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arXiv · 1712.04525

Scalable Graphene Aptasensors for Drug Quantification

Ramya Vishnubhotla·Jinglei Ping·Zhaoli Gao·Abigail Lee·Olivia Saouaf·Amey Vrudhula·A. T. Charlie Johnson
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Abstract

Simpler and more rapid approaches for therapeutic drug-level monitoring are highly desirable to enable use at the point-of-care. We have developed an all-electronic approach for detection of the HIV drug tenofovir based on scalable fabrication of arrays of graphene field-effect transistors (GFETs) functionalized with a commercially available DNA aptamer. The shift in the Dirac voltage of the GFETs varied systematically with the concentration of tenofovir in deionized water, with a detection limit less than 1 ng/mL. Tests against a set of negative controls confirmed the specificity of the sensor response. This approach offers the potential for further development into a rapid and convenient point-of-care tool with clinically relevant performance.

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Ramya Vishnubhotla, Jinglei Ping, Zhaoli Gao, Abigail Lee, Olivia Saouaf, Amey Vrudhula, A. T. Charlie Johnson. 2017-12-12. Scalable Graphene Aptasensors for Drug Quantification. https://doi.org/10.1063/1.4990798

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