live mouse was explored. NIR-IIb imaging can be generalized to a wide range of fluorophores emitting at up to 1700 nm for high-performance in vivo optical imaging.

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Shuo Diao, Jeffrey L. Blackburn, Guosong Hong, Alexander L. Antaris, Junlei Chang, Justin Z. Wu, Bo Zhang, Kai Cheng, Calvin J. Kuo, Hongjie Dai. 2015-02-10. Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm. https://doi.org/10.1002/anie.201507473

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