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arXiv · 2402.09803

An Inverse Problems Approach to Pulse Wave Analysis in the Human Brain

Lukas Weissinger·Simon Hubmer·Ronny Ramlau·Henning Uwe Voss
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Abstract

Cardiac pulsations in the human brain have received recent interest due to their possible role in the pathogenesis of neurodegenerative diseases. Further interest stems from their possible application as an endogenous signal source that can be utilized for brain imaging in general. The (pulse-)wave describing the blood flow velocity along an intracranial artery consists of a forward (anterograde) and a backward (retrograde, reflected) part, but measurements of this wave usually consist of a superposition of these components. In this paper, we provide a mathematical framework for the inverse problem of estimating the pulse wave velocity, as well as the forward and backward component of the pulse wave separately from MRI measurements on intracranial arteries. After a mathematical analysis of this problem, we consider possible reconstruction approaches, and derive an alternate direction approach for its solution. The resulting methods provide estimates for anterograde/retrograde wave forms and the pulse wave velocity under specified assumptions on a cerebrovascular model system. Numerical experiments on simulated and experimental data demonstrate the applicability and preliminary in vivo feasibility of the proposed methods.

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Lukas Weissinger, Simon Hubmer, Ronny Ramlau, Henning Uwe Voss. 2024-02-15. An Inverse Problems Approach to Pulse Wave Analysis in the Human Brain. https://doi.org/10.1137/24m163921x

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